{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:52:46Z","timestamp":1779299566321,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1995,4,1]],"date-time":"1995-04-01T00:00:00Z","timestamp":796694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":7564,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1995,4]]},"DOI":"10.1038\/ki.1995.170","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T17:08:07Z","timestamp":1179767287000},"page":"1199-1204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["A COL4A3 gene mutation and post-transplant anti-\u03b13(IV) collagen alloantibodies in Alport syndrome"],"prefix":"10.1016","volume":"47","author":[{"given":"Raghu","family":"Kalluri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.P.","family":"van den Heuvel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.J.M.","family":"Smeets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.H.","family":"Schroder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.H.","family":"Lemmink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Boutaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric G.","family":"Neilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Billy G.","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1995.170_bb0010","first-page":"617","author":"Atkins","year":"1988"},{"key":"10.1038\/ki.1995.170_bb0015","first-page":"249","article-title":"Mapping of the Alport syndrome to the long arm of the X chromosome","volume":"42","author":"Atkin","year":"1988","journal-title":"Am J Hum Genet"},{"key":"10.1038\/ki.1995.170_bb0020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/ki.1993.8","article-title":"Molecular genetics of Alport syndrome","volume":"43","author":"Tryggvason","year":"1993","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.170_bb0025","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/ki.1985.63","article-title":"Genetic heterogeneity of Alport syndrome","volume":"27","author":"Feingold","year":"1985","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.170_bb0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0888-7543(91)90215-Z","article-title":"Single base mutation in alpha 5(IV) collagen chain gene converting a conserved cysteine to serine in Alport syndrome","volume":"9","author":"Zhou","year":"1991","journal-title":"Genomics"},{"key":"10.1038\/ki.1995.170_bb0035","doi-asserted-by":"crossref","first-page":"12475","DOI":"10.1016\/S0021-9258(18)42301-0","article-title":"Complete amino acid sequence of the human alpha 5(IV) collagen chain and identification of a single base mutation in exon 29 from the 3\u2032 end converting glycine-521 in the collagenous domain to cysteine in an Alport syndrome patient","volume":"267","author":"Zhou","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.170_bb0040","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.2349482","article-title":"Identification of mutations in the COL4A5 collagen gene in Alport syndrome","volume":"248","author":"Barker","year":"1990","journal-title":"Science"},{"key":"10.1038\/ki.1995.170_bb0045","doi-asserted-by":"crossref","unstructured":"H.H. Lemmink T. Mochizuki L.P. von Heuvel C.H. Schroder A. Barrientos L.A.H. Monnens B.A. von Oost H.G. Brunner S.T. Reeders H.J.M. Smeets Mutations in the type IV alpha-3 (COL4A3) gene in the autosomal recessive alport syndrome Hum Mol Genet (in press)","DOI":"10.1093\/hmg\/3.8.1269"},{"key":"10.1038\/ki.1995.170_bb0050","unstructured":"T. Mochizuki H.H. Lemmink M. Mariyama C. Antignac M-C. Gubler Y. Pirson C. Verelien-Dumouth B. Chan H. Schroder H.J. Smeets S.T. Reeders Identification of mutations in the \u03b13(IV) and \u03b14(IV) collagen genes in autosomal recessive Alport syndrome Nature Genet (in press)"},{"key":"10.1038\/ki.1995.170_bb0055","first-page":"508","article-title":"Posttransplant antiglomeular basement membrane nephritis in related males with Alport syndrome","volume":"116","author":"Kashtan","year":"1990","journal-title":"J Lab Clin Med"},{"key":"10.1038\/ki.1995.170_bb0060","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ki.1992.276","article-title":"The pathogenesis of Alport syndrome involves type IV collagen molecules containing the alpha 3(IV) chain: Evidence from anti-GBM nephritis after renal transplantation","volume":"42","author":"Hudson","year":"1992","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.170_bb0065","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1172\/JCI112658","article-title":"Nephritogenic antigen determinants in epidermal and renal basement membrane of kindreds with Alport-type familial nephritis","volume":"78","author":"Kashtan","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.170_bb0070","first-page":"613","article-title":"Herediary nephritis: Immunoblotting studies of the glomerular basement membrane","volume":"60","author":"Savage","year":"1989","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1995.170_bb0075","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/BF00850217","article-title":"The development of anti-glomerular basement membrane nephritis in two children with Alport's syndrome after renal transplantation: Characterization of the antibody target","volume":"3","author":"vd