{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T21:01:07Z","timestamp":1780434067519,"version":"3.54.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1038\/jp.2017.130","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T19:31:45Z","timestamp":1504812705000},"page":"1310-1314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Bronchopulmonary dysplasia-associated pulmonary hypertension: clues from placental pathology"],"prefix":"10.1038","volume":"37","author":[{"given":"A M","family":"Kunjunju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K R","family":"Gopagondanahalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"BFjp2017130_CR1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ppedcard.2009.09.007","volume":"27","author":"PM Mourani","year":"2009","unstructured":"Mourani PM, Mullen M, Abman SH . Pulmonary hypertension in bronchopulmonary dysplasia. Prog Pediatr Cardiol 2009; 27: 43\u201348.","journal-title":"Prog Pediatr Cardiol"},{"key":"BFjp2017130_CR2","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1542\/peds.2009-2959","volume":"126","author":"BJ Stoll","year":"2010","unstructured":"Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010; 126: 443\u2013456.","journal-title":"Pediatrics"},{"key":"BFjp2017130_CR3","unstructured":"Chow SSW, Le Marsney R, Haslam R, Lui K . Report of the Australia and New Zealand Neonatal Network 2014. 2016."},{"key":"BFjp2017130_CR4","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4070\/kcj.2010.40.3.131","volume":"40","author":"HS An","year":"2010","unstructured":"An HS, Bae EJ, Kim GB, Kwon BS, Beak JS, Kim EK et al. Pulmonary hypertension in preterm infants with bronchopulmonary dysplasia. Korean Circ J 2010; 40: 131\u2013136.","journal-title":"Korean Circ J"},{"key":"BFjp2017130_CR5","doi-asserted-by":"publisher","first-page":"e682","DOI":"10.1542\/peds.2011-1827","volume":"129","author":"R Bhat","year":"2012","unstructured":"Bhat R, Salas AA, Foster C, Carlo WA, Ambalavanan N . Prospective analysis of pulmonary hypertension in extremely low birth weight infants. Pediatrics 2012; 129: e682\u2013e689.","journal-title":"Pediatrics"},{"key":"BFjp2017130_CR6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1542\/peds.65.3.529","volume":"65","author":"JC Fouron","year":"1980","unstructured":"Fouron JC, Le Guennec JC, Villemant D, Perreault G, Davignon A . Value of echocardiography in assessing the outcome of bronchopulmonary dysplasia of the newborn. Pediatrics 1980; 65: 529\u2013535.","journal-title":"Pediatrics"},{"key":"BFjp2017130_CR7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jpeds.2017.01.015","volume":"185","author":"GK Revanna","year":"2017","unstructured":"Revanna GK, Kunjunju A, Sehgal A . Bronchopulmonary dysplasia associated pulmonary hypertension: making the best use of bedside echocardiography. J Pediatr 2017; 185: 33\u201341.","journal-title":"J Pediatr"},{"key":"BFjp2017130_CR8","doi-asserted-by":"publisher","first-page":"688","DOI":"10.3345\/kjp.2010.53.6.688","volume":"53","author":"GB Kim","year":"2010","unstructured":"Kim GB . Pulmonary hypertension in infants with bronchopulmonary dysplasia. Korean J Pediatr 2010; 53: 688\u2013693.","journal-title":"Korean J Pediatr"},{"key":"BFjp2017130_CR9","doi-asserted-by":"publisher","first-page":"e450","DOI":"10.1542\/peds.2008-3249","volume":"124","author":"C Bose","year":"2009","unstructured":"Bose C, Van Marter LJ, Laughon M, O\u2019Shea TM, Allred EN, Karna P et al. Fetal growth restriction and chronic lung disease among infants born before the 28th week of gestation. Pediatrics 2009; 124: e450\u2013e458.","journal-title":"Pediatrics"},{"key":"BFjp2017130_CR10","doi-asserted-by":"publisher","first-page":"553e7","DOI":"10.1038\/jp.2012.164","volume":"33","author":"J Check","year":"2013","unstructured":"Check J, Gotteiner N, Liu X, Su E, Porta N, Steinhorn R et al. Fetal growth restriction and pulmonary hypertension in premature infants with bronchopulmonary dysplasia. J Perinatol 2013; 33: 553e7.","journal-title":"J Perinatol"},{"key":"BFjp2017130_CR11","doi-asserted-by":"publisher","first-page":"2681e5","DOI":"10.3109\/14767058.2012.708371","volume":"25","author":"H Ozkan","year":"2012","unstructured":"Ozkan H, Cetinkaya M, Koksal N . Increased incidence of bronchopulmonary dysplasia in preterm infants exposed to preeclampsia. J Matern Fetal Neonatal Med 2012; 25: 2681e5.