{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:48:34Z","timestamp":1791316114635,"version":"4.3.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":7311,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1995,12]]},"DOI":"10.1038\/ki.1995.490","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T16:05:05Z","timestamp":1179763505000},"page":"1907-1911","source":"Crossref","is-referenced-by-count":68,"title":["U.K. Prospective Diabetes Study XV: Relationship of renin-angiotensin system gene polymorphisms with microalbuminuria in NIDDM"],"prefix":"10.1016","volume":"48","author":[{"given":"Christopher R.K.","family":"Dudley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Keavney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M.","family":"Stratton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Ratcliffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1995.490_bb0010","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1056\/NEJM198402093100605","article-title":"Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes","volume":"310","author":"Mogensen","year":"1984","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"10.1038\/ki.1995.490_bb0015","first-page":"S28","article-title":"Microalbuminuria in non-insulin-dependent diabetes","volume":"38","author":"Mogensen","year":"1992","journal-title":"Clin Nephrol"},{"key":"10.1038\/ki.1995.490_bb0020","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/BF00404096","article-title":"Familial predisposition to renal disease in two generations of Pima Indians with Type 2 (non-insulin-dependent) diabetes mellitus","volume":"33","author":"Pettitt","year":"1990","journal-title":"Diabetologia"},{"key":"10.1038\/ki.1995.490_bb0025","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1464-5491.1988.tb00966.x","article-title":"Non-insulin-dependent diabetes and renal replacement therapy","volume":"5","author":"Grenfell","year":"1987","journal-title":"Diabet Med"},{"key":"10.1038\/ki.1995.490_bb0030","first-page":"510","article-title":"Vasoactive peptides and the kidney","author":"Ballerman","year":"1991"},{"key":"10.1038\/ki.1995.490_bb0035","doi-asserted-by":"crossref","first-page":"577","DOI":"10.7326\/0003-4819-118-8-199304150-00001","article-title":"Long-term stabilizing effect of angiotensin-converting enzyme inhibition on plasma creatinine and on proteinuria in normotensive type II diabetic patients","volume":"118","author":"Ravid","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.1995.490_bb0040","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1001\/jama.1994.03510280037029","article-title":"Effect of captopril on progression to clinical proteinuria in patients with insulin-dependent diabetes mellitus and miroalbuminuria. European Microalbuminuria Captopril Study Group","volume":"271","author":"Viberti","year":"1994","journal-title":"JAMA"},{"key":"10.1038\/ki.1995.490_bb0045","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI114844","article-title":"An insertion\/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels","volume":"86","author":"Rigat","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1995.490_bb0050","first-page":"197","article-title":"Evidence from combined segregation and linkage analysis that a variant of the angiotensin 1-converting enzyme (ACE) gene controls plasma ACE levels","volume":"51","author":"Tiret","year":"1992","journal-title":"Am J Hum Genet"},{"key":"10.1038\/ki.1995.490_bb0055","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/359641a0","article-title":"Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction","volume":"359","author":"Cambien","year":"1992","journal-title":"Nature"},{"key":"10.1038\/ki.1995.490_bb0060","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1007\/BF00400584","article-title":"U.K. Prospective Diabetes Study (UKPDS) XIV: Association of ACE insertion\/deletion polymorphism with myocardial infarction in non-insulin dependent diabetes (NIDDM)","volume":"38","author":"Keavney","year":"1995","journal-title":"Diabetologia"},{"key":"10.1038\/ki.1995.490_bb0065","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2337\/diab.43.3.384","article-title":"Relationship between angiotensin 1 converting enzyme gene polymorphism, plasma levels, and diabetic complications","volume":"43","author":"Marre","year":"1994","journal-title":"Diabetes"},{"key":"10.1038\/ki.1995.490_bb0070","first-page":"376","article-title":"Functional genetic markers of the renin-angiotensin system and the risk of diabetic nephropathy in insulin-dependent diabetes melitus","volume":"5","author":"Fogarty","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.1995.490_bb0075","first-page":"383","article-title":"Association of the ACE gene polymorphism and diabetic nephropathy","volume":"5","author":"Schmidt","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.1995.490_bb0080","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0092-8674(92)90275-H","article-title":"Molecular basis of human hypertension: Role of angiotensinogen","volume":"71","author":"Jeunemaitre","year":"1992","journal-title":"Cell"},{"key":"10.1038\/ki.1995.490_bb0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/ng0593-59","article-title":"A molecular variant of angiotensinogen associated with preeclampsia","volume":"4","author":"Ward","year":"1993","journal-title":"Nat Genet"},{"key":"10.1038\/ki.1995.490_bb0090","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/BF00400195","article-title":"UK Prospective Diabetes Study (UKPDS) VIII. Study design, progress and performance","volume":"34","author":"UK Prospective Diabetes Study Group","year":"1991","journal-title":"Diabetologia"},{"key":"10.1038\/ki.1995.490_bb0095","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/jcp.40.4.465","article-title":"Simple immunoturbidimetric method for determining urinary albumin at low concentrations using a Cobas-Bio centrifugal analyser","volume":"40","author":"Kearney","year":"1987","journal-title":"J Clin Pathol"},{"key":"10.1038\/ki.1995.490_bb0100","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0009-8981(90)90114-8","article-title":"How should urinary cotinine concentrations be adjusted for urinary creatinine concentration","volume":"187","author":"Thompson","year":"1990","journal-title":"Clin Chim Acta"},{"key":"10.1038\/ki.1995.490_bb0105","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1464-5491.1994.tb02032.x","article-title":"UK Prospective Diabetes Study (UKPDS) XI: Biochemical risk factors in Type 2 diabetic patients at diagnosis compared with age-matched normal subjects","volume":"11","author":"UK Prospective Diabetes Study Group","year":"1994","journal-title":"Diabetic Med"},{"key":"10.1038\/ki.1995.490_bb0110","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1093\/nar\/20.6.1433-a","article-title":"PCR detection of the insertion\/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase)","volume":"20","author":"Rigat","year":"1992","journal-title":"Nucl Acid Res"},{"key":"10.1038\/ki.1995.490_bb0115","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1101\/gr.3.2.120","article-title":"Mistyping ACE heterozygotes","volume":"3","author":"Shanmugam","year":"1993","journal-title":"PCR Meth Appl"},{"key":"10.1038\/ki.1995.490_bb0120","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/hmg\/2.5.609","article-title":"Rapid detection of the hypertension-associated Met235-Thr allele of the human angiotensinogen gene","volume":"2","author":"Russ","year":"1993","journal-title":"Hum Mol Genet"},{"key":"10.1038\/ki.1995.490_bb0125","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1056\/NEJM199406093302301","article-title":"Linkage of the angiotensinogen gene to essential hypertension","volume":"330","author":"Caulfield","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1995.490_bb0130","first-page":"382","article-title":"Relationship between angiotensin I converting enzyme (ACE) gene polymorphism and renal hemodynamic dysfunction in insulin dependent diabetes mellitus","volume":"5","author":"Pei","year":"1994","journal-title":"J Am Soc Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815592624?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815592624?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T23:30:16Z","timestamp":1635550216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815592624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["S0085253815592624"],"URL":"https:\/\/doi.org\/10.1038\/ki.1995.490","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1995,12]]}}}