{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:42:52Z","timestamp":1790613772326,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":2653,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1038\/ki.2008.246","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T08:19:26Z","timestamp":1213172366000},"page":"740-749","source":"Crossref","is-referenced-by-count":74,"title":["KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease"],"prefix":"10.1016","volume":"74","author":[{"given":"Mamdouh","family":"Albaqumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shekhar","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Zhdnova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Wulff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Itani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren P.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward Y.","family":"Skolnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2008.246_bb0010","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1046\/j.1523-1755.2003.00242.x","article-title":"Lillian Jean Kaplan International Prize for advancement in the understanding of polycystic kidney disease. Understanding polycystic kidney disease: a systems biology approach","volume":"64","author":"Grantham","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2008.246_bb0015","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/01.mnh.0000232888.65895.e7","article-title":"Understanding pathogenic mechanisms in polycystic kidney disease provides clues for therapy","volume":"15","author":"Harris","year":"2006","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1038\/ki.2008.246_bb0020","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1097\/01.ASN.0000028643.17901.42","article-title":"Genetics and pathogenesis of polycystic kidney disease","volume":"13","author":"Igarashi","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2008.246_bb0025","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1523-1755.2004.00843.x","article-title":"Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells","volume":"66","author":"Belibi","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2008.246_bb0030","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1111\/j.1523-1755.2005.00703.x","article-title":"Vasopressin antagonists in polycystic kidney disease","volume":"68","author":"Torres","year":"2005","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2008.246_bb0035","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1046\/j.1523-1755.2003.00023.x","article-title":"Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys","volume":"63","author":"Yamaguchi","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2008.246_bb0040","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/ki.1996.304","article-title":"The cystic fibrosis transmembrane conductance regulator mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease epithelium in vitro","volume":"50","author":"Davidow","year":"1996","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2008.246_bb0045","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1111\/j.1523-1755.2004.00967.x","article-title":"The relationship between cell proliferation, Cl- secretion, and renal cyst growth: a study using CFTR inhibitors","volume":"66","author":"Li","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2008.246_bb0050","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/S0272-6386(98)70072-1","article-title":"Cystic fibrosis and the phenotypic expression of autosomal dominant polycystic kidney disease","volume":"32","author":"O'Sullivan","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2008.246_bb0055","first-page":"529","article-title":"Autosomal dominant polycystic kidney disease coexisting with cystic fibrosis","volume":"19","author":"Xu","year":"2006","journal-title":"J Nephrol"},{"key":"10.1038\/ki.2008.246_bb0060","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1681\/ASN.V11122285","article-title":"CF gene and cystic fibrosis transmembrane conductance regulator expression in autosomal dominant polycystic kidney disease","volume":"11","author":"Persu","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2008.246_bb0065","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1046\/j.1523-1755.2000.00991.x","article-title":"cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway","volume":"57","author":"Yamaguchi","year":"2000","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2008.246_bb0070","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.devcel.2005.12.005","article-title":"Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease","volume":"10","author":"Low","year":"2006","journal-title":"Dev Cell"},{"key":"10.1038\/ki.2008.246_bb0075","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1073\/pnas.0509694103","article-title":"The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease","volume":"103","author":"Shillingford","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2008.246_bb0080","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature05348","article-title":"Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine","volume":"444","author":"Bukanov","year":"2006","journal-title":"Nature"},{"key":"10.1038\/ki.2008.246_bb0085","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4161\/cc.6.7.4047","article-title":"Targeting dysregulated cell cycle and apoptosis for polycystic kidney disease therapy","volume":"6","author":"Ibraghimov-Beskrovnaya","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1038\/ki.2008.246_bb0090","doi-asserted-by":"crossref","first-page":"C461","DOI":"10.1152\/ajpcell.2000.279.2.C461","article-title":"Pharmacological modulation of ion transport across wild-type and DeltaF508 CFTR-expressing human bronchial epithelia","volume":"279","author":"Devor","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1038\/ki.2008.246_bb0095","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00232-001-0145-7","article-title":"Vasoactive intestinal peptide-stimulated Cl- secretion: activation of cAMP-dependent K+ channels","volume":"186","author":"Izu","year":"2002","journal-title":"J Membr