{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:02:57Z","timestamp":1778680977014,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1038\/jp.2016.248","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T14:26:09Z","timestamp":1484231169000},"page":"558-562","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cerebral modulation of the autonomic nervous system in term infants"],"prefix":"10.1038","volume":"37","author":[{"given":"N","family":"Schneebaum Sender","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R B","family":"Govindan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M T","family":"Whitehead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A N","family":"Massaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Metzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y I","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"du Plessis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"key":"BFjp2016248_CR1","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1177\/0884217504263301","volume":"33","author":"MT Verklan","year":"2004","unstructured":"Verklan MT, Padhye NS . Spectral analysis of heart rate variability: an emerging tool for assessing stability during transition to extrauterine life. J Obstet Gynecol Neonatal Nurs 2004; 33: 256\u2013265.","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"key":"BFjp2016248_CR2","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.earlhumdev.2009.11.001","volume":"85","author":"JO van Laar","year":"2009","unstructured":"van Laar JO, Peters CH, Vullings R, Houterman S, Oei SG . Power spectrum analysis of fetal heart rate variability at near term and post term gestation during active sleep and quiet sleep. Early Hum Dev 2009; 85: 795\u2013798.","journal-title":"Early Hum Dev"},{"key":"BFjp2016248_CR3","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1093\/oxfordjournals.eurheartj.a014868","volume":"17","author":"Task Force. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use","year":"1996","unstructured":"Task Force. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J 1996; 17: 354\u2013381.","journal-title":"Eur Heart J"},{"key":"BFjp2016248_CR4","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.earlhumdev.2005.03.015","volume":"81","author":"E Longin","year":"2005","unstructured":"Longin E, Schaible T, Lenz T, Konig S . Short term heart rate variability in healthy neonates: normative data and physiological observations. Early Hum Dev 2005; 81: 663\u2013671.","journal-title":"Early Hum Dev"},{"issue":"2","key":"BFjp2016248_CR5","first-page":"177","volume":"35","author":"SR Yiallourou","year":"2012","unstructured":"Yiallourou SR, Sands SA, Walker AM, Horne RS . Maturation of heart rate and blood pressure variability during sleep in term-born infants. Sleep 2012; 35 (2): 177\u2013186.","journal-title":"Sleep"},{"key":"BFjp2016248_CR6","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1515\/JPM.2006.058","volume":"34","author":"E Longin","year":"2006","unstructured":"Longin E, Gerstner T, Schaible T, Lenz T, Konig S . Maturation of the autonomic nervous system: differences in heart rate variability in premature vs. term infants. J Perinat Med 2006; 34: 303\u2013308.","journal-title":"J Perinat Med"},{"key":"BFjp2016248_CR7","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/jp.2014.108","volume":"34","author":"AN Massaro","year":"2014","unstructured":"Massaro AN, Govindan RB, Al-Shargabi T, Andescavage NN, Metzler M, Chang T et al. Heart rate variability in encephalopathic newborns during and after therapeutic hypothermia. J Perinatol 2014; 34: 836\u2013841.","journal-title":"J Perinatol"},{"key":"BFjp2016248_CR8","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1007\/s12098-012-0703-2","volume":"79","author":"D Aliefendioglu","year":"2012","unstructured":"Aliefendioglu D, Dogru T, Albayrak M, Dibekmisirlioglu E, Sanli C . Heart rate variability in neonates with hypoxic ischemic encephalopathy. Indian J Pediatr 2012; 79: 1468\u20131472.","journal-title":"Indian J Pediatr"},{"issue":"10","key":"BFjp2016248_CR9","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1055\/s-0033-1361937","volume":"31","author":"BD Vergales","year":"2014","unstructured":"Vergales BD, Zanelli SA, Matsumoto JA, Goodkin HP, Lake DE, Moorman JR et