{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:28:59Z","timestamp":1770218939492,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1985,3,1]],"date-time":"1985-03-01T00:00:00Z","timestamp":478483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":11238,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1985,3]]},"DOI":"10.1038\/ki.1985.48","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T13:11:10Z","timestamp":1180617070000},"page":"565-573","source":"Crossref","is-referenced-by-count":88,"title":["Altered divalent ion metabolism in early renal failure: Role of 1,25(OH)2D"],"prefix":"10.1016","volume":"27","author":[{"given":"Lorraine","family":"Wilson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Felsenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc K.","family":"Drezner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Llach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1985.48_bb0010","first-page":"104","article-title":"Measurement of serum parathyroid hormone in renal insufficiency","volume":"81","author":"Reiss","year":"1968","journal-title":"Trans Assoc Am Physicians"},{"key":"10.1038\/ki.1985.48_bb0015","doi-asserted-by":"crossref","first-page":"357","DOI":"10.7326\/0003-4819-78-3-357","article-title":"Skeletal resistance to parathyroid hormone in renal failure: studies in 105 human subjects","volume":"78","author":"Massry","year":"1973","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.1985.48_bb0020","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/ki.1973.40","article-title":"Study of intestinal absorption of calcium in patients with chronic renal failure","volume":"3","author":"Coburn","year":"1973","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1985.48_bb0025","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1210\/jcem-41-2-339","article-title":"Skeletal resistance to endogenous parathyroid hormone in patients with early renal failure: A possible cause for secondary hyperparathyroidism","volume":"41","author":"Llach","year":"1975","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/ki.1985.48_bb0030","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/ki.1976.42","article-title":"Bone histology in incipient and advanced renal failure","volume":"9","author":"Malluche","year":"1976","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1985.48_bb0035","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1172\/JCI106517","article-title":"On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog","volume":"50","author":"Slatopolsky","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1985.48_bb0040","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00005792-194305000-00002","article-title":"Studies of calcium and phosphorus metabolism with special reference to pathogenesis and effects of dihydrotachyserol (AT 10) and Iron","volume":"22","author":"Liu","year":"1943","journal-title":"Medicine"},{"key":"10.1038\/ki.1985.48_bb0045","first-page":"459","article-title":"Secondary hyperparathyroidism in early renal failure: Role of phosphate retention","volume":"12","author":"Llach","year":"1977","journal-title":"Kidney Int abstract"},{"key":"10.1038\/ki.1985.48_bb0050","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/ki.1982.70","article-title":"Reduced plasma concentration of 1,25-dihydroxyvitamin D in children with moderate renal insufficiency","volume":"21","author":"Portale","year":"1982","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1985.48_bb0055","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1172\/JCI111365","article-title":"Dietary phosphorus affects circulating levels of 1,25(OH)2D and PTH in children with moderate renal insufficiency","volume":"73","author":"Portale","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1985.48_bb0060","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(75)92736-1","article-title":"Nomogram for derivation of renal phosphate threshold concentration","volume":"2","author":"Walton","year":"1975","journal-title":"Lancet"},{"key":"10.1038\/ki.1985.48_bb0065","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1210\/endo-104-4-1181","article-title":"Effect of epinephrine on parathyroid hormone secretion in calves","volume":"104","author":"Mayer","year":"1979","journal-title":"Endocrinology"},{"key":"10.1038\/ki.1985.48_bb0070","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJM198107163050301","article-title":"The pathophysiology of altered calcium metabolism in rhabdomyolysis-induced acute renal failure","volume":"305","author":"Llach","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1985.48_bb0075","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1210\/endo-102-4-1036","article-title":"Sigmoidal