{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:57:46Z","timestamp":1791061066254,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T00:00:00Z","timestamp":1449187200000},"content-version":"vor","delay-in-days":1464,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Investigative Dermatology Symposium Proceedings"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1038\/jidsymp.2011.8","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T09:56:00Z","timestamp":1320918960000},"page":"33-39","source":"Crossref","is-referenced-by-count":125,"title":["Neurovascular Aspects of Skin Neurogenic Inflammation"],"prefix":"10.1016","volume":"15","author":[{"given":"Aisah A.","family":"Aubdool","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Brain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/jidsymp.2011.8_bb0010","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2340\/00015555-0856","article-title":"Prevalence of rosacea in an Estonian working population using a standard classification","volume":"90","author":"Abram","year":"2010","journal-title":"Acta Derm Venereol"},{"key":"10.1038\/jidsymp.2011.8_bb0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.drup.2004.04.002","article-title":"Chemically modified tetracyclines as inhibitors of matrix metalloproteinases","volume":"7","author":"Acharya","year":"2004","journal-title":"Drug Resist Updat"},{"key":"10.1038\/jidsymp.2011.8_bb0020","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1523\/JNEUROSCI.5679-03.2004","article-title":"Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia","volume":"24","author":"Amadesi","year":"2004","journal-title":"J Neurosci"},{"key":"10.1038\/jidsymp.2011.8_bb0025","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1523\/JNEUROSCI.5369-07.2008","article-title":"Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress","volume":"28","author":"Andersson","year":"2008","journal-title":"J Neurosci"},{"key":"10.1038\/jidsymp.2011.8_bb0030","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/jid.2009.58","article-title":"Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin","volume":"129","author":"Atoyan","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0035","first-page":"S203","article-title":"A potential link between the TRPA1 and TRPV1 receptors in vivo","volume":"60","author":"Aubdool","year":"2011","journal-title":"Inflamm Res"},{"key":"10.1038\/jidsymp.2011.8_bb0040","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.neuroscience.2009.05.052","article-title":"Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without norrbottnian congenital insensitivity to pain","volume":"162","author":"Axelsson","year":"2009","journal-title":"Neuroscience"},{"key":"10.1038\/jidsymp.2011.8_bb0045","doi-asserted-by":"crossref","first-page":"243","DOI":"10.5021\/ad.2009.21.3.243","article-title":"Clinical evaluation of 168 Korean patients with rosacea: the sun exposure correlates with the erythematotelangiectatic subtype","volume":"21","author":"Bae","year":"2009","journal-title":"Ann Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0050","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2230.2006.02322.x","article-title":"The effect of azithromycin on reactive oxygen species in rosacea","volume":"32","author":"Bakar","year":"2007","journal-title":"Clin Exp Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0055","first-page":"1","article-title":"Systemic therapy for rosacea","volume":"12","author":"Baldwin","year":"2007","journal-title":"Skin Therapy Lett"},{"key":"10.1038\/jidsymp.2011.8_bb0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1053\/sder.2001.27553","article-title":"Rosacea: current thoughts on origin","volume":"20","author":"Bamford","year":"2001","journal-title":"Semin Cutan Med Surg"},{"key":"10.1038\/jidsymp.2011.8_bb0065","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"10.1038\/jidsymp.2011.8_bb0070","first-page":"419","article-title":"An epidemiological study of rosacea","volume":"69","author":"Berg","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"10.1038\/jidsymp.2011.8_bb0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1358\/dot.2007.43.1.1025697","article-title":"Update on rosacea and anti-inflammatory-dose doxycycline","volume":"43","author":"Berman","year":"2007","journal-title":"Drugs Today (Barc)"},{"key":"10.1038\/jidsymp.2011.8_bb0080","first-page":"435","article-title":"Rosacea: a common, yet commonly overlooked, condition","volume":"66","author":"Blount","year":"2002","journal-title":"Am Fam Physician"},{"key":"10.1038\/jidsymp.2011.8_bb0085","doi-asserted-by":"crossref","first-page":"S202","DOI":"10.1038\/sj.bjp.0706461","article-title":"Neuropeptides and their receptors: innovative science providing novel therapeutic targets","volume":"147","author":"Brain","year":"2006","journal-title":"Br J Pharmacol"},{"key":"10.1038\/jidsymp.2011.8_bb0090","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1365-2125.1990.tb05451.x","article-title":"Cutaneous blood flow responses in the