{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:54:11Z","timestamp":1782168851914,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T00:00:00Z","timestamp":1260403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T00:00:00Z","timestamp":1260403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1038\/jp.2009.191","type":"journal-article","created":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T11:07:13Z","timestamp":1260443233000},"page":"484-488","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Early cortisol values and long-term outcomes in extremely low birth weight infants"],"prefix":"10.1038","volume":"30","author":[{"given":"S W","family":"Aucott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K L","family":"Watterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P K","family":"Donohue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the PROPHET study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,10]]},"reference":[{"key":"BFjp2009191_CR1","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1016\/S0140-6736(83)92139-6","volume":"1","author":"MC Mammel","year":"1983","unstructured":"Mammel MC, Green TP, Johnson DE, Thompson TR . Controlled trial of dexamethasone therapy in infants with bronchopulmonary dysplasia. Lancet 1983; 1: 1356\u20131358.","journal-title":"Lancet"},{"issue":"2 Pt 1","key":"BFjp2009191_CR2","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S0022-3476(05)80547-5","volume":"117","author":"TF Yeh","year":"1990","unstructured":"Yeh TF, Torre JA, Rastogi A, Anyebuno MA, Pildes RS . Early postnatal dexamethasone therapy in premature infants with severe respiratory distress syndrome: a double-blind, controlled study. J Pediatr 1990; 117 (2 Pt 1): 273\u2013282.","journal-title":"J Pediatr"},{"key":"BFjp2009191_CR3","doi-asserted-by":"publisher","first-page":"F177","DOI":"10.1136\/fn.83.3.F177","volume":"83","author":"ES Shinwell","year":"2000","unstructured":"Shinwell ES, Karplus M, Reich D, Weintraub Z, Blazer S, Bader D et al. Early postnatal dexamethasone treatment and increased incidence of cerebral palsy. Arch Dis Child Fetal Neonatal Ed 2000; 83: F177\u2013F181.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFjp2009191_CR4","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1056\/NEJMoa032089","volume":"350","author":"TF Yeh","year":"2004","unstructured":"Yeh TF, Lin YJ, Lin HC, Huang CC, Hsieh WS, Lin CH et al. Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity. N Engl J Med 2004; 350: 1304\u20131313.","journal-title":"N Engl J Med"},{"key":"BFjp2009191_CR5","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1542\/peds.104.6.1258","volume":"104","author":"KL Watterberg","year":"1999","unstructured":"Watterberg KL, Gerdes JS, Gifford KL, Lin HM . Prophylaxis against early adrenal insufficiency to prevent chronic lung disease in premature infants. Pediatrics 1999; 104: 1258\u20131263.","journal-title":"Pediatrics"},{"key":"BFjp2009191_CR6","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1203\/00006450-200011000-00013","volume":"48","author":"MW Huysman","year":"2000","unstructured":"Huysman MW, Hokken-Koelega AC, De Ridder MA, Sauer PJ . Adrenal function in sick very preterm infants. Pediatr Res 2000; 48: 629\u2013633.","journal-title":"Pediatr Res"},{"key":"BFjp2009191_CR7","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1203\/00006450-200204000-00004","volume":"51","author":"KL Watterberg","year":"2002","unstructured":"Watterberg KL . Adrenal insufficiency and cardiac dysfunction in the preterm infant. Pediatr Res 2002; 51: 422\u2013424.","journal-title":"Pediatr Res"},{"key":"BFjp2009191_CR8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1542\/peds.95.1.120","volume":"95","author":"KL Watterberg","year":"1995","unstructured":"Watterberg KL, Scott SM . Evidence of early adrenal insufficiency in babies who develop bronchopulmonary dysplasia. Pediatrics 1995; 95: 120\u2013125.","journal-title":"Pediatrics"},{"key":"BFjp2009191_CR9","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1542\/peds.105.2.320","volume":"105","author":"KL Watterberg","year":"2000","unstructured":"Watterberg KL, Scott SM, Backstrom C, Gifford KL, Cook KL . Links between early adrenal function and respiratory outcome in preterm infants: airway inflammation and patent ductus arteriosus. Pediatrics 2000; 105: 320\u2013324.","journal-title":"Pediatrics"},{"key":"BFjp2009191_CR10","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/sj.jp.7211112","volume":"24","author":"SM Scott","year":"2004","unstructured":"Scott SM, Cimino DF . Evidence for developmental hypopituitarism in ill preterm infants. J Perinatol 2004; 24: 429\u2013434.","journal-title":"J Perinatol"},{"key":"BFjp2009191_CR11","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1542\/peds.2004-1159","volume":"114","author":"KL Watterberg","year":"2004","unstructured":"Watterberg KL, Gerdes JS, Cole CH, Aucott SW, Thilo EH, Mammel MC et al. Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multicenter trial. Pediatrics 2004; 114: 1649\u20131657.","journal-title":"Pediatrics"},{"key":"BFjp2009191_CR12","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.jpeds.2004.12.040","volume":"146","author":"O Peltoniemi","year":"2005","unstructured":"Peltoniemi O, Kari MA, Heinonen K, Saarela T, Nikolajev K, Andersson S et al. Pretreatment cortisol values may predict responses to hydrocortisone administration for the prevention of bronchopulmonary dysplasia in high-risk infants. J Pediatr 2005; 146: 632\u2013637.","journal-title":"J Pediatr"},{"key":"BFjp2009191_CR13","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000098168","volume":"91","author":"F Bonsante","year":"2007","unstructured":"Bonsante F, Latorre G, Iacobelli S, Forziati V, Laforgia N, Esposito L et al. Early low-dose hydrocortisone in very preterm infants: a randomized, placebo-controlled trial. Neonatology 2007; 91: 217\u2013221.","journal-title":"Neonatology"},{"key":"BFjp2009191_CR14","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1542\/peds.2007-2252","volume":"122","author":"SW Aucott","year":"2008","unstructured":"Aucott SW, Watterberg KL, Shaffer ML, Donohue PK . Do cortisol concentrations predict short-term outcomes in extremely low birth weight infants? Pediatrics 2008; 122: 775\u2013781.","journal-title":"Pediatrics"},{"key":"BFjp2009191_CR15","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1542\/peds.2006-3158","volume":"120","author":"KL Watterberg","year":"2007","unstructured":"Watterberg KL, Shaffer ML, Mishefske MJ, Leach CL, Mammel MC, Couser RJ et al. Growth and neurodevelopmental outcomes after early low-dose hydrocortisone treatment in extremely low birth weight infants. Pediatrics 2007; 120: 40\u201348.","journal-title":"Pediatrics"},{"key":"BFjp2009191_CR16","doi-asserted-by":"publisher","first-page":"F127","DOI":"10.1136\/adc.2002.021980","volume":"89","author":"PC Ng","year":"2004","unstructured":"Ng PC, Lee CH, Lam CW, Ma KC, Chan IH, Wong E et al. Early pituitary-adrenal response and respiratory outcomes in preterm infants. Arch Dis Child Fetal Neonatal Ed 2004; 89: F127\u2013F130.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFjp2009191_CR17","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/jp.2008.190","volume":"28","author":"EF Fernandez","year":"2008","unstructured":"Fernandez EF, Montman R, Watterberg KL . ACTH and cortisol response to critical illness in term and late preterm newborns. J Perinatol 2008; 28: 797\u2013802.","journal-title":"J Perinatol"},{"key":"BFjp2009191_CR18","doi-asserted-by":"publisher","first-page":"F119","DOI":"10.1136\/adc.2002.021972","volume":"89","author":"PC Ng","year":"2004","unstructured":"Ng PC, Lee CH, Lam CW, Ma KC, Fok TF, Chan IH et al. Transient adrenocortical insufficiency of prematurity and systemic hypotension in very low birthweight infants. Arch Dis Child Fetal Neonatal Ed 2004; 89: F119\u2013F126.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"2","key":"BFjp2009191_CR19","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1542\/peds.109.2.330","volume":"109","author":"Committee on Fetus and Newborn","year":"2002","unstructured":"Committee on Fetus and Newborn. Postnatal corticosteroids to treat or prevent chronic lung disease in preterm infants. Pediatrics 2002; 109: 330\u2013338.","journal-title":"PEDIATRICS"},{"key":"BFjp2009191_CR20","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1542\/peds.2005-0796","volume":"117","author":"NN Finer","year":"2006","unstructured":"Finer NN, Powers RJ, Ou CH, Durand D, Wirtschafter D, Gould JB . Prospective evaluation of postnatal steroid administration: a 1-year experience from the California Perinatal Quality Care Collaborative. Pediatrics 2006; 117: 