{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:08:36Z","timestamp":1792084116754,"version":"4.4.0"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T00:00:00Z","timestamp":1220486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T00:00:00Z","timestamp":1220486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1038\/jp.2008.130","type":"journal-article","created":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T08:23:19Z","timestamp":1220516599000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Oropharyngeal administration of colostrum to extremely low birth weight infants: theoretical perspectives"],"prefix":"10.1038","volume":"29","author":[{"given":"N A","family":"Rodriguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P P","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M W","family":"Groer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,9,4]]},"reference":[{"key":"BFjp2008130_CR1","first-page":"130","volume":"17","author":"A El-Mohandes","year":"1997","unstructured":"El-Mohandes A, Picard M, Simmens S, Keiser JF . Use of human milk in the intensive care nursery decreases the incidence of nosocomial sepsis. J Perinatol 1997; 17: 130\u2013134.","journal-title":"J Perinatol"},{"key":"BFjp2008130_CR2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1001\/archpedi.157.1.66","volume":"157","author":"L Furman","year":"2003","unstructured":"Furman L, Taylor G, Minich N, Hack M . The effect of maternal milk on neonatal morbidity of very-low-birth-weight infants. Arch Pediatr Adolesc Med 2003; 157: 66\u201371.","journal-title":"Arch Pediatr Adolesc Med"},{"key":"BFjp2008130_CR3","doi-asserted-by":"publisher","first-page":"E38","DOI":"10.1542\/peds.102.3.e38","volume":"102","author":"MA Hylander","year":"1998","unstructured":"Hylander MA, Strobino DM, Dhanireddy R . Human milk feedings and infection among very low birth weight infants. Pediatrics 1998; 102: E38.","journal-title":"Pediatrics"},{"key":"BFjp2008130_CR4","doi-asserted-by":"publisher","first-page":"e269","DOI":"10.1542\/peds.2004-1833","volume":"115","author":"A Ronnestad","year":"2005","unstructured":"Ronnestad A, Abrahamsen TG, Medbo S, Reigstad H, Lossius K, Kaaresen PI et al. Late-onset septicemia in a Norwegian national cohort of extremely premature infants receiving very early full human milk feeding. Pediatrics 2005; 115: e269\u2013e276.","journal-title":"Pediatrics"},{"key":"BFjp2008130_CR5","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1542\/peds.103.6.1150","volume":"103","author":"RJ Schanler","year":"1999","unstructured":"Schanler RJ, Schulman RJ, Lau C . Feeding strategies for premature infants: beneficial outcomes of feeding fortified human milk versus preterm formula. Pediatrics 1999; 103: 1150\u20131156.","journal-title":"Pediatrics"},{"key":"BFjp2008130_CR6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0031-3955(05)70283-2","volume":"48","author":"MC Neville","year":"2001","unstructured":"Neville MC . Anatomy and physiology of lactation. Pediatr Clin North Am 2001; 48: 13\u201334.","journal-title":"Pediatr Clin North Am"},{"key":"BFjp2008130_CR7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/00005176-199907000-00018","volume":"29","author":"P Montagne","year":"1999","unstructured":"Montagne P, Cuilliere ML, Mole C, Bene MC, Faure G . Immunological and nutritional composition of human milk in relation to prematurity and mother's parity during the first 2 weeks of lactation. J Pediatr Gastroenterol Nutr 1999; 29: 75\u201380.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"BFjp2008130_CR8","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/978-1-4615-1371-1_27","volume":"501","author":"ES Buescher","year":"2001","unstructured":"Buescher ES . Anti-inflammatory characteristics of human milk: how, where and why. Adv Exp Med Biol 2001; 501: 207\u2013222.","journal-title":"Adv Exp Med Biol"},{"key":"BFjp2008130_CR9","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1203\/00006450-199612000-00011","volume":"40","author":"ES Buescher","year":"1996","unstructured":"Buescher ES, Malinowska I . Soluble receptors and cytokine antagonists in human milk. Pediatr Res 1996; 40: 