Heuvel","year":"1989","journal-title":"Pediatr Nephrol"},{"key":"10.1038\/ki.1995.170_bb0080","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/ki.1994.96","article-title":"COL4A5 gene deletion and production of post-transplant anti-\u03b13(IV) alloantibodies in Alport syndrome","volume":"45","author":"Kalluri","year":"1993","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.170_bb0085","doi-asserted-by":"crossref","first-page":"15318","DOI":"10.1016\/S0021-9258(18)98618-7","article-title":"Glomerular basement membrane: Identification of dimeric subunits of the noncollagenous domain (hexamer) of collagen IV and the Goodpasture antigen","volume":"266","author":"Gunwar","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.170_bb0090","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.1016\/S0021-9258(18)52887-8","article-title":"Specificity of Goodpasture autoantibodies for the recombinant noncollagenous domains of human type IV collagen","volume":"268","author":"Neilson","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.170_bb0095","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1038\/ki.1995.170_bb0100","doi-asserted-by":"crossref","first-page":"10481","DOI":"10.1016\/S0021-9258(19)81541-7","article-title":"Structural heterogeneity of the noncollagenous domain of basement membrane collagen","volume":"263","author":"Langeveld","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.170_bb0105","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/03008209009152147","volume":"24","author":"Timoneda","year":"1990","journal-title":"Connect Tis Res"},{"key":"10.1038\/ki.1995.170_bb0110","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0003-2697(81)90281-5","article-title":"\u201cWestern blotting\u201d: Electrophoretic transfer of proteins from sodium dodecyl-sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein","volume":"112","author":"Burnette","year":"1981","journal-title":"Anal Biochem"},{"key":"10.1038\/ki.1995.170_bb0115","doi-asserted-by":"crossref","first-page":"8564","DOI":"10.1016\/S0021-9258(17)39510-8","article-title":"Physical and immunochemical studies of the globular domain of type IV collagen: Cryptic properties of the Goodpasture antigen","volume":"260","author":"Wieslander","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.170_bb0120","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1073\/pnas.91.13.6201","article-title":"The \u03b13 (IV) chain of type IV collagen induces autoimmune Goodpasture syndrome","volume":"91","author":"Kalluri","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1995.170_bb0125","doi-asserted-by":"crossref","first-page":"24018","DOI":"10.1016\/S0021-9258(18)54385-4","article-title":"Goodpasture syndrome: Localization of the epitope for the autoantibodies to the carboxylterminal region of the \u03b13(IV) chain of basement membrane collagen","volume":"266","author":"Kalluri","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.170_bb0130","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1016\/S0021-9258(19)50639-1","article-title":"Evidence for seperate networks of classical and novel membrane collagen: characerization of \u03b13(IV)-Alport antigen heterodimer","volume":"267","author":"Kleppel","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.170_bb0135","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1038\/ki.1992.235","article-title":"Immunochemical studies of Alport antigen","volume":"41","author":"Kleppel","year":"1992","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.170_bb0140","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1038\/ki.1994.196","article-title":"A monoclonal antibody marker for Alport syndrome identifies the Alport antigen as the \u03b15 (IV) chain of type IV collagen","volume":"46","author":"Ding","year":"1994","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.170_bb0145","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00041552-199403000-00001","article-title":"Overcoming tolerance in autoimmune renal disease: Commentary","volume":"3","author":"Heeger","year":"1994","journal-title":"Cur Opin Nephrol Hypertens"},{"key":"10.1038\/ki.1995.170_bb0150","doi-asserted-by":"crossref","first-page":"26033","DOI":"10.1016\/S0021-9258(19)74270-7","article-title":"Type IV collagen: Structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyoma tosis","volume":"268","author":"Hudson","year":"1993","journal-title":"J Biol Chem"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815589345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815589345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T10:46:56Z","timestamp":1698749216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815589345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,4]]}},"alternative-id":["S0085253815589345"],"URL":"https:\/\/doi.org\/10.1038\/ki.1995.170","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1995,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A COL4A3 gene mutation and post-transplant anti-\u03b13(IV) collagen alloantibodies in Alport syndrome","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/ki.1995.170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1995 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}