{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:43:24Z","timestamp":1773387804494,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1038\/jp.2009.146","type":"journal-article","created":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T15:58:58Z","timestamp":1254412738000},"page":"222-226","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Thrombocytosis in neonates and young infants: a report of 25 patients with platelet counts of \u2a7e1\u2009000\u2009000\u2009\u03bcl\u22121"],"prefix":"10.1038","volume":"30","author":[{"given":"S E","family":"Wiedmeier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Henry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Burnett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R D","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,10,1]]},"reference":[{"key":"BFjp2009146_CR1","first-page":"17","volume-title":"World Health Organization Classification of Tumors: Tumors of the Haematopoietic and Lymphoid Tissues","author":"JW Vardiman","year":"2001","unstructured":"Vardiman JW, Brunning RD, Harris NL . WHO histological classification of chronic myeloproliferative diseases. In: Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) World Health Organization Classification of Tumors: Tumors of the Haematopoietic and Lymphoid Tissues. International Agency for Research on Cancer (IARC) Press: France, 2001 pp 17\u201344."},{"issue":"6","key":"BFjp2009146_CR2","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1542\/peds.84.6.1064","volume":"84","author":"KW Chan","year":"1989","unstructured":"Chan KW, Kaikov Y, Wadsworth LD . Thrombocytosis in childhood: A survey of 94 patients. Pediatrics 1989; 84 (6): 1064\u20131067.","journal-title":"Pediatrics"},{"key":"BFjp2009146_CR3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1136\/adc.68.1.88","volume":"68","author":"AJ Vora","year":"1993","unstructured":"Vora AJ, Lilleyman JS . Secondary thrombocytosis. Arch Dis Child 1993; 68: 88\u201390.","journal-title":"Arch Dis Child"},{"issue":"6","key":"BFjp2009146_CR4","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1177\/000992289403300605","volume":"33","author":"MD Yohannan","year":"1994","unstructured":"Yohannan MD, Higgy KE, Al-Mashhadani SA, Santhosh-Kumar CR . Thrombocytosis: etiologic analysis of 663 patients. Clin Pediatr (Phil) 1994; 33 (6): 340\u2013343.","journal-title":"Clin Pediatr (Phil)"},{"key":"BFjp2009146_CR5","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1055\/s-2007-1000654","volume":"21","author":"AH Sutor","year":"1995","unstructured":"Sutor AH . Thrombocytosis in childhood. Semin Thromb Hemost 1995; 21: 330\u2013339.","journal-title":"Semin Thromb Hemost"},{"key":"BFjp2009146_CR6","first-page":"455","volume-title":"Pediatric Hematology","author":"AH Sutor","year":"1999","unstructured":"Sutor AH . Thrombocytosis. In: Lilleyman JS, Hann IM, Blanchette VS (eds) Pediatric Hematology. Harcourt Publishers Ltd: New York, 1999 pp 455\u2013464."},{"key":"BFjp2009146_CR7","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1159\/000076520","volume":"111","author":"K Matsubara","year":"2004","unstructured":"Matsubara K, Fukaya T, Nigami H, Harigaya H, Hirata T, Nozaki H et al. Age-dependent changes in the incidence and etiology of childhood thrombocytosis. Acta Haematol 2004; 111: 132\u2013137.","journal-title":"Acta Haematol"},{"issue":"2","key":"BFjp2009146_CR8","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/jp.2008.141","volume":"29","author":"SE Wiedmeier","year":"2008","unstructured":"Wiedmeier SE, Henry E, Sola-Visner MC, Christensen RD . Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system. J Perinatol 2008; 29 (2): 130\u2013136.","journal-title":"J Perinatol"},{"issue":"3","key":"BFjp2009146_CR9","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0002-9343(94)90150-3","volume":"96","author":"DH Buss","year":"1994","unstructured":"Buss DH, Cashell AW, O\u2019Connor ML, Richards 2nd F, Case LD . Occurrence, etiology, and clinical significance of extreme thrombocytosis: a study of 280 cases. Am J Med 1994; 96 (3): 247\u2013253.","journal-title":"Am J Med"},{"issue":"7","key":"BFjp2009146_CR10","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/S1010-7940(05)80172-1","volume":"9","author":"M Schmuziger","year":"1995","unstructured":"Schmuziger M, Christenson JT, Maurice J, Simonet R, Velebit V . Reactive thromobocytosis after coronary bypass surgery. An important risk factor. Eur J Cardiothorac Surg 1995; 9 (7): 393\u2013397.","journal-title":"Eur J Cardiothorac Surg"},{"issue":"4","key":"BFjp2009146_CR11","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1182\/blood.V91.4.1288","volume":"91","author":"HM Rinder","year":"1998","unstructured":"Rinder HM, Schuster JE, Rinder CS, Wang C, Schweidler HJ, Smith BR . Correlation of thrombosis with increased platelet turnover in thrombocytosis. Blood 1998; 91 (4): 1288\u20131294.","journal-title":"Blood"},{"issue":"4","key":"BFjp2009146_CR12","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1177\/107602960401000412","volume":"10","author":"Y-K