839\u2013844.","journal-title":"Pediatr Res"},{"key":"BFjp2008130_CR10","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1203\/00006450-199807000-00006","volume":"44","author":"ES Buescher","year":"1998","unstructured":"Buescher ES, McWilliams-Koeppen P . Soluble tumor necrosis factor-alpha (TNF-alpha) receptors in human colostrum and milk bind to TNF-alpha and neutralize TNF-alpha bioactivity. Pediatr Res 1998; 44: 37\u201342.","journal-title":"Pediatr Res"},{"key":"BFjp2008130_CR11","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1159\/000014019","volume":"74","author":"RP Garofalo","year":"1998","unstructured":"Garofalo RP, Goldman AS . Cytokines, chemokines and colony-stimulating factors in human milk: the 1997 update. Biol Neonate 1998; 74: 134\u2013142.","journal-title":"Biol Neonate"},{"key":"BFjp2008130_CR12","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1177\/0884217504272807","volume":"34","author":"NA Rodr\u00edguez","year":"2005","unstructured":"Rodr\u00edguez NA, Miracle DJ, Meier PP . Sharing the science on human milk feedings with mothers of very low birth weight infants. J Obstet Gynecol Neonatal Nurs 2005; 34: 109\u2013119.","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"key":"BFjp2008130_CR13","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1111\/j.1651-2227.1990.tb11380.x","volume":"79","author":"NB Mathur","year":"1990","unstructured":"Mathur NB, Dwarkadas AM, Sharma VK, Saha K, Jain K . Anti-infective factors in preterm colostrum. Acta Paediatr Scand 1990; 79: 1039\u20131044.","journal-title":"Acta Paediatr Scand"},{"key":"BFjp2008130_CR14","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/j.1651-2227.1993.tb12661.x","volume":"82","author":"AS Grumach","year":"1993","unstructured":"Grumach AS, Carmona RC, Lazarotti D, Ribeiro MA, Rozentraub RB, Racz ML et al. Immunological factors in milk from Brazilian mothers delivering small-for-date term neonates. Acta Paediatr 1993; 82: 284\u2013290.","journal-title":"Acta Paediatr"},{"key":"BFjp2008130_CR15","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/S0022-3476(82)80007-3","volume":"101","author":"AS Goldman","year":"1982","unstructured":"Goldman AS, Garza C, Nichols B, Johnson CA, Smith EO, Goldblum RM . Effects of prematurity on the immunologic system in human milk. J Pediatr 1982; 101: 901\u2013905.","journal-title":"J Pediatr"},{"key":"BFjp2008130_CR16","first-page":"357","volume":"9","author":"ED Araujo","year":"2005","unstructured":"Araujo ED, Goncalves AK, Cornetta M, Cunha H, Cardoso ML, Morais SS et al. Evaluation of the secretory immunoglobulin A levels in the colostrum and milk of mothers of term and preterm infants. Braz J Infect Dis 2005; 9: 357\u2013362.","journal-title":"Braz J Infect Dis"},{"key":"BFjp2008130_CR17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1203\/01.PDR.0000065729.74325.71","volume":"54","author":"B Dvorak","year":"2003","unstructured":"Dvorak B, Fituch CC, Williams CS, Hurst NM, Schanler RJ . Increased epidermal growth factor levels in human milk of mothers with extremely premature infants. Pediatr Res 2003; 54: 15\u201319.","journal-title":"Pediatr Res"},{"key":"BFjp2008130_CR18","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1177\/0890334405280652","volume":"21","author":"A Koenig","year":"2005","unstructured":"Koenig A, de Albuquerque Diniz EM, Barbosa SF, Vaz FA . Immunologic factors in human milk: the effects of gestational age and pasteurization. J Hum Lact 2005; 21: 439\u2013443.","journal-title":"J Hum Lact"},{"key":"BFjp2008130_CR19","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1080\/07315724.2000.10718933","volume":"19","author":"PA Ronayne de Ferrer","year":"2000","unstructured":"Ronayne de Ferrer PA, Baroni A, Sambucetti ME, Lopez NE, Cernadas JMC . Lactoferrin levels in term and preterm milk. J Am Coll Nutr 2000; 19: 370\u2013373.","journal-title":"J Am Coll Nutr"},{"key":"BFjp2008130_CR20","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0095-5108(18)30346-4","volume":"21","author":"E LaGamma","year":"1994","unstructured":"LaGamma E, Brown L . Feeding practices for infants weighing less than 1500\u2009g at birth and the pathogenesis of necrotizing