704\u2013713.","journal-title":"Pediatrics"},{"key":"BFjp2009191_CR21","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1159\/000164150","volume":"95","author":"OM Peltoniemi","year":"2009","unstructured":"Peltoniemi OM, Lano A, Puosi R, Yliherva A, Bonsante F, Kari MA et al. Trial of early neonatal hydrocortisone: two-year follow-up. Neonatology 2009; 95: 240\u2013247.","journal-title":"Neonatology"},{"key":"BFjp2009191_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2004-1275","volume":"116","author":"GA Lodygensky","year":"2005","unstructured":"Lodygensky GA, Rademaker K, Zimine S, Gex-Fabry M, Lieftink AF, Lazeyras F et al. Structural and functional brain development after hydrocortisone treatment for neonatal chronic lung disease. Pediatrics 2005; 116: 1\u20137.","journal-title":"Pediatrics"},{"key":"BFjp2009191_CR23","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jpeds.2006.10.051","volume":"150","author":"KJ Rademaker","year":"2007","unstructured":"Rademaker KJ, Uiterwaal CS, Groenendaal F, Venema MM, van Bel F, Beek FJ et al. Neonatal hydrocortisone treatment: neurodevelopmental outcome and MRI at school age in preterm-born children. J Pediatr 2007; 150: 351\u2013357.","journal-title":"J Pediatr"},{"key":"BFjp2009191_CR24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0006-8993(95)00350-Y","volume":"682","author":"RS Sloviter","year":"1995","unstructured":"Sloviter RS, Sollas AL, Neubort S . Hippocampal dentate granule cell degeneration after adrenalectomy in the rat is not reversed by dexamethasone. Brain Res 1995; 682: 227\u2013230.","journal-title":"Brain Res"},{"key":"BFjp2009191_CR25","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1210\/jcem.87.3.8295","volume":"87","author":"RJ Bolt","year":"2002","unstructured":"Bolt RJ, van Weissenbruch MM, Popp-Snijders C, Sweep CG, Lafeber HN, Delemarre-van de Waal HA . Fetal growth and the function of the adrenal cortex in preterm infants. J Clin Endocrinol Metab 2002; 87: 1194\u20131199.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFjp2009191_CR26","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S0022-3476(95)70229-6","volume":"126","author":"S al Saedi","year":"1995","unstructured":"al Saedi S, Dean H, Dent W, Cronin C . Reference ranges for serum cortisol and 17-hydroxyprogesterone levels in preterm infants. J Pediatr 1995; 126: 985\u2013987.","journal-title":"J Pediatr"},{"key":"BFjp2009191_CR27","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.metabol.2003.09.005","volume":"53","author":"AT Soliman","year":"2004","unstructured":"Soliman AT, Taman KH, Rizk MM, Nasr IS, Alrimawy H, Hamido MS . Circulating adrenocorticotropic hormone (ACTH) and cortisol concentrations in normal, appropriate-for-gestational-age newborns versus those with sepsis and respiratory distress: cortisol response to low-dose and standard-dose ACTH tests. Metabolism 2004; 53: 209\u2013214.","journal-title":"Metabolism"},{"key":"BFjp2009191_CR28","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1001\/archpedi.153.4.331","volume":"153","author":"KJ Anand","year":"1999","unstructured":"Anand KJ, Barton BA, McIntosh N, Lagercrantz H, Pelausa E, Young TE et al. Analgesia and sedation in preterm neonates who require ventilatory support: results from the NOPAIN trial. Neonatal Outcome and Prolonged Analgesia in Neonates. Arch Pediatr Adolesc Med 1999; 153: 331\u2013338.","journal-title":"Arch Pediatr Adolesc Med"},{"key":"BFjp2009191_CR29","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.earlhumdev.2006.04.003","volume":"83","author":"M Neu","year":"2007","unstructured":"Neu M, Goldstein M, Gao D, Laudenslager ML . Salivary cortisol in preterm infants: validation of a simple method for collecting saliva for cortisol determination. Early Hum Dev 2007; 83: 47\u201354.","journal-title":"Early Hum Dev"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp2009191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp2009191","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp2009191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T13:13:41Z","timestamp":1647609221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp2009191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,10]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["BFjp2009191"],"URL":"https:\/\/doi.org\/10.1038\/jp.2009.191","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,10]]},"assertion":[{"value":"2 August 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}