{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:43:06Z","timestamp":1761597786955},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Perinatol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1038\/jp.2017.7","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T14:26:02Z","timestamp":1487255162000},"page":"740-746","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The quest for sustained multiple morbidity reduction in very low-birth-weight infants: the Antifragility project"],"prefix":"10.1038","volume":"37","author":[{"given":"J W","family":"Kaempf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N M","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Novack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Friant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Tipping","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"BFjp20177_CR1","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1542\/peds.2011-3028","volume":"129","author":"JD Horbar","year":"2012","unstructured":"Horbar JD, Carpenter JH, Badger GJ, Kenny MJ, Soll RF, Morrow KA et al. Mortality and neonatal morbidity among infants 501 to 1500 grams from 2000 to 2009. Pediatrics 2012; 129: 1019\u20131026.","journal-title":"Pediatrics"},{"issue":"4","key":"BFjp20177_CR2","doi-asserted-by":"publisher","first-page":"e20150389","DOI":"10.1542\/peds.2015-0389","volume":"137","author":"DL Ellsbury","year":"2016","unstructured":"Ellsbury DL, Clark RH, Ursprung R, Handler DL, Dodd ED, Spitzer AR . A multifaceted approach to improving outcomes in the NICU: the Pediatrix 100,000 babies campaign. Pediatrics 2016; 137 (4): e20150389.","journal-title":"Pediatrics"},{"issue":"5","key":"BFjp20177_CR3","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1001\/jamapediatrics.2014.3566","volume":"169","author":"JW Kaempf","year":"2015","unstructured":"Kaempf JW, Zupancic JAF, Wang L, Grunkemeier GL . A risk-adjusted, composite outcomes score and resource utilization metrics for very low-birth-weight infants. JAMA Pediatrics 2015; 169 (5): 459\u2013465.","journal-title":"JAMA Pediatrics"},{"issue":"3","key":"BFjp20177_CR4","doi-asserted-by":"publisher","first-page":"e20150312","DOI":"10.1542\/peds.2015-0312","volume":"137","author":"D Dukhovny","year":"2016","unstructured":"Dukhovny D, Pursley DM, Kirpalani HM, Horbar JH, Zupancic JAF . Evidence, quality, and waste: solving the value equation in neonatology. Pediatrics 2016; 137 (3): e20150312.","journal-title":"Pediatrics"},{"key":"BFjp20177_CR5","volume-title":"Antifragile: Things That Gain from Disorder","author":"N Taleb","year":"2012","unstructured":"Taleb N . Antifragile: Things That Gain from Disorder. Random House: New York, 2012."},{"issue":"1","key":"BFjp20177_CR6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.clp.2010.01.003","volume":"37","author":"JD Horbar","year":"2010","unstructured":"Horbar JD, Soll RF, Edwards WH . The Vermont Oxford Network: a community of practice. Clin Perinatol 2010; 37 (1): 29\u201347.","journal-title":"Clin Perinatol"},{"key":"BFjp20177_CR7","unstructured":"Vermont Oxford Network Database Manual of Operations. Release 19.0. Vermont Oxford Network: Burlington, 2014."},{"issue":"10","key":"BFjp20177_CR8","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1001\/jama.299.10.1182","volume":"299","author":"DM Berwick","year":"2008","unstructured":"Berwick DM . The science of improvement. JAMA 2008; 299 (10): 1182\u20131184.","journal-title":"JAMA"},{"issue":"3","key":"BFjp20177_CR9","doi-asserted-by":"crossref","first-page":"e678","DOI":"10.1542\/peds.2010-0809","volume":"128","author":"J Van Cleave","year":"2011","unstructured":"Van Cleave J, Dougherty D, Perrin JM . Strategies for addressing barriers to publishing pediatric quality improvement research. Pediatrics 2011; 128 (3): e678\u2013e686.","journal-title":"Pediatrics"},{"issue":"7","key":"BFjp20177_CR10","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1056\/NEJMsb1002320","volume":"363","author":"MR Chassin","year":"2010","unstructured":"Chassin MR, Loeb JM, Schmaltz SP, Wachter RM . Accountability measures \u2013 using measurement to promote quality improvement. N Engl J Med 2010; 363 (7): 683\u2013688.","journal-title":"N Engl J Med"},{"issue":"13","key":"BFjp20177_CR11","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1056\/NEJMp1516803","volume":"374","author":"D Casarett","year":"2016","unstructured":"Casarett D . The science of choosing wisely \u2013 overcoming the therapeutic illusion. N Engl J Med 2016; 374 (13): 1203\u20131205.","journal-title":"N Engl J Med"},{"issue":"12","key":"BFjp20177_CR12","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1001\/jamapediatrics.2015.2702","volume":"169","author":"SL Ralston","year":"2015","unstructured":"Ralston SL, Schroeder AR . Doing more vs doing good: aligning our ethical principles from the personal to the societal. JAMA Pediatrics 2015; 169 (12): 1085\u20131086.","journal-title":"JAMA