enterocolitis. Clin Perinatol 1994; 21: 271\u2013306.","journal-title":"Clin Perinatol"},{"key":"BFjp2008130_CR21","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.clnu.2006.03.002","volume":"25","author":"E Westerbeek","year":"2006","unstructured":"Westerbeek E, van den Berg A, Lafeber HN, Knol J, Fetter WPF, van Elburg RM . The intestinal bacterial colonization in preterm infants: a review of the literature. Clin Nutr 2006; 25: 361\u2013368.","journal-title":"Clin Nutr"},{"key":"BFjp2008130_CR22","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1016\/S0140-6736(87)92671-7","volume":"2","author":"V Hutchinson","year":"1987","unstructured":"Hutchinson V, Cummins JM . Low-dose oral interferon in patients with AIDs. Lancet 1987; 2: 1530\u20131531.","journal-title":"Lancet"},{"key":"BFjp2008130_CR23","first-page":"91","volume":"2","author":"DK Koech","year":"1990","unstructured":"Koech DK, Obel AO, Minowada J, Hutchinson VA, Cummins JM . Low dose oral alpha-interferon therapy for patients seropositive for human immunodeficiency virus type-1 (HIV-1). Mol Biother 1990; 2: 91\u201395.","journal-title":"Mol Biother"},{"key":"BFjp2008130_CR24","first-page":"229","volume":"41","author":"J Caban","year":"1993","unstructured":"Caban J, Mossor-Ostrowska J, Zyrkowska-Bieda T, Zejc M, Janas-Skulina U, Ciesla A et al. Treatment of chronic viral hepatitis B with oral mucosal administration of natural human interferon alpha lozenges. Arch Immunol Ther Exp 1993; 41: 229\u2013235.","journal-title":"Arch Immunol Ther Exp"},{"key":"BFjp2008130_CR25","first-page":"241","volume":"41","author":"W Zielinska","year":"1993","unstructured":"Zielinska W, Paszkiewicz J, Korczak A, Wlasiuk M, Zoltowska A, Szutowicz A et al. Treatment of fourteen chronic active HBsAg+, HBeAg+ hepatitis patients with low dose natural human interferon alpha administered orally. Arch Immunol Ther Exp 1993; 41: 241\u2013251.","journal-title":"Arch Immunol Ther Exp"},{"key":"BFjp2008130_CR26","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1089\/107999099313361","volume":"19","author":"V Bocci","year":"1999","unstructured":"Bocci V . The oropharyngeal delivery of interferons: where are we and where do we need to go? J Interferon Cytokine Res 1999; 19: 859\u2013861.","journal-title":"J Interferon Cytokine Res"},{"key":"BFjp2008130_CR27","doi-asserted-by":"publisher","first-page":"411","DOI":"10.2165\/00003088-199121060-00002","volume":"21","author":"V Bocci","year":"1991","unstructured":"Bocci V . Absorption of cytokines via oropharyngeal-associated lymphoid tissues. Clin Pharmacokinet 1991; 21: 411\u2013417.","journal-title":"Clin Pharmacokinet"},{"key":"BFjp2008130_CR28","first-page":"121","volume":"5","author":"V Bocci","year":"1991","unstructured":"Bocci V, von Bremen K, Corradeschi F, Luzzi E, Paulesu L . What is the role of cytokines in human colostrum? J Biol Regul Homeost Agents 1991; 5: 121\u2013124.","journal-title":"J Biol Regul Homeost Agents"},{"key":"BFjp2008130_CR29","volume-title":"Immunology","author":"I Roitt","year":"2001","unstructured":"Roitt I, Brostoff J, Male D . Immunology (6th edn) Mosby, St. Louis, 2001."},{"key":"BFjp2008130_CR30","volume-title":"Immunology; A Short Course","author":"E Benjamini","year":"1996","unstructured":"Benjamini E, Sunshine G, Leskowitz S . Immunology; A Short Course. Wiley-Liss: New York, 1996."},{"key":"BFjp2008130_CR31","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1001\/archneur.1997.00550220098021","volume":"54","author":"S Brod","year":"1997","unstructured":"Brod S . Gut response: therapy with ingested immunomodulatory proteins. Arch Neurol 1997; 54: 1300\u20131302.","journal-title":"Arch Neurol"},{"key":"BFjp2008130_CR32","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1126\/science.272.5258.60","volume":"272","author":"E Butcher","year":"1996","unstructured":"Butcher E, Picker L . Lymphocyte homing and homeostasis. Science 1996; 272: 60\u201366.","journal-title":"Science"},{"key":"BFjp2008130_CR33","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/BF00638923","volume":"5","author":"GJ Kociba","year":"1995","unstructured":"Kociba GJ, Garg RC, Khan KNM, Reiter JA, Chatfield RC . Effects