{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:49:11Z","timestamp":1781714951893,"version":"3.54.5"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1038\/jp.2015.68","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T13:35:15Z","timestamp":1435239315000},"page":"700-704","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic association of AKAP10 gene polymorphism with reduced risk of preterm birth"],"prefix":"10.1038","volume":"35","author":[{"given":"I M","family":"Langmia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y D","family":"Apalasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Z","family":"Suki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Z","family":"Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"BFjp201568_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1471-2393-14-56","volume":"14","author":"J Vogel","year":"2014","unstructured":"Vogel J, Lee A, Souza J . Maternal morbidity and preterm birth in 22 low- and middle-income countries: a secondary analysis of the WHO Global Survey dataset. BMC Pregnancy Childbirth 2014; 14: 56.","journal-title":"BMC Pregnancy Childbirth"},{"key":"BFjp201568_CR2","first-page":"8","volume":"20","author":"RM Ward","year":"2001","unstructured":"Ward RM, Beachy JC . Neonatal complications following preterm birth. BJOG 2001; 20: 8\u201316.","journal-title":"BJOG"},{"key":"BFjp201568_CR3","doi-asserted-by":"publisher","first-page":"e52780","DOI":"10.1371\/journal.pone.0052780","volume":"7","author":"Y-P Zhang","year":"2012","unstructured":"Zhang Y-P, Liu X-H, Gao S-H, Wang J-M, Gu Y-S, Zhang J-Y et al. Risk factors for preterm birth in five maternal and Child Health Hospitals in Beijing. PLoS One 2012; 7: e52780.","journal-title":"PLoS One"},{"key":"BFjp201568_CR4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/j.1447-0756.2012.01929.x","volume":"39","author":"J Verli","year":"2013","unstructured":"Verli J, Klukovits A, Kormanyos Z, Hajagos-Toth J, Ducza E, Seres AB et al. Uterus-relaxing effect of beta2-agonists in combination with phosphodiesterase inhibitors: studies on pregnant rat in vivo and on pregnant human myometrium in vitro. J Obstet Gynaecol Res 2013; 39: 31\u201339.","journal-title":"J Obstet Gynaecol Res"},{"key":"BFjp201568_CR5","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1113\/eph8602182","volume":"86","author":"SA Price","year":"2001","unstructured":"Price SA, Bernal AL . Uterine quiescence: the role of cyclic AMP. Exp Physiol 2001; 86: 265\u2013272.","journal-title":"Exp Physiol"},{"key":"BFjp201568_CR6","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1210\/jc.2002-021862","volume":"88","author":"MW MacDougall","year":"2003","unstructured":"MacDougall MW, Europe-Finner GN, Robson SC . Human myometrial quiescence and activation during gestation and parturition involve dramatic changes in expression and activity of particulate type II (RII alpha) protein kinase A holoenzyme. J Clin Endocrinol Metab 2003; 88: 2194\u20132205.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFjp201568_CR7","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/jp.2011.85","volume":"32","author":"B Loniewska","year":"2012","unstructured":"Loniewska B, Clark JS, Kaczmarczyk M, Adler G, Binczak-Kuleta A, Kordek A et al. Possible counter effect in newborns of 1936\u2009A>G (I646V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10. J Perinatol 2012; 32: 230\u2013234.","journal-title":"J Perinatol"},{"key":"BFjp201568_CR8","doi-asserted-by":"publisher","first-page":"11184","DOI":"10.1073\/pnas.94.21.11184","volume":"94","author":"LJ Huang","year":"1997","unstructured":"Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS . D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci USA 1997; 94: 11184\u201311189.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFjp201568_CR9","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1095\/biolreprod67.2.605","volume":"67","author":"CY Ku","year":"2002","unstructured":"Ku CY, Sanborn BM . Progesterone prevents the pregnancy-related decline in protein kinase A association with rat myometrial plasma membrane and A-kinase anchoring protein. Biol Reprod 2002; 67: 605\u2013609.","journal-title":"Biol Reprod"},{"key":"BFjp201568_CR10","doi-asserted-by":"publisher","first-page":"8875","DOI":"10.1074\/jbc.M110.187815","volume":"286","author":"SH Kim","year":"2011","unstructured":"Kim SH, Serezani CH, Okunishi K, Zaslona Z, Aronoff DM . Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of Toll-like receptor signaling in alveolar macrophages. J Biol Chem 2011; 286: 8875\u20138883.","journal-title":"J Biol Chem"},{"key":"BFjp201568_CR11","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0955-0674(99)00085-X","volume":"12","author":"AS Edwards","year":"2000","unstructured":"Edwards AS, Scott JD . A-kinase anchoring proteins: protein kinase A and beyond. Curr Opin Cell Biol 2000; 12: 217\u2013221.","journal-title":"Curr Opin Cell Biol"},{"key":"BFjp201568_CR12","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1111\/j.1749-6632.2002.tb04328.x","volume":"968","author":"PS Amieux","year":"2002","unstructured":"Amieux PS, McKnight GS . The essential role of RI alpha in the maintenance of regulated PKA activity. Ann NY Acad Sci 2002; 968: 75\u201395.","journal-title":"Ann NY Acad Sci"},{"key":"BFjp201568_CR13","doi-asserted-by":"publisher","first-page":"4066","DOI":"10.1073\/pnas.2628028100","volume":"100","author":"S Kammerer","year":"2003","unstructured":"Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM et al. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci USA 2003; 100: 4066\u20134071.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFjp201568_CR14","doi-asserted-by":"publisher","first-page":"8461","DOI":"10.1073\/pnas.0610393104","volume":"104","author":"WG Tingley","year":"2007","unstructured":"Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG et al. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proc Natl Acad Sci USA 2007; 104: 8461\u20138466.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFjp201568_CR15","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0022-3565(24)35356-X","volume":"292","author":"C Mehats","year":"2000","unstructured":"Mehats C, Tanguy G, Paris B, Robert B, Pernin N . Pregnancy Induces a Modulation of the cAMP Phosphodiesterase 4-Conformers Ratio in Human Myometrium: Consequences for the Utero-Relaxant Effect of PDE4-Selective Inhibitors. J Pharmacol Exp Ther 2000; 292: 817\u2013823.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFjp201568_CR16","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1101\/gr.095000.109","volume":"19","author":"YY Teo","year":"2009","unstructured":"Teo YY, Sim X, Ong RT, Tan AK, Chen J, Tantoso E et al. Singapore Genome Variation Project: a haplotype map of three Southeast Asian populations. Genome Res 2009; 19: 2154\u20132162.","journal-title":"Genome Res"},{"key":"BFjp201568_CR17","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/msj.20169","volume":"77","author":"SM Dolan","year":"2010","unstructured":"Dolan SM . Genetic and environmental contributions to racial disparities in preterm birth. Mt Sinai J Med 2010; 77: 160\u2013165.","journal-title":"Mt Sinai J Med"},{"key":"BFjp201568_CR18","first-page":"1235","volume":"82","author":"S Engelhardt","year":"1997","unstructured":"Engelhardt S, Zieger W, Kassubek J, Michel MC, Lohse MJ . Tocolytic therapy with fenoterol induces selective down-regulation of beta-adrenergic receptors in human myometrium. J Clin Endocrinol Metab 1997; 82: 1235\u20131242.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFjp201568_CR19","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3109\/00016348509155160","volume":"64","author":"TS Kosasa","year":"1985","unstructured":"Kosasa TS, Nakayama RT, Hale RW, Rinzler GS, Freitas CA . Ritodrine and terbutaline compared for the treatment of preterm labor. Acta Obstet Gynecol Scanda 1985; 64: 421\u2013426.","journal-title":"Acta Obstet Gynecol Scanda"},{"key":"BFjp201568_CR20","first-page":"1012","volume":"87","author":"V Phupong","year":"2004","unstructured":"Phupong V, Charakorn C, Charoenvidhya D . Oral salbutamol for treatment of preterm labor. J Med Assoc Thai 2004; 87: 1012\u20131016.","journal-title":"J Med Assoc Thai"},{"key":"BFjp201568_CR21","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.lfs.2010.10.010","volume":"87","author":"A Klukovits","year":"2010","unstructured":"Klukovits A, Verli J, Falkay G, Gaspar R . Improving the relaxing effect of terbutaline with phosphodiesterase inhibitors: studies on pregnant rat uteri in vitro. Life Sci 2010; 87: 733\u2013737.","journal-title":"Life Sci"},{"key":"BFjp201568_CR22","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1177\/1933719111398150","volume":"18","author":"MS Soloff","year":"2011","unstructured":"Soloff MS, Jeng YJ, Izban MG, Sinha M, Luxon BA, England SK . Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci 2011; 18: 781\u2013797.","journal-title":"Reprod Sci"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp201568.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201568","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201568.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T21:29:47Z","timestamp":1748467787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp201568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,25]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["BFjp201568"],"URL":"https:\/\/doi.org\/10.1038\/jp.2015.68","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,25]]},"assertion":[{"value":"3 January 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}