{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:08:11Z","timestamp":1784099291961,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1993,6,1]],"date-time":"1993-06-01T00:00:00Z","timestamp":738892800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":8224,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1993,6]]},"DOI":"10.1038\/ki.1993.181","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T06:57:12Z","timestamp":1180076232000},"page":"1286-1297","source":"Crossref","is-referenced-by-count":9,"title":["ADH resistance of LLC-PK1 cells caused by overexpression of cAMP-phosphodiesterase type-IV"],"prefix":"10.1016","volume":"43","author":[{"given":"Mario","family":"Yamaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josie M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes V.","family":"Swinnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Dousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1993.181_bb0010","series-title":"Cyclic Nucleotide Phosphodiesterases: Structure, Regulation and Drug Action","first-page":"3","article-title":"Multiple phosphodiesterase isoenzymes; background, nomenclature and implications","author":"Beavo","year":"1990"},{"key":"10.1038\/ki.1993.181_bb0015","first-page":"1","article-title":"Multiple isozymes of cyclic nucleotide phosphodiesterase","volume":"22","author":"Beavo","year":"1988","journal-title":"Adv Sec Mess Phosphoprotein Res"},{"key":"10.1038\/ki.1993.181_bb0020","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0165-6147(90)90066-H","article-title":"Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of seletive inhibitors","volume":"11","author":"Beavo","year":"1990","journal-title":"Trend Pharmacol Sci"},{"key":"10.1038\/ki.1993.181_bb0025","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1210\/edrv-12-3-218","article-title":"Hormonal regulation of cyclic nucleotide phosphodiesterases","volume":"12","author":"Conti","year":"1991","journal-title":"Endocr Rev"},{"key":"10.1038\/ki.1993.181_bb0030","first-page":"87","article-title":"Structure and regulation of the rat high-affinity cyclic AMP phosphodiesterases","volume":"25","author":"Conti","year":"1992"},{"key":"10.1038\/ki.1993.181_bb0035","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0165-6147(91)90484-A","article-title":"Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes","volume":"12","author":"Nicholson","year":"1991","journal-title":"Trend Pharmacol Sci"},{"key":"10.1038\/ki.1993.181_bb0040","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1172\/JCI111072","article-title":"Concentrating defect in the adrenalectomized rat","volume":"72","author":"Jackson","year":"1983","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1993.181_bb0045","first-page":"F345","article-title":"Role of cAMP-phosphodiesterase isozymes in pathogenesis of murine nephrogenic diabetes insipidus","volume":"261","author":"Homma","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1993.181_bb0050","first-page":"F640","article-title":"Induction of intramembranous particle clusters in mice with nephrogenic diabetes insipidus","volume":"261","author":"Coffey","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1993.181_bb0055","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1210\/endo-129-1-287","article-title":"High activity of low-Michaelis-Menten constant 3\u2032,5\u2032-cyclic adenosine monophosphate-phosphodiesterase isozymes in renal inner medulla of mice with hereditary nephrogenic diabetes insipidus","volume":"129","author":"Takeda","year":"1991","journal-title":"Endocrinology"},{"key":"10.1038\/ki.1993.181_bb0060","first-page":"753","article-title":"Cellular action of vasopressin in medullary tubules of mice with hereditary nephrogenic diabetes insipidus","volume":"54","author":"Jackson","year":"1980","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1993.181_bb0065","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1021\/jm50001a001","article-title":"A new generation of phosphodiesterase inhibitors: Multiple molecular forms of phosphodiesterase and the potential for drug selectivity","volume":"28","author":"Weishaar","year":"1985","journal-title":"J Med Chem"},{"key":"10.1038\/ki.1993.181_bb0070","doi-asserted-by":"crossref","first-page":"14383","DOI":"10.1016\/S0021-9258(18)98696-5","article-title":"Attenuation of cAMP-mediated responses in MA-10 Leydig tumor cells by genetic manipulation of a cAMP-phosphodiesterase","volume":"266","author":"Swinnen","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1993.181_bb0075","doi-asserted-by":"crossref","first-page":"8197","DOI":"10.1073\/pnas.86.21.8197","article-title":"The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP","volume":"86","author":"Swinnen","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1993.181_bb0080","first-page":"2678","article-title":"Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase","volume":"10","author":"Livi","year":"1990","journal-title":"Mol Cell Biol"},{"key":"10.1038\/ki.1993.181_bb0085","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.1016\/S0021-9258(19)39439-6","article-title":"Cyclic AMP responses are suppressed in mammalian cells expressing the yeast low Km cAMP-phosphodiesterase gene","volume":"265","author":"Van Lookeren Campagne","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1993.181_bb0090","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/BF02797469","article-title":"The origin and characteristics of a pig kidney cell strain, LLC-PK1","volume":"12","author":"Hull","year":"1976","journal-title":"In Vitro"},{"key":"10.1038\/ki.1993.181_bb0095","doi-asserted-by":"crossref","first-page":"9796","DOI":"10.1016\/S0021-9258(19)68693-X","article-title":"Regulation