{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:24:25Z","timestamp":1793881465569,"version":"4.7.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T00:00:00Z","timestamp":1449187200000},"content-version":"vor","delay-in-days":1464,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology Symposium Proceedings"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1038\/jidsymp.2011.7","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T09:56:00Z","timestamp":1320918960000},"page":"2-11","source":"Crossref","is-referenced-by-count":239,"title":["Clinical, Cellular, and Molecular Aspects in the Pathophysiology of Rosacea"],"prefix":"10.1016","volume":"15","author":[{"given":"Martin","family":"Steinhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Buddenkotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Aubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Sulk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena D.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Mess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferda","family":"Cevikbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Rivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Carlavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"D\u00e9ret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Rosignoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Metze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Luger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes J.","family":"Voegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jidsymp.2011.7_bb0010","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1468-3083.2009.03472.x","article-title":"Risk factors associated with rosacea","volume":"24","author":"Abram","year":"2010","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1038\/jidsymp.2011.7_bb0015","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2340\/00015555-0856","article-title":"Prevalence of rosacea in an Estonian working population using a standard classification","volume":"90","author":"Abram","year":"2010","journal-title":"Acta Derm Venereol"},{"key":"10.1038\/jidsymp.2011.7_bb0020","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00402621","article-title":"The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne","volume":"282","author":"Akamatsu","year":"1990","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/jidsymp.2011.7_bb0025","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0190-9622(00)90220-2","article-title":"The clinicopathologic spectrum of rhinophyma","volume":"42","author":"Aloi","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0030","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00403-007-0816-z","article-title":"A study of the pathogenesis of rosacea: how angiogenesis and mast cells may participate in a complex multifactorial process","volume":"300","author":"Aroni","year":"2008","journal-title":"Arch Dermatol Res"},{"key":"10.1038\/jidsymp.2011.7_bb0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/jidsymp.2011.8","article-title":"Neurovascular aspects of skin neurogenic inflammation","volume":"15","author":"Aubdool","year":"2011","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1038\/jidsymp.2011.7_bb0040","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2230.2006.02322.x","article-title":"The effect of azithromycin on reactive oxygen species in rosacea","volume":"32","author":"Bakar","year":"2007","journal-title":"Clin Exp Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0045","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1053\/sder.2001.27553","article-title":"Rosacea: current thoughts on origin","volume":"20","author":"Bamford","year":"2001","journal-title":"Semin Cutan Med Surg"},{"key":"10.1038\/jidsymp.2011.7_bb0050","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1600-0625.2008.00716.x","article-title":"Tetracycline suppresses ATP gamma S-induced CXCL8 and CXCL1 production by the human dermal microvascular endothelial cell-1 (HMEC-1) cell line and primary human dermal microvascular endothelial cells","volume":"17","author":"Bender","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0055","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1038\/jidsymp.2011.7_bb0060","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/jcp.21750","article-title":"Role of connective tissue growth factor and its interaction with basic fibroblast growth factor and macrophage chemoattractant protein-1 in skin fibrosis","volume":"220","author":"Chujo","year":"2009","journal-title":"J Cell Physiol"},{"key":"10.1038\/jidsymp.2011.7_bb0065","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jaad.2005.07.021","article-title":"Symptomatic treatment of idiopathic and rosacea-associated cutaneous flushing with propranolol","volume":"53","author":"Craige","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20100965","article-title":"Proteases as therapeutics","volume":"435","author":"Craik","year":"2011","journal-title":"Biochem J"},{"key":"10.1038\/jidsymp.2011.7_bb0075","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jaad.2004.03.030","article-title":"Rosacea: I. Etiology, pathogenesis, and subtype classification","volume":"51","author":"Crawford","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0080","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jaad.2003.05.005","article-title":"Temperature regulates bacterial protein production: possible role in rosacea","volume":"50","author":"Dahl","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0085","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1549-8719.2010.00026.x","article-title":"Vanilloid