relationship between parathyroid hormone secretion rate and plasma calcium concentration in calves","volume":"102","author":"Mayer","year":"1978","journal-title":"Endocrinology"},{"key":"10.1038\/ki.1985.48_bb0080","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0003-9861(76)90161-2","article-title":"A sensitive, precise and convenient method for the determination of 1,25 dihydroxyvitamin D in human plasma","volume":"176","author":"Eisman","year":"1976","journal-title":"Arch Biochem Biophys"},{"key":"10.1038\/ki.1985.48_bb0085","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0003-2697(77)90648-0","article-title":"Determination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in human plasma using high-pressure liquid chromatography","volume":"80","author":"Eisman","year":"1977","journal-title":"Anal Biochem"},{"key":"10.1038\/ki.1985.48_bb0090","series-title":"Abs Fifth Ann Sci Meet Am Soc Bone and Min Res","first-page":"A49","article-title":"Pulsatile secretion of parathyroid hormone in humans","author":"Magliaro","year":"1983"},{"key":"10.1038\/ki.1985.48_bb0095","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000403271","article-title":"Clinical effects of 1,25 dihydroxyvitamin D3 in uremic patients with overt osteodystrophy","volume":"18","author":"Brickman","year":"1980","journal-title":"Contrib Nephrol"},{"key":"10.1038\/ki.1985.48_bb0100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000403274","article-title":"Controlled trial of the effects of 1,25 dihydroxycholecalciferol in patients treated with regular dialysis","volume":"18","author":"Berl","year":"1980","journal-title":"Contrib Nephrol"},{"key":"10.1038\/ki.1985.48_bb0105","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000403272","article-title":"Long term effects of 1,25(OH)2D3 in clinical and biochemical derangements of divalent ions in dialysis patients","volume":"18","author":"Goldstein","year":"1980","journal-title":"Contrib Nephrol"},{"key":"10.1038\/ki.1985.48_bb0110","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1001\/archinte.1980.00330190042017","article-title":"Effects of long term therapy with calcitrol in patients with moderate renal failure","volume":"140","author":"Healy","year":"1980","journal-title":"Arch Intern Med"},{"key":"10.1038\/ki.1985.48_bb0115","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1210\/jcem-44-6-1054","article-title":"Acute actions of 1,25-dihydroxyvitamin D3 in normal man: effect on calcium and parathyroid status","volume":"44","author":"Llach","year":"1977","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/ki.1985.48_bb0120","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/ki.1973.40","article-title":"Studies on intestinal absorption of calcium in patients with renal failure","volume":"3","author":"Coburn","year":"1973","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1985.48_bb0125","first-page":"245","article-title":"Elevated nephrogenous cyclic adenosine monophosphate to monitor early renal osteodystrophy","volume":"16","author":"Krensky","year":"1981","journal-title":"Clin Nephrol"},{"key":"10.1038\/ki.1985.48_bb0130","doi-asserted-by":"crossref","first-page":"739","DOI":"10.7326\/0003-4819-91-5-739","article-title":"Comparison of available parathyroid hormone immunoassays in the differential diagnosis of hypercalcemia due to primary hyperparathyroidism","volume":"91","author":"Raisz","year":"1979","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.1985.48_bb0135","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1172\/JCI109312","article-title":"Resistance to the phosphaturic and calcemic action of parathyroid hormone during phosphate depletion","volume":"63","author":"Gloor","year":"1979","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1985.48_bb0140","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0140-6736(73)90793-9","article-title":"Inadequate therapeutic response to 1,25 dihydroxycholecalciferol","volume":"2","author":"Glorieux","year":"1973","journal-title":"Lancet"},{"key":"10.1038\/ki.1985.48_bb0145","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/cs0380297","article-title":"Divalent ion excretion in chronic renal disease: relation to degree of renal insufficiency","volume":"38","author":"Popovtzer","year":"1970","journal-title":"Clin Sci"},{"key":"10.1038\/ki.1985.48_bb0150","doi-asserted-by":"crossref","first-page":"161","DOI":"10.7326\/0003-4819-80-2-161","article-title":"1,25-Dihydroxyvitamin D3 in normal man and patients with renal