forearms of Raynaud's patients induced by local cooling and intradermal injections of CGRP and histamine","volume":"30","author":"Brain","year":"1990","journal-title":"Br J Clin Pharmacol"},{"key":"10.1038\/jidsymp.2011.8_bb0095","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/1523-1747.ep12455620","article-title":"Potent vasodilator activity of calcitonin gene-related peptide in human skin","volume":"87","author":"Brain","year":"1986","journal-title":"J Invest Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0100","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/313054a0","article-title":"Calcitonin gene-related peptide is a potent vasodilator","volume":"313","author":"Brain","year":"1985","journal-title":"Nature"},{"key":"10.1038\/jidsymp.2011.8_bb0105","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1476-5381.1985.tb11107.x","article-title":"Inflammatory edema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability","volume":"86","author":"Brain","year":"1985","journal-title":"Br J Pharmacol"},{"key":"10.1038\/jidsymp.2011.8_bb0110","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000082564","article-title":"Rosacea: an update","volume":"210","author":"Buechner","year":"2005","journal-title":"Dermatology"},{"key":"10.1038\/jidsymp.2011.8_bb0115","first-page":"U79","article-title":"Analysis of neurokinin-1 (NK1) receptor-mediated oedema formation: use of NK1 knockout mice","volume":"126","author":"Cao","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1038\/jidsymp.2011.8_bb0120","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1126\/science.288.5464.306","article-title":"Impaired nociception and pain sensation in mice lacking the capsaicin receptor","volume":"288","author":"Caterina","year":"2000","journal-title":"Science"},{"key":"10.1038\/jidsymp.2011.8_bb0125","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"10.1038\/jidsymp.2011.8_bb0130","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pain.2007.06.006","article-title":"The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans","volume":"132","author":"Chizh","year":"2007","journal-title":"Pain"},{"key":"10.1038\/jidsymp.2011.8_bb0135","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuron.2007.04.017","article-title":"Attenuated cold sensitivity in TRPM8 null mice","volume":"54","author":"Colburn","year":"2007","journal-title":"Neuron"},{"key":"10.1038\/jidsymp.2011.8_bb0140","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jneuroim.2005.09.006","article-title":"Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNF alpha in the cutaneous microvasculature","volume":"171","author":"Costa","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.1038\/jidsymp.2011.8_bb0145","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jaad.2004.03.030","article-title":"Rosacea: I. Etiology, pathogenesis, and subtype classification","volume":"51","author":"Crawford","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0150","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jaad.2003.05.005","article-title":"Temperature regulates bacterial protein production: possible role in rosacea","volume":"50","author":"Dahl","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0155","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1523\/JNEUROSCI.0454-04.2004","article-title":"Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain","volume":"24","author":"Dai","year":"2004","journal-title":"J Neurosci"},{"key":"10.1038\/jidsymp.2011.8_bb0160","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1172\/JCI30951","article-title":"Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain","volume":"117","author":"Dai","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1038\/jidsymp.2011.8_bb0165","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1038\/jid.2010.32","article-title":"Topical application of TRPA1 agonists and brief cold exposure accelerate skin permeability barrier recovery","volume":"130","author":"Denda","year":"2010","journal-title":"J Invest Derm"},{"key":"10.1038\/jidsymp.2011.8_bb0170","doi-asserted-by":"crossref","first-page":"15165","DOI":"10.1523\/JNEUROSCI.2580-10.2010","article-title":"TRPA1 contributes to cold hypersensitivity","volume":"30","author":"del Camino","year":"2010","journal-title":"J Neurosci"},{"key":"10.1038\/jidsymp.2011.8_bb0175","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1189\/jlb.69.6.1013","article-title":"Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils","volume":"69","author":"Dianzani","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1038\/jidsymp.2011.8_bb0180","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1113\/jphysiol.1983.sp014543","article-title":"Structure activity relationships for some substance-P-related peptides that cause wheal and flare reactions in human-skin","volume":"335","author":"Foreman","year":"1983","journal-title":"J