of orally administered interferon-alpha on the pathogenesis of feline leukemia virus-induced erythroid aplasia. Comp Haematol Int 1995; 5: 79\u201383.","journal-title":"Comp Haematol Int"},{"key":"BFjp2008130_CR34","first-page":"211","volume":"2","author":"JG Lecce","year":"1990","unstructured":"Lecce JG, Cummins JM, Richards AB . Treatment of rotavirus infection in neonate and weanling pigs using natural human interferon alpha. Mol Biother 1990; 2: 211\u2013216.","journal-title":"Mol Biother"},{"key":"BFjp2008130_CR35","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.2460\/javma.1996.208.10.1711","volume":"208","author":"BR Moore","year":"1996","unstructured":"Moore BR . Clinical application of interferons in large animal medicine. J Am Vet Med Assoc 1996; 208: 1711\u20131715.","journal-title":"J Am Vet Med Assoc"},{"key":"BFjp2008130_CR36","first-page":"305","volume":"1","author":"GJ Stanton","year":"1989","unstructured":"Stanton GJ, Lloyd RE, Sarzotti M, Blalock JE . Protection of mice from Semliki Forest virus infection by lymphocytes treated with low levels of interferon. Mol Biother 1989; 1: 305\u2013310.","journal-title":"Mol Biother"},{"key":"BFjp2008130_CR37","first-page":"344","volume":"41","author":"JE Blalock","year":"1982","unstructured":"Blalock JE, Baron S, Johnson HM, Stanton GJ . Transmission of IFN-induced activities by cell to cell communication. Tex Rep Biol Med 1982; 41: 344\u2013349.","journal-title":"Tex Rep Biol Med"},{"key":"BFjp2008130_CR38","first-page":"3533","volume":"50","author":"H Yasui","year":"1990","unstructured":"Yasui H, Proietti E, Vignaux F, Eid P, Gresser I . Inhibition by mouse alpha interferon of the multiplication of alpha interferon resistant friend erythroleukemia cells cocultured with mouse hepatocytes. Cancer Res 1990; 50: 3533\u20133539.","journal-title":"Cancer Res"},{"key":"BFjp2008130_CR39","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/978-3-642-71272-2_3","volume":"128","author":"EC Butcher","year":"1986","unstructured":"Butcher EC . The regulation of lymphocytes traffic. Curr Top Microbiol Immunol 1986; 128: 85\u2013122.","journal-title":"Curr Top Microbiol Immunol"},{"key":"BFjp2008130_CR40","first-page":"340","volume":"4","author":"V Bocci","year":"1985","unstructured":"Bocci V . Immunomodulators as local hormones: new insights regarding their clinical utilization. J Biol Response Mod 1985; 4: 340\u2013352.","journal-title":"J Biol Response Mod"},{"key":"BFjp2008130_CR41","first-page":"5795","volume":"50","author":"G Boccoli","year":"1990","unstructured":"Boccoli G, Masciulli R, Ruggeri EM, Carlini P, Giannella G, Montesoro G et al. Adoptive immunotherapy of human cancer: the cytokine cascade and monocyte activation following high-dose interleukin 2 bolus treatment. Cancer Res 1990; 50: 5795\u20135800.","journal-title":"Cancer Res"},{"key":"BFjp2008130_CR42","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1084\/jem.163.6.1433","volume":"163","author":"CA Dinarello","year":"1986","unstructured":"Dinarello CA, Cannon JG, Wolff SM, Bernheim HA, Beutler B, Cerami A et al. Tumour necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin-1. J Exp Med 1986; 163: 1433\u20131450.","journal-title":"J Exp Med"},{"key":"BFjp2008130_CR43","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3181\/00379727-201-43499","volume":"201","author":"WR Fleishmann Jr","year":"1992","unstructured":"Fleishmann Jr WR, Koren S, Fleischmann CM . Orally administered interferons exert their white blood cell suppressive effects via a novel mechanism. Proc Soc Exp Biol Med 1992; 201: 200\u2013207.","journal-title":"Proc Soc Exp Biol Med"},{"key":"BFjp2008130_CR44","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1089\/cdd.1987.4.17","volume":"4","author":"A Pacini","year":"1987","unstructured":"Pacini A, Maioli M, Bocci V, Pessina GP . Studies on tumor necrosis factor (TNF) III: Plasma disappearance curves after intramuscular, subcutaneous, intraperitoneal, and oral administration of human recombinant TNF. Cancer Drug Deliv 1987; 4: 17\u201323.","journal-title":"Cancer Drug Deliv"},{"key":"BFjp2008130_CR45","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/0378-5173(88)90078-6","volume":"46","author":"L