{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:31:30Z","timestamp":1787167890852,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T00:00:00Z","timestamp":1436400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T00:00:00Z","timestamp":1436400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1038\/jp.2015.81","type":"journal-article","created":{"date-parts":[[2015,7,9]],"date-time":"2015-07-09T08:01:27Z","timestamp":1436428887000},"page":"788-792","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum"],"prefix":"10.1038","volume":"35","author":[{"given":"M","family":"Ergin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B D","family":"Cendek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Neselioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A F","family":"Avsar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Erel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,9]]},"reference":[{"key":"BFjp201581_CR1","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1056\/NEJMcp1003896","volume":"363","author":"JR Niebyl","year":"2010","unstructured":"Niebyl JR . Clinical practice. Nausea and vomiting in pregnancy. N Engl J Med 2010; 363: 1544\u20131550.","journal-title":"N Engl J Med"},{"issue":"5 Suppl","key":"BFjp201581_CR2","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1067\/mob.2002.122594","volume":"186","author":"F Miller","year":"2002","unstructured":"Miller F . Nause and vomiting in pregnancy: the problem of perception \u2014is it really a disease? Am J Obstet Gynecol 2002; 186 (5 Suppl): 182\u2013183.","journal-title":"Am J Obstet Gynecol"},{"issue":"3 Pt 1","key":"BFjp201581_CR3","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.ajog.2005.02.132","volume":"193","author":"JL Bailit","year":"2005","unstructured":"Bailit JL . Hyperemesis gravidarum: epidemiologic findings from large cohort. Am J Obstet Gynecol 2005; 193 (3 Pt 1): 811\u2013814.","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"BFjp201581_CR4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1515\/CCLM.2009.041","volume":"47","author":"PC Tan","year":"2009","unstructured":"Tan PC, Tan NC, Omar SZ . Effect of high levels of human chorionic gonadotropin and estradiol on the severity of hyperemesis gravidarum. Clin Chem Lab Med 2009; 47 (2): 165\u2013171.","journal-title":"Clin Chem Lab Med"},{"key":"BFjp201581_CR5","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1111\/j.1471-0528.2002.01223.x","volume":"109","author":"JYL Tan","year":"2002","unstructured":"Tan JYL, Loh KC, Yeo GSH, Chee YC . Transient hyperthyroidism of hyperemesis gravidarum. BJOG 2002; 109: 683\u2013688.","journal-title":"BJOG"},{"issue":"11","key":"BFjp201581_CR6","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.3109\/00016340903284927","volume":"88","author":"I Sandven","year":"2009","unstructured":"Sandven I, Abdelnoor M, Nesheim BI, Melby KK . Helicobacter pylori infection and hyperemesis gravidarum: a systematic review and meta-analysis of case-control studies. Acta Obstet Gynecol Scand 2009; 88 (11): 1190\u20131200.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"2","key":"BFjp201581_CR7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.ejogrb.2009.12.031","volume":"149","author":"PC Tan","year":"2010","unstructured":"Tan PC, Vani S, Lim BK, Omar SZ . Anxiety and depression in hyperemesis gravidarum: prevalence, risk factors and correlation with clinical severity. Eur J Obstet Gynecol Reprod Biol 2010; 149 (2): 153\u2013158.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"BFjp201581_CR8","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1093\/humupd\/dmi021","volume":"11","author":"MFG Verberg","year":"2005","unstructured":"Verberg MFG, Gillot DJ, Al-Fardan N, Grudzinskas JG . Hyperemesis gravidarum, a literature review. Hum Reprod Update 2005; 11: 527\u2013539.","journal-title":"Hum Reprod Update"},{"key":"BFjp201581_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/01.gco.0000193003.58158.4e","volume":"18","author":"A Agarwal","year":"2006","unstructured":"Agarwal A, Gupta S, Sikka S . The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol 2006; 18: 325\u2013332.","journal-title":"Curr Opin Obstet Gynecol"},{"key":"BFjp201581_CR10","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1055\/s-2002-23554","volume":"19","author":"V Fait","year":"2002","unstructured":"Fait V, Sela S, Ophir E, Khoury S, Nissimov J, Tkach M et al. Hyperemesis gravidarum is associated with oxidative stress. Am J Perinatol 