{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:29:30Z","timestamp":1770218970538,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1981,10,1]],"date-time":"1981-10-01T00:00:00Z","timestamp":370742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":12485,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1981,10]]},"DOI":"10.1038\/ki.1981.165","type":"journal-article","created":{"date-parts":[[2007,6,16]],"date-time":"2007-06-16T12:39:10Z","timestamp":1181997550000},"page":"482-490","source":"Crossref","is-referenced-by-count":34,"title":["Renal handling of potassium in dogs with chronic renal insufficiency"],"prefix":"10.1016","volume":"20","author":[{"given":"Jacques J.","family":"Bourgoignie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian","family":"Pincus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Gavellas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Rabinovitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1981.165_bb0010","series-title":"Disorders of potassium balance, in Acid-Base and Potassium Homeostasis","first-page":"168","author":"Kleger","year":"1978"},{"key":"10.1038\/ki.1981.165_bb0015","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1056\/NEJM198002213020803","article-title":"Adrenergic modulation of extrarenal potassium disposal","volume":"302","author":"Rosa","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1981.165_bb0020","first-page":"525","article-title":"The defense against hyperkalemia: The roles of insulin and aldosterone","volume":"229","author":"Cox","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1981.165_bb0025","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1172\/JCI108958","article-title":"Influence of basal insulin and glucagon secretion on potassium and sodium metabolism: Studies with somatostatin in normal dogs and in normal and diabetic human beings","volume":"61","author":"DeFronzo","year":"1978","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1981.165_bb0030","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1172\/JCI105769","article-title":"An extrarenal mechanism of potassium adaptation","volume":"47","author":"Alexander","year":"1968","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1981.165_bb0035","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0026-0495(77)90127-5","article-title":"Influence of physiologic hyperglucagonemia on urinary glucose, nitrogen and electrolyte excretion in diabetes","volume":"26","author":"Sherwin","year":"1977","journal-title":"Metabolism"},{"key":"10.1038\/ki.1981.165_bb0040","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1152\/jappl.1972.33.1.22","article-title":"Serum immunoreactive insulin and growth hormone response to potassium infusion in normal man","volume":"33","author":"Dluhy","year":"1972","journal-title":"J Appl Physiol"},{"key":"10.1038\/ki.1981.165_bb0045","first-page":"809","article-title":"Evidence for a role of endogenous insulin and glucagon in the regulation of potassium homeostasis","volume":"81","author":"Santeusanio","year":"1973","journal-title":"J Lab Clin Med"},{"key":"10.1038\/ki.1981.165_bb0050","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/ki.1980.69","article-title":"Effect of insulinopenia and adrenal hormone deficiency on acute potassium tolerance","volume":"17","author":"DeFronzo","year":"1980","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1981.165_bb0055","first-page":"114","article-title":"The role of Na-K activated adenosine triphosphate in potassium adaptation","volume":"266","author":"Silva","year":"1973","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1981.165_bb0060","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev.ph.41.030179.001325","article-title":"Potassium transport in the nephron","volume":"41","author":"Giebisch","year":"1979","journal-title":"Ann Rev Physiol"},{"key":"10.1038\/ki.1981.165_bb0065","article-title":"Luminal influences on potassium secretion: Sodium concentration and luminal flow rate","volume":"236","author":"Good","year":"1979","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1981.165_bb0070","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1172\/JCI106577","article-title":"On the adaptation to potassium excretion associated with nephron reduction in the dog","volume":"50","author":"Schultze","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1981.165_bb0075","article-title":"Relationship between blood pH and potassium and phosphorus during acute metabolic acidosis","volume":"235","author":"Oster","year":"1978","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1981.165_bb0080","first-page":"28","article-title":"Plasma potassium response to acute metabolic acidosis induced by mineral and nonmineral acids","volume":"4","author":"Oster","year":"1980","journal-title":"Mineral Electrolyte Metab"},{"key":"10.1038\/ki.1981.165_bb0085","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.1979.59.1.137","article-title":"Functional adaptation to reduction in renal mass","volume":"59","author":"Hayslett","year":"1979","journal-title":"Physiol Rev"},{"key":"10.1038\/ki.1981.165_bb0090","article-title":"Role of medullary structures in the functional adaptation of renal insufficiency","volume":"6","author":"Finckelstein","year":"1974","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1981.165_bb0095","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1172\/JCI107322","article-title":"A micropuncture study of potassium excretion by the remnant kidney","volume":"52","author":"Bank","year":"1973","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1981.165_bb0100","first-page":"193","article-title":"Effect of proportional reduction of sodium intake in the adaptive increase in glomerular filtration of nephron and potassium and phosphate excretion in chronic renal failure in the rat","volume":"49","author":"Espinel","year":"1975","journal-title":"Clin Sci Mol Med"},{"key":"10.1038\/ki.1981.165_bb0105","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1152\/ajplegacy.1974.227.6.1323","article-title":"Mechanisms of potassium excretion in renal insufficiency","volume":"227","author":"Schon","year":"1974","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1981.165_bb0110","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/ki.1977.64","article-title":"Adaptation