al. Depressed heart rate variability is associated with abnormal EEG, MRI, and death in neonates with hypoxic ischemic encephalopathy. Am J Perinatol 2014; 31 (10): 855\u2013862.","journal-title":"Am J Perinatol"},{"key":"BFjp2016248_CR10","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1203\/01.pdr.0000252438.65759.af","volume":"61","author":"MP Griffin","year":"2007","unstructured":"Griffin MP, Lake DE, O'Shea TM, Moorman JR . Heart rate characteristics and clinical signs in neonatal sepsis. Pediatr Res 2007; 61: 222\u2013227.","journal-title":"Pediatr Res"},{"key":"BFjp2016248_CR11","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/jp.2013.63","volume":"33","author":"ML Stone","year":"2013","unstructured":"Stone ML, Tatum PM, Weitkamp JH, Mukherjee AB, Attridge J, McGahren ED et al. Abnormal heart rate characteristics before clinical diagnosis of necrotizing enterocolitis. J Perinatol 2013; 33: 847\u2013850.","journal-title":"J Perinatol"},{"key":"BFjp2016248_CR12","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1111\/j.1467-8624.2007.01099.x","volume":"78","author":"JA DiPietro","year":"2007","unstructured":"DiPietro JA, Bornstein MH, Hahn CS, Costigan K, Achy-Brou A . Fetal heart rate and variability: stability and prediction to developmental outcomes in early childhood. Child Dev 2007; 78: 1788\u20131798.","journal-title":"Child Dev"},{"key":"BFjp2016248_CR13","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.earlhumdev.2008.04.010","volume":"84","author":"H Patural","year":"2008","unstructured":"Patural H, Pichot V, Jaziri F, Teyssier G, Gaspoz JM, Roche F et al. Autonomic cardiac control of very preterm newborns: a prolonged dysfunction. Early Hum Dev 2008; 84: 681\u2013687.","journal-title":"Early Hum Dev"},{"key":"BFjp2016248_CR14","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/jp.2009.81","volume":"29","author":"K Addison","year":"2009","unstructured":"Addison K, Griffin MP, Moorman JR, Lake DE, O'Shea TM . Heart rate characteristics and neurodevelopmental outcome in very low birth weight infants. J Perinatol 2009; 29: 750\u2013756.","journal-title":"J Perinatol"},{"key":"BFjp2016248_CR15","first-page":"293","volume-title":"The Integrative Action of the Autonomic Nervous System Neurobiology of Homeostasis","author":"W Janig","year":"2008","unstructured":"Janig W . The Integrative Action of the Autonomic Nervous System Neurobiology of Homeostasis. Cambridge University Press: New York, USA, 2008; 293\u2013317."},{"key":"BFjp2016248_CR16","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1212\/WNL.42.9.1727","volume":"42","author":"SM Oppenheimer","year":"1992","unstructured":"Oppenheimer SM, Gelb A, Girvin JP, Hachinski VC . Cardiovascular effects of human insular cortex stimulation. Neurology 1992; 42: 1727\u20131732.","journal-title":"Neurology"},{"key":"BFjp2016248_CR17","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0006-8993(01)02453-2","volume":"903","author":"MJ Westerhaus","year":"2001","unstructured":"Westerhaus MJ, Loewy AD . Central representation of the sympathetic nervous system in the cerebral cortex. Brain Res 2001; 903: 117\u2013127.","journal-title":"Brain Res"},{"key":"BFjp2016248_CR18","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/nrneurol.2012.100","volume":"8","author":"JA Hyam","year":"2012","unstructured":"Hyam JA, Kringelbach ML, Silburn PA, Aziz TZ, Green AL . The autonomic effects of deep brain stimulation\u2014a therapeutic opportunity. Nat Rev Neurol 2012; 8: 391\u2013400.","journal-title":"Nat Rev Neurol"},{"key":"BFjp2016248_CR19","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1113\/jphysiol.2005.091637","volume":"569","author":"DS Kimmerly","year":"2005","unstructured":"Kimmerly DS, O'Leary DD, Menon RS, Gati JS, Shoemaker JK . Cortical regions associated with autonomic cardiovascular regulation during lower body negative pressure in humans. J Physiol 2005; 569: 331\u2013345.","journal-title":"J Physiol"},{"key":"BFjp2016248_CR20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.neuroimage.2008.04.238","volume":"42","author":"V Napadow","year":"2008","unstructured":"Napadow V, Dhond R, Conti G, Makris N, Brown EN, Barbieri R . Brain correlates of autonomic modulation: combining heart rate variability with fMRI. Neuroimage 2008; 42: 