{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:52:27Z","timestamp":1771660347660,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1038\/jp.2017.133","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T13:01:17Z","timestamp":1507813277000},"page":"1272-1277","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Anti-cytomegalovirus immunoglobulin M titer for congenital infection in first-trimester pregnancy with primary infection: a multicenter prospective cohort study"],"prefix":"10.1038","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9372-1808","authenticated-orcid":false,"given":"K","family":"Toriyabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Minematsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ikejiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Suga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"BFjp2017133_CR1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1002\/rmv.535","volume":"17","author":"A Kenneson","year":"2007","unstructured":"Kenneson A, Cannon MJ . Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol 2007; 17: 253\u2013276.","journal-title":"Rev Med Virol"},{"key":"BFjp2017133_CR2","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1056\/NEJM199203053261003","volume":"326","author":"KB Fowler","year":"1992","unstructured":"Fowler KB, Stagno S, Pass RF, Britt WJ, Boll TJ, Alford CA . The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N Engl J Med 1992; 326: 663\u2013667.","journal-title":"N Engl J Med"},{"key":"BFjp2017133_CR3","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1542\/pir.28-3-92","volume":"28","author":"SP Adler","year":"2007","unstructured":"Adler SP, Marshall B . Cytomegalovirus infections. Pediatr Rev 2007; 28: 92\u2013100.","journal-title":"Pediatr Rev"},{"key":"BFjp2017133_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1055\/s-0032-1333133","volume":"30","author":"JM Johnson","year":"2013","unstructured":"Johnson JM, Anderson BL . Cytomegalovirus: should we screen pregnant women for primary infection? Am J Perinatol 2013; 30: 121\u2013124.","journal-title":"Am J Perinatol"},{"key":"BFjp2017133_CR5","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1128\/CMR.15.4.680-715.2002","volume":"15","author":"MG Revello","year":"2002","unstructured":"Revello MG, Gerna G . Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant. Clin Microbiol Rev 2002; 15: 680\u2013715.","journal-title":"Clin Microbiol Rev"},{"key":"BFjp2017133_CR6","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.jpeds.2004.09.025","volume":"146","author":"A Naessens","year":"2005","unstructured":"Naessens A, Casteels A, Decatte L, Foulon W . A serologic strategy for detecting neonates at risk for congenital cytomegalovirus infection. J Pediatr 2005; 146: 194\u2013197.","journal-title":"J Pediatr"},{"key":"BFjp2017133_CR7","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/jp.2013.87","volume":"33","author":"M Kaneko","year":"2013","unstructured":"Kaneko M, Sameshima H, Minematsu T, Kusumoto K, Yamauchi A, Ikenoue T . Maternal IgG avidity, IgM and ultrasound abnormalities: combined method to detect congenital cytomegalovirus infection with sequelae. J Perinatol 2013; 33: 831\u2013835.","journal-title":"J Perinatol"},{"key":"BFjp2017133_CR8","doi-asserted-by":"publisher","first-page":"4713","DOI":"10.1128\/JCM.43.9.4713-4718.2005","volume":"43","author":"SC Munro","year":"2005","unstructured":"Munro SC, Hall B, Whybin LR, Leader L, Robertson P, Maine GT et al. Diagnosis of and screening for cytomegalovirus infection in pregnant women. J Clin Microbiol 2005; 43: 4713\u20134718.","journal-title":"J Clin Microbiol"},{"key":"BFjp2017133_CR9","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1002\/jmv.23387","volume":"84","author":"A Sonoyama","year":"2012","unstructured":"Sonoyama A, Ebina Y, Morioka I, Tanimura K, Morizane M, Tairaku S et al. Low IgG avidity and ultrasound fetal abnormality predict congenital cytomegalovirus infection. J Med Virol 2012; 84: 1928\u20131933.","journal-title":"J Med Virol"},{"key":"BFjp2017133_CR10","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1128\/JCM.02172-08","volume":"47","author":"K Lagrou","year":"2009","unstructured":"Lagrou K, Bodeus M, Van Ranst M, Goubau P . Evaluation of the new architect cytomegalovirus immunoglobulin M (IgM), IgG, and IgG avidity assays. J Clin Microbiol 2009; 47: 1695\u20131699.","journal-title":"J Clin Microbiol"},{"key":"BFjp2017133_CR11","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/j.1442-200X.2009.03005.x","volume":"52","author":"M Tagawa","year":"2010","unstructured":"Tagawa M, Minematsu T, Masuzaki H, Ishimaru T, Moriuchi H . Seroepidemiological survey of cytomegalovirus infection among pregnant women in Nagasaki, Japan. Pediatr Int 2010; 52: 459\u2013462.","journal-title":"Pediatr Int"},{"key":"BFjp2017133_CR12","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1128\/CVI.00487-14","volume":"21","author":"HE Prince","year":"2014","unstructured":"Prince HE, Lape-Nixon M . Role of cytomegalovirus (CMV) IgG avidity testing in diagnosing primary CMV infection during pregnancy. Clin Vaccine Immunol 2014; 21: 1377\u20131384.","journal-title":"Clin Vaccine Immunol"},{"key":"BFjp2017133_CR13","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1002\/jmv.23863","volume":"86","author":"S