{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:48:17Z","timestamp":1791298097030,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:00:00Z","timestamp":1357776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T00:00:00Z","timestamp":1357776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1038\/jp.2012.165","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T18:25:29Z","timestamp":1357842329000},"page":"520-524","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["ACTH and cortisol cord plasma concentrations in preterm and term infants"],"prefix":"10.1038","volume":"33","author":[{"given":"F","family":"Bagnoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Fommei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Coriolani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Badii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Tomasini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,10]]},"reference":[{"issue":"3","key":"BFjp2012165_CR1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1159\/000263348","volume":"3","author":"DL Economides","year":"1988","unstructured":"Economides DL, Nicolaides KH, Linton EA, Perry LA, Chard T . Plasma cortisol and adrenocorticotropin in appropriate and small for gestational age fetuses. Fetal Ther 1988; 3 (3): 158\u2013164.","journal-title":"Fetal Ther"},{"key":"BFjp2012165_CR2","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/j.1365-2265.1991.tb03564.x","volume":"35","author":"A Donaldson","year":"1991","unstructured":"Donaldson A, Nicolini U, Symes EK, Rodeck CH, Tennirandorn Y . Changes in concentration of cortisol, dehydroepiandrosterone sulphate and progesterone in fetal and maternal serum during pregnancy. Clin Endocrinol (Oxf) 1991; 35: 447\u2013451.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"BFjp2012165_CR3","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/0022-4731(85)90191-8","volume":"23","author":"K Nahoul","year":"1985","unstructured":"Nahoul K, Daffog F, Forestier F, Scholler R . Cortisol, cortisone and dehydroepiandrosterone sulfate levels in umbilical cord and maternal plasma between 21 and 30 weeks of pregnancy. J Steroid Biochem 1985; 23: 445\u2013450.","journal-title":"J Steroid Biochem"},{"issue":"9","key":"BFjp2012165_CR4","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1080\/14767050600853179","volume":"19","author":"SY Oh","year":"2006","unstructured":"Oh SY, Romero R, Shim SS, Park JS, Jun JK, Yoon BH . Fetal plasma cortisol and dehydroepiandrosterone sulfate concentrations in pregnancy and term parturition. J Matern Fetal Neonatal Med 2006; 19 (9): 529\u2013536.","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2","key":"BFjp2012165_CR5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/01443610410001645389","volume":"24","author":"K Mears","year":"2004","unstructured":"Mears K, McAuliffe F, Grimes H, Morrison JJ . Fetal cortisol in relation to labour, intrapartum events and mode of delivery. J Obstet Gynaecol 2004; 24 (2): 129\u2013132.","journal-title":"J Obstet Gynaecol"},{"issue":"6","key":"BFjp2012165_CR6","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1016\/0002-9378(93)90409-C","volume":"169","author":"CR Parker","year":"1993","unstructured":"Parker CR, Favor JK, Carden LG, Brown CH . Effects of intrapartum stress on fetal adrenal function. Am J Obstet Gynecol 1993; 169 (6): 1407\u20131411.","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"BFjp2012165_CR7","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1471-0528.2006.00865.x","volume":"113","author":"SE Vogl","year":"2006","unstructured":"Vogl SE, Worda C, Egarter C, Bieglmayer C, Szekeres T, Huber J et al. Mode of delivery is associated with maternal and fetal endocrine stress response. Br J Obstet Gynaecol 2006; 113 (4): 441\u2013445.","journal-title":"Br J Obstet Gynaecol"},{"issue":"1","key":"BFjp2012165_CR8","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1210\/jcem-73-1-182","volume":"73","author":"SM Ramin","year":"1991","unstructured":"Ramin SM, Porter JC, Gilstrap LC, Rosenfeld CR . Stress hormones and acid-base status of human fetuses at delivery. J Clin Endocrinol Metab 1991; 73 (1): 182\u2013186.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"BFjp2012165_CR9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1515\/jpme.1987.15.1.45","volume":"15","author":"G Bacigalupo","year":"1987","unstructured":"Bacigalupo G, Langner K, Schmidt S, Saling E . Plasma immunoreactive beta-endorphin, ACTH and cortisol concentrations in mothers and their neonates immediately after delivery-their relationship to the duration of labor. J Perinat Med 1987; 15 (1): 45\u201352.","journal-title":"J Perinat Med"},{"issue":"1","key":"BFjp2012165_CR10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/S0301-2115(01)00298-6","volume":"98","author":"R Gitau","year":"2001","unstructured":"Gitau R, Menson E, Pickles V, Fisk NM, Glover V, MacLachlan N . Umbilical cortisol levels as an indicator of the fetal stress response to assisted vaginal delivery. Eur J Obstet Gynecol Reprod Biol 2001; 98 (1): 14\u201317.