Physiol"},{"key":"10.1038\/jidsymp.2011.8_bb0185","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1124\/jpet.107.125674","article-title":"Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade","volume":"323","author":"Gavva","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/jidsymp.2011.8_bb0190","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pain.2008.01.024","article-title":"Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans","volume":"136","author":"Gavva","year":"2008","journal-title":"Pain"},{"key":"10.1038\/jidsymp.2011.8_bb0195","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1124\/jpet.110.172403","article-title":"4-Oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo","volume":"337","author":"Graepel","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/jidsymp.2011.8_bb0200","article-title":"Protease-activated receptors: mechanisms by which proteases sensitize TRPV channels to induce neurogenic inflammation and pain","author":"Grant","year":"2007"},{"key":"10.1038\/jidsymp.2011.8_bb0205","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/sj.bjp.0704485","article-title":"Evidence of a role for NK1 and CGRP receptors in mediating neurogenic vasodilatation in the mouse ear","volume":"135","author":"Grant","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1038\/jidsymp.2011.8_bb0210","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejphar.2004.11.026","article-title":"An examination of neurogenic mechanisms involved in mustard oil-induced inflammation in the mouse","volume":"507","author":"Grant","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"10.1038\/jidsymp.2011.8_bb0215","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.drudis.2008.11.005","article-title":"Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway","volume":"14","author":"Gunthorpe","year":"2009","journal-title":"Drug Discov Today"},{"key":"10.1038\/jidsymp.2011.8_bb0220","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jaad.2007.06.009","article-title":"Enhanced skin blood flow and sensitivity to noxious heat stimuli in papulopustular rosacea","volume":"57","author":"Guzman-Sanchez","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0225","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature02282","article-title":"Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1","volume":"427","author":"Jordt","year":"2004","journal-title":"Nature"},{"key":"10.1038\/jidsymp.2011.8_bb0230","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1073\/pnas.0808487106","article-title":"TRPA1 acts as a cold sensor in vitro and in vivo","volume":"106","author":"Karashima","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/jidsymp.2011.8_bb0235","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.pain.2008.10.025","article-title":"Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms","volume":"141","author":"Keeble","year":"2009","journal-title":"Pain"},{"key":"10.1038\/jidsymp.2011.8_bb0240","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pain.2010.05.021","article-title":"TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo","volume":"150","author":"Knowlton","year":"2010","journal-title":"Pain"},{"key":"10.1038\/jidsymp.2011.8_bb0245","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0190-9622(08)80678-0","article-title":"Substance P immunoreactivity in rosacea","volume":"25","author":"Kurkcuoglu","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0250","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/archderm.140.11.1345","article-title":"Laser treatment of rosacea - a pathoetiological study","volume":"140","author":"Lonne-Rahm","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0255","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/09546630701485233","article-title":"The enigma of rosacea","volume":"18","author":"Marks","year":"2007","journal-title":"J Dermatolog Treat"},{"key":"10.1038\/jidsymp.2011.8_bb0260","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/archderm.1969.01610300033005","article-title":"Histopathology of rosacea","volume":"100","author":"Marks","year":"1969","journal-title":"Arch Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0265","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0738-081X(99)00128-5","article-title":"Pharmacologic modulation of neutrophil functions","volume":"18","author":"Miyachi","year":"2000","journal-title":"Clin Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0270","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10741-010-9186-2","article-title":"NADPH oxidases and cardiac remodelling","volume":"16","author":"Nabeebaccus","year":"2011","journal-title":"Heart Fail Rev"},{"key":"10.1038\/jidsymp.2011.8_bb0275","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1523\/JNEUROSCI.0013-05.2005","article-title":"Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing","volume":"25","author":"Nagata","year":"2005","journal-title":"J Neurosci"},{"key":"10.1038\/jidsymp.2011.8_bb0280","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.00021.2006","article-title":"Transient receptor potential cation channels in