Lumley","year":"2014","unstructured":"Lumley S, Patel M, Griffiths PD . The combination of specific IgM antibodies and IgG antibodies of low avidity does not always indicate primary infection with cytomegalovirus. J Med Virol 2014; 86: 834\u2013837.","journal-title":"J Med Virol"},{"key":"BFjp2017133_CR14","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1111\/j.1469-0691.2011.03564.x","volume":"17","author":"T Lazzarotto","year":"2011","unstructured":"Lazzarotto T, Guerra B, Gabrielli L, Lanari M, Landini MP . Update on the prevention, diagnosis and management of cytomegalovirus infection during pregnancy. Clin Microbiol Infect 2011; 17: 1285\u20131293.","journal-title":"Clin Microbiol Infect"},{"key":"BFjp2017133_CR15","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jcv.2013.12.013","volume":"59","author":"K Taniguchi","year":"2014","unstructured":"Taniguchi K, Watanabe N, Sato A, Jwa SC, Suzuki T, Yamanobe Y et al. Changes in cytomegalovirus seroprevalence in pregnant Japanese women - a 10-year single center study. J Clin Virol 2014; 59: 192\u2013194.","journal-title":"J Clin Virol"},{"key":"BFjp2017133_CR16","first-page":"73","volume":"95","author":"H Yamada","year":"2012","unstructured":"Yamada H, Morizane M, Tanimura K, Morioka I, Ebina Y, Matsuda H et al. A trial of immunoglobulin fetal therapy for symptomatic congenital cytomegalovirus infection. J Reprod Immunol 2012; 95: 73\u201379.","journal-title":"J Reprod Immunol"},{"key":"BFjp2017133_CR17","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1016\/j.ajic.2015.06.026","volume":"43","author":"D Shigemi","year":"2015","unstructured":"Shigemi D, Yamaguchi S, Otsuka T, Kamoi S, Takehshita T . Seroprevalence of cytomegalovirus IgG antibodies among pregnant women in Japan from 2009-2014. Am J Infect Control 2015; 43: 1218\u20131221.","journal-title":"Am J Infect Control"},{"key":"BFjp2017133_CR18","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1515\/jpm-2013-0333","volume":"42","author":"Y Ebina","year":"2014","unstructured":"Ebina Y, Minematsu T, Sonoyama A, Morioka I, Inoue N, Tairaku S et al. The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study. J Perinat Med 2014; 42: 755\u2013759.","journal-title":"J Perinat Med"},{"key":"BFjp2017133_CR19","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jcv.2010.06.021","volume":"49","author":"T Nagamori","year":"2010","unstructured":"Nagamori T, Koyano S, Inoue N, Yamada H, Oshima M, Minematsu T et al. Single cytomegalovirus strain associated with fetal loss and then congenital infection of a subsequent child born to the same mother. J Clin Virol 2010; 49: 134\u2013136.","journal-title":"J Clin Virol"},{"key":"BFjp2017133_CR20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1002\/jmv.1890330103","volume":"33","author":"NK Blackburn","year":"1991","unstructured":"Blackburn NK, Besselaar TG, Shoub BD, O\u2019Connell KF . Differentiation of primary cytomegalovirus infection from reactivation using the urea denaturation test for measuring antibody avidity. J Med Virol 1991; 33: 6\u20139.","journal-title":"J Med Virol"},{"key":"BFjp2017133_CR21","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1097\/PAT.0b013e328353bec0","volume":"44","author":"B Fatma","year":"2012","unstructured":"Fatma B, Peter WR, Monica L, William DR . Comparison of five CMV IgM immunoassays with CMV IgG avidity for diagnosis of primary CMV infection. Pathology 2012; 44: 381\u2013383.","journal-title":"Pathology"},{"key":"BFjp2017133_CR22","first-page":"824","volume":"9","author":"HE Prince","year":"2002","unstructured":"Prince HE, Leber AL . Validation of an in-house assay for cytomegalovirus immunoglobulin G (CMV IgG) avidity and relationship of avidity to CMV IgM levels. Clin Diagn Lab Immunol 2002; 9: 824\u2013827.","journal-title":"Clin Diagn Lab Immunol"},{"key":"BFjp2017133_CR23","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1056\/NEJMoa1310214","volume":"370","author":"MG Revello","year":"2014","unstructured":"Revello MG, Lazzarotto T, Guerra B, Spinillo A, Ferrazzi E, Kustermann A et al. A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus. N Engl J Med 2014; 370: 1316\u20131326.","journal-title":"N Engl J Med"},{"key":"BFjp2017133_CR24","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/cid\/ciw707","volume":"64","author":"K Tanimura","year":"2017","unstructured":"Tanimura K, Tairaku S, Ebina Y, Morioka I, Nagamata S, Deguchi K et al. Prediction of congenital cytomegalovirus infection in high-risk pregnant women. Clin Infect Dis 2017; 64: 159\u2013165.","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/jp2017133.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/jp2017133","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/jp.2017.133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/jp2017133.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T11:17:13Z","timestamp":1647602233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp2017133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,12]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["BFjp2017133"],"URL":"https:\/\/doi.org\/10.1038\/jp.2017.133","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,12]]},"assertion":[{"value":"10 October 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}