{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:54:06Z","timestamp":1791114846676,"version":"4.1.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1996,9,1]],"date-time":"1996-09-01T00:00:00Z","timestamp":841536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":7036,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1996,9]]},"DOI":"10.1038\/ki.1996.383","type":"journal-article","created":{"date-parts":[[2007,5,17]],"date-time":"2007-05-17T11:56:44Z","timestamp":1179403004000},"page":"835-844","source":"Crossref","is-referenced-by-count":55,"title":["Matrix metalloproteinases and TIMPS in cultured C57BL\/6J-cpk kidney tubules"],"prefix":"10.1016","volume":"50","author":[{"given":"Carolyn A.","family":"Rankin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Ziemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared J.","family":"Grantham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Calvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nagase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1996.383_bb0010","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0272-6386(12)80507-5","article-title":"Polycystic kidney disease: Neoplasia in disguise","volume":"15","author":"Grantham","year":"1990","journal-title":"Am J Kid Dis"},{"key":"10.1038\/ki.1996.383_bb0015","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/ki.1991.306","article-title":"Polycystic kidney disease: clues to pathogenesis","volume":"40","author":"Gabow","year":"1991","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.383_bb0020","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000184884","article-title":"Renal cystic disease. Insights from recent experimental investigations","volume":"48","author":"Avner","year":"1988","journal-title":"Nephron"},{"key":"10.1038\/ki.1996.383_bb0025","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/ki.1991.56","article-title":"Tubulocystic epithelium","volume":"39","author":"Wilson","year":"1991","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.383_bb0030","first-page":"437","article-title":"Biology of polycystic kidney disease","volume":"70","author":"Carone","year":"1994","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1996.383_bb0035","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0140-6736(70)90773-7","article-title":"Toxic metabolic defect in polycystic disease of kidney: Evidence from microscopic studies","volume":"1","author":"Darmady","year":"1970","journal-title":"Lancet"},{"key":"10.1038\/ki.1996.383_bb0040","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/ki.1980.43","article-title":"Ultrastructure and function of cysts from human adult polycystic kidneys","volume":"17","author":"Cuppage","year":"1980","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.383_bb0045","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/ki.1986.194","article-title":"A new method for studying human polycystic kidney disease epithelia in culture","volume":"30","author":"Wilson","year":"1986","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.383_bb0050","first-page":"262","article-title":"Altered mRNA expression of basement membrane components in a murine model of polycystic kidney disease","volume":"58","author":"Ebihara","year":"1988","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1996.383_bb0055","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/ki.1990.90","article-title":"Altered basement membrane protein biosynthesis by primary cultures of cpk\/cpk mouse kidney","volume":"37","author":"Taub","year":"1990","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.383_bb0060","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/ki.1991.56","article-title":"Tubulocystic epithelium","volume":"39","author":"Wilson","year":"1991","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.383_bb0065","first-page":"466","article-title":"Basement membrane antigens in renal polycystic disease","volume":"130","author":"Carone","year":"1988","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.1996.383_bb0070","series-title":"Textbook of Rheumatology","first-page":"248","article-title":"Proteinases and matrix degradation","author":"Werb","year":"1993"},{"key":"10.1038\/ki.1996.383_bb0075","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1096\/fasebj.5.8.1850705","article-title":"Matrix metalloproteinases and their inhibitors in connective tissue remodeling","volume":"5","author":"Woessner","year":"1991","journal-title":"FASEB J"},{"key":"10.1038\/ki.1996.383_bb0080","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1042\/bst0190715","article-title":"Substrate specificities and activation mechanisms of matrix metalloproteinases","volume":"19","author":"Nagase","year":"1991","journal-title":"Biochem Soc Trans"},{"key":"10.1038\/ki.1996.383_bb0085","doi-asserted-by":"crossref","first-page":"16766","DOI":"10.1016\/S0021-9258(19)89457-7","article-title":"Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas","volume":"269","author":"Freije","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0090","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1016\/S0021-9258(18)42885-2","article-title":"Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage met-alloelastase","volume":"267","author":"Shapiro","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0095","first-page":"291","article-title":"Cloning and characterization of the cDNA encoding a mouse tissue inhibitor of metalloprotein-ase-2","volume":"114","author":"Shapiro","year":"1993","journal-title":"Gene"},{"key":"10.1038\/ki.1996.383_bb0100","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/370061a0","article-title":"A matrix metalloproteinase expressed on the surface of invasive tumour cells","volume":"370","author":"Sato","year":"1994","journal-title":"Nature"},{"key":"10.1038\/ki.1996.383_bb0105","doi-asserted-by":"crossref","first-page":"23013","DOI":"10.1074\/jbc.270.39.23013","article-title":"Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library","volume":"270","author":"Takino","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0110","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1432-1033.1995.tb20738.x","article-title":"cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment","volume":"231","author":"Will","year":"1995","journal-title":"Eur J