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"BFjp2017130_CR12","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1097\/MOP.0b013e328360a3f6","volume":"25","author":"PM Mourani","year":"2013","unstructured":"Mourani PM, Abman SH . Pulmonary vascular disease in bronchopulmonary dysplasia: pulmonary hypertension and beyond. Curr Opin Pediatr 2013; 25: 329\u2013337.","journal-title":"Curr Opin Pediatr"},{"key":"BFjp2017130_CR13","doi-asserted-by":"publisher","first-page":"L860","DOI":"10.1152\/ajplung.00197.2011","volume":"301","author":"PJ Rozance","year":"2011","unstructured":"Rozance PJ, Seedorf GJ, Brown A, Roe G, O\u2019Meara MC, Gien J et al. Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro in fetal sheep. AJP Lung Cell Mol Physiol 2011; 301: L860\u2013L871.","journal-title":"AJP Lung Cell Mol Physiol"},{"key":"BFjp2017130_CR14","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","volume":"341","author":"DJ Barker","year":"1993","unstructured":"Barker DJ, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS . Fetal nutrition and cardiovascular disease in adult life. Lancet 1993; 341: 938\u2013941.","journal-title":"Lancet"},{"key":"BFjp2017130_CR15","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.placenta.2014.05.003","volume":"35","author":"KK Mestan","year":"2014","unstructured":"Mestan KK, Check J, Minturn L, Yallapragada S, Farrow KN, Liu X et al. Placental pathologic changes of maternal vascular under perfusion in bronchopulmonary dysplasia and pulmonary hypertension. Placenta 2014; 35: 570\u2013574.","journal-title":"Placenta"},{"key":"BFjp2017130_CR16","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","volume":"163","author":"AH Jobe","year":"2001","unstructured":"Jobe AH, Bancalari E . Bronchopulmonary dysplasia. Am J Respir Crit Care Med 2001; 163: 1723\u20131729.","journal-title":"Am J Respir Crit Care Med"},{"key":"BFjp2017130_CR17","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1093\/eurheartj\/ehr160","volume":"32","author":"EM Lau","year":"2011","unstructured":"Lau EM, Manes A, Celermajer DS, Gali\u00e8 N . Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward. Eur Heart J 2011; 32: 2489\u20132498.","journal-title":"Eur Heart J"},{"key":"BFjp2017130_CR18","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1111\/echo.12738","volume":"32","author":"M Nagiub","year":"2015","unstructured":"Nagiub M, Lee S, Guglani L . Echocardiographic assessment of pulmonary hypertension in infants with bronchopulmonary dysplasia: Systematic review of literature and a proposed algorithm for assessment. Echocardiography 2015; 32: 819\u2013833.","journal-title":"Echocardiography"},{"key":"BFjp2017130_CR19","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1161\/01.CIR.68.1.68","volume":"68","author":"ME King","year":"1983","unstructured":"King ME, Braun H, Goldblatt A, Liberthson R, Weyman AE . Interventricular septal configuration as a predictor of right ventricular systolic hypertension in children: a cross-sectional echocardiographic study. Circulation 1983; 68: 68\u201375.","journal-title":"Circulation"},{"key":"BFjp2017130_CR20","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/S0735-1097(10)80076-2","volume":"15","author":"NN Musewe","year":"1990","unstructured":"Musewe NN, Poppe D, Smallhorn JF . Doppler