{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:06:25Z","timestamp":1792317985074,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":7280,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1996,1]]},"DOI":"10.1038\/ki.1996.26","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T12:37:27Z","timestamp":1179751047000},"page":"190-199","source":"Crossref","is-referenced-by-count":24,"title":["Increased platelet retention in familial recurrent thrombotic thrombocytopenic purpura"],"prefix":"10.1016","volume":"49","author":[{"given":"Diana","family":"Karpman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Holmberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Jirg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Lethagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1996.26_bb0010","series-title":"The Principles and Practice of Nephrology","first-page":"326","article-title":"Hemolytic-uremic syndrome and thrombotic thrombocytopenic purpura","author":"Kaplan","year":"1991"},{"key":"10.1038\/ki.1996.26_bb0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0022-3476(05)80596-7","article-title":"Chronic relapsing thrombotic thrombocytopenic purpura in infants with large von willebrand factor multimers during remission","volume":"120","author":"Chintagumpala","year":"1992","journal-title":"J Pediatr"},{"key":"10.1038\/ki.1996.26_bb0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-0609.1986.tb02649.x","article-title":"Thrombotic thrombocytopenic purpura in 2 siblings: Defective platelet function and plasma factor deficiency occurring simultaneously","volume":"36","author":"Waage","year":"1986","journal-title":"Scand J Haematol"},{"key":"10.1038\/ki.1996.26_bb0025","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/08880019309029496","article-title":"Congenital microangiopathic haemolytic anemia: A variant of thrombotic thrombocytopenic purpura","volume":"10","author":"Sartori","year":"1993","journal-title":"Pediatr Hematol Oncol"},{"key":"10.1038\/ki.1996.26_bb0030","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/00043426-198624000-00010","article-title":"Factor VIII concentrate-responsive thrombocytopenia, hemolytic anemia and nephropathy","volume":"8","author":"Hara","year":"1986","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"10.1038\/ki.1996.26_bb0035","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/ajh.2830170311","article-title":"Efficacy of several plasma components in a young boy with chronic thrombocytopenia and hemolytic anemia who responds repeatedly to normal plasma infusions","volume":"17","author":"Miura","year":"1984","journal-title":"Am J Hematol"},{"key":"10.1038\/ki.1996.26_bb0040","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1136\/adc.63.6.644","article-title":"Thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome in three siblings","volume":"63","author":"Elias","year":"1988","journal-title":"Arch Dis Child"},{"key":"10.1038\/ki.1996.26_bb0045","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/0002-9343(75)90510-0","article-title":"Thrombotic thrombocytopenic purpura in four siblings","volume":"58","author":"Wallace","year":"1975","journal-title":"Am J Med"},{"key":"10.1038\/ki.1996.26_bb0050","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0002-9343(67)90172-6","article-title":"Thrombotic thrombocytopenic purpura in siblings","volume":"43","author":"Norkin","year":"1967","journal-title":"Am J Med"},{"key":"10.1038\/ki.1996.26_bb0055","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1001\/jama.1976.03260450038030","article-title":"Thrombotic thrombocytopenic purpura Occurence two years apart during late pregnancy in two sisters","volume":"235","author":"Fuchs","year":"1976","journal-title":"JAMA"},{"key":"10.1038\/ki.1996.26_bb0060","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000182427","article-title":"Hereditary thrombotic thrombocytpenic purpura: Microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency occurring in consecutive generations","volume":"30","author":"Kirchner","year":"1982","journal-title":"Nephron"},{"key":"10.1038\/ki.1996.26_bb0065","doi-asserted-by":"crossref","unstructured":"Wiznitzer A, Mazor M, Leiberman JR, Bar-Levie Y, Gurman G, Glezerman M: Familial occurrence of thrombotic thrombocytopenic purpura in two sisters during pregnancy. Am J Obst Gyn 166:20\u201321","DOI":"10.1016\/0002-9378(92)91820-Z"},{"key":"10.1038\/ki.1996.26_bb0070","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1182\/blood.V60.4.1030.1030","article-title":"Pathologic effects of plasma from patients with thrombotic thrombocytopenic purpura on platelets and cultured endothelial cells","volume":"60","author":"Burns","year":"1982","journal-title":"Blood"},{"key":"10.1038\/ki.1996.26_bb0075","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1172\/JCI112107","article-title":"Novel platelet agglutinating protein from a thrombotic thrombocytopenic purpura plasma","volume":"76","author":"Siddiqui","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1996.26_bb0080","doi-asserted-by":"crossref","first-page":"589","DOI":"10.7326\/0003-4819-101-5-589","article-title":"Detection of a platelet-agglutinating