{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:53:07Z","timestamp":1777571587403,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1038\/jp.2015.41","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T09:04:14Z","timestamp":1430384654000},"page":"595-600","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Intestinal perforation in very preterm neonates: risk factors and outcomes"],"prefix":"10.1038","volume":"35","author":[{"given":"J","family":"Shah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Rouvinez-Bouali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Seshia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S K","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P S","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Canadian Neonatal Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,4,30]]},"reference":[{"key":"BFjp201541_CR1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/sj.jp.7211429","volume":"26","author":"JT Attridge","year":"2006","unstructured":"Attridge JT, Clark R, Walker MW, Gordon PV . New insights into spontaneous intestinal perforation using a national data set: (1) SIP is associated with early indomethacin exposure. J Perinatol 2006; 26: 93\u201399.","journal-title":"J Perinatol"},{"key":"BFjp201541_CR2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1542\/peds.93.1.32","volume":"93","author":"JQ Buchheit","year":"1994","unstructured":"Buchheit JQ, Stewart DL . Clinical comparison of localized intestinal perforation and necrotizing enterocolitis in neonates. Pediatrics 1994; 93: 32\u201336.","journal-title":"Pediatrics"},{"key":"BFjp201541_CR3","first-page":"450","volume":"14","author":"CM Novack","year":"1994","unstructured":"Novack CM, Waffarn F, Sills JH, Pousti TJ, Warden MJ, Cunningham MD . Focal intestinal perforation in the extremely-low-birth-weight infant. J Perinatol 1994; 14: 450\u2013453.","journal-title":"J Perinatol"},{"key":"BFjp201541_CR4","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/S0022-3468(98)90475-4","volume":"33","author":"EE Adderson","year":"1998","unstructured":"Adderson EE, Pappin A, Pavia AT . Spontaneous intestinal perforation in premature infants: a distinct clinical entity associated with systemic candidiasis. J Pediatr Surg 1998; 33: 1463\u20131467.","journal-title":"J Pediatr Surg"},{"key":"BFjp201541_CR5","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1007\/s00383-002-0839-7","volume":"18","author":"H Okuyama","year":"2002","unstructured":"Okuyama H, Kubota A, Oue T, Kuroda S, Ikegami R, Kamiyama M . A comparison of the clinical presentation and outcome of focal intestinal perforation and necrotizing enterocolitis in very-low-birth-weight neonates. Pediatr Surg Int 2002; 18: 704\u2013706.","journal-title":"Pediatr Surg Int"},{"key":"BFjp201541_CR6","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/S1072-7515(02)01344-3","volume":"195","author":"W Pumberger","year":"2002","unstructured":"Pumberger W, Mayr M, Kohlhauser C, Weninger M . Spontaneous localized intestinal perforation in very-low-birth-weight infants: a distinct clinical entity different from necrotizing enterocolitis. J Am Coll Surg 2002; 195: 796\u2013803.","journal-title":"J Am Coll Surg"},{"key":"BFjp201541_CR7","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/sj.jp.7211589","volume":"26","author":"JT Attridge","year":"2006","unstructured":"Attridge JT, Clark R, Gordon PV . New insights into spontaneous intestinal perforation using a national data set (3): antenatal steroids have no adverse association with spontaneous intestinal perforation. J Perinatol 2006; 26: 667\u2013670.","journal-title":"J Perinatol"},{"key":"BFjp201541_CR8","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/sj.jp.7200269","volume":"19","author":"P Gordon","year":"1999","unstructured":"Gordon P, Rutledge J, Sawin R, Thomas S, Woodrum D . Early postnatal dexamethasone increases the risk of focal small bowel perforation in extremely low birth weight infants. J Perinatol 1999; 19: 573\u2013577.","journal-title":"J Perinatol"},{"key":"BFjp201541_CR9","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00383-003-0967-8","volume":"19","author":"AJ Holland","year":"2003","unstructured":"Holland AJ, Shun A, Martin HC, Cooke-Yarborough C, Holland J . Small bowel perforation in the premature neonate: congenital or acquired? Pediatr Surg Int 2003; 19: 489\u2013494.","journal-title":"Pediatr Surg Int"},{"key":"BFjp201541_CR10","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/sj.jp.7211548","volume":"26","author":"L Paquette","year":"2006","unstructured":"Paquette L, Friedlich P, Ramanathan R, Seri I . Concurrent use of indomethacin and dexamethasone