169\u2013177.","journal-title":"Neuroimage"},{"key":"BFjp2016248_CR21","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1159\/000014209","volume":"77","author":"BD Hanna","year":"2000","unstructured":"Hanna BD, Nelson MN, White-Traut RC, Silvestri JM, Vasan U, Rey PM et al. Heart rate variability in preterm brain-injured and very-low-birth-weight infants. Biol Neonate 2000; 77: 147\u2013155.","journal-title":"Biol Neonate"},{"key":"BFjp2016248_CR22","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.earlhumdev.2014.10.003","volume":"90","author":"N Schneebaum Sender","year":"2014","unstructured":"Schneebaum Sender N, Govindan RB, Sulemanji M, Al-Shargabi T, Lenin RB, Eksioglu YZ et al. Effects of regional brain injury on the newborn autonomic nervous system. Early Hum Dev 2014; 90: 893\u2013896.","journal-title":"Early Hum Dev"},{"key":"BFjp2016248_CR23","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","volume":"353","author":"S Shankaran","year":"2005","unstructured":"Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005; 353: 1574\u20131584.","journal-title":"N Engl J Med"},{"key":"BFjp2016248_CR24","first-page":"4666","volume":"2009","author":"UD Ulusar","year":"2009","unstructured":"Ulusar UD, Govindan RB, Wilson JD, Lowery CL, Preissl H, Eswaran H . Adaptive rule based fetal QRS complex detection using Hilbert transform. Conf Proc IEEE Eng Med Biol Soc 2009; 2009: 4666\u20134669.","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"BFjp2016248_CR25","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1016\/j.compbiomed.2013.09.019","volume":"43","author":"RB Govindan","year":"2013","unstructured":"Govindan RB, Massaro AN, Niforatos N, du Plessis A . Mitigating the effect of non-stationarity in spectral analysis-an application to neonate heart rate analysis. Comput Biol Med 2013; 43: 2001\u20132006.","journal-title":"Comput Biol Med"},{"key":"BFjp2016248_CR26","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1113\/jphysiol.2005.093641","volume":"568","author":"P Andriessen","year":"2005","unstructured":"Andriessen P, Oetomo SB, Peters C, Vermeulen B, Wijn PF, Blanco CE . Baroreceptor reflex sensitivity in human neonates: the effect of postmenstrual age. J Physiol 2005; 568: 333\u2013341.","journal-title":"J Physiol"},{"key":"BFjp2016248_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/0470867159","volume-title":"Applied Bayesian Modelling","author":"P Congdon","year":"2003","unstructured":"Congdon P . Applied Bayesian Modelling. Wiley Series in Probability and Statistics: West Sussex, England, 2003."},{"key":"BFjp2016248_CR28","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1207\/s15327906mbr3904_4","volume":"39","author":"S-Y Lee","year":"2004","unstructured":"Lee S-Y, Song X-Y . Evaluation of the Bayesian and maximum likelihood approaches in analyzing structural equation models with small sample sizes. Multivariate Behav Res 2004; 39: 653\u2013686.","journal-title":"Multivariate Behav Res"},{"key":"BFjp2016248_CR29","volume-title":"Mplus User's Guide","author":"B Muth\u00e9n","year":"1998","unstructured":"Muth\u00e9n B, Muth\u00e9n L . Mplus User's Guide. Muthen & Muthen: Los Angeles, CA, USA, 1998\u20132012."},{"key":"BFjp2016248_CR30","unstructured":"Muth\u00e9n B . Bayesian analysis in Mplus:A Brief Introduction. Unpublished manuscript. www.statmodel.com\/download\/IntroBayesVersion. 17May2010;pp203."},{"key":"BFjp2016248_CR31","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/00006842-198108000-00007","volume":"43","author":"GE Schwartz","year":"1981","unstructured":"Schwartz GE, Weinberger DA, Singer JA . Cardiovascular differentiation of happiness, sadness, anger, and fear following imagery and exercise. Psychosom Med 1981; 43: 343\u2013364.","journal-title":"Psychosom Med"},{"key":"BFjp2016248_CR32","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1212\/WNL.40.9.1408","volume":"40","author":"EY Zamrini","year":"1990","unstructured":"Zamrini EY, Meador KJ, Loring DW, Nichols FT, Lee GP, Figueroa RE et al. Unilateral cerebral inactivation produces differential left\/right heart rate responses. Neurology 1990; 40: 1408\u20131411.","journal-title":"Neurology"},{"key":"BFjp2016248_CR33","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/BF02281899","volume":"6","author":"SM