factor in thrombotic thrombocytopenic purpura","volume":"101","author":"Kelton","year":"1984","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.1996.26_bb0085","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1056\/NEJM198212023072306","article-title":"Unusually large plasma factor VIII:von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpura","volume":"307","author":"Moake","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1996.26_bb0090","first-page":"H1635","article-title":"Cryosupernatant regulates accumulation of unusually large vWF multimers from endothelial cells","volume":"256","author":"Frangos","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1996.26_bb0095","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/BF00857676","article-title":"Recent advances in understanding the pathogenesis of the hemolytic uremic syndromes","volume":"4","author":"Kaplan","year":"1990","journal-title":"Pediatr Nephrol"},{"key":"10.1038\/ki.1996.26_bb0100","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0140-6736(94)91227-0","article-title":"Haemolytic uraemic syndrome: Basic science","volume":"343","author":"Moake","year":"1994","journal-title":"Lancet"},{"key":"10.1038\/ki.1996.26_bb0105","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1056\/NEJM198504113121510","article-title":"Plasma therapy for thrombotic thrombocytopenic purpura","volume":"312","author":"Aster","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1996.26_bb0110","series-title":"Hemolytic Uremic Syndrome and Thrombotic Thromobocytopenic Purpura","first-page":"541","article-title":"An update on the therapy of thrombotic thrombocytopenic purpura","author":"Moake","year":"1992"},{"key":"10.1038\/ki.1996.26_bb0115","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/ajh.2830340303","article-title":"Effectiveness of the cryosupernatant fraction of plasma in the treatment of refractory thrombotic thrombocytopenic purpura","volume":"34","author":"Brynes","year":"1990","journal-title":"Am J Hematol"},{"key":"10.1038\/ki.1996.26_bb0120","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1182\/blood.V65.5.1232.1232","article-title":"Effects of fresh frozen plasma and its cryosupernatant fraction on the von Willebrand factor multimeric forms in chronic relapsing thrombotic thrombocytopenic purpura","volume":"65","author":"Moake","year":"1985","journal-title":"Blood"},{"key":"10.1038\/ki.1996.26_bb0125","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ajh.2830380116","article-title":"Treatment of thrombotic thrombocytopenic purpura using vincristine and factor VIII plasma free","volume":"38","author":"Delgado-Lamas","year":"1991","journal-title":"Am J Hematol"},{"key":"10.1038\/ki.1996.26_bb0130","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF01836069","article-title":"Pharmacokinetics and hemostatic effect of different factor VIII\/von Willebrand factor concentrates in von Willebrand's disease type III","volume":"65","author":"Lethagen","year":"1992","journal-title":"Ann Hematol"},{"key":"10.1038\/ki.1996.26_bb0135","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1055\/s-0038-1649634","article-title":"New bleeding time devices with retractable blades in children, healthy volunteers and patients with prolonged bleeding time","volume":"70","author":"Lethagen","year":"1993","journal-title":"Thrombos Haemostas"},{"key":"10.1038\/ki.1996.26_bb0140","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2141.1976.tb03533.x","article-title":"Immunoradiometric assay of factor VIII related antigen, with observations in 32 patients with von Willebrand's disease","volume":"33","author":"Ruggeri","year":"1976","journal-title":"Br J Haematol"},{"key":"10.1038\/ki.1996.26_bb0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/00365518509160967","article-title":"The use of monoclonal antibodies in measuring factor VIII\/von Willebrand factor","volume":"45","author":"Lamme","year":"1976","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1038\/ki.1996.26_bb0150","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/0049-3848(78)90268-2","article-title":"A method for measuring plasma ristocetin cofactor activity","volume":"12","author":"Zuzel","year":"1978","journal-title":"Thromb Res"},{"key":"10.1038\/ki.1996.26_bb0155","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0609.1992.tb00906.x","article-title":"DDAVP induced enhancement of platelet retention. Its dependence on platelet-von Willebrand factor and the platelet receptor GPIIb\/IIIa","volume":"49","author":"Lethagen","year":"1992","journal-title":"Eur J Haematol"},{"key":"10.1038\/ki.1996.26_bb0160","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1182\/blood.V57.6.1140.1140","article-title":"The complex multimeric composition of factor VIII\/von Willebrand factor","volume":"57","author":"Ruggeri","year":"1981","journal-title":"Blood"},{"key":"10.1038\/ki.1996.26_bb0165","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0049-3848(91)90094-D","article-title":"Influence of different surfactants on the separation of von Willebrand factor multimers by use of agarose gel electrophoresis and semi dry blotting