disease","volume":"87","author":"Nilius","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1038\/jidsymp.2011.8_bb0285","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1172\/JCI25437","article-title":"TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury","volume":"115","author":"Obata","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1038\/jidsymp.2011.8_bb0290","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0190-9622(08)80863-8","article-title":"Substance P and rosacea","volume":"28","author":"Powell","year":"1993","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0295","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/cvr\/cvq118","article-title":"Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo","volume":"87","author":"Pozsgai","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1038\/jidsymp.2011.8_bb0300","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1111\/j.1460-9568.2009.06702.x","article-title":"TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1","volume":"29","author":"Salas","year":"2009","journal-title":"Eur J Neurosci"},{"key":"10.1038\/jidsymp.2011.8_bb0305","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1096\/fj.02-1112com","article-title":"Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo","volume":"17","author":"Seeliger","year":"2003","journal-title":"FASEB J"},{"key":"10.1038\/jidsymp.2011.8_bb0310","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2125.2009.03543.x","article-title":"Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974)","volume":"69","author":"Sinclair","year":"2010","journal-title":"Br J Clin Pharmacol"},{"key":"10.1038\/jidsymp.2011.8_bb0315","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/cvr\/cvn012","article-title":"A reactive oxygen species-mediated component in neurogenic vasodilatation","volume":"78","author":"Starr","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1038\/jidsymp.2011.8_bb0320","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.1523\/JNEUROSCI.1483-07.2007","article-title":"Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defence effectors","volume":"27","author":"Steiner","year":"2007","journal-title":"J Neurosci"},{"key":"10.1038\/jidsymp.2011.8_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2003-0025","article-title":"Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response","volume":"26","author":"Steinhoff","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1038\/jidsymp.2011.8_bb0330","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/72247","article-title":"Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism","volume":"6","author":"Steinhoff","year":"2000","journal-title":"Nat Med"},{"key":"10.1038\/jidsymp.2011.8_bb0335","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/jlb.65.6.834","article-title":"Substance P primes the formation of hydrogen peroxide and nitric oxide in human neutrophils","volume":"65","author":"Sterner-Kock","year":"1999","journal-title":"J Leukoc Biol"},{"key":"10.1038\/jidsymp.2011.8_bb0340","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"10.1038\/jidsymp.2011.8_bb0345","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1067\/mjd.2002.120625","article-title":"Standard classification of rosacea: report of the national rosacea society expert committee on the classification and staging of rosacea","volume":"46","author":"Wilkin","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0350","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1001\/archderm.1980.01640290108028","article-title":"Vasodilator rosacea","volume":"116","author":"Wilkin","year":"1980","journal-title":"Arch Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0355","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0190-9622(88)70177-2","article-title":"Why is flushing limited to a mostly facial cutaneous distribution?","volume":"19","author":"Wilkin","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"10.1038\/jidsymp.2011.8_bb0360","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm1616","article-title":"Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea","volume":"13","author":"Yamasaki","year":"2007","journal-title":"Nat Med"},{"key":"10.1038\/jidsymp.2011.8_bb0365","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/j.1365-2133.2007.08196.x","article-title":"Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils","volume":"157","author":"Zheng","year":"2007","journal-title":"Br J Dermatol"}],"container-title":["Journal of Investigative Dermatology Symposium Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15526912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022202X15526912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T21:54:52Z","timestamp":1686434092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022202X15526912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0022202X15526912"],"URL":"https:\/\/doi.org\/10.1038\/jidsymp.2011.8","relation":{},"ISSN":["1087-0024"],"issn-type":[{"value":"1087-0024","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}