2002; 19: 93\u201398.","journal-title":"Am J Perinatol"},{"issue":"11","key":"BFjp201581_CR11","first-page":"840","volume":"82","author":"F Celik","year":"2011","unstructured":"Celik F, Guzel AI, Kuyumcuoglu U, Celik Y . Dietary antioxidant levels in hyperemesis gravidarum: a case control study. Ginekol Pol 2011; 82 (11): 840\u2013844.","journal-title":"Ginekol Pol"},{"key":"BFjp201581_CR12","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/0002-9378(95)90501-4","volume":"172","author":"ME Van Stuijvenberg","year":"1995","unstructured":"Van Stuijvenberg ME, Schabort I, Labadarios D, Nel JT . The nutritional status and treatment of patients with hyperemesis gravidarum. Am J Obstet Gynecol 1995; 172: 1585\u20131591.","journal-title":"Am J Obstet Gynecol"},{"key":"BFjp201581_CR13","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1055\/s-2007-981429","volume":"24","author":"M Guney","year":"2007","unstructured":"Guney M, Oral B, Mungan T . Serum lipid peroxidation and antioxidant potential levels in hyperemesis gravidarum. Am J Perinatol 2007; 24: 283\u2013289.","journal-title":"Am J Perinatol"},{"key":"BFjp201581_CR14","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1447-0756.2003.00173.x","volume":"30","author":"AS Cevrioglu","year":"2004","unstructured":"Cevrioglu AS, Altindis M, Yilmazer M, Fenkci IV, Ellidokuz E, Kose S . Efficient and non-invasive method for investigating Helicobacter pylori in gravida with hyperemesis gravidarum: Helicobacter pylori stool antigen test. J Obstet Gynaecol Res 2004; 30: 136\u2013141.","journal-title":"J Obstet Gynaecol Res"},{"key":"BFjp201581_CR15","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/jcla.20298","volume":"23","author":"H Aksoy","year":"2009","unstructured":"Aksoy H, Aksoy AN, Ozkan A, Polat H . Serum lipid profile, oxidative status, and paraoxonase 1 activity in hyperemesis gravidarum. J Clin Lab Anal 2009; 23: 105\u2013109.","journal-title":"J Clin Lab Anal"},{"issue":"3","key":"BFjp201581_CR16","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1179\/135100008X259259","volume":"13","author":"FF Verit","year":"2008","unstructured":"Verit FF, Erel O, Celik H . Paraoxonase-1 activity in patients with hyperemesis gravidarum. Redox Rep 2008; 13 (3): 134\u2013138.","journal-title":"Redox Rep"},{"issue":"2","key":"BFjp201581_CR17","first-page":"83","volume":"35","author":"R Kayal\u0131","year":"2004","unstructured":"Kayal\u0131 R, \u00c7akatay U . Protein oksidasyonunun ana mekanizmalar\u0131. Cerrahpa\u015fa J Med 2004; 35 (2): 83\u201389.","journal-title":"Cerrahpa\u015fa J Med"},{"key":"BFjp201581_CR18","doi-asserted-by":"publisher","first-page":"301982","DOI":"10.1155\/2013\/301982","volume":"2013","author":"CC Sung","year":"2013","unstructured":"Sung CC, Hsu YC, Chen CC, Lin YF, Wu CC . Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease. Oxid Med Cell Longev 2013; 2013: 301982.","journal-title":"Oxid Med Cell Longev"},{"key":"BFjp201581_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/10715769800300111","volume":"29","author":"MV Kumari","year":"1998","unstructured":"Kumari M.V., Hiramatsu M., Ebadi M . Free radical scavenging actions of metallothionein isoforms I and II. Free Radic Res 1998; 29: 93\u2013101.","journal-title":"Free Radic Res"},{"issue":"2 Suppl.","key":"BFjp201581_CR20","doi-asserted-by":"publisher","first-page":"653S","DOI":"10.1093\/ajcn\/72.2.653S","volume":"72","author":"CK Sen","year":"2000","unstructured":"Sen CK, Packer L . Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr 2000; 72 (2 Suppl.): 653S\u2013669SS.","journal-title":"Am J Clin Nutr"},{"key":"BFjp201581_CR21","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.freeradbiomed.2013.05.050","volume":"65","author":"L Turell","year":"2013","unstructured":"Turell L, Radi R, Alvarez B . The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radic Biol Med 2013; 65: 244\u2013253.","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"BFjp201581_CR22","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/j.freeradbiomed.2009.08.021","volume":"15","author":"DP Jones","year":"2009","unstructured":"Jones DP, Liang Y . Measuring the poise of thiol\/disulfide couples in vivo. Free Radic Biol Med 15; 2009; 47 (10): 1329\u20131338.","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"BFjp201581_CR23","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","volume":"48","author":"ML Circu","year":"2010","unstructured":"Circu ML . AwTY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 