{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:32:32Z","timestamp":1787002352093,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:00:00Z","timestamp":1267056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T00:00:00Z","timestamp":1267056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1038\/jp.2010.16","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T04:24:20Z","timestamp":1267071860000},"page":"610-615","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["High-mobility group box-1 protein in tracheal aspirates from premature infants: relationship with bronchopulmonary dysplasia and steroid therapy"],"prefix":"10.1038","volume":"30","author":[{"given":"Z H","family":"Aghai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J G","family":"Saslow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Meniru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Porter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Eydelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sannoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Pyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,25]]},"reference":[{"key":"BFjp201016_CR1","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1542\/peds.2008-1962","volume":"123","author":"A Bhandari","year":"2009","unstructured":"Bhandari A, Bhandari V . Pitfalls, problems, and progress in bronchopulmonary dysplasia. Pediatrics 2009; 123: 1562\u20131573.","journal-title":"Pediatrics"},{"key":"BFjp201016_CR2","first-page":"1","volume":"55","author":"BE Hamilton","year":"2006","unstructured":"Hamilton BE, Martin JA, Ventura SJ . Births: preliminary data for 2005. Natl Vital Stat Rep 2006; 55: 1\u201318.","journal-title":"Natl Vital Stat Rep"},{"key":"BFjp201016_CR3","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.ajog.2006.09.014","volume":"196","author":"AA Fanaroff","year":"2007","unstructured":"Fanaroff AA, Stoll BJ, Wright LL, Carlo WA, Ehrenkranz RA, Stark AR et al. Trends in neonatal morbidity and mortality for very low birth weight infants. Am J Obstet Gynecol 2007; 196: 147 e141\u2013148.","journal-title":"Am J Obstet Gynecol"},{"key":"BFjp201016_CR4","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1189\/jlb.72.6.1084","volume":"72","author":"U Andersson","year":"2002","unstructured":"Andersson U, Erlandsson-Harris H, Yang H, Tracey KJ . HMGB1 as a DNA-binding cytokine. J Leukoc Biol 2002; 72: 1084\u20131091.","journal-title":"J Leukoc Biol"},{"key":"BFjp201016_CR5","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/j.1365-2796.2003.01302.x","volume":"255","author":"H Wang","year":"2004","unstructured":"Wang H, Yang H, Tracey KJ . Extracellular role of HMGB1 in inflammation and sepsis. J Intern Med 2004; 255: 320\u2013331.","journal-title":"J Intern Med"},{"key":"BFjp201016_CR6","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1164\/rccm.200605-699OC","volume":"174","author":"EN Ogawa","year":"2006","unstructured":"Ogawa EN, Ishizaka A, Tasaka S, Koh H, Ueno H, Amaya F et al. Contribution of high-mobility group box-1 to the development of ventilator-induced lung injury. Am J Respir Crit Care Med 2006; 174: 400\u2013407.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFjp201016_CR7","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/S1359-6101(03)00059-5","volume":"14","author":"RB Goodman","year":"2003","unstructured":"Goodman RB, Pugin J, Lee JS, Matthay MA . Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev 2003; 14: 523\u2013535.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFjp201016_CR8","doi-asserted-by":"publisher","first-page":"F36","DOI":"10.1136\/adc.2003.045807","volume":"91","author":"A Bourbia","year":"2006","unstructured":"Bourbia A, Cruz MA, Rozycki HJ . NF-kappaB in tracheal lavage fluid from intubated premature infants: association with inflammation, oxygen, and outcome. Arch Dis Child Fetal Neonatal Ed 2006; 91: F36\u2013F39.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFjp201016_CR9","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1203\/PDR.0b013e318142582d","volume":"62","author":"ZH Aghai","year":"2007","unstructured":"Aghai ZH, Kode A, Saslow JG, Nakhla T, Farhath S, Stahl GE et al. Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants. Pediatr Res 2007; 62: 483\u2013488.","journal-title":"Pediatr Res"},{"key":"BFjp201016_CR10","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1038\/nm1494","volume":"12","author":"V Bhandari","year":"2006","unstructured":"Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL et al. