{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T16:18:53Z","timestamp":1769271533358,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1038\/jp.2015.46","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T13:44:26Z","timestamp":1431006266000},"page":"748-754","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Trends in treatment and in-hospital mortality for neonates with congenital diaphragmatic hernia"],"prefix":"10.1038","volume":"35","author":[{"given":"J I","family":"Hagadorn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E A","family":"Brownell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K W","family":"Herbst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Trzaski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Neff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B T","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"BFjp201546_CR1","unstructured":"The Congenital Diaphragmatic Hernia Study Group [Internet]. Report from the Congenital Diaphragmatic Hernia Study Group. 2010, Available at https:\/\/med.uth.edu\/pediatricsurgery\/files\/2013\/12\/CDHSG.pdf (accessed 10 April 2014)."},{"issue":"1","key":"BFjp201546_CR2","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jpeds.2012.06.048","volume":"162","author":"S Menon","year":"2012","unstructured":"Menon S, Tani L, Weng H, Lally P, Lally K, Yoder B . Clinical characteristics and outcomes of patients with cardiac defects and congenital diaphragmatic hernia. J Pediatr 2012; 162 (1): 114\u2013119 e112.","journal-title":"J Pediatr"},{"key":"BFjp201546_CR3","unstructured":"Pober B, Russell M, Ackerman K Congenital diaphragmatic hernia overview. GeneReviews\u2122 [Internet] 2010. Available at http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1359\/ (accessed 10 April 2014)."},{"issue":"2","key":"BFjp201546_CR4","doi-asserted-by":"publisher","first-page":"F137","DOI":"10.1136\/archdischild-2014-306174","volume":"100","author":"M McGivern","year":"2014","unstructured":"McGivern M, Best K, Rankin J, Wellesley D, Greenlees R, Addor M et al. Epidemiology of congenital diaphragmatic hernia in Europe: a register-based study. Arch Dis Child Fetal Neonatal Ed 2014; 100 (2): F137\u2013F144.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"2","key":"BFjp201546_CR5","first-page":"25","volume":"56","author":"Centers for Disease Control and Prevention (CDC)","year":"2007","unstructured":"Centers for Disease Control and Prevention (CDC). Hospital stays, hospital charges, and in-hospital deaths among infants with selected birth defects\u2014United States, 2003. MMWR Morb Mortal Wkly Rep 2007; 56 (2): 25\u201329.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"1","key":"BFjp201546_CR6","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jpedsurg.2010.09.060","volume":"46","author":"M Antonoff","year":"2011","unstructured":"Antonoff M, Hustead V, Groth S, Schmeling D . Protocolized management of infants with congenital diaphragmatic hernia: effect on survival. J Pediatr Surg 2011; 46 (1): 39\u201346.","journal-title":"J Pediatr Surg"},{"issue":"3","key":"BFjp201546_CR7","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jpedsurg.2003.11.009","volume":"39","author":"P Bagolan","year":"2004","unstructured":"Bagolan P, Casaccia G, Crescenzi F, Nahom A, Trucchi A, Giorlandino C . Impact of a current treatment protocol on outcome of high-risk congenital diaphragmatic hernia. J Pediatr Surg 2004; 39 (3): 313\u2013318.","journal-title":"J Pediatr Surg"},{"issue":"2","key":"BFjp201546_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S1875-9572(10)60018-6","volume":"51","author":"P Chao","year":"2010","unstructured":"Chao P, Huang C, Liu C, Chung M, Chen C, Chen F et al. Congenital diaphragmatic hernia in the neonatal period: review of 21 years' experience. Pediatr Neonatol 2010; 51 (2): 97\u2013102.","journal-title":"Pediatr Neonatol"},{"issue":"9","key":"BFjp201546_CR9","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1016\/j.jpedsurg.2007.04.015","volume":"42","author":"L Migliazza","year":"2007","unstructured":"Migliazza L, Bellan C, Alberti D, Auriemma A, Burgio G, Locatelli G et al. Retrospective study of 111 cases of congenital diaphragmatic hernia treated with early high-frequency oscillatory ventilation and presurgical stabilization. J Pediatr Surg 2007; 42 (9): 1526\u20131532.","journal-title":"J Pediatr Surg"},{"issue":"4","key":"BFjp201546_CR10","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1159\/000320622","volume":"98","author":"I Reiss","year":"2010","unstructured":"Reiss I, Schaible T, van den Hout L, Capolupo I, Allegaert K, van Heijst A et al. Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: the CDH EURO Consortium consensus. Neonatology 2010; 98 (4): 354\u2013364.","journal-title":"Neonatology"},{"issue":"3","key":"BFjp201546_CR11","first-page":"CD001340","volume":"16","author":"M Mugford","year":"2008","unstructured":"Mugford M, Elbourne D, Field D . Extracorporeal membrane oxygenation for severe respiratory failure in newborn infants. Cochrane Database Syst Rev 2008; 16 (3): CD001340.","journal-title":"Cochrane Database Syst Rev"},{"issue":"9020","key":"BFjp201546_CR12","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0140-6736(96)04100-1","volume":"348","author":"UK Collaborative ECMO Trail Group","year":"1996","unstructured":"UK Collaborative ECMO Trail Group. UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation. Lancet 1996; 348 (9020): 75\u201382.","journal-title":"Lancet"},{"issue":"6","key":"BFjp201546_CR13","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1542\/peds.99.6.838","volume":"99","author":"The Neonatal Inhaled Nitric Oxide Study Group","year":"1997","unstructured":"The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide and hypoxic respiratory failure in infants with congenital diaphragmatic hernia. The Neonatal Inhaled Nitric Oxide Study Group (NINOS). Pediatrics 1997; 99 (6): 838\u2013845.","journal-title":"Pediatrics"},{"issue":"1","key":"BFjp201546_CR14","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.clp.2011.12.006","volume":"39","author":"N Porta","year":"2012","unstructured":"Porta N, Steinhorn R . Pulmonary vasodilator therapy in the NICU: inhaled nitric oxide, sildenafil, and other pulmonary vasodilating agents. Clin Perinatol 2012; 39 (1): 149\u2013164.","journal-title":"Clin Perinatol"},{"issue":"4","key":"BFjp201546_CR15","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1067\/mpd.2003.140","volume":"142","author":"J Kinsella","year":"2003","unstructured":"Kinsella J, Parker T, Ivy D, Abman S . Noninvasive delivery of inhaled nitric oxide therapy for late pulmonary hypertension in newborn infants with congenital diaphragmatic hernia. J Pediatr 2003; 142 (4): 397\u2013401.","journal-title":"J Pediatr"},{"issue":"2","key":"BFjp201546_CR16","doi-asserted-by":"publisher","first-page":"e420","DOI":"10.1542\/peds.2013-2644","volume":"134","author":"B Campbell","year":"2014","unstructured":"Campbell B, Herbst K, Briden K, Neff S, Ruscher K, Hagadorn J . Inhaled nitric oxide use in neonates with congenital diaphragmatic hernia. Pediatrics 2014; 134 (2): e420\u2013e426.","journal-title":"Pediatrics"},{"key":"BFjp201546_CR17","unstructured":"Children's Hospital Association [Internet]. PHIS+: Augmenting the Pediatric Health Information System with Clinical Data. Available at http:\/\/www.childrenshospitals.org\/phisplus\/index.html (accessed 10 April 2014)."},{"issue":"2","key":"BFjp201546_CR18","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.surg.2010.03.018","volume":"148","author":"K Tsao","year":"2010","unstructured":"Tsao K, Allison N, Harting M, Lally P, Lally K . Congenital diaphragmatic hernia in the preterm infant. Surgery 2010; 148 (2): 404\u2013410.","journal-title":"Surgery"},{"issue":"2","key":"BFjp201546_CR19","doi-asserted-by":"publisher","first-page":"e413","DOI":"10.1542\/peds.2013-3367","volume":"134","author":"M Brindle","year":"2014","unstructured":"Brindle M, Cook E, Tibboel D, Lally P, Lally K, on behalf of the Congenital Diaphragmatic Hernia Study Group. A clinical prediction rule for the severity of congenital diaphragmatic hernias in newborns. Pediatrics 2014; 134 (2): e413\u2013e419.","journal-title":"Pediatrics"},{"issue":"1","key":"BFjp201546_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1399-0004.2008.01031.x","volume":"74","author":"B Pober","year":"2008","unstructured":"Pober B . Genetic aspects of human congenital diaphragmatic hernia. Clin Genet 2008; 74 (1): 1\u201315.","journal-title":"Clin Genet"},{"key":"BFjp201546_CR21","volume-title":"Hierarchical Linear Models: Applications and Data Analysis Methods","author":"S Raudenbush","year":"2002","unstructured":"Raudenbush S, Bryk A . Hierarchical Linear Models: Applications and Data Analysis Methods. 