{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:52:36Z","timestamp":1787997156405,"version":"build-2784847793"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1038\/jp.2016.95","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T13:02:44Z","timestamp":1466082164000},"page":"837-842","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnosis, gB genotype distribution and viral load of symptomatic congenitally infected CMV patients in Cuba"],"prefix":"10.1038","volume":"36","author":[{"given":"C","family":"Correa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Kour\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Limia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"BFjp201695_CR1","first-page":"2703","volume-title":"Fields Virology","author":"ES Mocarski","year":"2007","unstructured":"Mocarski ES, Shenk T, Pass RF . Cytomegaloviruses. In: Knipe DM, Howley PM (eds). Fields Virology vol. II. Lippincott Williams & Wilkins: Philadelphia, 2007, pp 2703\u20132772."},{"key":"BFjp201695_CR2","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/rmv.1744","volume":"23","author":"JJ de Vries","year":"2013","unstructured":"de Vries JJ, van Zwet EW, Dekker FW, Kroes AC, Verkerk PH, Vossen AC . The apparent paradox of maternal seropositivity as a risk factor for congenital cytomegalovirus infection: a population-based prediction model. Rev Med Virol 2013; 23: 241\u2013249.","journal-title":"Rev Med Virol"},{"key":"BFjp201695_CR3","doi-asserted-by":"publisher","first-page":"E4997","DOI":"10.1073\/pnas.1316517110","volume":"110","author":"DC Freed","year":"2013","unstructured":"Freed DC, Tang Q, Tang A, Li F, He X, Huang Z et al. Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine. Proc Natl Acad Sci USA 2013; 110: E4997\u2013E5005.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFjp201695_CR4","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/rmv.438","volume":"14","author":"S Pignatelli","year":"2004","unstructured":"Pignatelli S, Dal Monte P, Rossini G, Landini MP . Genetic polymorphisms among human cytomegalovirus (HCMV) wild-type strains. Rev Med Virol 2004; 14: 383\u2013410.","journal-title":"Rev Med Virol"},{"key":"BFjp201695_CR5","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1093\/infdis\/169.4.769","volume":"169","author":"BC Fries","year":"1994","unstructured":"Fries BC, Chou S, Boeckh M, Torok-Storb B . Frequency distribution of cytomegalovirus envelope glycoprotein genotypes in bone marrow transplant recipients. J Infect Dis 1994; 169: 769\u2013774.","journal-title":"J Infect Dis"},{"key":"BFjp201695_CR6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1159\/000093458","volume":"49","author":"ZS Yu","year":"2006","unstructured":"Yu ZS, Zou CC, Zheng JY, Zhao ZY . Cytomegalovirus gB genotype and clinical features in Chinese infants with congenital infections. Intervirology 2006; 49: 281\u2013285.","journal-title":"Intervirology"},{"key":"BFjp201695_CR7","doi-asserted-by":"publisher","first-page":"758","DOI":"10.3855\/jidc.3501","volume":"8","author":"J Arellano-Galindo","year":"2014","unstructured":"Arellano-Galindo J, Villanueva-Garcia D, Cruz-Ramirez JL, Yalaupari-Mejia JP, Uribe-Gutierrez G, Velazquez-Guadarrama N et al. Detection and gB genotyping of CMV in Mexican preterm infants in the context of maternal seropositivity. J Infect Dev Ctries 2014; 8: 758\u2013767.","journal-title":"J Infect Dev Ctries"},{"key":"BFjp201695_CR8","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1097\/INF.0b013e31829bb0b9","volume":"32","author":"SK Pati","year":"2013","unstructured":"Pati SK, Pinninti S, Novak Z, Chowdhury N, Patro RK, Fowler K et al. Genotypic diversity and mixed infection in newborn disease and hearing loss in congenital cytomegalovirus infection. Pediatr Infect Dis J 2013; 32: 1050\u20131054.","journal-title":"Pediatr Infect Dis J"},{"key":"BFjp201695_CR9","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1097\/INF.0b013e3181eb7388","volume":"29","author":"V Kouri","year":"2010","unstructured":"Kouri V, Correa CB, Verdasquera D, Martinez PA, Alvarez A, Aleman Y et al. Diagnosis and screening for cytomegalovirus infection in pregnant women in Cuba as prognostic markers of congenital infection in newborns: 2007-2008. Pediatr Infect Dis J 2010; 29: 1105\u20131110.","journal-title":"Pediatr Infect Dis J"},{"key":"BFjp201695_CR10","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0166-0934(93)90061-U","volume":"44","author":"A Tenorio","year":"1993","unstructured":"Tenorio A, Echevarria JE, Casas I, Echevarria JM, Tabar\u00e9s E . Detection and typing of human herpesviruses by multiplex polymerase chain reaction. J Virol Methods 1993; 44: 261\u2013269.","journal-title":"J Virol Methods"},{"key":"BFjp201695_CR11","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1128\/JCM.41.7.2872-2877.2003","volume":"41","author":"D