failure","volume":"80","author":"Brickman","year":"1974","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.1985.48_bb0155","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ki.1983.193","article-title":"Bone resorption stimulated by elevated serum 1,25(OH)2-vitamin D concentration in healthy men","volume":"24","author":"Maierhofer","year":"1983","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1985.48_bb0160","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/ki.1984.212","article-title":"Dietary calcium and serum 1, 25-(OH)2-vitamin D concentrations as determinants of calcium balance in healthy men","volume":"26","author":"Maierhofer","year":"1984","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1985.48_bb0165","first-page":"733","article-title":"Low serum levels of 1,25-dihydroxycholecalciferol are not responsible for the development of secondary hyperparathyroidism in early renal failure","volume":"14","author":"Slatopolsky","year":"1978","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1985.48_bb0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/ki.1982.9","article-title":"Circulating vitamin D metabolite concentration in childhood renal disease","volume":"21","author":"Chesney","year":"1982","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1985.48_bb0175","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2265.1981.tb00191.x","article-title":"Serum concentrations of metabolites of vitamin D in patients with chronic renal failure (CRF). Consequences for the treatment with 1 \u03b1-hydroxy-derivatives","volume":"14","author":"Juttmann","year":"1981","journal-title":"Clin Endocrinol"},{"key":"10.1038\/ki.1985.48_bb0180","first-page":"333","article-title":"Graded mass reduction and renal synthesis of 1,25 Dihydroxyvitamin D3 in the rat","volume":"4","author":"Kawaguchi","year":"1983","journal-title":"Metab Bone Dis Relat Res"},{"key":"10.1038\/ki.1985.48_bb0185","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1172\/JCI109516","article-title":"Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: Effect of age and dietary calcium","volume":"64","author":"Gallagher","year":"1979","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1985.48_bb0190","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/ki.1976.60","article-title":"Skeletal resistance to the calcemic action of parathyroid hormone in uremia. Role of 1,25(OH)2D3","volume":"9","author":"Massry","year":"1976","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1985.48_bb0195","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1001\/archinte.1978.03630300016003","article-title":"HOW important is phosphate in the pathogenesis of renal osteodystrophy","volume":"138","author":"Slatopolsky","year":"1978","journal-title":"Arch Intern Med"},{"key":"10.1038\/ki.1985.48_bb0200","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000180779","article-title":"Role of phosphate in the genesis of secondary hyperparathyroidism of renal failure","volume":"18","author":"Massry","year":"1977","journal-title":"Nephron"},{"key":"10.1038\/ki.1985.48_bb0205","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1093\/ajcn\/33.7.1546","article-title":"Early dietary phosphorus restriction and calcium supplementation in the prevention of renal osteodystrophy","volume":"33","author":"Maschio","year":"1980","journal-title":"Am J Clin Nutr"},{"key":"10.1038\/ki.1985.48_bb0210","series-title":"Kidney and Bone Paris, Nouvelle Imprimeri Fournier","first-page":"171","article-title":"Phosphate loading as a test for primary hyperparathyroidism. Phosphate metabolism","author":"Llach","year":"1975"},{"key":"10.1038\/ki.1985.48_bb0215","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/ajcn\/30.7.1064","article-title":"Action of 1 \u03b1-hydroxy vitamin D3 and 1,25-dihydroxyvitamin D3 on mineral metabolism in man","volume":"30","author":"Brickman","year":"1977","journal-title":"Am J Clin Nutr"},{"key":"10.1038\/ki.1985.48_bb0220","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-1-4684-7758-0_16","article-title":"Intestinal inorganic phosphate transport","volume":"103","author":"Walling","year":"1978","journal-title":"Adv Exp Med Biol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815333950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815333950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T18:54:38Z","timestamp":1635533678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815333950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,3]]}},"alternative-id":["S0085253815333950"],"URL":"https:\/\/doi.org\/10.1038\/ki.1985.48","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1985,3]]}}}