technology","volume":"61","author":"W\u00fcst","year":"1991","journal-title":"Thromb Res"},{"key":"10.1038\/ki.1996.26_bb0170","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1093\/clinchem\/32.12.2160","article-title":"Age dependence of tissue plasminogen activator concentrations in plasma, as studied by an improved enzyme-linked immunosorbent assay","volume":"32","author":"R\u00e5nby","year":"1986","journal-title":"Clin Chem"},{"key":"10.1038\/ki.1996.26_bb0175","series-title":"Applied Cardiovascular Biology 1989","first-page":"124","article-title":"Fibrinolytic activity in blood characterized by well-defined biochemical parameters; pro-urokinase is released upon venous occlusion","author":"R\u00e5nby","year":"1990"},{"key":"10.1038\/ki.1996.26_bb0180","first-page":"233","article-title":"An immunosorbent activity assay for single-chain urinary plasminogen activator (scuPA or pro-uPA) in plasma","volume":"62","author":"Jonsson-Berg","year":"1989","journal-title":"Thrombos Haemostas"},{"key":"10.1038\/ki.1996.26_bb0185","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0268-9499(93)90020-V","article-title":"Fibrinolytic components in individual consecutive plasma samples during normal pregnancy","volume":"7","author":"Lindoff","year":"1993","journal-title":"Fibnnolysis"},{"key":"10.1038\/ki.1996.26_bb0190","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0049-3848(88)90177-6","article-title":"Determination of plasminogen activator inhibitor in plasma using t-PA and a chromogenic single-point poly-D-lysine stimulated assay","volume":"50","author":"Eriksson","year":"1988","journal-title":"Thromb Res"},{"key":"10.1038\/ki.1996.26_bb0195","first-page":"597","article-title":"Effects of desmopressin acetate (DDAVP) and dextran on hemostatic and thrombo-prophylactic mechanisms","volume":"156","author":"Lethagen","year":"1990","journal-title":"Acta Chir Scand"},{"key":"10.1038\/ki.1996.26_bb0200","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1172\/JCI112736","article-title":"Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation","volume":"78","author":"Moake","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1996.26_bb0205","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1172\/JCI115124","article-title":"The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress","volume":"87","author":"Ikeda","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1996.26_bb0210","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1182\/blood.V51.2.267.267","article-title":"Correction by factor VIII of the impaired platelet adhesion to subendothelium in von Willebrand disease","volume":"51","author":"Weiss","year":"1978","journal-title":"Blood"},{"key":"10.1038\/ki.1996.26_bb0215","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1182\/blood.V63.1.128.128","article-title":"Adhesion of platelets to human artery subendothelium: Effect of factor VIII\u2014von Willebrand factor of various multimeric composition","volume":"63","author":"Sixma","year":"1984","journal-title":"Blood"},{"key":"10.1038\/ki.1996.26_bb0220","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1182\/blood.V84.2.490.490","article-title":"Solvent\/detergent-treated plasma suppresses shear-induced platelet aggregation and prevents episodes of thrombotic thrombocytopenic purpura","volume":"84","author":"Moake","year":"1994","journal-title":"Blood"},{"key":"10.1038\/ki.1996.26_bb0225","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0167-4889(90)90058-L","article-title":"DDAVP-induced release of von Willebrand factor from endothelial cells in vitro: The effect of plasma and blood cells","volume":"1052","author":"Hashemi","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/ki.1996.26_bb0230","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1016\/S0021-9258(19)49910-9","article-title":"Modulation of platelet function through adhesion receptors","volume":"267","author":"Savage","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.26_bb0235","unstructured":"Karpman D, Andreasson A, Thysell H, Kaplan BS, Svanborg C: Cytokines in childhood hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. Pediatr Nephrol (in press)"},{"key":"10.1038\/ki.1996.26_bb0240","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0167-5699(89)90270-3","article-title":"Cytokines as communication signals between leukocytes and endothelial cells","volume":"10","author":"Mantovani","year":"1989","journal-title":"Immunol Today"},{"key":"10.1038\/ki.1996.26_bb0245","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0092-8674(86)90735-X","article-title":"Inducible secretion of large, biologically potent von Willebrand factor multimers","volume":"46","author":"Sporn","year":"1986","journal-title":"Cell"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815593125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815593125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T23:32:08Z","timestamp":1635550328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815593125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["S0085253815593125"],"URL":"https:\/\/doi.org\/10.1038\/ki.1996.26","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1996,1]]}}}