Tarrago","year":"2003","unstructured":"Tarrago D, Quereda C, Tenorio A . Different cytomegalovirus glycoprotein B genotype distribution in serum and cerebrospinal fluid specimens determined by a novel multiplex nested PCR. J Clin Microbiol 2003; 41: 2872\u20132877.","journal-title":"J Clin Microbiol"},{"key":"BFjp201695_CR12","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jcv.2007.10.015","volume":"41","author":"T Lazzarotto","year":"2008","unstructured":"Lazzarotto T, Guerra B, Lanari M, Gabrielli L, Landini MP . New advances in the diagnosis of congenital cytomegalovirus infection. J Clin Virol 2008; 41: 192\u2013197.","journal-title":"J Clin Virol"},{"key":"BFjp201695_CR13","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1128\/CMR.15.4.680-715.2002","volume":"15","author":"MG Revello","year":"2002","unstructured":"Revello MG, Gerna G . Diagnosis and management of human cytomegalovirus infection in the mother, fetus and newborn infant. Clin Microbiol Rev 2002; 15: 680\u2013715.","journal-title":"Clin Microbiol Rev"},{"key":"BFjp201695_CR14","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0167-5877(00)00115-X","volume":"45","author":"M Greiner","year":"2000","unstructured":"Greiner M, Pfeiffer D, Smith RD . Principles and practical application of the receiver-operating characteristic analysis for diagnostic tests. Prev Vet Med 2000; 45: 23\u201341.","journal-title":"Prev Vet Med"},{"key":"BFjp201695_CR15","doi-asserted-by":"crossref","unstructured":"Baquero-Artigao F, Grupo de estudio de la infecci\u00f3n cong\u00e9nita por citomegalovirus de la Sociedad Espa\u00f1ola de Infectolog\u00eda Pedi\u00e1trica. Consensus document from the Spanish Society of Paediatric Infectious Diseases (SEIP) on the diagnosis and treatment of congenital cytomegalovirus infection. An Pediatr (Barc) 2009; 71: 535\u2013547.","DOI":"10.1016\/j.anpedi.2009.07.029"},{"key":"BFjp201695_CR16","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/rmv.535","volume":"17","author":"A Kenneson","year":"2007","unstructured":"Kenneson A, Cannon MJ . Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol 2007; 17: 253\u2013276.","journal-title":"Rev Med Virol"},{"key":"BFjp201695_CR17","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1007\/BF02763052","volume":"73","author":"I Gandhoke","year":"2006","unstructured":"Gandhoke I, Aggarwal R, Lal S, Khare S . Congenital CMV infection in symptomatic infants in Delhi and surrounding areas. Indian J Pediatr 2006; 73: 1095\u20131097.","journal-title":"Indian J Pediatr"},{"key":"BFjp201695_CR18","doi-asserted-by":"publisher","first-page":"222","DOI":"10.4103\/0255-0857.53204","volume":"27","author":"I Gandhoke","year":"2009","unstructured":"Gandhoke I, Aggarwal R, Hussain SA, Pasha ST, Sethi P, Thakur S et al. Congenital CMV infection; diagnosis in symptomatic infants. Indian J Med Microbiol 2009; 27: 222\u2013225.","journal-title":"Indian J Med Microbiol"},{"key":"BFjp201695_CR19","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.clp.2014.11.001","volume":"42","author":"N Neu","year":"2015","unstructured":"Neu N, Duchon J, Zachariah P . TORCH infections. Clin Perinatol 2015; 42: 77\u2013103 viii.","journal-title":"Clin Perinatol"},{"key":"BFjp201695_CR20","volume-title":"Nelson Textbook of Pediatrics","author":"RM Kliegman","year":"2011","unstructured":"Kliegman RM, Stanton B, Geme JS, Schor NF . Nelson Textbook of Pediatrics. Elsevier - Health Sciences Division: Philadelphia, 2011."},{"key":"BFjp201695_CR21","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1007\/s10096-011-1447-z","volume":"31","author":"E Paradowska","year":"2012","unstructured":"Paradowska E, Studzin'ska M, Nowakowska D, Wilczyn'ski J, Rycel M . Distribution of UL144, US28 and UL55 genotypes in Polish newborns with congenital cytomegalovirus infections. Eur J Clin Microbiol Infect Dis 2012; 31: 1335\u20131345.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"BFjp201695_CR22","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1080\/00365540701466165","volume":"39","author":"V Kouri","year":"2007","unstructured":"Kouri V, Gonzalez EE, Martinez PA, Capo V, Gonzalez R, Perez L et al. Distinct genotypic distribution of cytomegalovirus (CMV) envelope glycoprotein B (gB) in a Cuban cohort of patients with different CMV diseases. Scand J Infect Dis 2007; 39: 1038\u20131044.","journal-title":"Scand J Infect Dis"},{"key":"BFjp201695_CR23","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s10096-014-2266-9","volume":"34","author":"M Rycel","year":"2015","unstructured":"Rycel M, Wujcicka W, Zawili\u0144ska B, Paradowska E, Suski P, Gaj Z et al. Mixed infections with distinct cytomegalovirus glycoprotein B genotypes in Polish pregnant women, fetuses, and newborns. Eur J Clin Microbiol Infect Dis 2015; 34: 585\u2013591.