Pediatrics"},{"issue":"2","key":"BFjp20177_CR13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/AOG.0b013e31825f269f","volume":"120","author":"JW Kaempf","year":"2012","unstructured":"Kaempf JW, Tomlinson MW, Kaempf AJ, YingXing Wu, Wang L, Tipping N et al. Delayed umbilical cord clamping in premature infants. Ob Gyn 2012; 120 (2): 325\u2013330.","journal-title":"Ob Gyn"},{"issue":"3","key":"BFjp20177_CR14","doi-asserted-by":"publisher","first-page":"e20144210","DOI":"10.1542\/peds.2014-4210","volume":"137","author":"J Profit","year":"2016","unstructured":"Profit J, Gould JB, Bennett M, Goldstein BA, Draper D, Phibbs CS et al. The association of level of care with NICU quality. Pediatrics 2016; 137 (3): e20144210.","journal-title":"Pediatrics"},{"issue":"3","key":"BFjp20177_CR15","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1001\/jama.2016.0590","volume":"315","author":"D Blumenthal","year":"2016","unstructured":"Blumenthal D . Better health care: a way forward. JAMA 2016; 315 (3): 1333\u20131334.","journal-title":"JAMA"},{"issue":"3859","key":"BFjp20177_CR16","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1126\/science.162.3859.1243","volume":"162","author":"G Hardin","year":"1968","unstructured":"Hardin G . The tragedy of the commons. Science 1968; 162 (3859): 1243\u20131248.","journal-title":"Science"},{"key":"BFjp20177_CR17","volume-title":"Overskill: The Decline of Technology in Modern Civilization","author":"E Schwartz","year":"1971","unstructured":"Schwartz E . Overskill: The Decline of Technology in Modern Civilization. Quadrangle Books: Chicago, 1971."},{"key":"BFjp20177_CR18","volume-title":"False Hopes: Overcoming the Obstacles to a Sustainable, Affordable Medicine","author":"D Callahan","year":"1999","unstructured":"Callahan D . False Hopes: Overcoming the Obstacles to a Sustainable, Affordable Medicine. Rutgers University Press: New Brunswick, New Jersey, 1999."},{"key":"BFjp20177_CR19","volume-title":"Human Experimentation: A Guided Step into the Unknown","author":"WA Silverman","year":"1985","unstructured":"Silverman WA . Human Experimentation: A Guided Step into the Unknown. Oxford University Press: Oxford, England, 1985."},{"key":"BFjp20177_CR20","volume-title":"Straw Dogs","author":"J Gray","year":"2002","unstructured":"Gray J . Straw Dogs. Granta Publications: London, England, 2002."},{"key":"BFjp20177_CR21","doi-asserted-by":"publisher","first-page":"i5","DOI":"10.1136\/bmjqs.2010.046177","volume":"20","author":"F Davidoff","year":"2011","unstructured":"Davidoff F . Systems of service: reflections on the moral foundations of improvement. BMJ Qual Saf 2011; 20: i5\u2013i10.","journal-title":"BMJ Qual Saf"},{"key":"BFjp20177_CR22","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/jp.2015.171","volume":"36","author":"JW Kaempf","year":"2016","unstructured":"Kaempf JW, Tomlinson MW, Tuohey J . Extremely premature birth and the choice of neonatal intensive care versus palliative comfort care: an 18-year single-center experience. J Perinatol 2016; 36: 190\u2013195.","journal-title":"J Perinatol"},{"issue":"69","key":"BFjp20177_CR23","first-page":"1","volume":"16","author":"MP Kelly","year":"2015","unstructured":"Kelly MP, Heath I, Howick J, Greenhalgh T . The importance of values in evidence-based medicine. BMC Med Ethics 2015; 16 (69): 1\u20138.","journal-title":"BMC Med Ethics"},{"issue":"3","key":"BFjp20177_CR24","doi-asserted-by":"publisher","first-page":"F190","DOI":"10.1136\/archdischild-2014-306313","volume":"100","author":"D Wilkinson","year":"2015","unstructured":"Wilkinson D, Chalmers I, Cruz M, Tarnow-Mordi W . Dealing with the unknown: reducing the proportion of unvalidated treatments offered to children. Arch Dis Child Fetal Neonatal Ed 2015; 100 (3): F190\u2013F192.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"BFjp20177_CR25","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/jp.2013.172","volume":"34","author":"W Lefkowitz","year":"2014","unstructured":"Lefkowitz W, Jefferson TC . Medicine at the limits of evidence: the fundamental limitation of the randomized clinical trial and the end of equipoise. J Perinatol 2014; 34: 249\u2013251.","journal-title":"J Perinatol"}],"container-title":["Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/jp20177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/jp20177","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/jp.2017.7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/jp20177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:38:39Z","timestamp":1684431519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/jp20177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,16]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["BFjp20177"],"URL":"https:\/\/doi.org\/10.1038\/jp.2017.7","relation":{},"ISSN":["0743-8346","1476-5543"],"issn-type":[{"value":"0743-8346","type":"print"},{"value":"1476-5543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,16]]},"assertion":[{"value":"31 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}