{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T14:19:38Z","timestamp":1786371578804,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":6702,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[1997,8]]},"DOI":"10.1038\/ki.1997.346","type":"journal-article","created":{"date-parts":[[2007,5,7]],"date-time":"2007-05-07T09:33:45Z","timestamp":1178530425000},"page":"393-403","source":"Crossref","is-referenced-by-count":88,"title":["Podocytes are the major source of IL-1\u03b1 and IL-1\u03b2 in human glomerulonephritides"],"prefix":"10.1016","volume":"52","author":[{"given":"Zofia I.","family":"Niemir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Dworacki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mundel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Koehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Autschbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Andrassy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Ritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruediger","family":"Waldherr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herwart F.","family":"Otto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.1997.346_bb0010","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095","article-title":"Biologic basis for IL-1 in disease","volume":"87","author":"Dinarello","year":"1996","journal-title":"Blood"},{"key":"10.1038\/ki.1997.346_bb0015","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/ki.1993.98","article-title":"In situ expression of TNF-\u03b1, IL-1\u03b2 and IL-2R in ANCA-positive glomerulonephritis","volume":"43","author":"Noronha","year":"1993","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1997.346_bb0020","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.4049\/jimmunol.141.9.3050","article-title":"Increased tumor necrosis factor and IL-1\u03b2 gene expression in the kidney of mice with lupus nephritis","volume":"141","author":"Boswell","year":"1988","journal-title":"J Immunol"},{"key":"10.1038\/ki.1997.346_bb0025","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.4049\/jimmunol.138.10.3207","article-title":"The interleukin 1 gene is expressed by rat glomerular mesangial cells and is augmented in immune complex glomerulonephritis","volume":"138","author":"Werber","year":"1987","journal-title":"J Immunol"},{"key":"10.1038\/ki.1997.346_bb0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2249.1994.tb06138.x","article-title":"Podocyte expression of MHC class I and II and intercellular adhesion molecule-1 (ICAM-1) in experimental pauci-immune crescentic glomerulonephritis","volume":"98","author":"Coers","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/ki.1997.346_bb0035","first-page":"126","article-title":"Glomerular expression of interleukin-1 receptor antagonist and interleukin- 1\u03b2 genes in antibody-mediated glomerulonephritis","volume":"145","author":"Tam","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.1997.346_bb0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/path.1711730208","article-title":"Pathogenesis of IgAnephropathy: in vitro activation of human mesangial cells by IgA immune complex leads to cytokine secretion","volume":"173","author":"Chen","year":"1994","journal-title":"J Pathol"},{"key":"10.1038\/ki.1997.346_bb0045","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2249.1990.tb05248.x","article-title":"Mononuclear cells in glomeruli and cytokines in urine reflect the severity of experimental proliferative immune complex glomerulonephritis","volume":"80","author":"Noble","year":"1990","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/ki.1997.346_bb0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/ki.1991.13","article-title":"Glomerular interleukin 1 production is dependent on macrophage infiltration in anti-GBM glomerulonephritis","volume":"39","author":"Tipping","year":"1991","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1997.346_bb0055","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/ki.1993.317","article-title":"In situ expression of cytokines in IgA nephritis","volume":"44","author":"Yosioka","year":"1993","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1997.346_bb0060","first-page":"1553","article-title":"Urinary excretion of cytokines and complement SC5b-9 in idiopathic membranous glomerulonephritis","volume":"9","author":"Honkanen","year":"1994","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.1997.346_bb0065","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/ki.1993.70","article-title":"Suppression of experimental crescentic glomerulonephritis by interleukin-1 receptor antagonist","volume":"43","author":"Lan","year":"1993","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1997.346_bb0070","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0162-3109(95)00014-K","article-title":"Established murine lupus nephritis does not respond to exogenous interleukin-1 receptor antagonist; a role for the endogenous molecule","volume":"30","author":"Kiberd","year":"1995","journal-title":"Immunopharmacology"},{"key":"10.1038\/ki.1997.346_bb0075","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1073\/pnas.90.13.6155","article-title":"Interleukin 1 signaling occurs exclusively via the type 1 receptor","volume":"90","author":"Sims","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1997.346_bb0080","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.8332913","article-title":"Interleukin-1 type II receptor: A decoy target for IL-1 that is regulated by IL-4","volume":"261","author":"Colotta","year":"1993","journal-title":"Science"},{"key":"10.1038\/ki.1997.346_bb0085","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1073\/pnas.92.5.1714","article-title":"Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-\u03b2 precursor and loses affinity for IL-1 receptor antagonist","volume":"92","author":"Symons","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1997.346_bb0090","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/344633a0","article-title":"Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein","volume":"344","author":"Carter","year":"1990","journal-title":"Nature"},{"key":"10.1038\/ki.1997.346_bb0095","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1084\/jem.170.2.399","article-title":"A human endothelial cell-restricted externally disposed plasmalemmal protein enriched in inter-cellular junctions","volume":"170","author":"Muller","year":"1989","journal-title":"J Exp Med"},{"key":"10.1038\/ki.1997.346_bb0100","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1083\/jcb.110.4.1227","article-title":"EndoCAM: A novel endothelial cell-cell adhesion