and melastatin transient receptor potential channels in vascular smooth muscle","volume":"17","author":"Earley","year":"2010","journal-title":"Microcirculation"},{"key":"10.1038\/jidsymp.2011.7_bb0090","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1369\/jhc.2009.952572","article-title":"Expression of integrin alphavbeta6 and TGF-beta in scarless versus scar-forming wound healing","volume":"57","author":"Eslami","year":"2009","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/jidsymp.2011.7_bb0095","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/archderm.130.4.509","article-title":"Acquired persistent erythematous patch on the neck. Acquired nevus flammeus","volume":"130","author":"Flint","year":"1994","journal-title":"Arch Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0100","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2165\/11537020-000000000-00000","article-title":"Rosacea treatments: what's new and what's on the horizon?","volume":"11","author":"Gallo","year":"2010","journal-title":"Am J Clin Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0105","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/jidsymp.2011.9","article-title":"Rosacea: the cytokine and chemokine network","volume":"15","author":"Gerber","year":"2011","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1038\/jidsymp.2011.7_bb0110","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/ana.22126","article-title":"Capsaicin induces degeneration of cutaneous autonomic nerve fibers","volume":"68","author":"Gibbons","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1038\/jidsymp.2011.7_bb0115","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/j.1600-0560.2006.00695.x","article-title":"Lymphangiogenesis and angiogenesis in non-phymatous rosacea","volume":"34","author":"Gomaa","year":"2007","journal-title":"J Cutan Pathol"},{"key":"10.1038\/jidsymp.2011.7_bb0120","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1124\/jpet.110.172403","article-title":"4-Oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo","volume":"337","author":"Graepel","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/jidsymp.2011.7_bb0125","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1046\/j.1523-1747.2001.01284.x","article-title":"Expression of mast cell growth modulating and chemotactic factors and their receptors in human cutaneous scars","volume":"116","author":"Hermes","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0130","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tips.2010.05.008","article-title":"Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: clinical and therapeutic implications","volume":"31","author":"Hua","year":"2010","journal-title":"Trends Pharmacol Sci"},{"key":"10.1038\/jidsymp.2011.7_bb0135","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/jidsymp.2011.5","article-title":"The cutaneous vascular system in chronic skin inflammation","volume":"15","author":"Huggenberger","year":"2011","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1038\/jidsymp.2011.7_bb0140","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1084\/jem.20100559","article-title":"Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation","volume":"207","author":"Huggenberger","year":"2010","journal-title":"J Exp Med"},{"key":"10.1038\/jidsymp.2011.7_bb0145","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1365-2133.2007.08028.x","article-title":"Mite-related bacterial antigens stimulate inflammatory cells in rosacea","volume":"157","author":"Lacey","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0150","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1468-3083.2009.03424.x","article-title":"Clinical and laboratory study of rosacea in northern Greece","volume":"24","author":"Lazaridou","year":"2010","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1038\/jidsymp.2011.7_bb0155","first-page":"21","article-title":"The potential role of microorganisms in the development of rosacea","volume":"9","author":"Lazaridou","year":"2011","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1038\/jidsymp.2011.7_bb0160","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1002\/art.24801","article-title":"Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model","volume":"60","author":"Liu","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1038\/jidsymp.2011.7_bb0165","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1172\/JCI43426","article-title":"Labeled lines meet and talk: population coding of somatic sensations","volume":"120","author":"Ma","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1038\/jidsymp.2011.7_bb0170","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00417-005-0212-3","article-title":"Tear fluid levels of MMP-8 are elevated in ocular rosacea\u2014treatment effect of oral doxycycline","volume":"244","author":"Maatta","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1038\/jidsymp.2011.7_bb0175","first-page":"742","article-title":"Histogenesis of the inflammatory component of rosacea","volume":"66","author":"Marks","year":"1973","journal-title":"Proc R Soc Med"},{"key":"10.1038\/jidsymp.2011.7_bb0180","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/09546630701485233","article-title":"The enigma of rosacea","volume":"18","author":"Marks","year":"2007","journal-title":"J Dermatol Treat"},{"key":"10.1038\/jidsymp.2011.7_bb0185","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/archderm.1969.01610300033005","article-title":"Histopathology of