{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:21:23Z","timestamp":1789611683284,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1991,9,1]],"date-time":"1991-09-01T00:00:00Z","timestamp":683683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":8863,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1991,9]]},"DOI":"10.1038\/ki.1991.238","type":"journal-article","created":{"date-parts":[[2007,5,28]],"date-time":"2007-05-28T17:09:31Z","timestamp":1180372171000},"page":"501-508","source":"Crossref","is-referenced-by-count":76,"title":["Renal, cardiovascular and hormonal characteristics of young adults with autosomal dominant polycystic kidney disease"],"prefix":"10.1016","volume":"40","author":[{"given":"Stephen B.","family":"Harrap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Macnicol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna F.","family":"Dominiczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan F.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Douglas","family":"Briggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 328","key":"10.1038\/ki.1991.238_bb0010","first-page":"128","article-title":"Bilateral polycystic disease of the kidneys","volume":"158","author":"Dalgaard","year":"1957","journal-title":"Acta Medica Scand"},{"key":"10.1038\/ki.1991.238_bb0015","doi-asserted-by":"crossref","first-page":"238","DOI":"10.7326\/0003-4819-101-2-238","article-title":"Polycystic kidney disease: prospective analysis of nonazotemic patients and family members","volume":"101","author":"Gabow","year":"1984","journal-title":"Ann Int Med"},{"key":"10.1038\/ki.1991.238_bb0020","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0272-6386(83)80044-4","article-title":"Epidemiology of adult polycystic kidney disease, Olmsted county, Minnesota: 1935\u20131980","volume":"2","author":"Iglesias","year":"1983","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.1991.238_bb0025","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ki.1984.154","article-title":"Prognosis of adult onset polycystic kidney disease re-evaluated","volume":"26","author":"Churchill","year":"1984","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1991.238_bb0030","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ki.1987.121","article-title":"Cyst formation and growth in autosomal dominant polycystic kidney disease","volume":"31","author":"Grantham","year":"1987","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1991.238_bb0035","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1056\/NEJM198209093071104","article-title":"Dietary protein intake and the progressive nature of kidney disease: the role of hemody-namically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation and intrinsic renal disease","volume":"307","author":"Brenner","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1991.238_bb0040","series-title":"The Progressive Nature of Renal Disease","first-page":"81","article-title":"Blood pressure control and progression of renal insufficiency","author":"Baldwin","year":"1896"},{"key":"10.1038\/ki.1991.238_bb0045","first-page":"A29","article-title":"The renal hemodynamic response to amino-acids is different between autosomal dominant polycystic kidney disease and glomerular diseases","volume":"17","author":"Zeier","year":"1991","journal-title":"Am J Kidney Dis"},{"issue":"Suppl 6","key":"10.1038\/ki.1991.238_bb0050","first-page":"S40","article-title":"Genetic markers for polycystic kidney disease and their implications for detection of hypertension","volume":"4","author":"Watson","year":"1986","journal-title":"J Hypertension"},{"key":"10.1038\/ki.1991.238_bb0055","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000413217","article-title":"Hypertension in polycystic kidney disease","volume":"54","author":"Valvo","year":"1987","journal-title":"Contr Nephrol"},{"issue":"Suppl 5","key":"10.1038\/ki.1991.238_bb0060","first-page":"S379","article-title":"Arterial pressure in polycystic kidney disease: A 10-year prospective analysis in 267 members spanning four generations","volume":"5","author":"Timio","year":"1987","journal-title":"J Hyper-tens"},{"key":"10.1038\/ki.1991.238_bb0065","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ki.1988.233","article-title":"Hypertension in autosomal dominant polycystic kidney disease","volume":"34","author":"Bell","year":"1988","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1991.238_bb0070","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/archinte.1977.03630230057015","article-title":"Hypertension in polycystic kidney disease without renal failure","volume":"137","author":"Nash","year":"1977","journal-title":"Arch Int Med"},{"key":"10.1038\/ki.1991.238_bb0075","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/00365597409132130","article-title":"Hypertension in polycystic kidney disease","volume":"8","author":"Hansson","year":"1974","journal-title":"Scand J Urol Nephrol"},{"key":"10.1038\/ki.1991.238_bb0080","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1001\/archinte.1931.00140210163013","article-title":"Hypertension in cases of congenital polycystic disease","volume":"47","author":"Schacht","year":"1931","journal-title":"Arch Intern Med"},{"key":"10.1038\/ki.1991.238_bb0085","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/bmj.292.6524.851","article-title":"Two genetic markers closely linked to adult polycystic kidney disease on chromosome 16","volume":"292","author":"Reeders","year":"1986","journal-title":"Br Med J"},{"key":"10.1038\/ki.1991.238_bb0090","first-page":"460","article-title":"Easy