2010; 48 (6): 749\u2013762.","journal-title":"Free Radic Biol Med"},{"issue":"5","key":"BFjp201581_CR24","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.bcp.2005.10.044","volume":"71","author":"S Biswas","year":"2006","unstructured":"Biswas S, Chida AS, Rahman I . Redox modifications of protein\u2013thiols: emerging roles in cell signaling. Biochem Pharmacol 2006; 71 (5): 551\u2013564.","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"BFjp201581_CR25","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/S0003-2697(79)80122-0","volume":"93","author":"G Ellman","year":"1979","unstructured":"Ellman G, Lysko H . A precise method for the determination of plasma sulfhydryl groups. Anal Biochem 1979; 93 (1): 98\u2013102.","journal-title":"Anal Biochem"},{"issue":"18","key":"BFjp201581_CR26","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.clinbiochem.2014.09.026","volume":"47","author":"O Erel","year":"2014","unstructured":"Erel O, Neselioglu S . A novel and automated assay for thiol\/disulphide homeostasis. Clin Biochem 2014; 47 (18): 326\u2013332.","journal-title":"Clin Biochem"},{"key":"BFjp201581_CR27","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0301-2115(95)02238-4","volume":"63","author":"A Bashiri","year":"1995","unstructured":"Bashiri A, Neumann L, Maymon E, Katz M . Hyperemesis gravidarum: epidemiologic features, complications and outcome. Eur J Obstet Gynecol Reprod Biol 1995; 63: 135\u2013138.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"4","key":"BFjp201581_CR28","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1447-0756.2007.00552.x","volume":"33","author":"PC Tan","year":"2007","unstructured":"Tan PC, Jacob R, Quek KF, Omar SZ . Pregnancy outcome in hyperemesis gravidarum and the effect of laboratory clinical indicators of hyperemesis severity. J Obstet Gynaecol Res 2007; 33 (4): 457\u2013464.","journal-title":"J Obstet Gynaecol Res"},{"key":"BFjp201581_CR29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1399-3054.2008.01080.x","volume":"133","author":"C Jacob","year":"2008","unstructured":"Jacob C., Anwar A . The chemistry behind redox regulation with a focus on sulphur redox systems. Physiol Plant 2008; 133: 469\u2013480.","journal-title":"Physiol Plant"},{"key":"BFjp201581_CR30","doi-asserted-by":"publisher","first-page":"5899","DOI":"10.1021\/bi0500372","volume":"44","author":"RE Hansen","year":"2005","unstructured":"Hansen RE, \u00d8stergaard H, Winther JR . Increasing the reactivity of an artificial dithioldisulfide pair through modification of the electrostatic milieu. Biochemistry 2005; 44: 5899\u20135906.","journal-title":"Biochemistry"},{"key":"BFjp201581_CR31","doi-asserted-by":"publisher","first-page":"484","DOI":"10.2174\/138920307782411464","volume":"8","author":"MA Wouters","year":"2007","unstructured":"Wouters MA, George RA, Haworth NL . \u2018Forbidden\u2019 disulfides: their role as redox switches. Curr Protein Pept Sci 2007; 8: 484\u2013495.","journal-title":"Curr Protein Pept Sci"},{"issue":"12","key":"BFjp201581_CR32","doi-asserted-by":"publisher","first-page":"8890","DOI":"10.3390\/molecules15128890","volume":"15","author":"E Matteucci","year":"2010","unstructured":"Matteucci E, Giampietro O . Thiol signalling network with an eye to diabetes. Molecules 2010; 15 (12): 8890\u20138903.","journal-title":"Molecules"},{"issue":"3","key":"BFjp201581_CR33","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1158\/0008-5472.CAN-13-1423","volume":"4","author":"A Prabhu","year":"2014","unstructured":"Prabhu A, Sarcar B, Kahali S, Yuan Z, Johnson JJ, Adam KP et al. Cysteine catabolism:a novel metabolic pathway contributing to glioblastoma growth. Cancer Res 2014; 4 (3): 787\u2013796.","journal-title":"Cancer Res"},{"issue":"3\u20134","key":"BFjp201581_CR34","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1159\/000342627","volume":"34","author":"SD Rodrigues","year":"2012","unstructured":"Rodrigues SD, Batista GB, Ingberman M, Pecoits-Filho R, Nakao LS . Plasma cysteine\/cystine reduction potential correlates with plasma creatinine levels in chronic kidney disease. Blood Purif 2012; 34 (3\u20134): 231\u2013237.","journal-title":"Blood Purif"},{"key":"BFjp201581_CR35","first-page":"121","volume":"68","author":"JD Quinlan","year":"2003","unstructured":"Quinlan JD, Hill DA . Nausea and vomiting of pregnancy. Am Fam Physician 2003; 68: 121\u2013128.","journal-title":"Am Fam Physician"},{"issue":"8","key":"BFjp201581_CR36","doi-asserted-by":"publisher","first-page":"825","DOI":"10.3109\/14767058.2013.842549","volume":"27","author":"Y Onaran","year":"2014","unstructured":"Onaran Y, Kafali H, Duvan C\u0130, Keskin E, Celik H, Erel O . Relationship between oxidant and antioxidant activity in hyperemesis gravidarum. J Matern Fetal Neonatal Med 2014; 27 (8): 825\u2013828.