{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:23:00Z","timestamp":1791091380747,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T00:00:00Z","timestamp":1340236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T00:00:00Z","timestamp":1340236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1038\/jp.2012.78","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T13:09:02Z","timestamp":1340284142000},"page":"226-230","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Outcomes of extremely low birth weight infants given early high-dose erythropoietin"],"prefix":"10.1038","volume":"33","author":[{"given":"R M","family":"McAdams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R J","family":"McPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D E","family":"Mayock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S E","family":"Juul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,6,21]]},"reference":[{"key":"BFjp201278_CR1","doi-asserted-by":"publisher","first-page":"e564","DOI":"10.1542\/neo.12-10-e564","volume":"12","author":"RM McAdams","year":"2011","unstructured":"McAdams RM, Juul SE . Cerebral palsy: prevalence, predictability, and parental counseling. NeoReviews 2011; 12: e564\u2013e574.","journal-title":"NeoReviews"},{"issue":"6","key":"BFjp201278_CR2","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1056\/NEJM200008103430601","volume":"343","author":"NS Wood","year":"2000","unstructured":"Wood NS, Marlow N, Costeloe K, Gibson AT, Wilkinson AR . Neurologic and developmental disability after extremely preterm birth. EPICure Study Group. N Engl J Med 2000; 343 (6): 378\u2013384.","journal-title":"N Engl J Med"},{"issue":"1","key":"BFjp201278_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa041367","volume":"352","author":"N Marlow","year":"2005","unstructured":"Marlow N, Wolke D, Bracewell MA, Samara M . Neurologic and developmental disability at six years of age after extremely preterm birth. N Engl J Med 2005; 352 (1): 9\u201319.","journal-title":"N Engl J Med"},{"issue":"1","key":"BFjp201278_CR4","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ijdevneu.2007.08.012","volume":"26","author":"RJ McPherson","year":"2008","unstructured":"McPherson RJ, Juul SE . Recent trends in erythropoietin-mediated neuroprotection. Int J Dev Neurosci 2008; 26 (1): 103\u2013111.","journal-title":"Int J Dev Neurosci"},{"issue":"6","key":"BFjp201278_CR5","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1002\/jnr.10166","volume":"67","author":"TC Wen","year":"2002","unstructured":"Wen TC, Sadamoto Y, Tanaka J, Zhu PX, Nakata K, Ma YJ et al. Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up-regulating Bcl-xL expression. J Neurosci Res 2002; 67 (6): 795\u2013803.","journal-title":"J Neurosci Res"},{"issue":"1","key":"BFjp201278_CR6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1124\/jpet.105.094391","volume":"317","author":"L Wei","year":"2006","unstructured":"Wei L, Han BH, Li Y, Keogh CL, Holtzman DM, Yu SP . Cell death mechanism and protective effect of erythropoietin after focal ischemia in the whisker-barrel cortex of neonatal rats. J Pharmacol Exp Ther 2006; 317 (1): 109\u2013116.","journal-title":"J Pharmacol Exp Ther"},{"issue":"8","key":"BFjp201278_CR7","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1161\/01.STR.0000173406.04891.8c","volume":"36","author":"Y Sun","year":"2005","unstructured":"Sun Y, Calvert JW, Zhang JH . Neonatal hypoxia\/ischemia is associated with decreased inflammatory mediators after erythropoietin administration. Stroke 2005; 36 (8): 1672\u20131678.","journal-title":"Stroke"},{"issue":"4","key":"BFjp201278_CR8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1159\/000110348","volume":"30","author":"SE Juul","year":"2008","unstructured":"Juul SE, McPherson RJ, Bammler TK, Wilkerson J, Beyer RP, Farin FM. Recombinant erythropoietin is neuroprotective in a novel mouse oxidative injury model. Dev Neurosci 2008; 30 (4): 231\u2013242.","journal-title":"Dev Neurosci"},{"issue":"2","key":"BFjp201278_CR9","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.nbd.2010.01.015","volume":"38","author":"D Osredkar","year":"2010","unstructured":"Osredkar D, Sall JW, Bickler PE, Ferriero DM . Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke. Neurobiol Dis 2010; 38 (2): 259\u2013265.","journal-title":"Neurobiol Dis"},{"issue":"6","key":"BFjp201278_CR10","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.ijdevneu.2010.12.007","volume":"29","author":"T Xiong","year":"2011","unstructured":"Xiong T, Qu Y, Mu D, Ferriero D . Erythropoietin for neonatal brain injury: opportunity and challenge. Int J Dev Neurosci 2011; 29 (6): 583\u2013591.","journal-title":"Int J Dev Neurosci"},{"issue":"24","key":"BFjp201278_CR11","doi-asserted-by":"publisher","first-page":"9733","DOI":"10.1523\/JNEUROSCI.21-24-09733.2001","volume":"21","author":"T Shingo","year":"2001","unstructured":"Shingo T, Sorokan ST, Shimazaki T, Weiss S . Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci 2001; 21 (24): 9733\u20139743.","journal-title":"J Neurosci"},{"issue":"2","key":"BFjp201278_CR12","doi-asserted-by":"publisher","first-page":"140","DOI":"10.5115\/acb.2010.43.2.140","volume":"43","author":"YJ Kim","year":"2010","unstructured":"Kim YJ, Jung YW . Systemic injection of recombinant human erythropoietin after focal cerebral ischemia enhances oligodendroglial and endothelial progenitor cells in rat brain. Anat Cell Biol 2010; 43 (2): 140\u2013149.","journal-title":"Anat Cell Biol"},{"issue":"1","key":"BFjp201278_CR13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.33549\/physiolres.930749","volume":"55","author":"K Genc","year":"2006","unstructured":"Genc K, Genc S, Baskin H, Semin I . Erythropoietin decreases cytotoxicity and nitric oxide formation induced by inflammatory stimuli in rat oligodendrocytes. Physiol Res 2006; 55 (1): 33\u201338.","journal-title":"Physiol Res"},{"issue":"4","key":"BFjp201278_CR14","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0168-0102(02)00161-X","volume":"44","author":"M Sugawa","year":"2002","unstructured":"Sugawa M, Sakurai Y, Ishikawa-Ieda Y, Suzuki H, Asou H . Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation. Neurosci Res 2002; 44 (4): 391\u2013403.","journal-title":"Neurosci Res"},{"issue":"2","key":"BFjp201278_CR15","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1542\/peds.2007-2711","volume":"122","author":"SE Juul","year":"2008","unstructured":"Juul SE, McPherson RJ, Bauer LA, Ledbetter KJ, Gleason CA, Mayock DE . A phase I\/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safety. Pediatrics 2008; 122 (2): 383\u2013391.","journal-title":"Pediatrics"},{"issue":"2","key":"BFjp201278_CR16","doi-asserted-by":"publisher","first-page":"e55","DOI":"10.1111\/j.1651-2227.2011.02517.x","volume":"101","author":"JR Lowe","year":"2012","unstructured":"Lowe JR, Erickson SJ, Schrader R, Duncan AF . Comparison of the Bayley II Mental Developmental Index and the Bayley III Cognitive Scale: are we measuring the same thing? Acta Paediatr 2012; 101 (2): e55\u2013e58.","journal-title":"Acta Paediatr"},{"issue":"7","key":"BFjp201278_CR17","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1001\/archopht.1987.01060070041024","volume":"105","author":"A Patz","year":"1987","unstructured":"Patz A . An international classification of retinopathy of prematurity. II. The classification of retinal detachment. Arch Ophthalmol 1987; 105 (7): 905.","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"BFjp201278_CR18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/jp.2009.170","volume":"30","author":"JS Mercer","year":"2010","unstructured":"Mercer JS, Vohr BR, Erickson-Owens DA, Padbury JF, Oh W . Seven-month developmental outcomes of very low birth weight infants enrolled in a randomized controlled trial of delayed versus immediate cord clamping. J Perinatol 2010; 30 (1): 11\u201316.","journal-title":"J Perinatol"},{"issue":"4","key":"BFjp201278_CR19","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","volume":"92","author":"LA Papile","year":"1978","unstructured":"Papile LA, Burstein J, Burstein R, Koffler H . Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978; 92 (4): 529\u2013534.","journal-title":"J Pediatr"},{"issue":"5","key":"BFjp201278_CR20","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1203\/00006450-199911000-00009","volume":"46","author":"SE Juul","year":"1999","unstructured":"Juul SE, Stallings SA, Christensen RD . Erythropoietin in the cerebrospinal fluid of neonates who sustained CNS injury. Pediatr Res 1999; 46 (5): 543\u2013547.","journal-title":"Pediatr Res"},{"issue":"2","key":"BFjp201278_CR21","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1542\/peds.2007-2591","volume":"122","author":"JC Fauchere","year":"2008","unstructured":"Fauchere JC, Dame C, Vonthein R, Koller B, Arri S, Wolf M et al. An approach to using recombinant erythropoietin for neuroprotection in very preterm infants. Pediatrics 2008; 122 (2): 375\u2013382.","journal-title":"Pediatrics"},{"issue":"6 Part 1","key":"BFjp201278_CR22","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/sj.jp.7200244","volume":"19","author":"NR Newton","year":"1999","unstructured":"Newton NR, Leonard CH, Piecuch RE, Phibbs RH . Neurodevelopmental outcome of prematurely born children treated with recombinant human erythropoietin in infancy. J Perinatol 1999; 19 (6 Part 1): 403\u2013406.","journal-title":"J Perinatol"},{"issue":"3","key":"BFjp201278_CR23","doi-asserted-by":"publisher","first-page":"e635","DOI":"10.1542\/peds.2005-3186","volume":"118","author":"R Bierer","year":"2006","unstructured":"Bierer R, Peceny MC, Hartenberger CH, Ohls RK . Erythropoietin concentrations and neurodevelopmental outcome in preterm infants. Pediatrics 2006; 118 (3): e635\u2013e640.","journal-title":"Pediatrics"},{"issue":"5","key":"BFjp201278_CR24","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1542\/peds.2003-1129-L","volume":"114","author":"RK Ohls","year":"2004","unstructured":"Ohls RK, Ehrenkranz RA, Das A, Dusick AM, Yolton K, Romano E et al. Neurodevelopmental outcome and growth at 18 to 22 months\u2019 corrected age in extremely low birth weight infants treated with early erythropoietin and iron. Pediatrics 2004; 114 (5): 1287\u20131291.","journal-title":"Pediatrics"},{"issue":"4","key":"BFjp201278_CR25","doi-asserted-by":"publisher","first-page":"e681","DOI":"10.1542\/peds.2008-2701","volume":"124","author":"MS Brown","year":"2009","unstructured":"Brown MS, Eichorst D, Lala-Black B, Gonzalez R . Higher cumulative doses of erythropoietin and developmental outcomes in preterm infants. Pediatrics 2009; 124 (4): e681\u2013e687.","journal-title":"Pediatrics"},{"issue":"5","key":"BFjp201278_CR26","first-page":"657","volume":"67","author":"AP Neubauer","year":"2010","unstructured":"Neubauer AP, Voss W, Wachtendorf M, Jungmann T . Erythropoietin improves neurodevelopmental outcome of extremely preterm infants. Ann Neurol 2010; 67 (5): 657\u2013666.","journal-title":"Ann Neurol"},{"issue":"2","key":"BFjp201278_CR27","doi-asserted-by":"publisher","first-page":"e218","DOI":"10.1542\/peds.2008-3553","volume":"124","author":"C Zhu","year":"2009","unstructured":"Zhu C, Kang W, Xu F, Cheng X, Zhang Z, Jia L et al. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy. Pediatrics 2009; 124 (2): e218\u2013e226.","journal-title":"Pediatrics"},{"issue":"5","key":"BFjp201278_CR28","doi-asserted-by":"publisher","first-page":"e1135","DOI":"10.1542\/peds.2009-2268","volume":"125","author":"H El-Mahdy","year":"2010","unstructured":"El-Mahdy H, El-Mashad AR, El-Bahrawy H, El-Gohary T, El-Barbary A, Aly H . Human recombinant erythropoietin in asphyxia neonatorum: pilot trial. Pediatrics 2010; 125 (5): e1135\u2013e1142.","journal-title":"Pediatrics"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp201278.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201278","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201278.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T11:45:41Z","timestamp":1647603941000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp201278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,21]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["BFjp201278"],"URL":"https:\/\/doi.org\/10.1038\/jp.2012.78","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,21]]},"assertion":[{"value":"2 February 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}