rosacea","volume":"100","author":"Marks","year":"1969","journal-title":"Arch Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0190","first-page":"663","article-title":"The pathophysiology of rosacea","volume":"144","author":"Mc Aleer","year":"2009","journal-title":"G Ital Dermatol Venereol"},{"key":"10.1038\/jidsymp.2011.7_bb0195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jaad.2009.04.024","article-title":"Papulopustular rosacea: prevalence and relationship to photodamage","volume":"63","author":"McAleer","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0200","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1001\/archneur.55.12.1513","article-title":"Epidermal nerve fiber density: normative reference range and diagnostic efficiency","volume":"55","author":"McArthur","year":"1998","journal-title":"Arch Neurol"},{"key":"10.1038\/jidsymp.2011.7_bb0205","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/jidsymp.2011.2","article-title":"Epidermal proteases in the pathogenesis of rosacea","volume":"15","author":"Meyer-Hoffert","year":"2011","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1038\/jidsymp.2011.7_bb0210","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nature04946","article-title":"Intracellular pattern recognition receptors in the host response","volume":"442","author":"Meylan","year":"2006","journal-title":"Nature"},{"key":"10.1038\/jidsymp.2011.7_bb0215","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1540-9740.2003.01876.x","article-title":"The proposed inflammatory pathophysiology of rosacea: implications for treatment","volume":"2","author":"Millikan","year":"2003","journal-title":"Skinmed"},{"key":"10.1038\/jidsymp.2011.7_bb0220","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/jid.2009.435","article-title":"Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid","volume":"130","author":"Morizane","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0225","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/cne.22560","article-title":"Developmental expression of delta-opioid receptors during maturation of the parasympathetic, sympathetic, and sensory innervations of the neonatal heart: early targets for opioid regulation of autonomic control","volume":"519","author":"Mousa","year":"2011","journal-title":"J Comp Neurol"},{"key":"10.1038\/jidsymp.2011.7_bb0230","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-pathol-011110-130224","article-title":"Mechanisms of leukocyte transendothelial migration","volume":"6","author":"Muller","year":"2011","journal-title":"Annu Rev Pathol"},{"key":"10.1038\/jidsymp.2011.7_bb0235","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/lrb.2008.63404","article-title":"Molecular targets for therapeutic lymphangiogenesis in lymphatic dysfunction and disease","volume":"6","author":"Nakamura","year":"2008","journal-title":"Lymphat Res Biol"},{"key":"10.1038\/jidsymp.2011.7_bb0240","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/lrb.2010.0019","article-title":"Molecular characterization of dermal lymphatic endothelial cells from primary lymphedema skin","volume":"9","author":"Ogunbiyi","year":"2011","journal-title":"Lymphat Res Biol"},{"key":"10.1038\/jidsymp.2011.7_bb0245","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMcp042829","article-title":"Clinical practice. Rosacea","volume":"352","author":"Powell","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1038\/jidsymp.2011.7_bb0250","first-page":"801","article-title":"Rosacea: histopathologic study of 75 cases","volume":"115","author":"Ramelet","year":"1988","journal-title":"Ann Dermatol Venereol"},{"key":"10.1038\/jidsymp.2011.7_bb0255","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1152\/physrev.00026.2005","article-title":"Neuronal control of skin function: the skin as a neuroimmunoendocrine organ","volume":"86","author":"Roosterman","year":"2006","journal-title":"Physiol Rev"},{"key":"10.1038\/jidsymp.2011.7_bb0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000249558","article-title":"T-cell subsets in acne rosacea lesions and the possible role of Demodex folliculorum","volume":"169","author":"Rufli","year":"1984","journal-title":"Dermatologica"},{"key":"10.1038\/jidsymp.2011.7_bb0265","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1001\/archdermatol.2010.413","article-title":"Neurogenic rosacea: a distinct clinical subtype requiring a modified approach to treatment","volume":"147","author":"Scharschmidt","year":"2011","journal-title":"Arch Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0270","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/jidsymp.2011.6","article-title":"Neurovascular and neuroimmune aspects in the pathophysiology of rosacea","volume":"15","author":"Schwab","year":"2011","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1038\/jidsymp.2011.7_bb0275","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1001\/archderm.143.11.1369","article-title":"Successful treatment of the erythema and flushing of rosacea using a topically applied selective alpha1-adrenergic receptor agonist, oxymetazoline","volume":"143","author":"Shanler","year":"2007","journal-title":"Arch Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0280","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2174\/1871530311006040320","article-title":"Wound-associated skin fibrosis: mechanisms and treatments based on modulating the inflammatory response","volume":"10","author":"Shaw","year":"2010","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"10.1038\/jidsymp.2011.7_bb0285","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/bjo.2006.101121","article-title":"Expression of vascular endothelial