{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:47:50Z","timestamp":1783342070715,"version":"3.54.6"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[1996,11,1]],"date-time":"1996-11-01T00:00:00Z","timestamp":846806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":6975,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1996,11]]},"DOI":"10.1038\/ki.1996.461","type":"journal-article","created":{"date-parts":[[2007,5,17]],"date-time":"2007-05-17T12:54:01Z","timestamp":1179406441000},"page":"1476-1482","source":"Crossref","is-referenced-by-count":44,"title":["Selective effect of thiazides on the human osteoblast-like cell line MG-63"],"prefix":"10.1016","volume":"50","author":[{"given":"R.","family":"Aubin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"M\u00e9nard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lajeunesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1996.461_bb0010","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1600-0773.1982.tb01013.x","article-title":"Renal tubular secretion and effects of chlorothiazide, hydrochlorothiazide and clopamide: A study in the avian kidney","volume":"51","author":"Odlind","year":"1982","journal-title":"Acta Pharmacol Toxicol"},{"key":"10.1038\/ki.1996.461_bb0015","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1016\/0006-2952(80)90267-1","article-title":"Effects of diuretics on calcium uptake and release in renal microsomes","volume":"29","author":"Dan","year":"1980","journal-title":"Biochem Pharmacol"},{"key":"10.1038\/ki.1996.461_bb0020","first-page":"F492","article-title":"Calcium and sodium transport by the distal convoluted tubule of the rat","volume":"235","author":"Costanzo","year":"1978","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1996.461_bb0025","first-page":"F527","article-title":"Localization of diuretic action in microperfused rat distal tubules: Ca and Na transport","volume":"17","author":"Costanzo","year":"1985","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1996.461_bb0030","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1073\/pnas.85.7.2311","article-title":"Thiazide diuretic receptors in rat kidney: Identification with [3H]metalozone","volume":"85","author":"Beaumont","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1996.461_bb0035","first-page":"414","article-title":"Thiazide diuretic receptors: autoradiographic localization in rat kidney with [3H]Metolazone","volume":"250","author":"Beaumont","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/ki.1996.461_bb0040","series-title":"Proceedings of the Third International Conference on Diuretics. Diuretics III Chemistry, Pharmacology and Clinical Applications","first-page":"225","article-title":"The hypocalciuric effect of thiazides: study of the mechanisms","author":"Brunette","year":"1989"},{"key":"10.1038\/ki.1996.461_bb0045","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/BF00370939","article-title":"The hypocalciuric effect of thiazides: Subcellular localization of the action","volume":"417","author":"Lajeunesse","year":"1991","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1038\/ki.1996.461_bb0050","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/ki.1988.122","article-title":"Chlorthalidone promotes mineral retention in patients with idiopathic hypercalciuria","volume":"33","author":"Coe","year":"1988","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.461_bb0055","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM198308113090605","article-title":"Thiazide effect on the mineral content of bone","volume":"309","author":"Wasnich","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1996.461_bb0060","first-page":"457","article-title":"Differential effects of thiazide and estrogen upon bone mineral content and fracture prevalence","volume":"67","author":"Wasnich","year":"1986","journal-title":"Obstetrics Gynecol"},{"issue":"Suppl 1","key":"10.1038\/ki.1996.461_bb0065","first-page":"216","article-title":"Thiazide diuretics preserve bone mass and reduce the risk of fractures in elderly women: A prospective study","volume":"4","author":"Cauley","year":"1989","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.1996.461_bb0070","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(89)92205-8","article-title":"Long-term use of thiazide diuretics and risk of hip fracture","volume":"1","author":"Ray","year":"1989","journal-title":"Lancet"},{"key":"10.1038\/ki.1996.461_bb0075","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0002-9378(85)80035-1","article-title":"Thiazide diuretics and bone mineral content in postmenopausal women","volume":"152","author":"Adland-Davenport","year":"1985","journal-title":"Am J Obstet Gynecol"},{"issue":"Suppl 1","key":"10.1038\/ki.1996.461_bb0080","first-page":"157","article-title":"Thiazides reduce bone loss rate among men. A longitudinal study","volume":"5","author":"Wasnich","year":"1990","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.1996.461_bb0085","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1056\/NEJM199002013220502","article-title":"Thiazide diuretic agents and the incidence of hip fracture","volume":"322","author":"Lacroix","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.1996.461_bb0090","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ki.1985.223","article-title":"Hydrochlorothiazide inhibits bone resorption in men despite experimentally elevated serum 1,25-dihydroxyvitamin D concentrations","volume":"28","author":"Lemann","year":"1985","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.461_bb0095","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jbmr.5650100115","article-title":"Thiazide diuretics and fractures: Can meta-analysis help","volume":"10","author":"Jones","year":"1995","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.1996.461_bb0100","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/jbmr.5650050904","article-title":"Osteocalcin secretion by the human osteosarcoma cell line MG-63","volume":"5","author":"Lajeunesse","year":"1990","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.1996.461_bb0105","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/BF02553298","article-title":"The effect of bone cell stimulatory factors can be measured with thymidine incorporation only under specific conditions","volume":"39","author":"Puzas","year":"1986","journal-title":"Calcif Tissue Int"},{"key":"10.1038\/ki.1996.461_bb0110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.461_bb0115","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0169-6009(91)90025-U","article-title":"Regulation