{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:21:02Z","timestamp":1791562862253,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1995,10,1]],"date-time":"1995-10-01T00:00:00Z","timestamp":812505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":7372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1995,10]]},"DOI":"10.1038\/ki.1995.414","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T14:46:22Z","timestamp":1179758782000},"page":"1298-1307","source":"Crossref","is-referenced-by-count":229,"title":["Induction of heme oxygenase in toxic renal injury: A protective role in cisplatin nephrotoxicity in the rat"],"prefix":"10.1016","volume":"48","author":[{"given":"Anupam","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Balla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawed","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Croatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl A.","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1995.414_bb0010","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.61.2.748","article-title":"The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase","volume":"61","author":"Tenhunen","year":"1968","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1995.414_bb0015","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1096\/fasebj.2.10.3290025","article-title":"Heme oxygenase: Function, multiplicity, regulatory mechanisms and clinical application","volume":"2","author":"Maines","year":"1988","journal-title":"FASEB J"},{"key":"10.1038\/ki.1995.414_bb0020","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0020-711X(88)90093-6","article-title":"The physiological significance of heme oxygenase","volume":"20","author":"Abraham","year":"1988","journal-title":"Int J Biochem"},{"key":"10.1038\/ki.1995.414_bb0025","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1073\/pnas.86.1.99","article-title":"Heme oxygenase is the major 32-kDA stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite","volume":"86","author":"Keyse","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1995.414_bb0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/10715769009148577","article-title":"Induction of haem oxygenase as a defense against oxidative stress","volume":"9","author":"Stocker","year":"1990","journal-title":"Free Rad Res Commun"},{"key":"10.1038\/ki.1995.414_bb0035","first-page":"974","article-title":"Induction of heme oxygenase: A general response to oxidant stress in cultured mammalian cells","volume":"51","author":"Applegate","year":"1991","journal-title":"Cancer Res"},{"key":"10.1038\/ki.1995.414_bb0040","first-page":"461","article-title":"The functional significance of the induction of heme oxygenase by oxidative stress","volume":"123","author":"Nath","year":"1994","journal-title":"J Lab Clin Med"},{"key":"10.1038\/ki.1995.414_bb0045","first-page":"136","article-title":"Pathobiology of heme interaction with the erythrocyte membrane","volume":"26","author":"Hebbel","year":"1989","journal-title":"Semin Hematol"},{"key":"10.1038\/ki.1995.414_bb0050","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1172\/JCI115847","article-title":"Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat","volume":"90","author":"Nath","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.414_bb0055","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.3029864","article-title":"Bilirubin is an antioxidant of possible physiologic significance","volume":"235","author":"Stocker","year":"1987","journal-title":"Science"},{"key":"10.1038\/ki.1995.414_bb0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0167-4889(94)90067-1","article-title":"Heme oxygenase and oxidative stress: Evidence of involvement of bilirubin as physiological protector against oxidative damage","volume":"1223","author":"Llesuy","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/ki.1995.414_bb0065","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1172\/JCI115980","article-title":"Mitochondrial oxidative stress after carbon monoxide hypoxia in rat brain","volume":"90","author":"Zhang","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.414_bb0070","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0021-5198(19)43504-X","article-title":"Stimulatory effect of cisplatin on production of lipid peroxidation in renal tissues","volume":"43","author":"Sugihara","year":"1987","journal-title":"Jpn J Pharmacol"},{"key":"10.1038\/ki.1995.414_bb0075","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0300-483X(88)90143-6","article-title":"Cisplatin-induced lipid peroxidation and decrease of gluconeogenesis in rat kidney cortex: Different effects of antioxidants and radical