increases the risk of spontaneous intestinal perforation in very low birth weight neonates. J Perinatol 2006; 26: 486\u2013492.","journal-title":"J Perinatol"},{"key":"BFjp201541_CR11","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0022-3476(85)80305-X","volume":"106","author":"G Alpan","year":"1985","unstructured":"Alpan G, Eyal F, Vinograd I, Udassin R, Amir G, Mogle P et al. Localized intestinal perforations after enteral administration of indomethacin in premature infants. J Pediatr 1985; 106: 277\u2013281.","journal-title":"J Pediatr"},{"key":"BFjp201541_CR12","doi-asserted-by":"publisher","first-page":"F127","DOI":"10.1136\/archdischild-2011-300659","volume":"98","author":"R Wadhawan","year":"2013","unstructured":"Wadhawan R, Oh W, Vohr BR, Saha S, Das A, Bell EF et al. Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age. Arch Dis Child Fetal Neonatal Ed 2013; 98: F127\u2013F132.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFjp201541_CR13","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/0022-3468(91)90017-N","volume":"26","author":"CL Meyer","year":"1991","unstructured":"Meyer CL, Payne NR, Roback SA . Spontaneous, isolated intestinal perforations in neonates with birth weight less than 1,000\u2009g not associated with necrotizing enterocolitis. J Pediatr Surg 1991; 26: 714\u2013717.","journal-title":"J Pediatr Surg"},{"key":"BFjp201541_CR14","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/jp.2011.176","volume":"32","author":"TA Shah","year":"2012","unstructured":"Shah TA, Meinzen-Derr J, Gratton T, Steichen J, Donovan EF, Yolton K et al. Hospital and neurodevelopmental outcomes of extremely low-birth-weight infants with necrotizing enterocolitis and spontaneous intestinal perforation. J Perinatol 2012; 32: 552\u2013558.","journal-title":"J Perinatol"},{"key":"BFjp201541_CR15","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1016\/j.jpedsurg.2013.11.051","volume":"49","author":"JG Fisher","year":"2014","unstructured":"Fisher JG, Jones BA, Gutierrez IM, Hull MA, Kang KH, Kenny M et al. Mortality associated with laparotomy-confirmed neonatal spontaneous intestinal perforation: A prospective 5-year multicenter analysis. J Pediatr Surg 2014; 49: 1215\u20131219.","journal-title":"J Pediatr Surg"},{"key":"BFjp201541_CR16","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0031-3955(16)34975-6","volume":"33","author":"MC Walsh","year":"1986","unstructured":"Walsh MC, Kliegman RM . Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am 1986; 33: 179\u2013201.","journal-title":"Pediatr Clin North Am"},{"key":"BFjp201541_CR17","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1542\/peds.82.4.527","volume":"82","author":"AT Shennan","year":"1988","unstructured":"Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hoskins EM . Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period. Pediatrics 1988; 82: 527\u2013532.","journal-title":"Pediatrics"},{"key":"BFjp201541_CR18","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1001\/archopht.123.7.991","volume":"123","author":"International Committee for the Classification of Retinopathy of Prematurity","year":"2005","unstructured":"International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol 2005; 123: 991\u2013999.","journal-title":"Arch Ophthalmol"},{"key":"BFjp201541_CR19","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1542\/peds.91.3.617","volume":"91","author":"DK Richardson","year":"1993","unstructured":"Richardson DK, Gray JE, McCormick MC, Workman K, Goldmann DA . Score for Neonatal Acute Physiology: a physiologic severity index for neonatal intensive care. Pediatrics 1993; 91: 617\u2013623.","journal-title":"Pediatrics"},{"key":"BFjp201541_CR20","unstructured":"Canadian Neonatal Network. Canadian Neonatal Network Abstractor's Manual. v 2.1.2, 1\u201394, 2014. Canadian Neonatal Network. Toronto, Canada. Available from http:\/\/www.canadianneonatalnetwork.org\/portal\/CNNHome\/Publications.aspx (last accessed: 26 September 2014)."