echocardiographic measurement of pulmonary artery pressure from ductal Doppler velocities in the newborn. J Am Coll Cardiol 1990; 15: 446\u2013456.","journal-title":"J Am Coll Cardiol"},{"key":"BFjp2017130_CR21","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1111\/echo.13171","volume":"33","author":"S Abraham","year":"2016","unstructured":"Abraham S, Weismann CG . Left ventricular end-systolic eccentricity index for assessment of pulmonary hypertension in infants. Echocardiography 2016; 33: 910\u2013915.","journal-title":"Echocardiography"},{"key":"BFjp2017130_CR22","doi-asserted-by":"publisher","first-page":"92","DOI":"10.4103\/0974-2069.132475","volume":"7","author":"A Pande","year":"2014","unstructured":"Pande A, Sarkar A, Ahmed I, Naveen Chandra G, Patil SK, Kundu CK et al. Non-invasive estimation of pulmonary vascular resistance in patients of pulmonary hypertension in congenital heart disease with unobstructed pulmonary flow. Ann Pediatr Cardiol 2014; 7: 92\u201397.","journal-title":"Ann Pediatr Cardiol"},{"key":"BFjp2017130_CR23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10024-003-8083-2","volume":"7","author":"RW Redline","year":"2004","unstructured":"Redline RW, Boyd T, Campbell V, Hyde S, Kaplan C, Khong TY et al. Maternal vascular under-perfusion: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol 2004; 7: 237\u2013249.","journal-title":"Pediatr Dev Pathol"},{"key":"BFjp2017130_CR24","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1542\/peds.2007-0971","volume":"120","author":"E Khemani","year":"2007","unstructured":"Khemani E, McElhinney DB, Rhein L, Andraade O, Lacro RV, Thomas KC et al. Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Pediatrics 2007; 120: 1260\u20131269.","journal-title":"Pediatrics"},{"key":"BFjp2017130_CR25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1159\/000327891","volume":"101","author":"D-H Kim","year":"2012","unstructured":"Kim D-H, Kim H-S, Choi CW, Kim E-K, Kim BI, Choi J-H . Risk factors for pulmonary artery hypertension in preterm infants with moderate or severe bronchopulmonary dysplasia. Neonatology 2012; 101: 40\u201346.","journal-title":"Neonatology"},{"key":"BFjp2017130_CR26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jpeds.2017.01.015","volume":"185","author":"KK Mestan","year":"2017","unstructured":"Mestan KK, Gotteiner N, Porta N, Grobman W, Su EJ, Ernst LM . Cord blood biomarkers of placental maternal vascular underperfusion predict bronchopulmonary dysplasia-associated pulmonary hypertension. J Pediatr 2017; 185: 33\u201346 pii: S0022-S3476(17)30033-1.","journal-title":"J Pediatr"},{"key":"BFjp2017130_CR27","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/jp.2016.10","volume":"36","author":"A Sehgal","year":"2016","unstructured":"Sehgal A, Malikiwi A, Paul E, Tan K, Menahem S . Systemic arterial stiffness in infants with bronchopulmonary dysplasia: potential cause of systemic hypertension. J Perinatol 2016; 36: 564\u2013569.","journal-title":"J Perinatol"},{"key":"BFjp2017130_CR28","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1378\/chest.07-1246","volume":"132","author":"CTJ Gan","year":"2007","unstructured":"Gan CTJ, Lankhaar JW, Westerhof N, Marcus JT, Becker A, Twisk JWR et al. Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension. Chest 2007; 132: 1906\u20131912.","journal-title":"Chest"},{"key":"BFjp2017130_CR29","doi-asserted-by":"publisher","first-page":"212","DOI":"10.4103\/2045-8932.83453","volume":"1","author":"Z Wang","year":"2011","unstructured":"Wang Z, Chesler N . Pulmonary vascular wall stiffness: an important contributor to the increased right ventricular afterload with pulmonary hypertension. Pulm Circ 2011; 1: 212\u2013223.","journal-title":"Pulm Circ"},{"key":"BFjp2017130_CR30","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1001\/2012.jama.10931","volume":"308","author":"D Mukherjee","year":"2012","unstructured":"Mukherjee D . Atherogenic vascular stiffness and hypertension cause or effect? JAMA 2012; 308: 919\u2013920.","journal-title":"JAMA"},{"key":"BFjp2017130_CR31","first-page":"151","volume-title":"The Guide to Cardiology","author":"JEL Willard","year":"1995","unstructured":"Willard JEL, Richard A, Hillis LD Cardiac catheterization. In: Kloner RA. The Guide to Cardiology, 3rd edn. Le Jacq Communications: Greenwich, CT, 1995; 151."