{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:13:08Z","timestamp":1771002788116,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":7249,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1996,2]]},"DOI":"10.1038\/ki.1996.64","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T12:39:06Z","timestamp":1179751146000},"page":"449-460","source":"Crossref","is-referenced-by-count":38,"title":["Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels"],"prefix":"10.1016","volume":"49","author":[{"given":"Manjeri A.","family":"Venkatachalam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogendra","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pothana","family":"Saikumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1996.64_bb0010","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1172\/JCI113224","article-title":"Cytoprotective effects of glycine and glutathione against hypoxic injury to rat tubules","volume":"80","author":"Weinberg","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1996.64_bb0015","first-page":"F80","article-title":"Mechanisms of perfused kidney cytoprotection by alanine and glycine","volume":"259","author":"Baines","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1996.64_bb0020","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1096\/fasebj.4.15.2253849","article-title":"Structural requirements for protection by small amino-acids against hypoxic injury in kidney proximal tubules","volume":"4","author":"Weinberg","year":"1990","journal-title":"FASEB J"},{"key":"10.1038\/ki.1996.64_bb0025","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/ki.1992.258","article-title":"Mechanisms of glycine protection in hypoxic injury: Analogies with glycine receptor","volume":"42","author":"Heymann","year":"1992","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.64_bb0030","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1172\/JCI114440","article-title":"Intracellular glutathione in the protection from anoxic injury in renal proximal tubules","volume":"85","author":"Mandel","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1996.64_bb0035","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/0016-5085(92)90338-Y","article-title":"Mechanisms of protection by glycine against lethal hepatocellular injury during ATP depletion","volume":"102","author":"Dickson","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1038\/ki.1996.64_bb0040","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/ki.1992.218","article-title":"Acute phosphate depletion and in vitro rat proximal tubule injury: Protection by glycine and acidosis","volume":"41","author":"Almeida","year":"1992","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.64_bb0045","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1172\/JCI115033","article-title":"Role of increased cytosolic free calcium in the pathogenesis or rabbit proximal tubule cell injury and protection by glycine or acidosis","volume":"87","author":"Weinberg","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1996.64_bb0050","first-page":"F605","article-title":"Conservation of structure in ATP-depleted proximal tubules: Role of calcium, polyphosphoinositides, and glycine","volume":"265","author":"Garza-Quintero","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1996.64_bb0055","first-page":"671","article-title":"Amino acid protection of cultured kidney tubule cells against calcium ionophore-induced lethal cell injury","volume":"65","author":"Weinberg","year":"1991","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1996.64_bb0060","first-page":"656","article-title":"Strychnine protects against hypoxic injury in freshly isolated rat renal proximal tubules","volume":"2","author":"Wang","year":"1991","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.1996.64_bb0065","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/0024-3205(92)90048-T","article-title":"The neurotoxicants strychnine and bicuculline protect renal proximal tubules from mitochondrial inhibitor-induced cell death","volume":"51","author":"Aleo","year":"1992","journal-title":"Life Sci"},{"key":"10.1038\/ki.1996.64_bb0070","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0197-0186(88)90048-4","article-title":"The mammalian glycine receptor: Biology and structure of a neuronal chloride channel protein","volume":"13","author":"Betz","year":"1988","journal-title":"Neurochem Int"},{"key":"10.1038\/ki.1996.64_bb0075","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/0024-3205(93)90539-F","article-title":"Cytoprotection by inhibition of chloride channels: The mechanism of action of glycine and strychnine","volume":"53","author":"Miller","year":"1993","journal-title":"Life Sci"},{"key":"10.1038\/ki.1996.64_bb0080","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0024-3205(94)90078-7","article-title":"A putative cytoprotective receptor in the kidney: Relation to the neuronal strychnine-sensitive glycine receptor","volume":"55","author":"Miller","year":"1994","journal-title":"Life Sci"},{"key":"10.1038\/ki.1996.64_bb0085","first-page":"907","article-title":"Cytoprotective effects of Cl-channel blockers in hypoxic injury","volume":"5","author":"Reeves","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.1996.64_bb0090","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/ki.1995.275","article-title":"Effects of Ca2+ and glycine on lipid breakdown and death of ATP-depleted MDCK cells","volume":"48","author":"Venkatachalam","year":"1995","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1996.64_bb0095","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal Biochem"},{"key":"10.1038\/ki.1996.64_bb0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/33.1.2578146","article-title":"An improved method to determine cell viability by simultaneous staining with fluorescein diacetate - propidium iodide","volume":"33","author":"Jones","year":"1985","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/ki.1996.64_bb0105","series-title":"Pest Control with Enhanced Environmental Safety","first-page":"169","article-title":"Recent progress in avermectin research","author":"Fisher","year":"1993"},{"key":"10.1038\/ki.1996.64_bb0110","series-title":"Ivermectin and Abamectin","first-page":"1","article-title":"Chemistry","author":"Fisher","year":"1989"},{"key":"10.1038\/ki.1996.64_bb0115","first-page":"590","article-title":"The