{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:18:04Z","timestamp":1790835484133,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1992,10,1]],"date-time":"1992-10-01T00:00:00Z","timestamp":717897600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":8467,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1992,10]]},"DOI":"10.1038\/ki.1992.359","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T07:07:04Z","timestamp":1180076824000},"page":"843-850","source":"Crossref","is-referenced-by-count":21,"title":["Effect of loop diuretics on organic osmolytes and cell electrolytes in the renal outer medulla"],"prefix":"10.1016","volume":"42","author":[{"given":"Franz-X.","family":"Beck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Sone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolf","family":"D\u00f6rge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Thurau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1992.359_bb0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.ph.50.030188.000551","article-title":"Chloride transport in thick ascending limb, distal convolution, and collecting duct","volume":"50","author":"Greger","year":"1988","journal-title":"Ann Rev Physiol"},{"key":"10.1038\/ki.1992.359_bb0015","series-title":"The Regulation of Acid-Base Balance","first-page":"139","article-title":"Segmental hydrogen ion transport","author":"Koeppen","year":"1989"},{"key":"10.1038\/ki.1992.359_bb0020","first-page":"245","article-title":"Renal transport of glucose, amino acids, sodium, chloride, and water","volume":"I","author":"Berry","year":"1991"},{"key":"10.1038\/ki.1992.359_bb0025","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1172\/JCI109917","article-title":"Effect of vasopressin on electrical potential difference and chloride transport in mouse medullary thick ascending limb of Henle's loop","volume":"66","author":"Hall","year":"1980","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1992.359_bb0030","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00656711","article-title":"Chloride transport in the thick ascending limb of Henle's loop: Potassium dependence and stoichiometry of the NaCl cotransport system in plasma membrane vesicles","volume":"399","author":"Koenig","year":"1983","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1038\/ki.1992.359_bb0035","first-page":"F412","article-title":"NaCl transport in mouse medullary thick ascending limbs. I. Functional nephron heterogeneity and ADH-stimulated NaCl cotransport","volume":"241","author":"Hebert","year":"1981","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0040","first-page":"F745","article-title":"Control of NaCl transport in the thick ascending limb","volume":"246","author":"Hebert","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0045","first-page":"144","article-title":"Element composition of tubule cells in the inner stripe of the renal outer medulla","volume":"15","author":"Beck","year":"1989","journal-title":"Miner Electrol Metab"},{"key":"10.1038\/ki.1992.359_bb0050","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00585112","article-title":"The distribution of potassium, sodium and chloride across the apical membrane of renal tubular cells: Effect of acute metabolic alkalosis","volume":"411","author":"Beck","year":"1988","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1038\/ki.1992.359_bb0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF01869200","article-title":"Intracellular electrolyte concentrations in the frog skin epithelium: Effect of vasopressin and dependence on the Na concentration in the bathing media","volume":"78","author":"Rick","year":"1984","journal-title":"J Membr Biol"},{"key":"10.1038\/ki.1992.359_bb0060","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/BF00370227","article-title":"Sodium entry routes in principal and intercalated cells of the isolated perfused cortical collecting duct","volume":"415","author":"Sauer","year":"1990","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1038\/ki.1992.359_bb0065","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/ki.1988.47","article-title":"Cell rubidium uptake: A method for studying functional heterogeneity in the nephron","volume":"33","author":"Beck","year":"1988","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1992.359_bb0070","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1038\/ki.1990.132","article-title":"Effect of diuretics on cell potassium transport: An electron microprobe study","volume":"37","author":"Beck","year":"1990","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1992.359_bb0075","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3181\/00379727-118-29846","article-title":"Effect of furosemide on renal medullary sodium gradient","volume":"118","author":"Hook","year":"1965","journal-title":"Proc Soc Exper Biol Med"},{"key":"10.1038\/ki.1992.359_bb0080","first-page":"F679","article-title":"Effect of atrial natriuretic peptides on renal medullary solute gradients","volume":"253","author":"Davis","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0085","series-title":"Cell Volume Regulation. Comp. Physiology","first-page":"132","article-title":"Cell osmoregulation in the countercurrent system of the renal medulla: The role of organic osmolytes","author":"Beck","year":"1990"},{"key":"10.1038\/ki.1992.359_bb0090","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1152\/physrev.1991.71.4.1081","article-title":"Renal medullary organic osmolytes","volume":"710","author":"Garcia-Perez","year":"1991","journal-title":"Physiol Rev"},{"key":"10.1038\/ki.1992.359_bb0095","first-page":"F128","article-title":"Regulation of organic osmolyte concentrations in tubules from rat renal inner medulla","volume":"256","author":"Wirthensohn","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0100","first-page":"F602","article-title":"Distribution of major organic osmolytes in rabbit kidneys in diuresis and antidiuresis","volume":"257","author":"Yancey","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0105","first-page":"F676","article-title":"Acute regulation of the predominant organic solutes of the rabbit renal inner medulla","volume":"257","author":"Wolff","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0110","first-page":"F154","article-title":"In vivo osmoregulation of