{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:08:33Z","timestamp":1761764913465},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":7464,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1995,7]]},"DOI":"10.1038\/ki.1995.278","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T13:46:33Z","timestamp":1179755193000},"page":"146-154","source":"Crossref","is-referenced-by-count":29,"title":["Platelet-derived growth factor A-chain expression in developing and mature human kidneys and in Wilms' tumor"],"prefix":"10.1016","volume":"48","author":[{"given":"Charles E.","family":"Alpers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly L.","family":"Hudkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe C.","family":"Rutledge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1995.278_bb0010","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(86)90733-6","article-title":"The biology of PDGF","volume":"46","author":"Ross","year":"1986","journal-title":"Cell"},{"key":"10.1038\/ki.1995.278_bb0015","first-page":"74","article-title":"Platelet-derived growth factor in vivo","volume":"5","author":"Raines","year":"1993"},{"key":"10.1038\/ki.1995.278_bb0020","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1073\/pnas.86.3.1056","article-title":"Platelet-derived growth factor synthesis in mesangial cells: Induction by multiple peptide mitogens","volume":"86","author":"Silver","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1995.278_bb0025","first-page":"F674","article-title":"Mesangial cells express PDGF mRNAs and proliferate in response to PDGF","volume":"255","author":"Shultz","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1995.278_bb0030","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-2249.1991.tb05819.x","article-title":"Mitogenic effect of platelet-derived growth factor in human glomerular mesangial cells: Modulation and\/or suppression by inflammatory cytokines","volume":"86","author":"Floege","year":"1991","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/ki.1995.278_bb0035","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/ki.1993.39","article-title":"Growth factors in glomerulonephritis","volume":"43","author":"Abboud","year":"1993","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.278_bb0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1681\/ASN.V42119","article-title":"Role of platelet-derived growth factor in glomerular disease","volume":"4","author":"Johnson","year":"1993","journal-title":"JASN"},{"key":"10.1038\/ki.1995.278_bb0045","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/ki.1994.230","article-title":"The glomerular response to injury: Progression or resolution","volume":"45","author":"Johnson","year":"1994","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.278_bb0050","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ki.1992.300","article-title":"Developmental patterns of PDGF B-chain, PDGF-receptor, and \u03b1 actin expression in human glomerulogenesis","volume":"42","author":"Alpers","year":"1992","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.278_bb0055","first-page":"160","article-title":"Platelet-derived growth factor expression in mesangial proliferative glomerulonephritis","volume":"64","author":"Gesualdo","year":"1991","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1995.278_bb0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/ndt\/6.1.11","article-title":"Platelet-derived growth factor mesangial deposits in mesangial IgA glomerulonephritis","volume":"6","author":"Nakajima","year":"1991","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.1995.278_bb0065","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1172\/JCI117348","article-title":"Expression of platelet-derived growth factor receptors in normal and diseased human kidney: An immunohistochemistry and in situ hybridization study","volume":"94","author":"Gesualdo","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.278_bb0070","doi-asserted-by":"crossref","first-page":"6560","DOI":"10.1073\/pnas.88.15.6560","article-title":"Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat: An effect mediated by platelets and complement","volume":"88","author":"Iida","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1995.278_bb0075","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0303-7207(93)90271-K","article-title":"Platelet derived growth factor-A chain gene expression in cultured mesangial cells: Regulation by phorbol ester at the level of mRNA abundance, transcription and mRNA stability","volume":"91","author":"Bhandari","year":"1993","journal-title":"Mol Cell Endocrinol"},{"key":"10.1038\/ki.1995.278_bb0080","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/bj2970385","article-title":"Platelet-derived growth factor (PDGF) BB homodimer regulates PDGF A- and PDGF B-chain gene transcription in human mesangial cells","volume":"297","author":"Bhandari","year":"1994","journal-title":"Biochem J"},{"key":"10.1038\/ki.1995.278_bb0085","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1073\/pnas.86.3.1056","article-title":"Platelet-derived growth factor (PDGF) synthesis in mesangial cells: Induction by multiple peptide mitogens","volume":"86","author":"Silver","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1995.278_bb0090","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1021\/bi00453a022","article-title":"Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets","volume":"29","author":"Hart","year":"1990","journal-title":"Biochem"},{"key":"10.1038\/ki.1995.278_bb0095","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1083\/jcb.103.6.2787","article-title":"A monoclonal antibody against \u03b1-smooth muscle actin: A new probe for smooth muscle differentiation","volume":"103","author":"Skalli","year":"1986","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.1995.278_bb0100","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1172\/JCI115089","article-title":"Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis: \u03b1-smooth muscle actin is a marker of mesangial cell proliferation","volume":"87","author":"Johnson","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.278_bb0105","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1172\/JCI116670","article-title":"Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques: Implications for the mode of progression of advanced coronary atherosclerosis","volume":"92","author":"O'Brien","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.278_bb0110","first-page":"309","article-title":"Monoclonal antibodies to intermediate filaments proteins of human cells. II. Distribution of filament proteins in normal human tissues","volume":"114","author":"Gown","year":"1984","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.1995.278_bb0115","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/320695a0","article-title":"cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines","volume":"320","author":"Betsholtz","year":"1986","journal-title":"Nature"},{"key":"10.1038\/ki.1995.278_bb0120","series-title":"Organogenesis of the Kidney","author":"Saxen","year":"1987"},{"key":"10.1038\/ki.1995.278_bb0125","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1096\/fasebj.3.10.2666230","article-title":"Developmentally regulated conversion of mesenchyme to