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"10","key":"BFjp2012165_CR11","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1111\/j.1471-0528.1985.tb03000.x","volume":"92","author":"RG Farquharson","year":"1985","unstructured":"Farquharson RG, Dyas J, Pierrepoint CG . Cortisol concentrations in the umbilical artery and vein of breech-presenting infants at term in relation to the method of delivery. Br J Obstet Gynaecol 1985; 92 (10): 1040\u20131043.","journal-title":"Br J Obstet Gynaecol"},{"issue":"4","key":"BFjp2012165_CR12","first-page":"317","volume":"64","author":"F Bagnoli","year":"1988","unstructured":"Bagnoli F, Bruchi S, Garosi G, Caniggia I, Inaudi PA . Phenomenon of neonatal adaptation: progesterone, ACTH and cortisol during the 1st 24 hours of life. [Article in Italian]. Boll Soc Ital Biol Sper 1988; 64 (4): 317\u2013322.","journal-title":"Boll Soc Ital Biol Sper"},{"issue":"2","key":"BFjp2012165_CR13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1055\/s-2007-994641","volume":"10","author":"V Ruth","year":"1993","unstructured":"Ruth V, Hallman M, Laatikainen T . Corticotropin-releasing hormone and cortisol in cord plasma in relation to gestational age, labor, and fetal distress. Am J Perinatol 1993; 10 (2): 115\u2013118.","journal-title":"Am J Perinatol"},{"issue":"2","key":"BFjp2012165_CR14","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1159\/000293314","volume":"29","author":"P Hercz","year":"1990","unstructured":"Hercz P, Sikl\u00f3s P, Ung\u00e1r L . Serum dehydroepiandrosterone and cortisol concentration in the maternal-fetoplacental hormonal system in elective caesarean section and spontaneous vaginal delivery in the 28th to 36th and 40th weeks of pregnancy. Gynecol Obstet Invest 1990; 29 (2): 112\u2013114.","journal-title":"Gynecol Obstet Invest"},{"issue":"2","key":"BFjp2012165_CR15","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1210\/edrv-4-2-150","volume":"4","author":"BE Murphy","year":"1983","unstructured":"Murphy BE . Human fetal serum cortisol levels at delivery: a review. Endocr Rev 1983; 4 (2): 150\u2013154.","journal-title":"Endocr Rev"},{"issue":"4","key":"BFjp2012165_CR16","first-page":"278","volume":"25","author":"T Ochedalski","year":"2004","unstructured":"Ochedalski T, Lachowicz A . Maternal and fetal hypothalamo-pituitary-adrenal axis: different response depends upon the mode of parturition. Neuro Endocrinol Lett 2004; 25 (4): 278\u2013282.","journal-title":"Neuro Endocrinol Lett"},{"issue":"3","key":"BFjp2012165_CR17","first-page":"378","volume":"18","author":"S Mesiano","year":"1997","unstructured":"Mesiano S, Jaffe RB . Developmental and functional biology of the primate fetal adrenal cortex. Endocr Rev 1997; 18 (3): 378\u2013403.","journal-title":"Endocr Rev"},{"issue":"4","key":"BFjp2012165_CR18","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1172\/JCI25091","volume":"116","author":"M Goto","year":"2006","unstructured":"Goto M, Piper Hanley K, Marcos J, Wood PJ, Wright S, Postle AD et al. In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development. J Clin Invest 2006; 116 (4): 953\u2013960.","journal-title":"J Clin Invest"},{"issue":"2","key":"BFjp2012165_CR19","first-page":"266","volume":"78","author":"RV Hingre","year":"1994","unstructured":"Hingre RV, Gross SJ, Hingre KS, Mayes DM, Richman RA . Adrenal steroidogenesis in very low birth weight preterm infants. J Clin Endocrinol Metab 1994; 78 (2): 266\u2013270.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"BFjp2012165_CR20","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0022-3476(96)70404-3","volume":"128","author":"C Korte","year":"1996","unstructured":"Korte C, Styne D, Merritt TA, Mayes D, Wertz A, Helbock HJ . Adrenocortical function in the very low birth weight infant: improved testing sensitivity and association with neonatal outcome. J Pediatr 1996; 128 (2): 257\u2013263.","journal-title":"J Pediatr"},{"issue":"10","key":"BFjp2012165_CR21","doi-asserted-by":"publisher","first-page":"4621","DOI":"10.1210\/jc.2001-011620","volume":"87","author":"PC Ng","year":"2002","unstructured":"Ng PC, Lam CW, Lee CH, Ma KC, Fok TF, Chan IH et al. Reference ranges and factors affecting the human corticotropin-releasing hormone test in preterm, very low birth weight infants. J Clin Endocrinol Metab 2002; 87 (10): 4621\u20134628.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"BFjp2012165_CR22","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1210\/jcem-69-6-1133","volume":"69","author":"MM Lee","year":"1989","unstructured":"Lee MM, Rajagopalan L, Berg GJ, Moshang T . Serum adrenal steroid concentrations in premature infants. J Clin Endocrinol Metab 1989; 69 (6): 1133\u20131136.