2nd edn. Sage Publications Thousand Oaks, CA, USA, 2002."},{"issue":"8","key":"BFjp201546_CR22","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.jclinepi.2014.03.012","volume":"67","author":"M Glickman","year":"2014","unstructured":"Glickman M, Rao S, Schultz M . False discovery rate control is a recommended alternative to Bonferroni-type adjustments in health studies. J Clin Epidemiol 2014; 67 (8): 850\u2013857.","journal-title":"J Clin Epidemiol"},{"issue":"3","key":"BFjp201546_CR23","doi-asserted-by":"publisher","first-page":"e356","DOI":"10.1542\/peds.2004-2845","volume":"116","author":"J Colvin","year":"2005","unstructured":"Colvin J, Bower C, Dickinson J, Sokol J . Outcomes of congenital diaphragmatic hernia: a population-based study in Western Australia. Pediatrics 2005; 116 (3): e356\u2013e363.","journal-title":"Pediatrics"},{"issue":"3","key":"BFjp201546_CR24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0022-3468(78)80391-1","volume":"13","author":"M Harrison","year":"1978","unstructured":"Harrison M, Bjordal R, Langmark F, Knutrud O . Congenital diaphragmatic hernia: the hidden mortality. J Pediatr Surg 1978; 13 (3): 227\u2013230.","journal-title":"J Pediatr Surg"},{"issue":"2","key":"BFjp201546_CR25","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/oxfordjournals.aje.a115848","volume":"133","author":"D Petitti","year":"1991","unstructured":"Petitti D . Associations are not effects. Am J Epidemiol 1991; 133 (2): 101\u2013102.","journal-title":"Am J Epidemiol"},{"issue":"3","key":"BFjp201546_CR26","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s00383-004-1138-2","volume":"20","author":"J Bedoyan","year":"2004","unstructured":"Bedoyan J, Blackwell S, Treadwell M, Johnson A, Klein M . Congenital diaphragmatic hernia: associated anomalies and antenatal diagnosis. Outcome-related variables at two Detroit hospitals. Pediatr Surg Int 2004; 20 (3): 170\u2013176.","journal-title":"Pediatr Surg Int"},{"issue":"2 Pt2","key":"BFjp201546_CR27","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/01.AOG.0000254174.25795.d6","volume":"109","author":"E Grethel","year":"2007","unstructured":"Grethel E, Farrell J, Ball R, Lee H, Nobuhara K . Congenital diaphragmatic hernia associated with spinal anomalies. Obstet Gynecol 2007; 109 (2 Pt2): 485\u2013488.","journal-title":"Obstet Gynecol"},{"issue":"8","key":"BFjp201546_CR28","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/S0022-3468(99)90151-3","volume":"34","author":"J Kaiser","year":"1999","unstructured":"Kaiser J, Rosenfeld C . A population-based study of congenital diaphragmatic hernia: impact of associated anomalies and preoperative blood gases on survival. J Pediatr Surg 1999; 34 (8): 1196\u20131202.","journal-title":"J Pediatr Surg"},{"issue":"6","key":"BFjp201546_CR29","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.jpedsurg.2005.03.025","volume":"40","author":"J Graziano","year":"2005","unstructured":"Graziano J . Cardiac anomalies in patients with congenital diaphragmatic hernia and their prognosis: a report from the Congenital Diaphragmatic Hernia Study Group. J Pediatr Surg 2005; 40 (6): 1045\u20131049; discussion 1049\u20131050.","journal-title":"J Pediatr Surg"},{"issue":"2","key":"BFjp201546_CR30","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/ajmg.c.30131","volume":"145C","author":"A Lin","year":"2007","unstructured":"Lin A, Pober B, Adatia I . Congenital diaphragmatic hernia and associated cardiovascular malformations: type, frequency, and impact on management. Am J Med Genet C Semin Med Genet 2007; 145C (2): 201\u2013216.","journal-title":"Am J Med Genet C Semin Med Genet"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp201546.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201546","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201546.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T16:23:24Z","timestamp":1647620604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp201546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,7]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["BFjp201546"],"URL":"https:\/\/doi.org\/10.1038\/jp.2015.46","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,7]]},"assertion":[{"value":"5 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}