{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:06:49Z","timestamp":1778609209783,"version":"3.51.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1984,7,1]],"date-time":"1984-07-01T00:00:00Z","timestamp":457488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":11481,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1984,7]]},"DOI":"10.1038\/ki.1984.126","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T13:17:14Z","timestamp":1180617434000},"page":"1-9","source":"Crossref","is-referenced-by-count":141,"title":["Light-chain deposition disease: Its relation with AL-type amyloidosis"],"prefix":"10.1016","volume":"26","author":[{"given":"Dominique","family":"Ganeval","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure-H\u00e9l\u00e8ne","family":"No\u00ebl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Preud'homme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Droz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Gr\u00fcnfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1984.126_bb0010","series-title":"Abs 7th Annu Mtg Soc Nephrol","article-title":"Light chain deposits in multiple myeloma","author":"Antonovych","year":"1973"},{"key":"10.1038\/ki.1984.126_bb0015","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0002-9343(76)90440-X","article-title":"Manifestations of systemic light chain deposition","volume":"60","author":"Randall","year":"1976","journal-title":"Am J Med"},{"key":"10.1038\/ki.1984.126_bb0020","first-page":"291","article-title":"The kidney in lymphoplasmacytic disorders","volume":"17","author":"Gallo","year":"1982","journal-title":"Pathology Annual"},{"key":"10.1038\/ki.1984.126_bb0025","first-page":"325","article-title":"Glomerular lesions in multiple myeloma","volume":"28","author":"Tange","year":"1978","journal-title":"Acta Pathol Jpn"},{"key":"10.1038\/ki.1984.126_bb0030","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0002-9343(80)90421-0","article-title":"Synthesis of abnormal immunoglobulins in lymphoplasmacytic disorder with light chain deposition","volume":"69","author":"Preud'homme","year":"1980","journal-title":"Am J Med"},{"key":"10.1038\/ki.1984.126_bb0035","first-page":"839","article-title":"Ultrastructure des l\u00e9sions glom\u00e9rulaires dans un cas de my\u00e9lome avec syndrome n\u00e9phrotique","volume":"73","author":"Fries","year":"1967","journal-title":"J Urol N\u00e9phrol"},{"key":"10.1038\/ki.1984.126_bb0040","first-page":"145","article-title":"Detection, significance and treatment of paraprotein in patients with \u201cidiopathic\u201d proteinuria without myeloma","volume":"47","author":"Mallick","year":"1978","journal-title":"Q J Med"},{"key":"10.1038\/ki.1984.126_bb0045","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1136\/jcp.27.10.800","article-title":"Glomerular nodules and long-spacing collagen in kidneys of patients with multiple myeloma","volume":"27","author":"Schubert","year":"1974","journal-title":"J Clin Pathol"},{"key":"10.1038\/ki.1984.126_bb0050","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.0954-6820.1973.tb19409.x","article-title":"Multiple myeloma with urinary excretion of heavy chain components of IgG and nodular glomerulosclerosis","volume":"194","author":"S\u00f8lling","year":"1973","journal-title":"Acta Med Stand"},{"key":"10.1038\/ki.1984.126_bb0055","series-title":"Actualit\u00e9s N\u00e9phrologiques de l'h\u00f4pital Necker","first-page":"167","article-title":"Les l\u00e9sions glom\u00e9rulaires des gammapathies monoclonales et des cryoglobulin\u00e9mies idiopathiques IgG-IgM","author":"Verroust","year":"1971"},{"key":"10.1038\/ki.1984.126_bb0060","first-page":"33","article-title":"Case records of the Massachusetts General Hospital","volume":"304","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1984.126_bb0065","first-page":"579","article-title":"Renal transplantation in a patient with multiple myeloma and light chain nephropathy","volume":"93","author":"Briefel","year":"1983","journal-title":"Surgery"},{"key":"10.1038\/ki.1984.126_bb0070","first-page":"710","article-title":"Nodular mesangial lesions and nephrotic syndrome in multiple myeloma without amyloidosis","volume":"14","author":"Elfenbein","year":"1978","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1984.126_bb0075","first-page":"621","article-title":"Nodular