},{"key":"BFjp201541_CR21","first-page":"489","volume":"31","author":"AM Bhatia","year":"2014","unstructured":"Bhatia AM, Stoll BJ, Cismowski MJ, Hamrick SE . Cytokine levels in the preterm infant with neonatal intestinal injury. Am J Perinatol 2014; 31: 489\u2013496.","journal-title":"Am J Perinatol"},{"key":"BFjp201541_CR22","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1055\/s-2008-1072384","volume":"10","author":"MH De Laet","year":"2000","unstructured":"De Laet MH, Dassonville M, Johansson A, Lerminiaux C, Seghers V, Van den Eijnden S et al. Small-bowel perforation in very low birth weight neonates treated with high-dose dexamethasone. Eur J Pediatr Surg 2000; 10: 323\u2013327.","journal-title":"Eur J Pediatr Surg"},{"key":"BFjp201541_CR23","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/S0022-3468(99)90495-5","volume":"34","author":"NA Shorter","year":"1999","unstructured":"Shorter NA, Liu JY, Mooney DP, Harmon BJ . Indomethacin-associated bowel perforations: a study of possible risk factors. J Pediatr Surg 1999; 34: 442\u2013444.","journal-title":"J Pediatr Surg"},{"key":"BFjp201541_CR24","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/jp.2010.59","volume":"30","author":"R Sharma","year":"2010","unstructured":"Sharma R, Hudak ML, Tepas JJ III, Wludyka PS, Teng RJ, Hastings LK et al. Prenatal or postnatal indomethacin exposure and neonatal gut injury associated with isolated intestinal perforation and necrotizing enterocolitis. J Perinatol 2010; 30: 786\u2013793.","journal-title":"J Perinatol"},{"key":"BFjp201541_CR25","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/sj.jp.7211439","volume":"26","author":"JT Attridge","year":"2006","unstructured":"Attridge JT, Clark R, Walker MW, Gordon PV . New insights into spontaneous intestinal perforation using a national data set: (2) two populations of patients with perforations. J Perinatol 2006; 26: 185\u2013188.","journal-title":"J Perinatol"},{"key":"BFjp201541_CR26","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1097\/01.sla.0000164181.67862.7f","volume":"241","author":"ML Blakely","year":"2005","unstructured":"Blakely ML, Lally KP, McDonald S, Brown RL, Barnhart DC, Ricketts RR et al. Postoperative outcomes of extremely low birth-weight infants with necrotizing enterocolitis or isolated intestinal perforation: a prospective cohort study by the NICHD Neonatal Research Network. Ann Surg 2005; 241: 984\u2013989.","journal-title":"Ann Surg"},{"key":"BFjp201541_CR27","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jpedsurg.2013.09.045","volume":"49","author":"S Lai","year":"2014","unstructured":"Lai S, Yu W, Wallace L, Sigalet D . Intestinal muscularis propria increases in thickness with corrected gestational age and is focally attenuated in patients with isolated intestinal perforations. J Pediatr Surg 2014; 49: 114\u2013119.","journal-title":"J Pediatr Surg"},{"key":"BFjp201541_CR28","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.jpeds.2013.09.055","volume":"164","author":"SL Merhar","year":"2014","unstructured":"Merhar SL, Ramos Y, Meinzen-Derr J, Kline-Fath BM . Brain magnetic resonance imaging in infants with surgical necrotizing enterocolitis or spontaneous intestinal perforation versus medical necrotizing enterocolitis. J Pediatr 2014; 164: 410\u2013412.","journal-title":"J Pediatr"},{"issue":"2","key":"BFjp201541_CR29","first-page":"59","volume":"1","author":"JT Attridge","year":"2011","unstructured":"Attridge JT, Zanelli SA, Gurka MJ, Kaufman DA . Randomized controlled trials need stratification by types of acquired neonatal intestinal diseases. e-J Neonatol Res 2011; 1 (2): 59\u201364.","journal-title":"e-J Neonatol Res"},{"key":"BFjp201541_CR30","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1203\/PDR.0b013e31818c7920","volume":"65","author":"PV Gordon","year":"2009","unstructured":"Gordon PV . Understanding intestinal vulnerability to perforation in the extremely low birth weight infant. Pediatr Res 2009; 65: 138\u2013144.","journal-title":"Pediatr Res"},{"key":"BFjp201541_CR31","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/0022-3468(93)90345-L","volume":"28","author":"AC Mintz","year":"1993","unstructured":"Mintz AC, Applebaum H . Focal gastrointestinal perforations not associated with necrotizing enterocolitis in very low birth weight neonates. J Pediatr Surg 1993; 28: 857\u2013860.","journal-title":"J Pediatr Surg"},{"key":"BFjp201541_CR32","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s003830050668","volume":"15","author":"Y Tatekawa","year":"1999","unstructured":"Tatekawa Y, Muraji T, Imai Y, Nishijima E, Tsugawa C . The mechanism of focal intestinal perforations in neonates with low birth weight. Pediatr Surg Int 1999; 15: 549\u2013552.","journal-title":"Pediatr Surg Int"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp201541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201541","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T10:25:04Z","timestamp":1647599104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp201541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,30]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["BFjp201541"],"URL":"https:\/\/doi.org\/10.1038\/jp.2015.41","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,30]]},"assertion":[{"value":"30 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}