calculations of lod scores and genetic risks on small computers","volume":"36","author":"Lithrop","year":"1984","journal-title":"Am J Hum Genet"},{"key":"10.1038\/ki.1991.238_bb0095","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ajmg.1320180108","article-title":"Age at clinical onset and at ultrasonographic detection of adult polycystic kidney disease: Data for genetic counselling","volume":"18","author":"Bear","year":"1984","journal-title":"Am J Med Genet"},{"key":"10.1038\/ki.1991.238_bb0100","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/01.CIR.58.6.1072","article-title":"Recommendations regarding quantitation in M-mode echocardiography: Results of a survey of echocardiographic measurements","volume":"58","author":"Sahn","year":"1978","journal-title":"Circulation"},{"key":"10.1038\/ki.1991.238_bb0105","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.CIR.55.4.613","article-title":"Echocardigraphic determination of left ventricular mass in man. Anatomic validation of the method","volume":"55","author":"Devereux","year":"1977","journal-title":"Circulation"},{"key":"10.1038\/ki.1991.238_bb0110","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/0002-8703(87)90955-0","article-title":"Diagnosis and classification of severity of mitral valve prolapse: Methologic, biologic and prognostic considerations","volume":"113","author":"Devereux","year":"1987","journal-title":"Am Heart J"},{"key":"10.1038\/ki.1991.238_bb0115","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0009-8981(80)90050-9","article-title":"A micro-assay for active and total renin concentration in human plasma based on antibody trapping","volume":"101","author":"Millar","year":"1980","journal-title":"Clin Chim Acta"},{"key":"10.1038\/ki.1991.238_bb0120","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00004872-198704000-00015","article-title":"Radioimmunoassay for plasma alpha-human atrial natriuretic peptide; a comparison of direct and pre-extracted methods","volume":"5","author":"Richards","year":"1987","journal-title":"J Hypertens"},{"key":"10.1038\/ki.1991.238_bb0125","first-page":"411","article-title":"A comparison of double isotope derivative and radioimmunological estimation of plasma aldosterone concentration in man","volume":"45","author":"Fraser","year":"1973","journal-title":"Clin Sci Mol Med"},{"key":"10.1038\/ki.1991.238_bb0130","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0022-4731(89)90297-5","article-title":"Effect of benzodiazepines diazepam, des-N-methyldiazepam and midazolam on corticosteroid biosynthesis in bovine adrenocortical cells in vitro; location of site of action","volume":"33","author":"Holloway","year":"1989","journal-title":"J Steroid Biochem"},{"key":"10.1038\/ki.1991.238_bb0135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0026-0495(73)90263-1","article-title":"Simultaneous measurement of total exchangeable potassium and sodium using 43K and 24Na","volume":"22","author":"Davies","year":"1973","journal-title":"Metabolism"},{"key":"10.1038\/ki.1991.238_bb0140","series-title":"Radioisotope Techniques in Clinical Research and Diagnosis","author":"Veall","year":"1985"},{"key":"10.1038\/ki.1991.238_bb0145","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1042\/cs0630257","article-title":"Relation of arterial pressure with body sodium, body potassium and plamsa potassium in essential hypertension","volume":"63","author":"Beretta-Piccoli","year":"1982","journal-title":"Clin Sci"},{"key":"10.1038\/ki.1991.238_bb0150","first-page":"793","article-title":"Recommended Methods for Measurement of Red Cell and Plasma Volume. International Committee for Standardisation in Hematology","volume":"21","year":"1980","journal-title":"J Nuc Med"},{"key":"10.1038\/ki.1991.238_bb0155","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1056\/NEJM197211302872202","article-title":"Measurement of renal function without urine collection","volume":"287","author":"Cole","year":"1972","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1991.238_bb0160","first-page":"475","article-title":"Determination of inulin in plasma and urine by use of anthrone","volume":"43","author":"White","year":"1954","journal-title":"J Lab Clin Med"},{"key":"10.1038\/ki.1991.238_bb0165","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1172\/JCI101618","article-title":"The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man","volume":"24","author":"Smith","year":"1945","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1991.238_bb0170","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1172\/JCI102101","article-title":"The measurement of glomerular and tubular plasma flow in the normal and diseased human kidney","volume":"28","author":"Cargill","year":"1948","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1991.238_bb0175","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/0002-9343(84)90529-1","article-title":"Short-term protein loading in assessment of patients with renal disease","volume":"77","author":"Bosch","year":"1984","journal-title":"Am J Med"},{"key":"10.1038\/ki.1991.238_bb0180","series-title":"Br Med J","article-title":"Confidence Interval Analysis (CAI)","author":"Gardner","year":"1989"},{"key":"10.1038\/ki.1991.238_bb0185","unstructured":"M.J. Norusis, SPSS Inc, 444N Michigan Ave, Chicago, Illinois SPSS\/PC+ for IBM PC\/XT\/AT and Advanced Statistics"},{"key":"10.1038\/ki.1991.238_bb0190","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/imammb\/1.2.193","article-title":"Nonrandom sampling in human genetics: Familial correlations","volume":"1","author":"Hanis","year":"1984","journal-title":"IMA