of osteocalcin secretion by human primary bone cells and by the human osteosarcoma cell line MG-63","volume":"14","author":"Lajeunesse","year":"1991","journal-title":"Bone Miner"},{"key":"10.1038\/ki.1996.461_bb0120","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/BF00310404","article-title":"Hydrochlorothiazide inhibits osteoclastic bone resorption in vitro","volume":"55","author":"Hall","year":"1994","journal-title":"Calcif Tissue Int"},{"key":"10.1038\/ki.1996.461_bb0125","first-page":"S362","article-title":"Hydrochlorothiazide stimulates proliferation of human osteoblasts in vitro","volume":"8","author":"Song","year":"1993","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.1996.461_bb0130","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1210\/jcem-59-6-1037","article-title":"Reduction in intestinal calcium absorption by hydrochlorothiazide in postmenopausal osteoporosis","volume":"59","author":"Sakhaee","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/ki.1996.461_bb0135","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF01623678","article-title":"Metabolic effects of thiazide and 1,25(OH)2-vitamin D in postmenopausal osteoporosis","volume":"3","author":"Sakhaee","year":"1993","journal-title":"Osteoporosis Int"},{"key":"10.1038\/ki.1996.461_bb0140","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1532-5415.1993.tb01887.x","article-title":"The effect of chlorothiazide on bone-related biochemical variables in normal post-menopausal women","volume":"41","author":"Peh","year":"1993","journal-title":"J Amer Geriatric Soc"},{"key":"10.1038\/ki.1996.461_bb0145","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1152\/physrev.1989.69.3.990","article-title":"Osteocalcin and matrix Gla protein: Vitamin K-dependent proteins in bone","volume":"69","author":"Hauschka","year":"1989","journal-title":"Physiol Rev"},{"key":"10.1038\/ki.1996.461_bb0150","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00609982","article-title":"Antihypertensive effect of various doses of hydrochlorothiazide and its relation to the plasma level of the drug","volume":"13","author":"Beermann","year":"1978","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1038\/ki.1996.461_bb0155","first-page":"29","article-title":"Action of the colony-stimulating factor, CSF-1","volume":"118","author":"Stanley","year":"1986"},{"key":"10.1038\/ki.1996.461_bb0160","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0025-7125(16)32020-X","article-title":"The site and mode of action of some sulfonamide-derived diuretics","volume":"59","author":"Beyer","year":"1975","journal-title":"Med Clin N Am"},{"key":"10.1038\/ki.1996.461_bb0165","first-page":"266","article-title":"A simplified micromethod for the determination of carbonic anhydrase and its inhibitors","volume":"130","author":"Maren","year":"1960","journal-title":"J Pharm Exp Ther"},{"key":"10.1038\/ki.1996.461_bb0170","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1749-6632.1968.tb19050.x","article-title":"The effects of diazoxide and benzothiadiazine diuretics upon phosphodiesterase","volume":"150","author":"Moore","year":"1968","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/ki.1996.461_bb0175","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/BF00593171","article-title":"Ursachen der St\u00f6rungen im Kohlenhydratstoffwechsel unter dem Einfluss sulfonamidierter Diuretica","volume":"255","author":"Senft","year":"1966","journal-title":"Arch Exp Pathol Pharmakol"},{"key":"10.1038\/ki.1996.461_bb0180","first-page":"759","article-title":"Calcium oxalate urolithiasis in the rat: Is it a model for human stone disease","volume":"II","author":"Khan","year":"1985","journal-title":"Scanning EM"},{"issue":"Suppl 1","key":"10.1038\/ki.1996.461_bb0185","first-page":"C190","article-title":"Ultrastructural immunodetection of osteopontin and osteocalcin as major matrix components of urinary calculi","volume":"9","author":"McKee","year":"1994","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.1996.461_bb0190","doi-asserted-by":"crossref","first-page":"18202","DOI":"10.1016\/S0021-9258(19)84697-5","article-title":"Normal rat kidney cells secrete both phosphorylated and nonphosphorylated forms of osteopontin showing different physiological properties","volume":"264","author":"Nemir","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.461_bb0195","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/jbmr.5650070804","article-title":"Evidence for the formation of a complex between osteopontin and osteocalcin","volume":"7","author":"Ritter","year":"1992","journal-title":"J Bone Miner Res"},{"issue":"Suppl 1","key":"10.1038\/ki.1996.461_bb0200","first-page":"B155","article-title":"The effect of alendronate on immobilization-induced bone loss and stone-forming propensity","volume":"9","author":"Rumll","year":"1994","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.1996.461_bb0205","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/BF02553751","article-title":"Bisphosphonates inhibit 1,25-dihydroxyvitamin D3-induced increase of osteocalcin in plasma of rats in vivo and in culture medium of rat calvaria in vitro","volume":"42","author":"Stronski","year":"1988","journal-title":"Calcif Tissue Int"},{"key":"10.1038\/ki.1996.461_bb0210","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1532-5415.1993.tb06176.x","article-title":"The effects of thiazide diuretics on calcium metabolism in the aged","volume":"41","author":"Perry","year":"1993","journal-title":"J Am Geriatrics Soc"},{"key":"10.1038\/ki.1996.461_bb0215","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0169-6009(08)80119-5","article-title":"Thiazides and seasonal bone change in healthy postmenopausal women","volume":"21","author":"Dawson-Hughes","year":"1993","journal-title":"Bone Miner"},{"issue":"Suppl 1","key":"10.1038\/ki.1996.461_bb0220","first-page":"B468","article-title":"Role of monokines in bone demineralization of calcium stone formers with idiopathic hypercalciuria","volume":"9","author":"Ghazali","year":"1994","journal-title":"J Bone Miner Res"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381559755X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381559755X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T10:31:47Z","timestamp":1707906707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S008525381559755X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,11]]}},"alternative-id":["S008525381559755X"],"URL":"https:\/\/doi.org\/10.1038\/ki.1996.461","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1996,11]]}}}