Paulesu","year":"1988","unstructured":"Paulesu L, Corradeschi F, Nicoletti C, Bocci V . Oral administration of human recombinant interferon-alpha in rats. Int J Pharm 1988; 46: 199\u2013202.","journal-title":"Int J Pharm"},{"key":"BFjp2008130_CR46","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1203\/00006450-199905010-00007","volume":"45","author":"CG Siafakas","year":"1999","unstructured":"Siafakas CG, Anatolitou F, Fusunyan RD, Walker WA, Sanderson IR . Vascular endothelial growth factor (VEGF) is present in human breast milk and its receptor is present on intestinal epithelial cells. Pediatr Res 1999; 45: 652\u2013657.","journal-title":"Pediatr Res"},{"key":"BFjp2008130_CR47","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1542\/peds.105.1.e7","volume":"105","author":"DA Calhoun","year":"2000","unstructured":"Calhoun DA, Lunoe M, Du Y, Christensen RD . Granulocyte colony-stimulating factor is present in human milk and its receptor is present in human fetal intestine. Pediatrics 2000; 105: e7.","journal-title":"Pediatrics"},{"key":"BFjp2008130_CR48","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1203\/00006450-199912000-00021","volume":"46","author":"DA Calhoun","year":"1999","unstructured":"Calhoun DA, Lunoe M, Du Y, Staba SI, Christensen RD . Concentrations of granulocyte colony-stimulating factor in human milk after in vitro stimulations of digestion. Pediatr Res 1999; 46: 767\u2013771.","journal-title":"Pediatr Res"},{"key":"BFjp2008130_CR49","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1089\/107999099313451","volume":"19","author":"MG Tovoy","year":"1999","unstructured":"Tovoy MG, Meritet JF, Guymarho J, Maury C . Mucosal cytokine therapy: marked antiviral and antitumor activity. J Interferon Cytokine Res 1999; 19: 911\u2013921.","journal-title":"J Interferon Cytokine Res"},{"key":"BFjp2008130_CR50","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1089\/107999099314306","volume":"19","author":"P Eid","year":"1999","unstructured":"Eid P, Meritet JF, Maury C, Lasfar A, Weill D, Tovey MG . Oromucosal interferon therapy: pharmacokinetics and pharmacodynamics. J Interferon Cytokine Res 1999; 19: 157\u2013169.","journal-title":"J Interferon Cytokine Res"},{"key":"BFjp2008130_CR51","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1089\/107999099313334","volume":"19","author":"WR Fleischmann Jr","year":"1999","unstructured":"Fleischmann Jr WR, Koren S . Systemic effects of orally administered interferons and interleukin-2. J Interferon Cytokine Res 1999; 19: 829\u2013839.","journal-title":"J Interferon Cytokine Res"},{"key":"BFjp2008130_CR52","first-page":"245","volume-title":"Interferon Therapy in Multiple Sclerosis","author":"S Brod","year":"1997","unstructured":"Brod S . Effect of oral administration of type 1 interferon on experimental autoimmune encephalomyelitis. In: Reder AT (ed). Interferon Therapy in Multiple Sclerosis. Marcel Dekker: New York, 1997, pp 245\u2013286."},{"key":"BFjp2008130_CR53","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/00002371-199307000-00007","volume":"14","author":"K Dhingra","year":"1993","unstructured":"Dhingra K, Duvic M, Hymes S, McLaughlin P, Rothberg J, Gutterman JU . A phase -1 clinical study of low-dose oral interferon alpha. J Immunother 1993; 14: 51\u201355.","journal-title":"J Immunother"},{"key":"BFjp2008130_CR54","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1089\/jir.1992.12.411","volume":"12","author":"PL Witt","year":"1992","unstructured":"Witt PL, Goldstein D, Storer BE, Grossberg SE, Flashner M, Colby CB et al. Absence of biological effects of orally administered interferon-beta. J Interferon Res 1992; 12: 411\u2013413.","journal-title":"J Interferon Res"},{"key":"BFjp2008130_CR55","first-page":"253","volume":"41","author":"W Zielinska","year":"1993","unstructured":"Zielinska W, Paszkiewicz J, Korczak A, Wlasiuk M, Zoltowska A, Szutowicz A et al. Treatment of six patients with chronic active HCV hepatitis with low dose natural human interferon alpha administered orally. Arch Immunol Ther Exp 1993; 41: 253\u2013257.","journal-title":"Arch Immunol Ther