glomerulopathy associated with nonamyloidotic kappa light chain deposits and excess immunoglobulin light chain synthesis","volume":"99","author":"Gallo","year":"1980","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.1984.126_bb0080","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1136\/bmj.282.6265.681","article-title":"Systemic lambda light-chain deposition in a patient with myeloma","volume":"282","author":"Ganeval","year":"1981","journal-title":"Br Med J"},{"key":"10.1038\/ki.1984.126_bb0085","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/0002-9343(79)90462-5","article-title":"An evaluation of diabetic and pseudodiabetic glomerulosclerosis","volume":"66","author":"Herf","year":"1979","journal-title":"Am J Med"},{"key":"10.1038\/ki.1984.126_bb0090","first-page":"167","article-title":"D\u00e9p\u00f4ts h\u00e9patiques et r\u00e9naux de cha\u00eenes l\u00e9g\u00e8res kappa, r\u00e9v\u00e9lateurs d'une dysglobulin\u00e9mie","volume":"1","author":"Mignon","year":"1980","journal-title":"N\u00e9phrologie"},{"key":"10.1038\/ki.1984.126_bb0095","first-page":"545","article-title":"Synthesis of abnormal heavy and light chains in multiple myeloma with visceral deposition of monoclonal immunoglobulin","volume":"42","author":"Preud'homme","year":"1980","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/ki.1984.126_bb0100","series-title":"Abs VIIth Int Congr Nephrol, Montreal","first-page":"L16","article-title":"Glom\u00e9ruloscl\u00e9rose nodulaire du my\u00e9lome","author":"No\u00ebl","year":"1978"},{"key":"10.1038\/ki.1984.126_bb0105","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/path.1711300404","article-title":"Proliferative glomerulonephropathy in multiple myeloma","volume":"130","author":"Silva","year":"1980","journal-title":"J Pathol"},{"key":"10.1038\/ki.1984.126_bb0110","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0002-9343(76)90422-8","article-title":"Monoclonal IgE with renal failure","volume":"61","author":"Vladutiu","year":"1976","journal-title":"Am J Med"},{"key":"10.1038\/ki.1984.126_bb0115","first-page":"659","article-title":"Membranoproliferative glomerulonephritis, an unusual manifestation of multiple myeloma","volume":"14","author":"Rao","year":"1978","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1984.126_bb0120","first-page":"591","article-title":"Granular dense deposit disease","volume":"39","author":"King","year":"1978","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1984.126_bb0125","first-page":"557","article-title":"Kappa light chain glomerulosclerosis in multiple myeloma","volume":"101","author":"Seymour","year":"1980","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.1984.126_bb0130","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0002-9343(81)90127-3","article-title":"Light chain nephropathy","volume":"71","author":"Tubbs","year":"1981","journal-title":"Am J Med"},{"key":"10.1038\/ki.1984.126_bb0135","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1159\/000166661","article-title":"Kappa light chain nephropathy without evidence of myeloma cells","volume":"2","author":"Gipstein","year":"1982","journal-title":"Am J Nephrol"},{"key":"10.1038\/ki.1984.126_bb0140","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000166540","article-title":"Nephrotic syndrome in a 52-year-old woman with monoclonal gammopathy","volume":"1","author":"Glassock","year":"1981","journal-title":"Am J Nephrol"},{"key":"10.1038\/ki.1984.126_bb0145","first-page":"278","article-title":"Aspect inhabituel des vitr\u00e9es tubulaires du rein au cours du my\u00e9lome multiple","volume":"83","author":"No\u00ebl","year":"1977","journal-title":"J Urol N\u00e9phrol"},{"key":"10.1038\/ki.1984.126_bb0150","first-page":"306","article-title":"The kidney in lymphoplasmacytic disorders","volume":"17","author":"Gallo","year":"1982","journal-title":"Pathology Annual"},{"key":"10.1038\/ki.1984.126_bb0155","series-title":"Actualit\u00e9s N\u00e9phrologiques de l'H\u00f4pital Necker","first-page":"179","article-title":"D\u00e9p\u00f4ts de cha\u00eenes l\u00e9g\u00e8res et d'immunoglobulines monoclonales: Aspects n\u00e9phrologiques et hypoth\u00e8ses physiopathologiques","author":"Ganeval","year":"1981"},{"key":"10.1038\/ki.1984.126_bb0160","first-page":"3259","article-title":"La maladie