molecule","volume":"110","author":"Albelda","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.1997.346_bb0105","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1177\/39.8.1856454","article-title":"Podocytes in glomerulus of rat kidney express a characteristic 44 kD protein","volume":"39","author":"Mundel","year":"1991","journal-title":"J Histochem Cytochem"},{"key":"10.1038\/ki.1997.346_bb0110","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/ki.1995.443","article-title":"PDGF and TGF-\u03b2 contribute to the natural course of human IgA glomerulonephritis","volume":"48","author":"Niemir","year":"1995","journal-title":"Kidney Int"},{"key":"10.1038\/ki.1997.346_bb0115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/j.1460-2075.1987.tb04743.x","article-title":"A novel leader peptide which allows efficient secretion of a fragment of human interleukin 1\u03b2 in Saccharomyces cerevisiae","volume":"6","author":"Baldari","year":"1987","journal-title":"EMBO J"},{"key":"10.1038\/ki.1997.346_bb0120","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/315641a0","article-title":"Cloning, sequence and expression of two distinct interleukin-1 complementary DNAs","volume":"315","author":"March","year":"1985","journal-title":"Nature"},{"key":"10.1038\/ki.1997.346_bb0125","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0166-0934(89)90115-8","article-title":"Detection of human papilloma virus (HPV) DNA in genital biopsy specimens by in situ hybridization with digoxigenin-labeled probes","volume":"26","author":"Heino","year":"1989","journal-title":"J Virol Meth"},{"key":"10.1038\/ki.1997.346_bb0130","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/356768a0","article-title":"A novel heterodimeric cysteine protease is required for interleukin-1\u03b2 processing in monocytes","volume":"356","author":"Thornberry","year":"1992","journal-title":"Nature"},{"key":"10.1038\/ki.1997.346_bb0135","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1002\/eji.1830190821","article-title":"Fate and biological action of human recombinant interleukin 1\u03b2 in the rat in vivo","volume":"19","author":"Klapproth","year":"1989","journal-title":"Eur J Immunol"},{"key":"10.1038\/ki.1997.346_bb0140","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/j.1460-2075.1990.tb08268.x","article-title":"A novel secretory pathway for interleukin-1\u03b2, a protein lacking a signal sequence","volume":"9","author":"Rubartelli","year":"1990","journal-title":"EMBO J"},{"key":"10.1038\/ki.1997.346_bb0145","doi-asserted-by":"crossref","first-page":"8485","DOI":"10.1073\/pnas.88.19.8485","article-title":"Interleukin 1 is processed and released during apoptosis","volume":"88","author":"Hogoouist","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1997.346_bb0150","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4049\/jimmunol.139.1.98","article-title":"Localization of human mononuclear interleukin 1","volume":"139","author":"Conlon","year":"1987","journal-title":"J Immunol"},{"key":"10.1038\/ki.1997.346_bb0155","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/S0021-9258(18)61450-4","article-title":"The interleukin-1 receptor binds the human interleukin-1\u03b1 precursor but not the interleukin-1\u03b2 precursor","volume":"262","author":"Mosley","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.1997.346_bb0160","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1073\/pnas.88.9.3681","article-title":"cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium","volume":"88","author":"Haskill","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.1997.346_bb0165","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1172\/JCI117679","article-title":"Novel production of interleukin-1 receptorantagonist peptides in normal human cornea","volume":"95","author":"Kennedy","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.1997.346_bb0170","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.93.20.11008","article-title":"Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice","volume":"93","author":"Hirsch","year":"1996","journal-title":"Proc Natl AcadSci USA"},{"key":"10.1038\/ki.1997.346_bb0175","first-page":"F273","article-title":"IL-1\u03b2 increases laminin B2 chain mRNA levels and activates NF-kB in rat glomerular epithelial cells","volume":"268","author":"Richardson","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1997.346_bb0180","first-page":"F447","article-title":"Interleukin-4 modulates collagen synthesis by human mesangial cells in a type-specific manner","volume":"270","author":"Nakazato","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.1997.346_bb0185","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3109\/00313028909061069","article-title":"The structure of the normal human glomerular basement membrane","volume":"21","author":"Smith","year":"1989","journal-title":"Pathology"},{"key":"10.1038\/ki.1997.346_bb0190","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0046-8177(88)80317-4","article-title":"The glomerular distribution of type IV collagen and laminin in human membranous glomerulonephritis","volume":"19","author":"Fukatsu","year":"1988","journal-title":"Hum Pathol"},{"key":"10.1038\/ki.1997.346_bb0195","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000174083","article-title":"A frequent pathway to glomerulosclerosis: Deterioration of tuft architecture\u2014podocyte damage\u2014segmental sclerosis","volume":"19","author":"Kriz","year":"1996","journal-title":"Kidney Blood Press Res"},{"key":"10.1038\/ki.1997.346_bb0200","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF00230355","article-title":"Podocyte damage is a critical step in the development of glomerulosclerosis in the unine-phrectomised-desoxycortisterone hypertensive rat","volume":"425","author":"Kretzler","year":"1994","journal-title":"Virchows Arch"},{"key":"10.1038\/ki.1997.346_bb0205","first-page":"205","article-title":"Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat","volume":"60","author":"Fries","year":"1989","journal-title":"Lab Invest"},{"key":"10.1038\/ki.1997.346_bb0210","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ki.1994.47","article-title":"A role for podocytes to counteract capillary wall distension","volume":"45","author":"Kriz","year":"1994","journal-title":"Kidney Int"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815601867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815601867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T02:27:28Z","timestamp":1736994448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815601867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["S0085253815601867"],"URL":"https:\/\/doi.org\/10.1038\/ki.1997.346","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[1997,8]]}}}