Exp"},{"key":"BFjp2008130_CR56","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1089\/jir.1998.18.647","volume":"18","author":"JA Lecciones","year":"1998","unstructured":"Lecciones JA, Abejar NH, Dimaano EE, Bartolome R, Cinco S, Mariano N et al. A pilot double-blind, randomized, and placebo-controlled study of orally administered IFN-alpha in pediatric patients with measles. J Interferon Cytokine Res 1998; 18: 647\u2013652.","journal-title":"J Interferon Cytokine Res"},{"key":"BFjp2008130_CR57","first-page":"1","volume-title":"Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation","author":"P Brandtzaeg","year":"2002","unstructured":"Brandtzaeg P . The secretory immunoglobulin system: regulation and biological significance: focusing on human mammary glands. In: Davis MK, Isaacs CE, Hanson LA, Wright AL (eds). Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation. Plenum: New York, 2002, pp 1\u201316."},{"key":"BFjp2008130_CR58","first-page":"23","volume-title":"Ontogeny of the Immune System of the Gut","author":"J Spencer","year":"1990","unstructured":"Spencer J, MacDonald TT . Ontogeny of human mucosal immunity. In: MacDonald TT (ed). Ontogeny of the Immune System of the Gut. CRC Press: Boca Raton, FL, 1990, pp 23\u201350."},{"key":"BFjp2008130_CR59","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1016\/S0022-3476(06)80026-0","volume":"122","author":"BJ Stoll","year":"1993","unstructured":"Stoll BJ, Lee FK, Hale E, Schwartz D, Holmes R, Ashby R et al. Immunoglobulin secretion by the normal and the infected newborn infant. J Pediatr 1993; 122: 780\u2013786.","journal-title":"J Pediatr"},{"key":"BFjp2008130_CR60","doi-asserted-by":"publisher","first-page":"F209","DOI":"10.1136\/fn.88.3.F209","volume":"88","author":"PC Ng","year":"2003","unstructured":"Ng PC, Li K, Wong RPO, Chui K, Wong E, Li G et al. Proinflammatory and anti-inflammatory cytokine responses in preterm infants with systemic infections. Arch Dis Child Fetal Neonatal Ed 2003; 88: F209\u2013F213.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFjp2008130_CR61","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0095-5108(18)30355-5","volume":"21","author":"RM Kliegman","year":"1994","unstructured":"Kliegman RM, Walker WA, Yolken RH . Necrotizing enterocolitis: research agenda for a disease of unknown etiology and pathogenesis. Clin Perinatol 1994; 21: 437\u2013455.","journal-title":"Clin Perinatol"},{"key":"BFjp2008130_CR62","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1203\/00006450-200104000-00023","volume":"49","author":"RD Fusunyan","year":"2001","unstructured":"Fusunyan RD, Nanthakumar NN, Baldeon ME, Walker WA . Evidence for an innate immune response in the immature human intestine: toll-like receptors on fetal enterocytes. Pediatr Res 2001; 49: 589\u2013593.","journal-title":"Pediatr Res"},{"key":"BFjp2008130_CR63","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1203\/01.PDR.0000050141.73528.AD","volume":"53","author":"EC Claud","year":"2003","unstructured":"Claud EC, Savidge T, Walker WA . Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors. Pediatr Res 2003; 53: 419\u2013425.","journal-title":"Pediatr Res"},{"key":"BFjp2008130_CR64","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","volume":"118","author":"S Rakoff-Nahoum","year":"2004","unstructured":"Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R . Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004; 118: 229\u2013241.","journal-title":"Cell"},{"key":"BFjp2008130_CR65","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1203\/01.PDR.0000050657.56817.E0","volume":"53","author":"B Dvorak","year":"2003","unstructured":"Dvorak B, Halpern MD, Holubec H, Dvorakova K, Dominguez JA, Williams CS et al. Maternal milk reduces severity of necrotizing enterocolitis and increases intestinal IL-10 in a neonatal rat model. Pediatr Res 2003; 53: 426\u2013433.","journal-title":"Pediatr Res"},{"key":"BFjp2008130_CR66","doi-asserted-by":"publisher","first-page":"G156","DOI":"10.1152\/ajpgi.00196.2001","volume":"282","author":"B Dvorak","year":"2002","unstructured":"Dvorak B, Halpern MD, Holubec H, Williams CS, McWilliam DL, Dominguez JA . Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Am J Physiol Gastrointest Liver Physiol 2002; 282: G156\u2013G164.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"BFjp2008130_CR67","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1203\/00006450-199712000-00010","volume":"42","author":"MS Caplan","year":"1997","unstructured":"Caplan MS, Lickerman M, Adler L, Dietsch GN, Yu A . The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis. Pediatr Res 1997; 42: 779\u2013783.","journal-title":"Pediatr Res"},{"key":"BFjp2008130_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jn\/135.1.1","volume":"135","author":"CJ Field","year":"2005","unstructured":"Field CJ . The immunological components of human milk and their effect on immune development in infants. J Nutr 2005; 135: 1\u20134.","journal-title":"J Nutr"},{"key":"BFjp2008130_CR69","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1023\/A:1020652215048","volume":"22","author":"JS Hawkes","year":"2002","unstructured":"Hawkes JS, Bryan DL, Gibson RA . Cytokine production by human milk cells and peripheral mononuclear cells from the same mother. J Clin Immunol 2002; 22: 338\u2013344.","journal-title":"J Clin Immunol"},{"key":"BFjp2008130_CR70","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/S0271-5317(03)00035-6","volume":"23","author":"A-RMA Meki","year":"2003","unstructured":"Meki A-RMA, Saleem RTH, Al-Ghazali MH, Sayed AA . Interleukins-6, -8 and -10 and tumor necrosis factor alpha and its soluble receptor I in human milk at different periods of lactation. Nutr Res 2003; 23: 845\u2013855.","journal-title":"Nutr Res"},{"key":"BFjp2008130_CR71","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/978-0-387-74087-4_16","volume":"606","author":"JW Blum","year":"2008","unstructured":"Blum JW, Baumrucker CR . Insulin-like growth factors (IGFs), IGF binding proteins and other endocrine factors in milk: role in the newborn. Adv Exp Med Biol 2008; 606: 397\u2013422.","journal-title":"Adv Exp Med Biol"},{"key":"BFjp2008130_CR72","first-page":"124","volume":"68","author":"MW Elmlinger","year":"2007","unstructured":"Elmlinger MW, Hochhaus F, Loui A, Frommer KW, Obladen M, Ranke MB . Insulin-like growth factors and binding proteins in early milk from mothers of preterm and term infants. Horm Res 2007; 68: 124\u2013131.","journal-title":"Horm Res"},{"key":"BFjp2008130_CR73","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1189\/jlb.0404248","volume":"76","author":"R Kooijman","year":"2004","unstructured":"Kooijman R, Coppens A . Insulin-like growth factor -1 stimulates IL-10 production in human T cells. J Leukoc Biol 2004; 76: 862\u2013867.","journal-title":"J Leukoc Biol"},{"key":"BFjp2008130_CR74","doi-asserted-by":"publisher","first-page":"428","DOI":"10.2527\/1994.722428x","volume":"72","author":"CR Baumrucker","year":"1994","unstructured":"Baumrucker CR, Hadsell DL, Blum JW . Effects of dietary insulin-like growth factor 1 on growth and insulin-like growth factor receptors in neonatal calf intestine. J Anim Sci 1994; 72: 428\u2013433.","journal-title":"J Anim Sci"},{"key":"BFjp2008130_CR75","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1677\/joe.0.1760121","volume":"176","author":"IP Georgiev","year":"2003","unstructured":"Georgiev IP, Georgieva TM, Pfaffl M, Hammon HM, Blum JW . Insulin-like growth factor and insulin receptors in intestinal mucosa of neonatal calves. J Endocrinol 2003; 176: 121\u2013132.","journal-title":"J Endocrinol"},{"key":"BFjp2008130_CR76","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1034\/j.1399-3038.2003.02120.x","volume":"14","author":"MF Bottcher","year":"2003","unstructured":"Bottcher MF, Jenmalm MC, Bjorksten B . Cytokine, chemokine and secretory IgA levels in human milk in relation to atopic disease and IgA production in infants. Pediatr Allergy Immunol 2003; 14: 35\u201341.","journal-title":"Pediatr Allergy Immunol"},{"key":"BFjp2008130_CR77","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.earlhumdev.2004.01.005","volume":"77","author":"J Ogawa","year":"2004","unstructured":"Ogawa J, Sasahara A, Yoshida T, Sira MM, Futatani T, Kanegane H et al. Role of transforming growth factor-beta in breast milk for initiation of IgA production in