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med 2006; 12: 1286\u20131293.","journal-title":"Nat Med"},{"key":"BFjp201016_CR11","first-page":"245","volume":"17","author":"W Lutz","year":"2004","unstructured":"Lutz W, Stetkiewicz J . High mobility group box 1 protein as a late-acting mediator of acute lung inflammation. Int J Occup Med Environ Health 2004; 17: 245\u2013254.","journal-title":"Int J Occup Med Environ Health"},{"key":"BFjp201016_CR12","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1126\/science.285.5425.248","volume":"285","author":"H Wang","year":"1999","unstructured":"Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999; 285: 248\u2013251.","journal-title":"Science"},{"key":"BFjp201016_CR13","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1164\/rccm.200402-188OC","volume":"170","author":"H Ueno","year":"2004","unstructured":"Ueno H, Matsuda T, Hashimoto S, Amaya F, Kitamura Y, Tanaka M et al. Contributions of high mobility group box protein in experimental and clinical acute lung injury. Am J Respir Crit Care Med 2004; 170: 1310\u20131316.","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"BFjp201016_CR14","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1164\/rccm.200809-1433OC","volume":"180","author":"BS Ding","year":"2009","unstructured":"Ding BS, Hong N, Christofidou-Solomidou M, Gottstein C, Albelda SM, Cines DB et al. Anchoring fusion thrombomodulin to the endothelial lumen protects injury-induced lung thrombosis and inflammation. Am J Respir Crit Care Med 2009; 180 (3): 247\u2013256.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFjp201016_CR15","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1097\/SHK.0b013e318157eddd","volume":"29","author":"MA van Zoelen","year":"2008","unstructured":"van Zoelen MA, Ishizaka A, Wolthuls EK, Choi G, van der Poll T, Schultz MJ . Pulmonary levels of high-mobility group box 1 during mechanical ventilation and ventilator-associated pneumonia. Shock 2008; 29: 441\u2013445.","journal-title":"Shock"},{"key":"BFjp201016_CR16","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.2174\/138161208784980572","volume":"14","author":"E Crouser","year":"2008","unstructured":"Crouser E, Exline M, Knoell D, Wewers MD . Sepsis: links between pathogen sensing and organ damage. Curr Pharm Des 2008; 14: 1840\u20131852.","journal-title":"Curr Pharm Des"},{"key":"BFjp201016_CR17","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/00075198-200502000-00013","volume":"11","author":"V Lionetti","year":"2005","unstructured":"Lionetti V, Recchia FA, Ranieri VM . Overview of ventilator-induced lung injury mechanisms. Curr Opin Crit Care 2005; 11: 82\u201386.","journal-title":"Curr Opin Crit Care"},{"key":"BFjp201016_CR18","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.4161\/cc.6.9.4229","volume":"6","author":"V Bhandari","year":"2007","unstructured":"Bhandari V, Elias JA . The role of angiopoietin 2 in hyperoxia-induced acute lung injury. Cell Cycle 2007; 6: 1049\u20131052.","journal-title":"Cell Cycle"},{"issue":"3","key":"BFjp201016_CR19","doi-asserted-by":"publisher","first-page":"958","DOI":"10.2353\/ajpath.2009.090156","volume":"175","author":"CS Buhimschi","year":"2009","unstructured":"Buhimschi CS, Baumbusch MA, Dulay AT, Oliver EA, Lee S, Zhao G et al. Characterization of RAGE, HMGB1, and S100{beta} in inflammation-induced preterm birth and fetal tissue injury. Am J Pathol 2009; 175 (3): 958\u2013975.","journal-title":"Am J Pathol"},{"key":"BFjp201016_CR20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1165\/rcmb.2006-0116OC","volume":"36","author":"K Bry","year":"2007","unstructured":"Bry K, Whitsett JA, Lappalainen U . IL-1beta disrupts postnatal lung morphogenesis in the mouse. Am J Respir Cell Mol Biol 2007; 36: 32\u201342.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFjp201016_CR21","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1164\/ajrccm.160.4.9810071","volume":"160","author":"JJ Coalson","year":"1999","unstructured":"Coalson JJ, Winter VT, Siler-Khodr T, Yoder BA . Neonatal chronic lung disease in extremely immature baboons. Am J Respir Crit Care Med 1999; 160: 1333\u20131346.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFjp201016_CR22","first-page":"361","volume":"3","author":"A Thomson","year":"2008","unstructured":"Thomson A, Bhandari V . Pulmonary biomarkers of bronchopulmonary dysplasia. Biomarker Insights 2008; 3: 361\u2013373.","journal-title":"Biomarker Insights"},{"key":"BFjp201016_CR23","doi-asserted-by":"publisher","first-page":"G643","DOI":"10.1152\/ajpgi.00067.2005","volume":"289","author":"R Zamora","year":"2005","unstructured":"Zamora R, Grishin A, Wong C, Boyle P, Wang J, Hackam D et al. High-mobility group box 1 protein is an inflammatory mediator in necrotizing enterocolitis: protective effect of the macrophage deactivator semapimod. Am J Physiol Gastrointest Liver Physiol 2005; 289: G643\u2013G652.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"BFjp201016_CR24","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1159\/000116635","volume":"94","author":"K Okazaki","year":"2008","unstructured":"Okazaki K, Kondo M, Kato M, Kakinuma R, Nishida A, Noda M et al. Elevation of high-mobility group box 1 concentration in asphyxiated neonates. Neonatology 2008; 94: 105\u2013109.","journal-title":"Neonatology"},{"key":"BFjp201016_CR25","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1097\/01.shk.0000055237.25446.80","volume":"19","author":"CH Lang","year":"2003","unstructured":"Lang CH, Silvis C, Deshpande N, Nystrom G, Frost RA . Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin- 1beta, -6, and high-mobility-group protein-1 in skeletal muscle. Shock 2003; 19: 538\u2013546.","journal-title":"Shock"},{"key":"BFjp201016_CR26","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1046\/j.1365-2796.2003.01204.x","volume":"254","author":"CJ Treutiger","year":"2003","unstructured":"Treutiger CJ, Mullins GE, Johansson AS, Rouhiainen A, Rauvala HM, Erlandsson-Harris H et al. High mobility group 1 B-box mediates activation of human endothelium. J Intern Med 2003; 254: 375\u2013385.","journal-title":"J Intern Med"},{"key":"BFjp201016_CR27","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/j.0300-9475.2004.01518.x","volume":"60","author":"GE Mullins","year":"2004","unstructured":"Mullins GE, Sunden-Cullberg J, Johansson AS, Rouhiainen A, Erlandsson-Harris H, Yang H et al. Activation of human umbilical vein endothelial cells leads to relocation and release of high-mobility group box chromosomal protein 1. Scand J Immunol 2004; 60: 566\u2013573.","journal-title":"Scand J Immunol"},{"key":"BFjp201016_CR28","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1203\/01.pdr.0000219120.92049.b3","volume":"59","author":"ZH Aghai","year":"2006","unstructured":"Aghai ZH, Kumar S, Farhath S, Kumar MA, Saslow J, Nakhla T et al. Dexamethasone suppresses expression of nuclear factor-kappa B in the cells of tracheobronchial lavage fluid in premature neonates with respiratory distress. Pediatr Res 2006; 59: 811\u2013815.","journal-title":"Pediatr Res"},{"key":"BFjp201016_CR29","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.4049\/jimmunol.178.6.3856","volume":"178","author":"W Li","year":"2007","unstructured":"Li W, Li J, Ashok M, Wu R, Chen D, Yang L et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol 2007; 178: 3856\u20133864.","journal-title":"J Immunol"},{"key":"BFjp201016_CR30","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/S0022-3476(09)90024-5","volume":"122","author":"P Groneck","year":"1993","unstructured":"Groneck P, Reuss D, Gotze-Speer B, Speer CP . Effects of dexamethasone on chemotactic activity and inflammatory mediators in tracheobronchial aspirates of preterm infants at risk for chronic lung disease. J Pediatr 1993; 122: 938\u2013944.","journal-title":"J Pediatr"},{"key":"BFjp201016_CR31","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1136\/thx.47.1.44","volume":"47","author":"SH Murch","year":"1992","unstructured":"Murch SH, MacDonald TT, Wood CB, Costeloe KL . Tumour necrosis factor in the bronchoalveolar secretions of infants with the respiratory distress syndrome and the effect of dexamethasone treatment. Thorax 1992; 47: 44\u201347.","journal-title":"Thorax"},{"key":"BFjp201016_CR32","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1159\/000063608","volume":"82","author":"CT D'Angio","year":"2002","unstructured":"D'Angio CT, Basavegowda K, Avissar NE, Finkelstein JN, Sinkin RA . Comparison of tracheal aspirate and bronchoalveolar lavage specimens from premature infants. Biol Neonate 2002; 82: 145\u2013149.","journal-title":"Biol Neonate"},{"key":"BFjp201016_CR33","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1165\/rcmb.2007-0024OC","volume":"39","author":"V Bhandari","year":"2008","unstructured":"Bhandari V, Choo-Wing R, Lee CG, Yusuf K, Nedrelow JH, Ambalavanan N et al. Developmental regulation of NO-mediated VEGF-induced effects in the lung. Am J Respir Cell Mol Biol 2008; 39: 420\u2013430.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFjp201016_CR34","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1067\/S0022-3476(03)00297-X","volume":"143","author":"P Lassus","year":"2003","unstructured":"Lassus P, Heikkila P, Andersson LC, von Boguslawski K, Andersson S . Lower concentration of pulmonary hepatocyte growth factor is associated with more severe lung disease in preterm infants. J Pediatr 2003; 143: 199\u2013202.","journal-title":"J Pediatr"},{"key":"BFjp201016_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1365-3083.2008.02194.x","volume":"69","author":"Q Gong","year":"2009","unstructured":"Gong Q, Xu JF, Yin H, Liu SF, Duan LH, Bian ZL . Protective effect of antagonist of high-mobility group box 1 on lipopolysaccharide-induced acute lung injury in mice. Scand J Immunol 2009; 69: 29\u201335.","journal-title":"Scand J Immunol"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp201016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201016","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T12:44:23Z","timestamp":1685450663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp201016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,25]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["BFjp201016"],"URL":"https:\/\/doi.org\/10.1038\/jp.2010.16","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,25]]},"assertion":[{"value":"11 September 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2009","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 December 2009","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}