Biochem"},{"key":"10.1038\/ki.1996.383_bb0115","first-page":"944","article-title":"Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma","volume":"56","author":"Puente","year":"1996","journal-title":"Can Res"},{"key":"10.1038\/ki.1996.383_bb0120","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/375244a0","article-title":"Furin-dependent intracellular activation of the human stromelysin-3 zymogen","volume":"375","author":"Pei","year":"1995","journal-title":"Nature"},{"key":"10.1038\/ki.1996.383_bb0125","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1042\/bj3080645","article-title":"Steps involved in activation of the complex of pro-matrix metalloproteinase 2 (progelatinase A) and tissue inhibitor of metalloproteinases (TIMP)-2 by 4-aminophenyl-mercuric acetate","volume":"308","author":"Itoh","year":"1995","journal-title":"Biochem J"},{"key":"10.1038\/ki.1996.383_bb0130","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1073\/pnas.76.7.3338","article-title":"Growth of Madin-Darby canine kidney epithelial cell (MDCK) line in hormone-supplemented, serum-free medium","volume":"76","author":"Taub","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1996.383_bb0135","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/jcp.1041050220","article-title":"Growth of functional primary cultures of kidney epithelial cells in defined medium","volume":"105","author":"Taub","year":"1980","journal-title":"J Cell Physiol"},{"key":"10.1038\/ki.1996.383_bb0140","first-page":"3","article-title":"Growth of primary and established kidney cell cultures in serum-free media","volume":"2","author":"Taub","year":"1984"},{"key":"10.1038\/ki.1996.383_bb0145","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1038\/ki.1996.383_bb0150","first-page":"148","article-title":"An improvement of the single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction","volume":"8","author":"Puissant","year":"1990","journal-title":"Biotechniques"},{"key":"10.1038\/ki.1996.383_bb0155","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/S0021-9258(18)89580-1","article-title":"Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase","volume":"260","author":"Hibbs","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0160","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0021-9673(00)80500-2","article-title":"Analysis of protein and peptide mixtures. Evaluation of three sodium dodecyl sulfate-polyacrylamide gel electrophoresis buffer systems","volume":"213","author":"Bury","year":"1981","journal-title":"J Chromatogr"},{"key":"10.1038\/ki.1996.383_bb0165","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0003-2697(77)90107-5","article-title":"Polyacrylamide gel electrophoresis in sodium dodecyl sulfate-containing buffers using multiphasic buffer systems: Properties of the stack, valid Rf-measurement, and optimized procedure","volume":"78","author":"Wyckoff","year":"1977","journal-title":"Anal Biochem"},{"key":"10.1038\/ki.1996.383_bb0170","doi-asserted-by":"crossref","first-page":"11424","DOI":"10.1016\/S0021-9258(19)49927-4","article-title":"Induction of 103-kDa gelatinase\/type IV collagenase by acidic culture conditions in mouse metastatic melanoma cell lines","volume":"267","author":"Kato","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0175","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1042\/bj2850603","article-title":"Purification and characterization of matrix metalloproteinase 9 from U937 monocytic leukaemia and HT1080 fibrosarcoma cells","volume":"285","author":"Morodomi","year":"1992","journal-title":"J Biochem"},{"key":"10.1038\/ki.1996.383_bb0180","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF02899418","article-title":"Immunohistochemical demonstration of collagenase and tissue inhibitor of metalloproteinases (TIMP) in synovial cells of rheumatoid synovium","volume":"59","author":"Okada","year":"1990","journal-title":"Virchows Arch B"},{"key":"10.1038\/ki.1996.383_bb0185","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1016\/S0021-9258(18)42873-6","article-title":"Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with strome-lysin","volume":"267","author":"Goldberg","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0190","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1016\/S0021-9258(19)50563-4","article-title":"Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9","volume":"267","author":"Ogata","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0195","doi-asserted-by":"crossref","first-page":"21712","DOI":"10.1016\/S0021-9258(19)36670-0","article-title":"Matrix metalloproteinase 9 (92-kDa gelatinase\/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymatic properties","volume":"267","author":"Okada","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0200","doi-asserted-by":"crossref","first-page":"17213","DOI":"10.1016\/S0021-9258(18)71480-4","article-title":"SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages","volume":"264","author":"Wilhelm","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0205","doi-asserted-by":"crossref","first-page":"8207","DOI":"10.1073\/pnas.86.21.8207","article-title":"Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteinases designated TIMP-2","volume":"86","author":"Goldberg","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1996.383_bb0210","doi-asserted-by":"crossref","first-page":"17374","DOI":"10.1016\/S0021-9258(18)71503-2","article-title":"Tissue inhibitors of metalloproteinase (TIMP-2): A new member of the metalloproteinase inhibitor family","volume":"264","author":"Stetler-Stevenson","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0215","doi-asserted-by":"crossref","first-page":"17445","DOI":"10.1016\/S0021-9258(18)71515-9","article-title":"Purification and characterization of two related but distinct metalloproteinase inhibitors secreted by bovine aortic endothelial cells","volume":"264","author":"Declerck","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0220","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1681\/ASN.V5155","article-title":"Presence of a distinct extracellular matrix-degrading metalloproteinase activity in renal tubules","volume":"5","author":"Walker","year":"1994","journal-title":"Am Soc Nephrol"},{"key":"10.1038\/ki.1996.383_bb0225","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1083\/jcb.126.5.1319","article-title":"An