Oppenheimer","year":"1996","unstructured":"Oppenheimer SM, Kedem G, Martin WM . Left-insular cortex lesions perturb cardiac autonomic tone in humans. Clin Auton Res 1996; 6: 131\u2013140.","journal-title":"Clin Auton Res"},{"key":"BFjp2016248_CR34","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1161\/01.STR.0000138452.81003.4c","volume":"35","author":"F Colivicchi","year":"2004","unstructured":"Colivicchi F, Bassi A, Santini M, Caltagirone C . Cardiac autonomic derangement and arrhythmias in right-sided stroke with insular involvement. Stroke 2004; 35: 2094\u20132098.","journal-title":"Stroke"},{"key":"BFjp2016248_CR35","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1161\/01.STR.0000099964.34430.2D","volume":"34","author":"A Algra","year":"2003","unstructured":"Algra A, Gates PC, Fox AJ, Hachinski V, Barnett HJ . Side of brain infarction and long-term risk of sudden death in patients with symptomatic carotid disease. Stroke 2003; 34: 2871\u20132875.","journal-title":"Stroke"},{"key":"BFjp2016248_CR36","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.brainresrev.2006.01.003","volume":"52","author":"JN Zhu","year":"2006","unstructured":"Zhu JN, Yung WH, Kwok-Chong Chow B, Chan YS, Wang JJ . The cerebellar-hypothalamic circuits: potential pathways underlying cerebellar involvement in somatic-visceral integration. Brain Res Rev 2006; 52: 93\u2013106.","journal-title":"Brain Res Rev"},{"key":"BFjp2016248_CR37","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.neuroimage.2006.12.027","volume":"35","author":"SW Wong","year":"2007","unstructured":"Wong SW, Mass\u00e9 N, Kimmerly DS, Menon RS, Shoemaker JK . Ventral medial prefrontal cortex and cardiovagal control in conscious humans. Neuroimage 2007; 35: 698\u2013708.","journal-title":"Neuroimage"},{"key":"BFjp2016248_CR38","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1113\/expphysiol.2011.060848","volume":"97","author":"SD Basnayake","year":"2012","unstructured":"Basnayake SD, Green AL, Paterson DJ . Mapping the central neurocircuitry that integrates the cardiovascular response to exercise in humans. Exp Physiol 2012; 97: 29\u201338.","journal-title":"Exp Physiol"},{"key":"BFjp2016248_CR39","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195051063.001.0001","volume-title":"Central Regulation of Autonomic Function","author":"AD Loewy","year":"1990","unstructured":"Loewy AD, Spyer KM . Central Regulation of Autonomic Function. Oxford University Press: New York, USA, 1990."},{"key":"BFjp2016248_CR40","doi-asserted-by":"publisher","first-page":"F151","DOI":"10.1136\/fn.86.3.F151","volume":"86","author":"V Gournay","year":"2002","unstructured":"Gournay V, Drouin E, Roz\u00e9 JC . Development of baroreflex control of heart rate in preterm and full term infants. Arch Dis Child Fetal Neonatal Ed 2002; 86: F151\u2013F154.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFjp2016248_CR41","first-page":"343","volume":"21","author":"MM Myers","year":"1998","unstructured":"Myers MM, Fifer WP, Schaeffer L, Sahni R, Ohira-Kist K, Stark RI et al. Effects of sleeping position and time after feeding on the organization of sleep\/wake states in prematurely born infants. Sleep 1998; 21: 343\u2013349.","journal-title":"Sleep"},{"key":"BFjp2016248_CR42","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1365-2869.2009.00793.x","volume":"19","author":"NB Witcombe","year":"2010","unstructured":"Witcombe NB, Yiallourou SR, Walker AM, Horne RS . Delayed blood pressure recovery after head-up tilting during sleep in preterm infants. J Sleep Res 2010; 19: 93\u2013102.","journal-title":"J Sleep Res"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp2016248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp2016248","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/jp.2016.248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/jp2016248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T19:30:10Z","timestamp":1718998210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp2016248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,12]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["BFjp2016248"],"URL":"https:\/\/doi.org\/10.1038\/jp.2016.248","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,12]]},"assertion":[{"value":"26 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}