J Math Appl Med Biol"},{"key":"10.1038\/ki.1991.238_bb0195","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1056\/NEJM199010183231601","article-title":"The diagnosis and prognosis of autosomal dominant polycystic kidney disease","volume":"323","author":"Parfrey","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1991.238_bb0200","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/ki.1985.46","article-title":"Progression of renal failure in patients with renal disease of diverse etiology on protein-restricted diet","volume":"27","author":"Oldrizzi","year":"1985","journal-title":"Kidney Int"},{"issue":"Suppl 27","key":"10.1038\/ki.1991.238_bb0205","first-page":"S106","article-title":"Protein-restricted diets in chronic renal failure: A four year follow-up shows limited indications","volume":"36","author":"Rosman","year":"1989","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1991.238_bb0210","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1056\/NEJM199010183231602","article-title":"The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease","volume":"323","author":"Chapman","year":"1990","journal-title":"N Eng J Med"},{"key":"10.1038\/ki.1991.238_bb0215","first-page":"688","article-title":"Renal vascular resistance and the renin angiotensin system in adult polycystic kidney disease","volume":"5","author":"Macnicol","year":"1990","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.1991.238_bb0220","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/ki.1988.121","article-title":"Mechanisms affecting the development of renal cystic disease induced by diphenylthiazole","volume":"33","author":"Torres","year":"1988","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1991.238_bb0225","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1152\/physrev.1985.65.3.658","article-title":"Concept of natriuretic hormone","volume":"65","author":"De Wardener","year":"1985","journal-title":"Physiol Rev"},{"key":"10.1038\/ki.1991.238_bb0230","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0024-3205(76)90284-8","article-title":"The role of humoral agents in volume expanded hypertension","volume":"19","author":"Haddy","year":"1976","journal-title":"Life Sci"},{"key":"10.1038\/ki.1991.238_bb0235","doi-asserted-by":"crossref","first-page":"C165","DOI":"10.1152\/ajpcell.1977.232.5.C165","article-title":"Sodium ions, calcium ions, blood pressure regulation and hypertension: A reassessment and a hypothesis","volume":"232","author":"Blaustein","year":"1977","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1991.238_bb0240","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0002-9149(85)91043-4","article-title":"Mitral valve prolapse and systemic hypertension","volume":"56","author":"Roberts","year":"1985","journal-title":"Am J Cardiol"},{"key":"10.1038\/ki.1991.238_bb0245","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM198810063191404","article-title":"Echocardiographic findings in autosomal dominant polycystic kidney disease","volume":"319","author":"Hossack","year":"1988","journal-title":"N Eng J Med"},{"key":"10.1038\/ki.1991.238_bb0250","doi-asserted-by":"crossref","first-page":"826","DOI":"10.7326\/0003-4819-97-6-826","article-title":"Inheritance of mitral valve prolapse: Effect of age and sex on gene expression","volume":"97","author":"Devereux","year":"1982","journal-title":"Ann Int Med"},{"key":"10.1038\/ki.1991.238_bb0255","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000183488","article-title":"Vascular architecture modifications in the steroid-induced polycystic kidney","volume":"40","author":"Ros","year":"1985","journal-title":"Nephron"},{"key":"10.1038\/ki.1991.238_bb0260","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/ki.1990.64","article-title":"Glucocorticoid-inijuced polycystic kidney disease-a threshold trait","volume":"37","author":"McDonald","year":"1990","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1991.238_bb0265","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/ki.1985.151","article-title":"Sodium-potassium ATPase activity mediates cyst formation in metanephric organ culture","volume":"28","author":"Avner","year":"1985","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1991.238_bb0270","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000184884","article-title":"Renal cystic disease: Insights from recent experimental investigations","volume":"48","author":"Avner","year":"1988","journal-title":"Nephron"},{"key":"10.1038\/ki.1991.238_bb0275","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ki.1987.112","article-title":"Polycystic kidney and liver disease and corticosterone changes in the cpk mouse","volume":"31","author":"Crocker","year":"1987","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1991.238_bb0280","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0022-4731(87)90412-2","article-title":"RU38486 prolongs survival in murine congenital polycystic kidney disease","volume":"28","author":"Ogborn","year":"1987","journal-title":"J Steroid Biochem"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815573286?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815573286?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T21:44:02Z","timestamp":1635543842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815573286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,9]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,9]]}},"alternative-id":["S0085253815573286"],"URL":"https:\/\/doi.org\/10.1038\/ki.1991.238","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1991,9]]}}}