aldose reductase mRNA, protein, and sorbitol in renal medulla","volume":"258","author":"Cowley","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0115","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1152\/ajplegacy.1974.227.5.1181","article-title":"Characteristics of sodium reabsorption in the loop of Henle and distal tubule","volume":"227","author":"Kunau","year":"1974","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0120","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1152\/ajplegacy.1975.228.4.1262","article-title":"Effects of graded solute diuresis on renal tubular sodium transport in the rat","volume":"228","author":"Khuri","year":"1975","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0125","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1152\/ajplegacy.1971.221.2.632","article-title":"Effect of amiloride, ouabain, and furosemide on distal tubular function in the rat","volume":"221","author":"Duarte","year":"1971","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0130","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/ki.1980.88","article-title":"Electron microprobe analysis of intracellular elements in the rat kidney","volume":"17","author":"Beck","year":"1980","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1992.359_bb0135","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/ki.1984.30","article-title":"Intra- and extracellular element concentrations of rat renal papilla in antidiuresis","volume":"25","author":"Beck","year":"1984","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1992.359_bb0140","first-page":"F954","article-title":"A simple HPLC method for quantitating major organic solutes of renal medulla","volume":"256","author":"Wolff","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0145","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/BF01473295","article-title":"Eine einfache colorimetrische Methode zur Inulinbestimmung f\u00fcr Nieren-Clearance-Untersuchungen bei Stoffwechselgesunden und Diabetikern","volume":"33","author":"F\u00fchr","year":"1955","journal-title":"Klin Wochenschr"},{"issue":"II","key":"10.1038\/ki.1992.359_bb0150","first-page":"1527","article-title":"Renal effects of the high ceiling diuretic torasemide in rats and dogs","volume":"35","author":"Ghys","year":"1985","journal-title":"Drug Res"},{"issue":"Suppl 3","key":"10.1038\/ki.1992.359_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003495-199100413-00003","article-title":"How do loop diuretics act","volume":"41","author":"Wittner","year":"1991","journal-title":"Drugs"},{"key":"10.1038\/ki.1992.359_bb0160","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/BF00579306","article-title":"Mikropunktionsuntersuchungen zur Wirkung von Furosemid","volume":"284","author":"Deetjen","year":"1965","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1038\/ki.1992.359_bb0165","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1152\/ajplegacy.1970.218.1.292","article-title":"Effect of furosemide on Na+ and K+ transport studied by microperfusion of the rat nephron","volume":"218","author":"Morgan","year":"1970","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0170","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1152\/ajplegacy.1973.225.1.119","article-title":"Furosemide effect on isolated perfused tubules","volume":"225","author":"Burg","year":"1973","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0175","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/BF01063936","article-title":"Evidence for electroneutral sodium chloride cotransport in the cortical thick ascending limb of Henle's loop of rabbit kidney","volume":"396","author":"Greger","year":"1983","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1038\/ki.1992.359_bb0180","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF01063937","article-title":"Properties of the lumen membrane of the cortical thick ascending limb of Henle's loop of rabbit kidney","volume":"396","author":"Greger","year":"1983","journal-title":"Pfl\u00fcgers Arch"},{"issue":"II","key":"10.1038\/ki.1992.359_bb0185","first-page":"1532","article-title":"Renal effects of torasemide in the rat. Clearance and micropuncture studies","volume":"35","author":"Hermes","year":"1985","journal-title":"Drug Res"},{"key":"10.1038\/ki.1992.359_bb0190","first-page":"F847","article-title":"Factors affecting the ratio of different organic osmolytes in renal medullary cells","volume":"259","author":"Moriyama","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0195","first-page":"F962","article-title":"Hypotonic cell volume regulation in mouse medullary thick ascending limb: effects of ADH","volume":"255","author":"Hebert","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1992.359_bb0200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00652518","article-title":"Chloride activity in cells of isolated perfused cortical thick ascending limbs of rabbit kidney","volume":"399","author":"Greger","year":"1983","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1038\/ki.1992.359_bb0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF01108308","article-title":"Effects of inhibition of chloride transport on intracellular sodium activity in distal amphibian nephron","volume":"394","author":"Oberleithner","year":"1982","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1038\/ki.1992.359_bb0210","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1152\/physrev.1980.60.3.864","article-title":"Sodium and potassium ion pump in the kidney tubules","volume":"60","author":"J\u00f8rgensen","year":"1980","journal-title":"Physiol Rev"},{"key":"10.1038\/ki.1992.359_bb0215","first-page":"F244","article-title":"A potassium channel in the apical membrane of rabbit thick ascending limb of Henle's loop","volume":"258","author":"Wang","year":"1990","journal-title":"Am J Physiol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815577880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815577880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T22:02:39Z","timestamp":1635544959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815577880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,10]]}},"alternative-id":["S0085253815577880"],"URL":"https:\/\/doi.org\/10.1038\/ki.1992.359","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1992,10]]}}}