scavengers","volume":"51","author":"Hannemann","year":"1988","journal-title":"Toxicology"},{"key":"10.1038\/ki.1995.414_bb0080","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0378-4274(92)90033-G","article-title":"Mechanism of the increase in lipid peroxide induced by cisplatin in the kidneys of rats","volume":"62","author":"Sadzuka","year":"1992","journal-title":"Toxicol Lett"},{"key":"10.1038\/ki.1995.414_bb0085","first-page":"1421","article-title":"Differential actions of cisplatin on renal proximal tubule and inner medullary collecting duct cells","volume":"265","author":"Brady","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/ki.1995.414_bb0090","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1006\/bbrc.1994.2306","article-title":"Cisplatin generates superoxide anion by interaction with DNA in a cell-free system","volume":"203","author":"Masuda","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/ki.1995.414_bb0095","first-page":"267","article-title":"Amelioration of cis-platinum nephrotoxicity by orgotein (superoxide dismutase)","volume":"10","author":"McGinness","year":"1978","journal-title":"Physiol Chem Phys"},{"key":"10.1038\/ki.1995.414_bb0100","first-page":"557","article-title":"Protective effects of O-(\u03b2-hydroxyethyl)-rutoside on cis-platinuminduced acute renal failure in the rat","volume":"55","author":"Dobyan","year":"1986","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1995.414_bb0105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/08860229309046144","article-title":"Role of glutathione for cisplatin nephrotoxicity in young and adult rats","volume":"15","author":"Appenroth","year":"1993","journal-title":"Renal Fail"},{"key":"10.1038\/ki.1995.414_bb0110","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1254\/jjp.57.259","article-title":"The iron chelator, deferoxamine, prevents cisplatin-induced lipid peroxidation in rat kidney cortical slices","volume":"57","author":"Kameyama","year":"1991","journal-title":"Jpn J Pharmacol"},{"key":"10.1038\/ki.1995.414_bb0115","doi-asserted-by":"crossref","first-page":"C495","DOI":"10.1152\/ajpcell.1987.253.4.C495","article-title":"Gentamicin enhanced production of hydrogen peroxide by renal cortical mitochondria","volume":"253","author":"Walker","year":"1987","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1995.414_bb0120","first-page":"F158","article-title":"In vivo generation of hydrogen peroxide by rat kidney cortex and glomeruli","volume":"256","author":"Guidet","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1995.414_bb0125","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1172\/JCI113325","article-title":"Evidence suggesting a role for hydroxyl radical in Gentamicin-induced acute renal failure in rats","volume":"81","author":"Walker","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.414_bb0130","first-page":"F425","article-title":"Mechanisms of protective effects of free radical scavengers on gentamicin-mediated nephropathy in rats","volume":"266","author":"Nakajima","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1995.414_bb0135","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1172\/JCI114824","article-title":"Induction of renal growth and injury in the intact rat kidney by dietary deficiency of antioxidants","volume":"86","author":"Nath","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.414_bb0140","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1172\/JCI115511","article-title":"Hydrogen peroxide-induced renal injury. A protective role for pyruvate in vitro and in vivo","volume":"88","author":"Salahudeen","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.414_bb0145","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1172\/JCI114546","article-title":"Effect of dietary protein on rat renin and angiotensinogen gene expression","volume":"85","author":"Rosenberg","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.414_bb0150","first-page":"154","article-title":"Loading and transfer control for Northern hybridization","volume":"12","author":"Correa-Rotter","year":"1992","journal-title":"Biotechniques"},{"key":"10.1038\/ki.1995.414_bb0155","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0021-9258(17)42488-4","article-title":"Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible","volume":"261","author":"Maines","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.414_bb0160","doi-asserted-by":"crossref","first-page":"18148","DOI":"10.1016\/S0021-9258(19)37165-0","article-title":"Ferritin: A cytoprotective antioxidant stratagem of endothelium","volume":"267","author":"Balla","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1995.414_bb0165","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3891\/acta.chem.scand.07-1284","article-title":"The molar light absorption of pyridine ferroprotoporphyrin (Pyridine Haemochromogen)","volume":"7","author":"Paul","year":"1953","journal-title":"Acta