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"BFjp201581_CR37","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1179\/1351000214Y.0000000110","volume":"20","author":"S Yilmaz","year":"2014","unstructured":"Yilmaz S, Ozgu-Erdinc AS, Demirtas C, Ozturk G, Erkaya S, Uygur D . The oxidative stress index increases among patients with hyperemesis gravidarum but not in normal pregnancies. Redox Rep 2014; 20: 97\u2013102.","journal-title":"Redox Rep"},{"key":"BFjp201581_CR38","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","volume":"37","author":"O Erel","year":"2004","unstructured":"Erel O . A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 2004; 37: 277\u2013285.","journal-title":"Clin Biochem"},{"key":"BFjp201581_CR39","doi-asserted-by":"publisher","first-page":"1641S","DOI":"10.1093\/jn\/136.6.1641S","volume":"136","author":"Y Ingenbleek","year":"2006","unstructured":"Ingenbleek Y . The nutritional relationship linking sulfur to nitrogen in living organisms. J Nutr 2006; 136: 1641S\u20131651S.","journal-title":"J Nutr"},{"key":"BFjp201581_CR40","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1053\/plac.2001.0693","volume":"22","author":"E Shibata","year":"2001","unstructured":"Shibata E, Ejima K, Nanri H, Toki N, Koyama C, Ikeda M. et al. Enhanced protein levels of protein thiol\/disulphide oxidoreductases in placentae from pre-eclamptic subjects. Placenta 2001; 22: 566\u2013572.","journal-title":"Placenta"},{"key":"BFjp201581_CR41","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.freeradbiomed.2004.04.035","volume":"37","author":"E Llurba","year":"2004","unstructured":"Llurba E, Grataco E, Mart\u0131n-Gallan P, Cabero L, Dom\u0131nguez C . A comprehens\u0131ve study of ox\u0131dat\u0131ve stress and ant\u0131ox\u0131dant status \u0131n preeclamps\u0131a and normal pregnancy. Free Rad\u0131cal B\u0131o Med 2004; 37: 557\u2013570.","journal-title":"Free Rad\u0131cal B\u0131o Med"},{"key":"BFjp201581_CR42","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1053\/plac.2000.0554","volume":"21","author":"L Sahlin","year":"2000","unstructured":"Sahlin L, Ostlund E, Wang H, Holmgren A, Fried G . Decreased expression of thioredoxin and glutaredoxin in placentas from pregnancies with pre-eclampsia and \u0131ntrauterine growth restriction. Placenta 2000; 21: 603\u2013609.","journal-title":"Placenta"},{"key":"BFjp201581_CR43","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1002\/pmic.200300537","volume":"3","author":"G Sawicki","year":"2003","unstructured":"Sawicki G, Dakour J, Morrish DW . Functional proteomics of neurokinin B in the placenta indicates a novel role in regulating cytotrophoblast antioxidant defences. Proteomics 2003; 3: 2044\u20132051.","journal-title":"Proteomics"},{"key":"BFjp201581_CR44","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ijgo.2008.06.017","volume":"103","author":"S Kharb","year":"2008","unstructured":"Kharb S . Total radical-trapping antioxidant potential in gestational diabetes. Int J Gynaecol Obstet 2008; 103: 257\u2013258.","journal-title":"Int J Gynaecol Obstet"},{"issue":"3","key":"BFjp201581_CR45","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3109\/07435800.2012.654556","volume":"37","author":"M Vural","year":"2012","unstructured":"Vural M, Camuzcuoglu H, Toy H, Cece H, Aydin H, Eren MA et al. Evaluation of the future atherosclerotic heart disease with oxidative stress and carotid artery intima media thickness in gestational diabetes mellitus. Endocr Res 2012; 37 (3): 145\u2013153.","journal-title":"Endocr Res"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp201581.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201581","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201581.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T12:24:31Z","timestamp":1647606271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp201581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,9]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["BFjp201581"],"URL":"https:\/\/doi.org\/10.1038\/jp.2015.81","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,9]]},"assertion":[{"value":"10 January 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}