of vasopressin-sensitive adenylate cyclase by calmodulin","volume":"256","author":"Ausiello","year":"1981","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1993.181_bb0100","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1042\/bj1860773","article-title":"Modulation of cyclic AMP-dependent protein kinase by vasopressin and calcitonin in cultured porcine renal LLC-PK1 cells","volume":"186","author":"Ausiello","year":"1980","journal-title":"Biochem J"},{"key":"10.1038\/ki.1993.181_bb0105","first-page":"38","article-title":"Formation of endothelium-derived relaxing factor in porcine kidney epithelial LLC-PK1 cells: An intra- and intercellular messenger for activation of soluble guanylate cyclase","volume":"256","author":"Ishii","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/ki.1993.181_bb0110","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1210\/endo-122-4-1478","article-title":"Atrial natriuretic peptide, oxytocin, and vasopressin increase guanosine 3\u2032,5\u2032-monophosphate in LLC-PK1 kidney epithelial cells","volume":"122","author":"Leitman","year":"1988","journal-title":"Endocrinology"},{"key":"10.1038\/ki.1993.181_bb0115","series-title":"Kidney Int","first-page":"88","article-title":"Isozymes of cyclic-3\u2032,5\u2032-nucleotide phosphodiesterases in renal epithelial LLC-PK1 cells","author":"Rassier","year":"1992"},{"key":"10.1038\/ki.1993.181_bb0120","doi-asserted-by":"crossref","first-page":"5325","DOI":"10.1073\/pnas.86.14.5325","article-title":"Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: Evidence for a family of genes","volume":"86","author":"Swinnen","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1993.181_bb0125","series-title":"Current Protocols in Molecular Biology","first-page":"901","article-title":"Introduction of DNA into mammalian cells","author":"Ausubel","year":"1990"},{"issue":"R31","key":"10.1038\/ki.1993.181_bb0130","first-page":"F957","article-title":"Cyclic 3\u2032,5\u2032-nucleotide diesterases in dynamics of cAMP and cGMP in rat collecting duct cells","volume":"262","author":"Yamaki","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1993.181_bb0135","first-page":"327","article-title":"Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter","volume":"1","author":"Southern","year":"1982","journal-title":"J Mol Appl Genet"},{"key":"10.1038\/ki.1993.181_bb0140","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/ki.1978.149","article-title":"Cyclic nucleotide phosphodiesterases in glomeruli of rat renal cortex","volume":"14","author":"Torres","year":"1978","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1993.181_bb0145","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1038\/ki.1993.181_bb0150","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1172\/JCI109254","article-title":"Modulation of cyclic nucleotides in isolated rat glomeruli: Role of histamine, carbamylcholine, parathyroid hormone and angiotensin-II","volume":"62","author":"Torres","year":"1978","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1993.181_bb0155","first-page":"708","article-title":"Effects of dexamethasone on cyclic nucleotide accumulation in glomeruli","volume":"94","author":"Abboud","year":"1979","journal-title":"J Lab Clin Med"},{"key":"10.1038\/ki.1993.181_bb0160","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1993.181_bb0165","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ki.1974.37","article-title":"Effects of demethylchlortetracycline on cellular action of antidiuretic hormone in vitro","volume":"5","author":"Dousa","year":"1974","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1993.181_bb0170","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczyviski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1038\/ki.1993.181_bb0175","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1073\/pnas.81.7.1991","article-title":"Genomic sequencing","volume":"81","author":"Church","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1993.181_bb0180","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1021\/jm00140a008","article-title":"Inhibition of separated forms of cyclic nucleotide phosphodiesterase from pig coronary arteries by 1,3-disubstituted and 1,3,8-trisubstituted xanthines","volume":"24","author":"Wells","year":"1981","journal-title":"J Med Chem"},{"key":"10.1038\/ki.1993.181_bb0185","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0076-6879(88)59045-6","article-title":"Assay of cyclic nucleotide phosphodiesterase using radiolabeled and fluorescent substrates","author":"Kincaid","year":"1988"},{"key":"10.1038\/ki.1993.181_bb0190","doi-asserted-by":"crossref","first-page":"18370","DOI":"10.1016\/S0021-9258(18)55280-7","article-title":"Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell","volume":"266","author":"Swinnen","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1993.181_bb0195","first-page":"7","article-title":"Rat homologs of the Drosophila dunce gene code for cyclic AMP phosphodiesterases sensitive to rolipram and RO 20-1724","volume":"37","author":"Henkel-Tigges","year":"1990","journal-title":"Mol Pharmacol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815580629?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815580629?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T22:17:38Z","timestamp":1635545858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815580629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,6]]}},"alternative-id":["S0085253815580629"],"URL":"https:\/\/doi.org\/10.1038\/ki.1993.181","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1993,6]]}}}