},{"key":"BFjp2017130_CR32","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1037\/0033-2909.86.2.420","volume":"86","author":"PE Shrout","year":"1979","unstructured":"Shrout PE, Fleiss JL . Intraclass correlations: uses in assessing rater reliability. Psychol Bull 1979; 86: 420\u2013428.","journal-title":"Psychol Bull"},{"key":"BFjp2017130_CR33","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1161\/01.CIR.70.4.657","volume":"70","author":"PG Yock","year":"1984","unstructured":"Yock PG, Popp RL . Non-invasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation. Circulation 1984; 70: 657\u2013662.","journal-title":"Circulation"},{"key":"BFjp2017130_CR34","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/S0735-1097(02)02973-X","volume":"41","author":"AE Abbas","year":"2003","unstructured":"Abbas AE, Fortuin FD, Schiller NB, Appleton CP, Moreno CA, Lester SJ . A simple method for non-invasive estimation of pulmonary vascular resistance. J Am Coll Cardiol 2003; 41: 1021\u20131027.","journal-title":"J Am Coll Cardiol"},{"key":"BFjp2017130_CR35","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1007\/s00246-011-0035-4","volume":"32","author":"GH Ajami","year":"2011","unstructured":"Ajami GH, Cheriki S, Amoozgar H, Borzouee M, Soltani M . Accuracy of Doppler-derived estimation of pulmonary vascular resistance in congenital heart disease: an index of operability. Pediatr Cardiol 2011; 32: 1168\u20131174.","journal-title":"Pediatr Cardiol"},{"key":"BFjp2017130_CR36","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.echo.2007.10.004","volume":"21","author":"AP Vlahos","year":"2008","unstructured":"Vlahos AP, Feinstein JA, Schiller NB, Silverman NH . Extension of Doppler-derived echocardiographic measures of pulmonary vascular resistance to patients with moderate or severe pulmonary vascular disease. J Am Soc Echocardiogr 2008; 21: 711\u2013714.","journal-title":"J Am Soc Echocardiogr"},{"key":"BFjp2017130_CR37","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1183\/09059180.00003912","volume":"21","author":"LS Howard","year":"2012","unstructured":"Howard LS, Grapsa J, Dawson D, Bellamy M, Chambers JB, Masani ND et al. Echocardiographic assessment of pulmonary hypertension: standard operating procedure. Eur Respir Rev 2012; 21: 239\u2013248.","journal-title":"Eur Respir Rev"},{"key":"BFjp2017130_CR38","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.clp.2015.08.004","volume":"42","author":"CV Lal","year":"2015","unstructured":"Lal CV, Ambalavanan N . Biomarkers, early diagnosis, and clinical predictors of BPD. Clin Perinatol 2015; 42: 739\u2013754.","journal-title":"Clin Perinatol"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp2017130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp2017130","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/jp.2017.130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/jp2017130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T12:17:01Z","timestamp":1647605821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp2017130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,7]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["BFjp2017130"],"URL":"https:\/\/doi.org\/10.1038\/jp.2017.130","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,7]]},"assertion":[{"value":"6 March 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}