des d\u00e9p\u00f4ts de cha\u00eenes l\u00e9g\u00e8res ou d'immunoglobulines monoclonales: Concepts physiopathog\u00e9niques","volume":"11","author":"Preud'homme","year":"1982","journal-title":"Nouv Presse Med"},{"key":"10.1038\/ki.1984.126_bb0165","first-page":"203","article-title":"Mesangial thickening and nodular glomerular sclerosis in diabetes mellitus and other diseases","volume":"80","author":"Olsen","year":"1972","journal-title":"Acta Pathol Microbiol Scand"},{"key":"10.1038\/ki.1984.126_bb0170","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1159\/000180846","article-title":"Nephrotic syndrome associated with amyloid-like glomerular deposits","volume":"18","author":"Rosenmann","year":"1977","journal-title":"Nephron"},{"key":"10.1038\/ki.1984.126_bb0175","first-page":"41","article-title":"Les manifestations r\u00e9nales du my\u00e9lome","volume":"63","author":"Cauchie","year":"1962","journal-title":"J Urol N\u00e9phrol"},{"key":"10.1038\/ki.1984.126_bb0180","first-page":"201","article-title":"Kidney involvement in multiple myeloma and related disorders","volume":"33","author":"Ganeval","year":"1982","journal-title":"Contrib Nephrol"},{"key":"10.1038\/ki.1984.126_bb0185","first-page":"319","article-title":"Crescentic light-chain glomerulopathy","volume":"107","author":"Lapenas","year":"1983","journal-title":"Arch Pathol Lab Med"},{"key":"10.1038\/ki.1984.126_bb0190","first-page":"3","article-title":"The pathogenesis of \u201camyloidosis\u201d: Studies on the role of abnormal gammaglobulin fragments of the Bence Jones (L-polypeptide) type in the pathogenesis of \u201cprimary\u201d and \u201csecondary amyloidosis\u201d and the \u201camyloidosis\u201d associated with plasma cell myeloma","volume":"1","author":"Osserman","year":"1964","journal-title":"Semin Hematol"},{"key":"10.1038\/ki.1984.126_bb0195","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00005792-197507000-00001","article-title":"Amyloidosis: Review of 236 cases","volume":"54","author":"Kyle","year":"1975","journal-title":"Medicine"},{"key":"10.1038\/ki.1984.126_bb0200","first-page":"428","article-title":"Intracytoplasmic and surface-bound immunoglobulins in \u201cnon-secretory\u201d and Bence Jones myeloma","volume":"25","author":"Preud'homme","year":"1976","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/ki.1984.126_bb0205","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1182\/blood.V56.6.1136.1136","article-title":"Synthesis of abnormal heavy chains in Bence Jones plasma cell leukemia with intracellular IgG","volume":"56","author":"Preud'homme","year":"1980","journal-title":"Blood"},{"key":"10.1038\/ki.1984.126_bb0210","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1432-1033.1972.tb01734.x","article-title":"The primary structure of a monoclonal human \u03bb type immunoglobulin L-chain of subgroup II","volume":"26","author":"Garver","year":"1972","journal-title":"Eur J Biochem"},{"key":"10.1038\/ki.1984.126_bb0215","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1073\/pnas.66.3.975","article-title":"Attachment of carbohydrate to the variable region of myeloma immunoglobulin light chains","volume":"66","author":"Sox","year":"1970","journal-title":"Proc Natl Acad Sci"},{"key":"10.1038\/ki.1984.126_bb0220","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1021\/bi00823a025","article-title":"Localization of the carbohydrate within the variable region of light and heavy chains of human \u03b3 G myeloma proteins","volume":"9","author":"Spiegelberg","year":"1970","journal-title":"Biochemistry"},{"key":"10.1038\/ki.1984.126_bb0225","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1073\/pnas.71.9.3478","article-title":"Variants of mouse myeloma cell that produce short immunoglobulin heavy chains","volume":"71","author":"Birshtein","year":"1974","journal-title":"Proc Natl Acad Sci"},{"key":"10.1038\/ki.1984.126_bb0230","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1084\/jem.147.6.1535","article-title":"IgG2a-producing variants of an IgG2b-producing mouse myeloma cell line","volume":"147","author":"Francus","year":"1978","journal-title":"J Exp Med"},{"key":"10.1038\/ki.1984.126_bb0235","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1073\/pnas.72.4.1427","article-title":"Variants of a mouse myeloma cell line that synthetize