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFjp2012165_CR23","first-page":"491","volume-title":"Williams Textbook of Endocrinology Larsen PR, Kronenberg HM, Melmed S, Polonsky KS","author":"PM Steward","year":"2003","unstructured":"Steward PM . The adrenal cortex In: Saunders, (ed) Williams Textbook of Endocrinology Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, Philadelphia, 2003 pp 491\u2013551 2003."},{"issue":"4 Pt 1","key":"BFjp2012165_CR24","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1203\/01.pdr.0000203106.59832.7a","volume":"59","author":"E Kajantie","year":"2006","unstructured":"Kajantie E, Dunkel L, Turpeinen U, Stenman UH, Andersson S . Placental 11beta-HSD2 activity, early postnatal clinical course, and adrenal function in extremely low birth weight infants. Pediatr Res 2006; 59 (4 Pt 1): 575\u2013578.","journal-title":"Pediatr Res"},{"key":"BFjp2012165_CR25","first-page":"570","volume-title":"Fetal and Neonatal Physiology-4th edn","author":"CA Stanley","year":"2011","unstructured":"Stanley CA, Hardy OT . Pathophysiology of hypoglicemia In: Polin RA, Fox WW, Steven H, (ed). Fetal and Neonatal Physiology-4th edn. Elsevier Saunders: Abman, USA pp 570\u2013573 2011."},{"issue":"12","key":"BFjp2012165_CR26","doi-asserted-by":"publisher","first-page":"6380","DOI":"10.1210\/jc.2005-0734","volume":"90","author":"KL Watterberg","year":"2005","unstructured":"Watterberg KL, Shaffer ML, Garland JS, Thilo EH, Mammel MC, Couser RJ et al. Effect of dose on response to adrenocorticotropin in extremely low birth weight infants. J Clin Endocrinol Metab 2005; 90 (12): 6380\u20136385.","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"BFjp2012165_CR27","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1210\/jcem-36-5-1037","volume":"36","author":"BE Murphy","year":"1973","unstructured":"Murphy BE . Steroid arteriovenous differences in umbilical cord plasma: evidence of cortisol production by the human fetus in early gestation. J Clin Endocrinol Metab 1973; 36 (5): 1037\u20131038.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"BFjp2012165_CR28","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1203\/00006450-199501000-00021","volume":"37","author":"SM Scott","year":"1995","unstructured":"Scott SM, Watterberg KL . Effect of gestational age, postnatal age and illness on plasma cortisol concentrations in premature infants. Pediat Res 1995; 37 (1): 112\u2013116.","journal-title":"Pediat Res"},{"issue":"5","key":"BFjp2012165_CR29","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1203\/00006450-198805000-00018","volume":"23","author":"HD Doerr","year":"1988","unstructured":"Doerr HD, Wg Sippell, Versmold HT, Bidlingmaier F, Knorr D . Plasma mineralocorticoids, glucocorticoids and progestins in premature infants:longitudinal study during the first week of life. Pediat Res 1988; 23 (5): 525\u2013529.","journal-title":"Pediat Res"},{"issue":"2","key":"BFjp2012165_CR30","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/j.1447-0756.2007.00493.x","volume":"33","author":"T Strinic","year":"2007","unstructured":"Strinic T, Roje D, Marusic J, Capkun V . Cord blood cortisol level is lower in growth-restricted newborns. J Obstet Gynaecol Res 2007; 33 (2): 144\u2013150.","journal-title":"J Obstet Gynaecol Res"},{"issue":"1","key":"BFjp2012165_CR31","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1210\/jcem-33-1-14","volume":"33","author":"ED Weitzman","year":"1971","unstructured":"Weitzman ED, Fukushima D, Nogeire C, Roffwarg H, Gallagher TF, Hellman L et al. Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects. J Clin Endocrinol Metab 1971; 33 (1): 14\u201322.","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp2012165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp2012165","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp2012165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T13:08:10Z","timestamp":1647608890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp2012165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,10]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["BFjp2012165"],"URL":"https:\/\/doi.org\/10.1038\/jp.2012.165","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,10]]},"assertion":[{"value":"23 April 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.<b>Author contributions<\/b>FB, CF, GC and BT led the design, data analysis and interpretation of results. FB coordinated the study, AM and SB prepared study materials and statistical analysis, and FB assisted with data acquisition. FB is guarantor of the paper.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}