newborn infants. Early Hum Dev 2004; 77: 67\u201375.","journal-title":"Early Hum Dev"},{"key":"BFjp2008130_CR78","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1183\/09031936.98.11051043","volume":"11","author":"V Godding","year":"1998","unstructured":"Godding V, Sibille Y, Massion PP, Delos M, Sibille C, Thurion P et al. Secretory component production by human bronchial epithelial cells is upregulated by interferon gamma. Eur Respir J 1998; 11: 1043\u20131052.","journal-title":"Eur Respir J"},{"key":"BFjp2008130_CR79","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1542\/peds.112.2.421","volume":"112","author":"DA Calhoun","year":"2003","unstructured":"Calhoun DA, Maheshwari A, Christensen RD . Recombinant granulocyte colony-stimulating factors administered enterally to neonates is not absorbed. Pediatrics 2003; 112: 421\u2013423.","journal-title":"Pediatrics"},{"key":"BFjp2008130_CR80","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S1043-6618(03)00249-4","volume":"48","author":"JA Gersting","year":"2003","unstructured":"Gersting JA, Kotto-kome CA, Du Y, Christensen RD, Calhoun DA . Bioavailablity of granulocyte colony-stimulating factors administered enterally to suckling mice. Pharmacol Res 2003; 48: 643\u2013647.","journal-title":"Pharmacol Res"},{"key":"BFjp2008130_CR81","first-page":"3","volume":"143","author":"AB Kulkarni","year":"1993","unstructured":"Kulkarni AB, Karlsson S . Transforming growth factor beta knockout mice: a mutation in one cytokine gene causes a dramatic inflammatory disease. Am J Pathol 1993; 143: 3\u20139.","journal-title":"Am J Pathol"},{"key":"BFjp2008130_CR82","doi-asserted-by":"publisher","first-page":"985S","DOI":"10.1093\/jn\/127.5.985S","volume":"127","author":"LA Ellis","year":"1997","unstructured":"Ellis LA, Mastro AM, Picciano MF . Do milk-borne cytokines and hormones influence neonatal immune function? J Nutr 1997; 127: 985S\u2013988S.","journal-title":"J Nutr"},{"key":"BFjp2008130_CR83","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1203\/00006450-199103000-00005","volume":"29","author":"TW Hutchins","year":"1991","unstructured":"Hutchins TW, Henry JF, Yip TT, Hachey DL, Schanler RJ, Motil KJ et al. Origin of intact lactoferrin and its DNA-binding fragments in the urine of human milk-fed preterm infants. Evaluation by stable isotope enrichment. Pediatr Res 1991; 29: 243\u2013250.","journal-title":"Pediatr Res"},{"key":"BFjp2008130_CR84","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1203\/00006450-198902000-00021","volume":"25","author":"RM Goldblum","year":"1989","unstructured":"Goldblum RM, Schanler RJ, Garza C, Goldman AS . Human milk feeding enhances the urinary excretion of immunological factors in low birth weight infants. Pediatr Res 1989; 25: 184\u2013188.","journal-title":"Pediatr Res"},{"key":"BFjp2008130_CR85","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1136\/adc.62.8.792","volume":"62","author":"A Prentice","year":"1987","unstructured":"Prentice A . Breastfeeding increased concentrations of IgA in infant's urine. Arch Dis Child 1987; 62: 792\u2013795.","journal-title":"Arch Dis Child"},{"key":"BFjp2008130_CR86","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1203\/00006450-198608000-00002","volume":"20","author":"RJ Schanler","year":"1986","unstructured":"Schanler RJ, Goldblum RM, Garza C, Goldman AS . Enhanced fecal excretion of selected immune factors in very low birth weight infants fed fortified human milk. Pediatr Res 1986; 20: 711\u2013715.","journal-title":"Pediatr Res"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp2008130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp2008130","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp2008130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T16:30:53Z","timestamp":1709224253000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp2008130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,4]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["BFjp2008130"],"URL":"https:\/\/doi.org\/10.1038\/jp.2008.130","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,4]]},"assertion":[{"value":"1 February 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}