immunoglobulin chains having an altered serotype","volume":"72","author":"Preud'homme","year":"1975","journal-title":"Proc Natl Acad Sci"},{"key":"10.1038\/ki.1984.126_bb0240","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/245320a0","article-title":"Mutagenesis of mouse myeloma cells with melphalan","volume":"245","author":"Preud'homme","year":"1973","journal-title":"Nature"},{"key":"10.1038\/ki.1984.126_bb0245","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0092-8674(77)90101-5","article-title":"Abnormalities in the glycosylation of immunoglobulin heavy chains and an H-2 transplantation antigen in a mouse myeloma mutant","volume":"10","author":"Weitzmann","year":"1977","journal-title":"Cell"},{"key":"10.1038\/ki.1984.126_bb0250","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/bmj.2.5753.67","article-title":"Immunocytoma o'mice an'men","volume":"2","author":"Hobbs","year":"1971","journal-title":"Br Med J"},{"key":"10.1038\/ki.1984.126_bb0255","first-page":"242","article-title":"The renal handling of human immunoglobulin light chain (IgLC) in the Munich-Wistar rat","volume":"21","author":"Baylis","year":"1982","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1984.126_bb0260","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0272-6386(83)80075-4","article-title":"Renal lesions in multiple myeloma: their relationship to associated protein abnormalities","volume":"2","author":"Hill","year":"1983","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.1984.126_bb0265","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.174.4010.712","article-title":"Creation of \u201camyloid\u201d fibrils from Bence Jones proteins in vitro","volume":"174","author":"Glenner","year":"1971","journal-title":"Science"},{"key":"10.1038\/ki.1984.126_bb0270","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.110.1.21","article-title":"Fibrillar assemblage of variable segments of immunoglobulin light chains","volume":"110","author":"Shirahama","year":"1973","journal-title":"J Immunol"},{"key":"10.1038\/ki.1984.126_bb0275","series-title":"Pathology of the Kidney","first-page":"993","article-title":"Multiple myeloma, amyloidosis, Waldenstr\u00f6m's macroglobulinemia, cryoglobulinemias and benign monoclonal gammopathies","author":"Hill","year":"1983"},{"key":"10.1038\/ki.1984.126_bb0280","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0002-9343(79)90747-2","article-title":"Amyloidosis of the AL type: Clinical, morphologic and biochemical aspects of the response to therapy with alkylating agents and prednisone","volume":"67","author":"Buxbaum","year":"1979","journal-title":"Am J Med"},{"key":"10.1038\/ki.1984.126_bb0285","first-page":"A5","article-title":"Association systemic light chain deposition: Amyloidosis, one case","volume":"13","author":"Jacquot","year":"1983","journal-title":"Eur J Clin Invest"},{"key":"10.1038\/ki.1984.126_bb0290","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1056\/NEJM198006053022305","article-title":"Amyloid deposits and amyloidosis: The \u03b2-fibrilloses","volume":"302","author":"Glenner","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1984.126_bb0295","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2141.1981.tb02758.x","article-title":"Relation of osteoclast activating factor production to extent of bone disease in multiple myeloma","volume":"47","author":"Durie","year":"1981","journal-title":"Br J Haematol"},{"key":"10.1038\/ki.1984.126_bb0300","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1056\/NEJM198212303072706","article-title":"Amyloid production in human myeloma stem-cell culture, with morphologic evidence of amyloid secretion by associated macrophages","volume":"307","author":"Durie","year":"1982","journal-title":"N Engl J Med"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381533235X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381533235X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T03:11:15Z","timestamp":1683861075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S008525381533235X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,7]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,7]]}},"alternative-id":["S008525381533235X"],"URL":"https:\/\/doi.org\/10.1038\/ki.1984.126","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1984,7]]}}}