glycine receptor: Pharmacological studies and mathematical modeling of the allosteric interaction between the glycine- and strychnine-binding sites","volume":"30","author":"Carlos","year":"1986","journal-title":"Mol Pharmacol"},{"key":"10.1038\/ki.1996.64_bb0120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0014-2999(84)90133-X","article-title":"Properties of a high affinity binding site for [3H]Avermectin B1a","volume":"99","author":"Drexler","year":"1984","journal-title":"Eur J Pharmacol"},{"key":"10.1038\/ki.1996.64_bb0125","doi-asserted-by":"crossref","first-page":"8950","DOI":"10.1073\/pnas.91.19.8950","article-title":"Cyanotriphenylborate Subtype-specific blocker of glycine receptor chloride channels","volume":"91","author":"Rundstrom","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1996.64_bb0130","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0896-6273(90)90077-S","article-title":"Ligand-gated ion channels in the brain: The amino acid receptor superfamily","volume":"5","author":"Betz","year":"1990","journal-title":"Neuron"},{"key":"10.1038\/ki.1996.64_bb0135","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/00007890-198804000-00001","article-title":"Principles of solid organ preservation by cold storage","volume":"45","author":"Belzer","year":"1988","journal-title":"Transplantation"},{"key":"10.1038\/ki.1996.64_bb0140","doi-asserted-by":"crossref","first-page":"C803","DOI":"10.1152\/ajpcell.1992.262.4.C803","article-title":"Chemical probes for anion transporters of mammalian cell membranes","volume":"262","author":"Cabantchik","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1996.64_bb0145","first-page":"457","article-title":"Protection of humam umbilical vein endothelial cells by glycine and structurally similar amino acids against calcium and hydrogen peroxide-induced lethal cell injury","volume":"140","author":"Weinberg","year":"1992","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.1996.64_bb0150","first-page":"793","article-title":"Chloride channel blockers","volume":"191","author":"Greger","year":"1990"},{"key":"10.1038\/ki.1996.64_bb0155","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF01961377","article-title":"Inhibition of anion permeability by amphiphilic compounds in human red cell: Evidence for an interaction of niflumic acid with the Band 3 protein","volume":"46","author":"Cousin","year":"1979","journal-title":"J Membr Biol"},{"key":"10.1038\/ki.1996.64_bb0160","series-title":"Physiology of Membrane Disorders","first-page":"311","article-title":"Regulation of cellular volume","author":"MacKnight","year":"1986"},{"key":"10.1038\/ki.1996.64_bb0165","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.1073\/pnas.77.9.5445","article-title":"Protection of cultured renal tubular epithelial cells from anoxic cell swelling and cell death","volume":"77","author":"Kreisberg","year":"1980","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1996.64_bb0170","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/bbrc.1995.1025","article-title":"Sodium-mediated cell swelling is associated with irreversible damage in isolated hepatocytes exposed to hypoxia or mitochondrial toxins","volume":"206","author":"Carini","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/ki.1996.64_bb0175","first-page":"583","article-title":"The membrane actions of anesthetics and tranquilizers","volume":"24","author":"Seeman","year":"1972","journal-title":"Pharmacol Rev"},{"key":"10.1038\/ki.1996.64_bb0180","series-title":"Ionic Channels of Excitable Membranes","author":"Hille","year":"1992"},{"key":"10.1038\/ki.1996.64_bb0185","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/305805a0","article-title":"Activation of multiple-conductance state chloride channels in spinal neurons by glycine and GABA","volume":"305","author":"Hamill","year":"1983","journal-title":"Nature"},{"key":"10.1038\/ki.1996.64_bb0190","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/371707a0","article-title":"Cloning of an Avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans","volume":"371","author":"Cully","year":"1994","journal-title":"Nature"},{"key":"10.1038\/ki.1996.64_bb0195","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/jbt.2570060408","article-title":"Activation of g-aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by Avermectin B1a","volume":"6","author":"Payne","year":"1991","journal-title":"J Biochem Toxicol"},{"key":"10.1038\/ki.1996.64_bb0200","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/BF00167239","article-title":"Activation of Cl-channels by Avermectin in rat cultured hippocampal neurons","volume":"348","author":"Schonrock","year":"1993","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1038\/ki.1996.64_bb0205","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1749-6632.1991.tb33836.x","article-title":"Heterogeneity of the inhibitory glycine receptor","volume":"625","author":"Kuhse","year":"1991","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/ki.1996.64_bb0210","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.8211147","article-title":"Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA","volume":"262","author":"Schmieden","year":"1993","journal-title":"Science"},{"key":"10.1038\/ki.1996.64_bb0215","doi-asserted-by":"crossref","first-page":"14608","DOI":"10.1016\/S0021-9258(18)82376-6","article-title":"Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. II. Transmembrane segment M2 of the brain glycine receptor is a plausible candidate for the pore-lining structure","volume":"268","author":"Reddy","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1996.64_bb0220","first-page":"318","article-title":"Colocalization of GABA transporter and receptor in rat kidney","volume":"5","author":"Plotkin","year":"1994","journal-title":"J Am Soc Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815593587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815593587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T23:34:13Z","timestamp":1635550453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815593587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["S0085253815593587"],"URL":"https:\/\/doi.org\/10.1038\/ki.1996.64","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}