to potassium","volume":"11","author":"Silva","year":"1977","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1981.165_bb0115","first-page":"661","article-title":"Factors related to potassium transport in chronic stable renal disease in man","volume":"54","author":"Kahn","year":"1978","journal-title":"Clin Sci Mol Med"},{"key":"10.1038\/ki.1981.165_bb0120","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ki.1977.66","article-title":"Potassium homeostasis in renal failure","volume":"11","author":"Van Ypersele de Strihou","year":"1977","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1981.165_bb0125","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ki.1978.112","article-title":"Interrelations between phosphorus, calcium, parathyroid hormone and renal phosphate excretion in response to an oral phosphorus load in normal and uremic dogs","volume":"14","author":"Kaplan","year":"1978","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1981.165_bb0130","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1210\/jcem-25-10-1375","article-title":"Coated charcoal immunoassay of insulin","volume":"25","author":"Herbert","year":"1965","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/ki.1981.165_bb0135","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2337\/diab.18.11.717","article-title":"Effects of starvation on plasma pancreatic glucagon in normal man","volume":"18","author":"Aguilar-Parada","year":"1969","journal-title":"Diabetes"},{"key":"10.1038\/ki.1981.165_bb0140","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/ki.1978.114","article-title":"Role of aldosterone in the control of sodium excretion in patients with advanced chronic renal failure","volume":"14","author":"Berl","year":"1978","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1981.165_bb0145","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1172\/JCI108165","article-title":"Potassium transport by the isolated perfused kidney","volume":"56","author":"Silva","year":"1975","journal-title":"Clin Invest"},{"key":"10.1038\/ki.1981.165_bb0150","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1172\/JCI109540","article-title":"Functional profile of the isolated uremic nephron: Potassium adaptation in the rabbit cortical collecting tubule","volume":"64","author":"Fine","year":"1979","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1981.165_bb0155","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1172\/JCI107624","article-title":"Hyperglucagonemia of renal failure","volume":"53","author":"Bilbrey","year":"1974","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1981.165_bb0160","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ki.1973.116","article-title":"Dynamic studies of aldosterone in anephric man","volume":"4","author":"Weidmann","year":"1973","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1981.165_bb0165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ki.1980.11","article-title":"Prevalence, pathogenesis, and functional significance of aldosterone deficiency in hyperkalemic patients with chronic renal insufficiency","volume":"17","author":"Schamberlan","year":"1980","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1981.165_bb0170","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1172\/JCI101204","article-title":"The toxicity of orally administered potassium salts in renal insufficiency","volume":"20","author":"Winkler","year":"1941","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1981.165_bb0175","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1172\/JCI101860","article-title":"The tolerance for potassium in severe renal insufficiency: A study often cases","volume":"26","author":"Keith","year":"1947","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1981.165_bb0180","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00000441-197105000-00007","article-title":"Functional impairment in chronic renal disease: III. Studies of potassium excretion","volume":"261","author":"Gonick","year":"1971","journal-title":"Am J Med Sci"},{"key":"10.1038\/ki.1981.165_bb0185","first-page":"207","article-title":"An extrarenal mechanism for the maintenance of potassium balance in severe chronic renal failure","volume":"80","author":"Hayes","year":"1967","journal-title":"Trans Assoc Am Physicians"},{"key":"10.1038\/ki.1981.165_bb0190","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/ki.1977.73","article-title":"Increased large intestinal secretion of potassium in renal insufficiency","volume":"12","author":"Bastl","year":"1977","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1981.165_bb0195","series-title":"The renal response to progressive nephron loss, in The Kidney","first-page":"703","author":"Bricker","year":"1976"},{"key":"10.1038\/ki.1981.165_bb0200","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/ki.1979.85","article-title":"Disposition of intravenous potassium in anuric man: A kinetic analysis","volume":"15","author":"Sterns","year":"1979","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1981.165_bb0205","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1440-1681.1977.tb02625.x","article-title":"Increased renal sensitivity to aldosterone in the rat: Induction by a high potassium diet","volume":"4","author":"Adam","year":"1977","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1038\/ki.1981.165_bb0210","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1113\/expphysiol.1976.sp002345","article-title":"The effect of potassium in determining normal rates of excretion of potassium in dogs","volume":"61","author":"Bayliss","year":"1976","journal-title":"Q J Exp Physiol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815325825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815325825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T18:28:21Z","timestamp":1635532101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815325825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,10]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,10]]}},"alternative-id":["S0085253815325825"],"URL":"https:\/\/doi.org\/10.1038\/ki.1981.165","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1981,10]]}}}