Chem Scand"},{"key":"10.1038\/ki.1995.414_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0003-2697(87)90643-9","article-title":"Simultaneous determination of hemes a, b, and c, from pyridine hemochrome spectra","volume":"161","author":"Berry","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1038\/ki.1995.414_bb0175","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"key":"10.1038\/ki.1995.414_bb0180","first-page":"351","article-title":"Glutathione peroxidase activity in selenium deficient rat liver","volume":"95","author":"Lawrence","year":"1976","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/ki.1995.414_bb0185","first-page":"673","article-title":"Catalase","volume":"2","author":"Aebi","year":"1974"},{"key":"10.1038\/ki.1995.414_bb0190","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/ki.1990.320","article-title":"Dietary Deficiency of antioxidants exacerbates ischemic injury in the rat kidney","volume":"38","author":"Nath","year":"1990","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1995.414_bb0195","first-page":"341","article-title":"Heme oxygenase is not expressed as a stress protein after renal ischemia","volume":"122","author":"Paller","year":"1993","journal-title":"J Lab Clin Med"},{"key":"10.1038\/ki.1995.414_bb0200","first-page":"301","article-title":"Drug-induced oxidative denaturation in red blood cells","volume":"26","author":"Stern","year":"1989","journal-title":"Semin Hematol"},{"key":"10.1038\/ki.1995.414_bb0205","series-title":"Contemporary Issues in Nephrology","article-title":"Functional consequences of induction of heme oxygenase","author":"Nath","year":"1989"},{"key":"10.1038\/ki.1995.414_bb0210","first-page":"F1181","article-title":"Mitochondrial injury: An early event in cisplatin toxicity to renal proximal tubules","volume":"258","author":"Brady","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1995.414_bb0215","first-page":"F991","article-title":"Mitochondrial alterations in cisplatin-induced acute renal failure","volume":"250","author":"Gordon","year":"1986","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1995.414_bb0220","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1042\/bj2370713","article-title":"Differential effect of cis-platinum (cis-diamminedichloro-platinum) on regulation of liver and kidney haem and haemoprotein metabolism. Possible involvement of gamma-glutamyl-cycle enzymes","volume":"237","author":"Maines","year":"1986","journal-title":"Biochem J"},{"key":"10.1038\/ki.1995.414_bb0225","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0165-6147(91)90544-3","article-title":"Does carbon monoxide have a physiological function","volume":"12","author":"Marks","year":"1991","journal-title":"Trends Pharmacol Sci"},{"key":"10.1038\/ki.1995.414_bb0230","first-page":"52","article-title":"Endothelial-dependent and independent vasodilatation involving cGMP: relaxation induced by nitric oxide, carbon monoxide and light","volume":"28","author":"Furchgott","year":"1991","journal-title":"Blood Vessels"},{"key":"10.1038\/ki.1995.414_bb0235","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1126\/science.7678352","article-title":"Carbon monoxide: A putative neural messenger","volume":"259","author":"Verma","year":"1993","journal-title":"Science"},{"key":"10.1038\/ki.1995.414_bb0240","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.1073\/pnas.91.22.10512","article-title":"Heme coordination of NO in NO synthase","volume":"91","author":"Wang","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1995.414_bb0245","first-page":"H655","article-title":"Role of endotheliumderived relaxing factor in regulation of renal hemodynamic responses","volume":"258","author":"Tolins","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1995.414_bb0250","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0272-6386(12)80170-3","article-title":"Nitric oxide in the kidney: Synthesis, localization, and function","volume":"24","author":"Bachmann","year":"1994","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.1995.414_bb0255","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/BF01649323","article-title":"The endothelial L-arginine\/nitric oxide pathway and the renal circulation","volume":"69","author":"Luscher","year":"1991","journal-title":"Klin Wochenschrift"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815591862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815591862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T23:10:10Z","timestamp":1635549010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815591862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["S0085253815591862"],"URL":"https:\/\/doi.org\/10.1038\/ki.1995.414","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}