Biol"},{"key":"10.1038\/ki.2008.246_bb0100","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1203\/01.PDR.0000057204.51420.DC","article-title":"Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia","volume":"53","author":"Mall","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1038\/ki.2008.246_bb0105","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/S0022-3565(24)38765-8","article-title":"Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease","volume":"296","author":"Singh","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/ki.2008.246_bb0110","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1074\/jbc.275.1.585","article-title":"Kinase-dependent regulation of the intermediate conductance, calcium-dependent potassium channel, hIK1","volume":"275","author":"Gerlach","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2008.246_bb0115","doi-asserted-by":"crossref","first-page":"10963","DOI":"10.1074\/jbc.M007716200","article-title":"ATP-dependent activation of the intermediate conductance, Ca2+-activated K+ channel, hIK1, is conferred by a C-terminal domain","volume":"276","author":"Gerlach","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2008.246_bb0120","doi-asserted-by":"crossref","first-page":"32040","DOI":"10.1074\/jbc.M105231200","article-title":"Delineation of the clotrimazole\/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1","volume":"276","author":"Wulff","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2008.246_bb0125","doi-asserted-by":"crossref","first-page":"8151","DOI":"10.1073\/pnas.97.14.8151","article-title":"Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant","volume":"97","author":"Wulff","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2008.246_bb0130","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00232-002-1055-z","article-title":"Bending the primary cilium opens Ca2+-sensitive intermediate-conductance K+ channels in MDCK cells","volume":"191","author":"Praetorius","year":"2003","journal-title":"J Membr Biol"},{"key":"10.1038\/ki.2008.246_bb0135","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1152\/physrev.1998.78.4.1165","article-title":"Epithelial transport in polycystic kidney disease","volume":"78","author":"Sullivan","year":"1998","journal-title":"Physiol Rev"},{"key":"10.1038\/ki.2008.246_bb0140","doi-asserted-by":"crossref","first-page":"8476","DOI":"10.1074\/jbc.M210072200","article-title":"Trafficking of the Ca2+-activated K+ channel, hIK1, is dependent upon a C-terminal leucine zipper","volume":"278","author":"Syme","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2008.246_bb0145","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1097\/01.ASN.0000034220.09301.9C","article-title":"Sulfonylurea-sensitive K(+) transport is involved in Cl(\u2212) secretion and cyst trowth by cultured ADPKD cells","volume":"13","author":"Sullivan","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2008.246_bb0150","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1091\/mbc.E05-08-0763","article-title":"Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1","volume":"17","author":"Srivastava","year":"2006","journal-title":"Mol Biol Cell"},{"key":"10.1038\/ki.2008.246_bb0155","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.1128\/MCB.00352-06","article-title":"Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells","volume":"26","author":"Srivastava","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1038\/ki.2008.246_bb0160","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1128\/MCB.25.9.3630-3638.2005","article-title":"The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1","volume":"25","author":"Srivastava","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1038\/ki.2008.246_bb0165","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nm1004","article-title":"Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease","volume":"10","author":"Torres","year":"2004","journal-title":"Nat Med"},{"key":"10.1038\/ki.2008.246_bb0170","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/01.CIR.0000086464.04719.DD","article-title":"Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis","volume":"108","author":"Kohler","year":"2003","journal-title":"Circulation"},{"key":"10.1038\/ki.2008.246_bb0175","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4049\/jimmunol.173.2.776","article-title":"K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity","volume":"173","author":"Wulff","year":"2004","journal-title":"J Immunol"},{"key":"10.1038\/ki.2008.246_bb0180","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1681\/ASN.2005060645","article-title":"Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells","volume":"17","author":"Yamaguchi","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2008.246_bb0185","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/nm935","article-title":"Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist","volume":"9","author":"Gattone","year":"2003","journal-title":"Nat Med"},{"key":"10.1038\/ki.2008.246_bb0190","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.molcel.2006.11.012","article-title":"Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells","volume":"24","author":"Srivastava","year":"2006","journal-title":"Mol Cell"},{"key":"10.1038\/ki.2008.246_bb0195","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1681\/ASN.2006111218","article-title":"Identification of a Forskolin-like molecule in human renal cysts","volume":"3","author":"Putnam","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2008.246_bb0200","first-page":"F381","article-title":"Anion secretion drives fluid secretion by monolayers of cultured human polycystic cells","volume":"269","author":"Mangoo-Karim","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.2008.246_bb0205","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.4049\/jimmunol.171.7.3542","article-title":"Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation","volume":"171","author":"Sundrud","year":"2003","journal-title":"J Immunol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815533899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815533899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T12:36:28Z","timestamp":1738240588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815533899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0085253815533899"],"URL":"https:\/\/doi.org\/10.1038\/ki.2008.246","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1115347.571366","asserted-by":"object"}]},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}