old enzyme with a new function: Purification and characterization of a distinct matrix-degrading metalloproteinase in rat kidney cortex and its identification as meprin","volume":"126","author":"Kaushal","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.1996.383_bb0230","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1074\/jbc.270.2.801","article-title":"The C-terminal region of membrane type matrix metalloproteinase is a functional transmembrane domain required for pro-gelatinase A activation","volume":"270","author":"Cao","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.383_bb0235","first-page":"5845","article-title":"Tumor cell surface-associated binding site for the M(r) 72,000 type IV collagenase","volume":"52","author":"Emonard","year":"1992","journal-title":"Can Res"},{"key":"10.1038\/ki.1996.383_bb0240","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0014-5793(95)00345-A","article-title":"Cell surface binding of TIMP-2 and pro-MMP-2\/TIMP-2 complex","volume":"364","author":"Emmert-Buck","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1038\/ki.1996.383_bb0245","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1177\/37.6.2723404","article-title":"Heterogenous distribution of typeIV collagen, entactin, heparan sulfate proteoglycan, and laminin among renal basement membranes as demonstrated by quantitative immunocytochemistry","volume":"37","author":"Desjardins","year":"1989","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/ki.1996.383_bb0250","first-page":"F697","article-title":"Altered synthesis of proteoglycans by cyst-derived cells from autosomal-dominant polycystic kidneys","volume":"32","author":"Liu","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1996.383_bb0255","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ki.1994.253","article-title":"Characterization of the Han:SPRD rat model for hereditary polycystic kidney disease","volume":"46","author":"Schafer","year":"1994","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.383_bb0260","first-page":"413","article-title":"Decreased synthesis and delayed processing of sulfated glycoproteins by cells from human polycystic kidneys","volume":"68","author":"Carone","year":"1993","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1996.383_bb0265","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ki.1993.17","article-title":"Polycystic kidney disease: Primary extracellular matrix abnormality or defective cellular differentiation","volume":"43","author":"Calvet","year":"1993","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.383_bb0270","first-page":"53","article-title":"An overview of polycystic kidney disease and acquired cystic kidney disease: Neoplasia in disguise","volume":"3","author":"Grantham","year":"1990","journal-title":"Adv Urol"},{"key":"10.1038\/ki.1996.383_bb0275","first-page":"617","article-title":"Understanding human cystic disease through experimental models","volume":"11","author":"Gattone","year":"1991","journal-title":"Semin Nephrol"},{"key":"10.1038\/ki.1996.383_bb0280","first-page":"245","article-title":"Basement membrane gene expression in polycystic kidney disease","volume":"58","author":"Haverty","year":"1988","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1996.383_bb0285","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0092-8674(94)90137-6","article-title":"The polycystic kidney disease 1 gene encodes a 14kb transcript and lies within a duplicated region on chromosome 16","volume":"77","author":"The European Polycystic Kidney Disease Consortium","year":"1994","journal-title":"Cell"},{"key":"10.1038\/ki.1996.383_bb0290","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/hmg\/4.4.575","article-title":"Analysis of the genomic sequence for the autosomal dominant polycystic kidney disease (PKD1) gene predicts the presence of a leucine-rich repeat","volume":"4","author":"The American PKD1 Consortium (ADPKD1 Consortium)","year":"1995","journal-title":"Hum Mol Genet"},{"key":"10.1038\/ki.1996.383_bb0295","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0092-8674(95)90339-9","article-title":"Polycystic Kidney Disease: The complete structure of the PKD1 gene and its protein","volume":"81","author":"The International Polycystic Kidney Disease Consortium","year":"1995","journal-title":"Cell"},{"key":"10.1038\/ki.1996.383_bb0300","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ng0695-151","article-title":"The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains","volume":"10","author":"Hughes","year":"1995","journal-title":"Nature Genet"},{"key":"10.1038\/ki.1996.383_bb0305","first-page":"635","article-title":"Deficit of tubular proteinases in polycystic kidney disease: The role of aberrant secretion","volume":"5","author":"Schafer","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.1996.383_bb0310","first-page":"817","article-title":"Changes in the expression of matrix metalloproteinases (MMPs) in a mouse model of polycystic kidney disease (PKD)","volume":"5","author":"Norman","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.1996.383_bb0315","first-page":"715","article-title":"Changes in fibroblast growth and extracellular matrix metabolism in ADPKD","volume":"47","author":"Norman","year":"1995"},{"key":"10.1038\/ki.1996.383_bb0320","first-page":"634","article-title":"Abnormally high levels of MMPs and TIMPs are synthesized by kidney cells from C57BL\/6J cpk mice","volume":"5","author":"Rankin","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.1996.383_bb0325","first-page":"88","article-title":"Matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases expression by tubular epithelial and interstitial fibroblasts in the normal kidney and in fibrosis","volume":"3","author":"Norman","year":"1995","journal-title":"Exp Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815596774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815596774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T23:48:15Z","timestamp":1635551295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815596774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,9]]}},"alternative-id":["S0085253815596774"],"URL":"https:\/\/doi.org\/10.1038\/ki.1996.383","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1996,9]]}}}