Keung","year":"2004","unstructured":"Keung Y-K, Owen J . Iron deficiency and thrombosis: literature review. Clin Appl Thromb Hemost 2004; 10 (4): 387\u2013391.","journal-title":"Clin Appl Thromb Hemost"},{"issue":"1","key":"BFjp2009146_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/(SICI)1096-8652(199905)61:1<10::AID-AJH3>3.0.CO;2-I","volume":"61","author":"RA Mesa","year":"1999","unstructured":"Mesa RA, Silverstein MN, Jacobsen SJ . Population based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia, Olmsted County Study, 1976\u20131995. Am J Hematol 1999; 61 (1): 10\u201315.","journal-title":"Am J Hematol"},{"key":"BFjp2009146_CR14","first-page":"1400","volume":"91","author":"KJ Phekoo","year":"2006","unstructured":"Phekoo KJ, Richard MA, Moller H, Schey SA . South Thames Haematology Specialist Committee. The incidence and outcome of myeloid malignancies in 2112 adult patients in southeast England. Haematologica 2006; 91: 1400\u20131404.","journal-title":"Haematologica"},{"issue":"2","key":"BFjp2009146_CR15","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1365-2796.2004.01357.x","volume":"256","author":"P Johansson","year":"2004","unstructured":"Johansson P, Kutti J, Andreasson B, Safai-Kutti S, Vilen L, Wedel H et al. Trends in the incidence of chronic Philadelphia chromosome negative (Ph-) myeloproliferative disorders in the city of Goteborg, Sweden, during 1983\u201399. J Intern Med 2004; 256 (2): 161\u2013165.","journal-title":"J Intern Med"},{"key":"BFjp2009146_CR16","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1034\/j.1600-0609.2000.90236.x","volume":"65","author":"MK Jensen","year":"2000","unstructured":"Jensen MK, de Nully Brown P, Nielsen OJ, Hasselbalch HC . Incidence, clinical features and outcome of essential thrombocythaemia in a well defined geographical area. Eur J Haematol 2000; 65: 132\u2013139.","journal-title":"Eur J Haematol"},{"key":"BFjp2009146_CR17","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1056\/NEJMra035363","volume":"350","author":"AI Schafer","year":"2004","unstructured":"Schafer AI . Thrombocystosis. N Engl J Med 2004; 350: 1211\u20131219.","journal-title":"N Engl J Med"},{"key":"BFjp2009146_CR18","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/00043426-199909000-00005","volume":"21","author":"Y Dror","year":"1999","unstructured":"Dror Y, Zipursky A, Blanchette VS . Essential thrombocythemia in children. J Pediatr Hematol Oncol 1999; 21: 356\u2013363.","journal-title":"J Pediatr Hematol Oncol"},{"key":"BFjp2009146_CR19","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1046\/j.1365-2141.2000.02239-7.x","volume":"110","author":"H Hasle","year":"2000","unstructured":"Hasle H . Incidence of essential thrombocythaemia in children. Br J Haematol 2000; 110: 751.","journal-title":"Br J Haematol"},{"key":"BFjp2009146_CR20","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1365-2141.2004.05329.x","volume":"129","author":"C Dame","year":"2005","unstructured":"Dame C, Sutor AH . Primary and secondary thrombocytosis in childhood. Br J Haematol 2005; 129: 165\u2013177.","journal-title":"Br J Haematol"},{"key":"BFjp2009146_CR21","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1002\/9780470987001.ch24","volume-title":"Pediatric Hematology","author":"C Dame","year":"2006","unstructured":"Dame C . Thrombocytosis. In: Arceci RJ, Hann IM, Smith OP (eds) Pediatric Hematology. Blackwell Publishing: Massachusetts, 2006 pp 548\u2013561."},{"key":"BFjp2009146_CR22","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/S0140-6736(80)90373-6","volume":"2","author":"RF Schilling","year":"1980","unstructured":"Schilling RF . Platelet millionaires. Lancet 1980; 2: 372\u2013373.","journal-title":"Lancet"},{"key":"BFjp2009146_CR23","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1136\/adc.2006.111484","volume":"92","author":"A Denton","year":"2007","unstructured":"Denton A, Davis P . Extreme thrombocytosis in admissions to paediatric intensive care: no requirement for treatment. Arch Dis Child 2007; 92: 515\u2013516.","journal-title":"Arch Dis Child"},{"key":"BFjp2009146_CR24","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1056\/NEJM199809103391107","volume":"339","author":"K Kaushansky","year":"1998","unstructured":"Kaushansky K . Thrombopoietin. N Engl J Med 1998; 339: 746\u2013754.","journal-title":"N Engl J Med"},{"key":"BFjp2009146_CR25","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0037-1963(00)90049-0","volume":"37","author":"CG Begley","year":"2000","unstructured":"Begley CG, Basser RL . Biologic and structural differences of thrombopoietic growth factors. Semin Hematol 2000; 37: 19\u201327.","journal-title":"Semin Hematol"},{"key":"BFjp2009146_CR26","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1046\/j.0007-1048.2001.03304.x","volume":"116","author":"A Ishiguro","year":"2002","unstructured":"Ishiguro A, Suzuki Y, Mito M, Shimbo T, Matsubara K, Kato T et al. Elevations of serum thrombopoietin precedes thrombocytosis in acute infections. Br J Haematol 2002; 116: 612\u2013618.","journal-title":"Br J