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"BFjp201695_CR24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S1386-6532(00)00188-8","volume":"21","author":"M Barbi","year":"2001","unstructured":"Barbi M, Binda S, Caroppo S, Primache V, Dido P, Guidotti P et al. CMV gB genotypes and outcome of vertical transmission: study on dried blood spots of congenitally infected babies. J Clin Virol 2001; 21: 75\u201379.","journal-title":"J Clin Virol"},{"key":"BFjp201695_CR25","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1002\/pd.942","volume":"24","author":"O Picone","year":"2004","unstructured":"Picone O, Costa JM, Leruez-Ville M, Ernault P, Olivi M, Ville Y . Cytomegalovirus (CMV) glycoprotein B genotype and CMV DNA load in the amniotic fluid of infected fetuses. Prenat Diagn 2004; 24: 1001\u20131006.","journal-title":"Prenat Diagn"},{"key":"BFjp201695_CR26","doi-asserted-by":"publisher","first-page":"e51224","DOI":"10.1371\/journal.pone.0051224","volume":"7","author":"X Zhang","year":"2012","unstructured":"Zhang X, Huang YP, Gao HN, Yang MF, Zhao H, Hu JH et al. Quantification of cytomegalovirus glycoprotein Bn DNA in hematopoietic stem cell transplant recipients by real-time PCR. PLoS One 2012; 7: e51224.","journal-title":"PLoS One"},{"key":"BFjp201695_CR27","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1128\/JCM.05253-11","volume":"50","author":"JJ de Vries","year":"2012","unstructured":"de Vries JJ, Wessels E, Korver AM, van der Eijk AA, Rusman LG, Kroes AC et al. Rapid genotyping of cytomegalovirus in dried blood spots by multiplex real-time PCR assays targeting the envelope glycoprotein gB and gH genes. J Clin Microbiol 2012; 50: 232\u2013237.","journal-title":"J Clin Microbiol"},{"key":"BFjp201695_CR28","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1093\/infdis\/jir457","volume":"204","author":"SA Ross","year":"2011","unstructured":"Ross SA, Novak Z, Pati S, Patro RK, Blumenthal J, Danthuluri VR et al. Mixed infection and strain diversity in congenital cytomegalovirus infection. J Infect Dis 2011; 204: 1003\u20131007.","journal-title":"J Infect Dis"},{"key":"BFjp201695_CR29","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1056\/NEJM200105033441804","volume":"344","author":"SB Boppana","year":"2001","unstructured":"Boppana SB, Rivera LB, Fowler KB, Mach M, Britt WJ . Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity. N Engl J Med 2001; 344: 1366\u20131371.","journal-title":"N Engl J Med"},{"key":"BFjp201695_CR30","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.1542\/peds.2005-0629","volume":"117","author":"M Lanari","year":"2006","unstructured":"Lanari M, Lazzarotto T, Venturi V, Papa I, Gabrielli L, Guerra B et al. Neonatal cytomegalovirus blood load and risk of sequelae in symptomatic and asymptomatic congenitally infected newborns. Pediatrics 2006; 117: e76\u2013e83.","journal-title":"Pediatrics"},{"key":"BFjp201695_CR31","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.jpeds.2005.01.059","volume":"146","author":"SB Boppana","year":"2005","unstructured":"Boppana SB, Fowler KB, Pass RF, Rivera LB, Bradford RD . Congenital cytomegalovirus infection: association between virus burden in infancy and hearing loss. J Pediatr 2005; 146: 817\u2013823.","journal-title":"J Pediatr"},{"key":"BFjp201695_CR32","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1067\/mob.2000.106347","volume":"183","author":"B Guerra","year":"2000","unstructured":"Guerra B, Lazzarotto T, Quarta S, Lanari M, Bovicelli L, Nicolosi A . Prenatal diagnosis of symptomatic congenital cytomegalovirus infection. Am J Obstet Gynecol 2000; 183: 476\u2013482.","journal-title":"Am J Obstet Gynecol"},{"key":"BFjp201695_CR33","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1097\/INF.0b013e3181979a27","volume":"28","author":"SA Ross","year":"2009","unstructured":"Ross SA, Novak Z, Fowler KB, Arora N, Britt WJ, Boppana SB . Cytomegalovirus blood viral load and hearing loss in young children with congenital infection. Pediatr Infect Dis J 2009; 28: 588\u2013592.","journal-title":"Pediatr Infect Dis J"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp201695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201695","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp201695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T15:09:04Z","timestamp":1647616144000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp201695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,16]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["BFjp201695"],"URL":"https:\/\/doi.org\/10.1038\/jp.2016.95","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,16]]},"assertion":[{"value":"10 January 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}