epithelium","volume":"3","author":"Ekblom","year":"1989","journal-title":"FASEB J"},{"key":"10.1038\/ki.1995.278_bb0130","first-page":"375","article-title":"Glomerulogenesis in the developing kidney","volume":"11","author":"Abrahamsom","year":"1991","journal-title":"Semin Nephrol"},{"key":"10.1038\/ki.1995.278_bb0135","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1096\/fasebj.7.10.8393820","article-title":"The WT1 Wilms tumor gene product: A developmentally regulated transcriptional factor in the kidney that functions as a tumor suppressor","volume":"7","author":"Rauscher","year":"1993","journal-title":"FASEB J"},{"key":"10.1038\/ki.1995.278_bb0140","doi-asserted-by":"crossref","first-page":"10984","DOI":"10.1073\/pnas.89.22.10984","article-title":"Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms Tumor Suppressor WT1","volume":"89","author":"Gashler","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1995.278_bb0145","doi-asserted-by":"crossref","first-page":"21999","DOI":"10.1016\/S0021-9258(18)41624-9","article-title":"The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene","volume":"267","author":"Wang","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.278_bb0150","doi-asserted-by":"crossref","first-page":"9172","DOI":"10.1016\/S0021-9258(18)98329-8","article-title":"The Wilms' tumor gene product WT1 activates or suppresses transcription through separate functional domains","volume":"268","author":"Wang","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.278_bb0155","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1002\/1097-0142(197805)41:5<1937::AID-CNCR2820410538>3.0.CO;2-U","article-title":"Histopathology and prognosis of Wilms tumors: Results from the First National Wilms' tumor study","volume":"41","author":"Beckwith","year":"1978","journal-title":"Cancer"},{"key":"10.1038\/ki.1995.278_bb0160","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/346194a0","article-title":"The candidate Wilms' tumour gene is involved in genitourinary development","volume":"346","author":"Pritchard-Jones","year":"1990","journal-title":"Nature"},{"key":"10.1038\/ki.1995.278_bb0165","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1242\/dev.119.4.1329","article-title":"Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues","volume":"119","author":"Mundlos","year":"1993","journal-title":"Development"},{"key":"10.1038\/ki.1995.278_bb0170","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0092-8674(93)90515-R","article-title":"WT-1 is required for early kidney development","volume":"74","author":"Kreidberg","year":"1993","journal-title":"Cell"},{"key":"10.1038\/ki.1995.278_bb0175","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1083\/jcb.111.5.2149","article-title":"PDGF ligand and receptor gene expression during repair of arterial injury","volume":"111","author":"Majesky","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.1995.278_bb0180","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/01.RES.75.3.410","article-title":"Does platelet-derived growth factor-A chain stimulate proliferation of arterial mesenchymal cells in human atherosclerotic plaques","volume":"75","author":"Rekhter","year":"1994","journal-title":"Circ Res"},{"key":"10.1038\/ki.1995.278_bb0185","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/ki.1993.45","article-title":"PDGF-receptor localizes to mesangial, parietal epithelial, and interstitial cells in human and primate kidneys","volume":"43","author":"Alpers","year":"1993","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.278_bb0190","first-page":"637","article-title":"Visceral glomerular epithelial cells can proliferate in vivo and synthesize PDGF B-chain","volume":"142","author":"Floege","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.1995.278_bb0195","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/ki.1992.441","article-title":"Vascular permeability factor mRNA and protein expression in human kidney","volume":"42","author":"Brown","year":"1992","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.278_bb0200","first-page":"33","article-title":"Growth factors and the glomerulus: Relations between development and injury","volume":"24","author":"Alpers","year":"1995","journal-title":"Adv Nephrol"},{"key":"10.1038\/ki.1995.278_bb0205","first-page":"156A","article-title":"Localization of basic fibroblast growth factor (bFGF) and its receptor (FGFR1. flg) in fetal, mature, and transplanted human kidneys","volume":"70","author":"Alpers","year":"1994","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1995.278_bb0210","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.2479986","article-title":"Vascular endothelial growth factor is a secreted angiogenic mitogen","volume":"246","author":"Leung","year":"1989","journal-title":"Science"},{"key":"10.1038\/ki.1995.278_bb0215","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.2479987","article-title":"Vascular permeability factor, an endothelial cell mitogen related to PDGF","volume":"246","author":"Keck","year":"1989","journal-title":"Science"},{"key":"10.1038\/ki.1995.278_bb0220","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3109\/08977199209046408","article-title":"Platelet-derived growth factor is angiogenic in vivo","volume":"7","author":"Risau","year":"1992","journal-title":"Growth Factors"},{"key":"10.1038\/ki.1995.278_bb0225","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/01.ATV.9.3.269","article-title":"Biological and biochemical properties of fibroblast growth factors","volume":"9","author":"Klagsbrun","year":"1989","journal-title":"Arteriosclerosis"},{"key":"10.1038\/ki.1995.278_bb0230","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1016\/S0021-9258(19)49853-0","article-title":"Angiogenesis","volume":"267","author":"Judah","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.278_bb0235","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1172\/JCI113671","article-title":"Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization","volume":"82","author":"Wilcox","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.278_bb0240","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1073\/pnas.85.8.2810","article-title":"Platelet-derived growth factor gene expression in human atherosclerotic plaques and normal artery wall","volume":"85","author":"Barrett","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1995.278_bb0245","first-page":"157A","article-title":"Platelet-derived growth factor (PDGF) A-chain expression in normal and rejecting renal arteries","volume":"72","author":"Alpers","year":"1995","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1995.278_bb0250","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1101\/gad.8.16.1875","article-title":"Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities","volume":"8","author":"Leveen","year":"1994","journal-title":"Gene Develop"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815590509?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815590509?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T23:03:11Z","timestamp":1635548591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815590509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["S0085253815590509"],"URL":"https:\/\/doi.org\/10.1038\/ki.1995.278","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1995,7]]}}}