Haematol"},{"key":"BFjp2009146_CR27","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1159\/000084454","volume":"113","author":"J O\u2019Shea","year":"2005","unstructured":"O\u2019Shea J, Sherlock M, Philip R . Thrombocytosis in childhood. Acta Haematol 2005; 113: 212.","journal-title":"Acta Haematol"},{"key":"BFjp2009146_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1159\/000206719","volume":"70","author":"G Robbins","year":"1983","unstructured":"Robbins G, Barnard DL . Thrombocytosis and microthrombocytosis: a clinical evaluation of 372 cases. Acta Haematologica 1983; 70: 175\u2013182.","journal-title":"Acta Haematologica"},{"key":"BFjp2009146_CR29","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1046\/j.1365-2141.2001.02888.x","volume":"114","author":"CC Folman","year":"2001","unstructured":"Folman CC, Ooms M, Kuenen BB, de Jong SM, Vet RJ, de Haas M et al. The role of thrombopoietin in post-operative thrombocytosis. Br J Haematol 2001; 114: 126\u2013133.","journal-title":"Br J Haematol"},{"key":"BFjp2009146_CR30","first-page":"107","volume":"66","author":"LL Schloesser","year":"1965","unstructured":"Schloesser LL, Kipp MA, Wenzel FJ . Thrombocytosis in iron-deficiency anemia. J Lab Clin Med 1965; 66: 107\u2013114.","journal-title":"J Lab Clin Med"},{"key":"BFjp2009146_CR31","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1542\/peds.34.3.315","volume":"34","author":"S Gross","year":"1964","unstructured":"Gross S, Keefer V, Newman AJ . The platelets in iron-deficiency anemia. I. The response to oral and parenteral iron. Pediatrics 1964; 34: 315\u2013323.","journal-title":"Pediatrics"},{"key":"BFjp2009146_CR32","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1542\/peds.105.5.1066","volume":"105","author":"H Donato","year":"2000","unstructured":"Donato H, Vain N, Rendo P, Vivas N, Prudent L, Larguia M et al. Effect of early versus late administration of human recombinant erythropoietin on transfusion requirements in premature infants: result of a randomized, placebo-controlled, multicenter trial. Pediatrics 2000; 105: 1066\u20131072.","journal-title":"Pediatrics"},{"key":"BFjp2009146_CR33","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1177\/000992289603500507","volume":"35","author":"N Gasparini","year":"1996","unstructured":"Gasparini N, Franzese A, Argenziano A, Di Maio S, Tenore A . Thrombocytosis in congenital adrenal hyperplasia at diagnosis. Clin Pediatr 1996; 35: 267\u2013269.","journal-title":"Clin Pediatr"},{"key":"BFjp2009146_CR34","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0022-3476(79)80209-7","volume":"94","author":"Y Burstein","year":"1979","unstructured":"Burstein Y, Giardina PJV, Rausen AR, Kandall SR, Siljestrom K, Peterson CM . Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users. J Pediatr 1979; 94: 895\u2013899.","journal-title":"J Pediatr"},{"key":"BFjp2009146_CR35","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/S0022-3476(82)80474-5","volume":"100","author":"Y Burstein","year":"1982","unstructured":"Burstein Y, Rausen AR, Peterson CM . Duration of thrombocytosis in infants of polydrug (including methadone) users. J Pediatr 1982; 100: 506.","journal-title":"J Pediatr"},{"key":"BFjp2009146_CR36","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1136\/adc.64.3.426","volume":"64","author":"HM Chambers","year":"1989","unstructured":"Chambers HM, Haslam RR . Maternal narcotic abuse and neonatal thrombocytosis. Arch Dis Child 1989; 64: 426.","journal-title":"Arch Dis Child"},{"key":"BFjp2009146_CR37","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/088800102753541341","volume":"19","author":"O Garcia-Algar","year":"2002","unstructured":"Garcia-Algar O, Brichs LF, Garcia ES, Fabrega DM, Torne EE, Sierra AM . Methadone and neonatal thrombocytosis. Pediatr Hematol Oncol. 2002; 19: 193\u2013195.","journal-title":"Pediatr Hematol Oncol."},{"key":"BFjp2009146_CR38","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3181\/00379727-164-40861","volume":"164","author":"Y Burstein","year":"1980","unstructured":"Burstein Y, Grady RW, Kreek MJ, Kreek MJ, Rausen AR, Peterson CM . Thrombocytosis in the offspring of female mice receiving DL-methadone (40861). Proc Soc Exp Biol Med 1980; 164: 275\u2013279.","journal-title":"Proc Soc Exp Biol Med"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp2009146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp2009146","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp2009146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T11:48:32Z","timestamp":1647604112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp2009146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,1]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["BFjp2009146"],"URL":"https:\/\/doi.org\/10.1038\/jp.2009.146","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,1]]},"assertion":[{"value":"10 July 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2009","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2009","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2009","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}