growth factor and its receptors in rosacea","volume":"91","author":"Smith","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"10.1038\/jidsymp.2011.7_bb0290","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1365-2133.1987.tb07349.x","article-title":"Effect of PUVA on plasma and skin immunoreactive alpha-melanocyte stimulating hormone concentrations","volume":"117","author":"Spiro","year":"1987","journal-title":"Br J Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2003-0025","article-title":"Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response","volume":"26","author":"Steinhoff","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1038\/jidsymp.2011.7_bb0300","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1001\/archderm.139.11.1479","article-title":"Modern aspects of cutaneous neurogenic inflammation","volume":"139","author":"Steinhoff","year":"2003","journal-title":"Arch Dermatol"},{"issue":"Suppl 11","key":"10.1038\/jidsymp.2011.7_bb0305","first-page":"S15","article-title":"Molecular and morphometric characterization of neuroinflammatory and neurovascular changes in the development of rosacea","volume":"130","author":"Steinhoff","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0310","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/72247","article-title":"Agonists of proteinase-activated receptor-2 induce inflammation by a neurogenic mechanism","volume":"6","author":"Steinhoff","year":"2000","journal-title":"Nat Med"},{"key":"10.1038\/jidsymp.2011.7_bb0315","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.clindermatol.2010.03.002","article-title":"The role of Helicobacter pylori infection in skin diseases: facts and controversies","volume":"28","author":"Tuzun","year":"2010","journal-title":"Clin Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0320","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nm.2092","article-title":"Kynurenine is an endothelium-derived relaxing factor produced during inflammation","volume":"16","author":"Wang","year":"2010","journal-title":"Nat Med"},{"key":"10.1038\/jidsymp.2011.7_bb0325","first-page":"7","article-title":"An open-label, community-based, 12-week assessment of the effectiveness and safety of monotherapy with doxycycline 40\u2009mg (30-mg immediate-release and 10-mg delayed-release beads)","volume":"86","author":"Webster","year":"2010","journal-title":"Cutis"},{"key":"10.1038\/jidsymp.2011.7_bb0330","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.mcna.2009.08.007","article-title":"Rosacea","volume":"93","author":"Webster","year":"2009","journal-title":"Med Clin North Am"},{"key":"10.1038\/jidsymp.2011.7_bb0335","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1067\/mjd.2002.120625","article-title":"Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea","volume":"46","author":"Wilkin","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0340","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jaad.2004.01.048","article-title":"Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea","volume":"50","author":"Wilkin","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0345","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/1523-1747.ep12524458","article-title":"Oral thermal-induced flushing in erythematotelangiectatic rosacea","volume":"76","author":"Wilkin","year":"1981","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0350","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1001\/archderm.1983.01650270029012","article-title":"Effect of subdepressor clonidine on flushing reactions in rosacea. Change in malar thermal circulation index during provoked flushing reactions","volume":"119","author":"Wilkin","year":"1983","journal-title":"Arch Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0355","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm1616","article-title":"Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea","volume":"13","author":"Yamasaki","year":"2007","journal-title":"Nat Med"},{"key":"10.1038\/jidsymp.2011.7_bb0360","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jdermsci.2009.04.007","article-title":"The molecular pathology of rosacea","volume":"55","author":"Yamasaki","year":"2009","journal-title":"J Dermatol Sci"},{"key":"10.1038\/jidsymp.2011.7_bb0365","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/jidsymp.2011.4","article-title":"Rosacea as a disease of cathelicidins and skin innate immunity","volume":"15","author":"Yamasaki","year":"2011","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1038\/jidsymp.2011.7_bb0370","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/jid.2010.351","article-title":"TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes","volume":"131","author":"Yamasaki","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2011.7_bb0375","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1096\/fj.06-6075com","article-title":"Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin","volume":"20","author":"Yamasaki","year":"2006","journal-title":"FASEB J"}],"container-title":["Journal of Investigative Dermatology Symposium Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15526900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15526900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T07:01:24Z","timestamp":1560927684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15526900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0022202X15526900"],"URL":"https:\/\/doi.org\/10.1038\/jidsymp.2011.7","relation":{},"ISSN":["1087-0024"],"issn-type":[{"value":"1087-0024","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}