{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:52:44Z","timestamp":1777639964037,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":2500,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1038\/ki.2008.613","type":"journal-article","created":{"date-parts":[[2009,1,30]],"date-time":"2009-01-30T11:00:35Z","timestamp":1233313235000},"page":"S20-S24","source":"Crossref","is-referenced-by-count":72,"special_numbering":"S112","title":["Ticlopidine- and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): review of clinical, laboratory, epidemiological, and pharmacovigilance findings (1989\u20132008)"],"prefix":"10.1016","volume":"75","author":[{"given":"Anaadriana","family":"Zakarija","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hau C","family":"Kwaan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel L","family":"Moake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Bandarenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilip K","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June M","family":"McKoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R","family":"Yarnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis W","family":"Raisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey L","family":"Winters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J","family":"Raife","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F","family":"Cursio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh Ha","family":"Luu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Richey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas L","family":"Ortel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin S","family":"Tallman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X Long","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles L","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2008.613_bb0010","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1056\/NEJMra020528","article-title":"Thrombotic microangiopathies","volume":"347","author":"Moake","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2008.613_bb0015","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1055\/s-2005-925474","article-title":"Drug-induced thrombotic microangiopathy","volume":"31","author":"Zakarija","year":"2005","journal-title":"Semin Thromb Hemost"},{"key":"10.1038\/ki.2008.613_bb0020","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/01.STR.0000109253.66918.5E","article-title":"Clopidogrel-associated TTP: an update of pharmacovigilance efforts conducted by independent researchers, pharmaceutical suppliers, and the Food and Drug Administration","volume":"35","author":"Zakarija","year":"2004","journal-title":"Stroke"},{"key":"10.1038\/ki.2008.613_bb0025","first-page":"1315","article-title":"Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP\u2013HUS): frequency, presenting features, and clinical outcomes","volume":"110","author":"Saste","year":"2007","journal-title":"ASH Annu Meet Abstr"},{"key":"10.1038\/ki.2008.613_bb0030","doi-asserted-by":"crossref","first-page":"394","DOI":"10.7326\/0003-4819-129-5-199809010-00009","article-title":"The antiplatelet effects of ticlopidine and clopidogrel","volume":"129","author":"Sharis","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2008.613_bb0035","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0002-9149(97)01005-9","article-title":"Frequency of adverse clinical events in the 12 months following successful intracoronary stent placement in patients treated with aspirin and ticlopidine (without warfarin)","volume":"81","author":"Berger","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1038\/ki.2008.613_bb0040","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM198908243210804","article-title":"A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group","volume":"321","author":"Hass","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2008.613_bb0045","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(96)09457-3","article-title":"A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)","volume":"348","author":"CAPRIE Steering Committee","year":"1996","journal-title":"Lancet"},{"key":"10.1038\/ki.2008.613_bb0050","unstructured":"IMS Health, Inc. Leading Products by Global Pharmaceutical Sales, 2007, in (vol 2008), IMS Health, Inc. 2008. Accessed on 10 December 2008. Available at http:\/\/www.imshealth.com\/deployedfiles\/imshealth\/Global\/Content\/StaticFile\/TopLine_Data\/Top10GlobalProducts.pdf"},{"key":"10.1038\/ki.2008.613_bb0055","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0014-5793(98)00025-8","article-title":"Role of P2Y1 purinoceptor in ADP-induced platelet activation","volume":"422","author":"Savi","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1038\/ki.2008.613_bb0060","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/0140-6736(91)91383-6","article-title":"Thrombotic thrombocytopenic purpura related to ticlopidine","volume":"337","author":"Page","year":"1991","journal-title":"Lancet"},{"key":"10.1038\/ki.2008.613_bb0065","doi-asserted-by":"crossref","first-page":"541","DOI":"10.7326\/0003-4819-128-7-199804010-00004","article-title":"Thrombotic thrombocytopenic purpura associated with ticlopidine. A review of 60 cases","volume":"128","author":"Bennett","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2008.613_bb0070","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1001\/jama.282.18.1717","article-title":"Ticlopidine and TTP after coronary stenting","volume":"282","author":"Bennett","year":"1999","journal-title":"JAMA"},{"key":"10.1038\/ki.2008.613_bb0075","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1001\/archinte.159.21.2524","article-title":"Thrombotic thrombocytopenic purpura associated with ticlopidine in the setting of coronary artery stents and stroke prevention","volume":"159","author":"Bennett","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1038\/ki.2008.613_bb0080","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0140-6736(05)60079-7","article-title":"Thrombotic thrombocytopenic purpura after stenting and ticlopidine","volume":"352","author":"Bennett","year":"1998","journal-title":"Lancet"},{"key":"10.1038\/ki.2008.613_bb0085","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/jama.281.9.806","article-title":"Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. EPISTENT Investigators. Evaluation of platelet IIb\/IIIa inhibitor for stenting","volume":"281","author":"Steinhubl","year":"1999","journal-title":"JAMA"},{"key":"10.1038\/ki.2008.613_bb0090","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1056\/NEJM200006153422402","article-title":"Thrombotic thrombocytopenic purpura associated with clopidogrel","volume":"342","author":"Bennett","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2008.613_bb0095","unstructured":"Clopidogrel (Plavix) [package insert]. Bristol-Myers Squibb and Sanofi-Synthelabo: New York, NY 2006"},{"key":"10.1038\/ki.2008.613_bb0100","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/ajh.2830500203","article-title":"Increasing mortality from thrombotic thrombocytopenic purpura in the United States\u2014analysis of national mortality data, 1968\u20131991","volume":"50","author":"Torok","year":"1995","journal-title":"Am J Hematol"},{"key":"10.1038\/ki.2008.613_bb0105","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.jacc.2007.04.093","article-title":"Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project","volume":"50","author":"Bennett","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1038\/ki.2008.613_bb0110","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.7326\/0003-4819-135-12-200112180-00008","article-title":"Quinine-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: frequency, clinical features, and long-term outcomes","volume":"135","author":"Kojouri","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2008.613_bb0115","doi-asserted-by":"crossref","first-page":"794","DOI":"10.7326\/0003-4819-132-10-200005160-00005","article-title":"Antibody inhibitors to von Willebrand factor metalloproteinase and increased binding of von Willebrand factor to platelets in ticlopidine-associated thrombotic thrombocytopenic purpura","volume":"132","author":"Tsai","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2008.613_bb0120","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1046\/j.1365-2141.2003.04743.x","article-title":"Thienopyridine-linked thrombotic microangiopathy: association with endothelial cell apoptosis and activation of MAP kinase signalling cascades","volume":"124","author":"Mauro","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1038\/ki.2008.613_bb0125","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1172\/JCI26007","article-title":"Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice","volume":"115","author":"Motto","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2008.613_bb0130","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/ccd.20433","article-title":"Clopidogrel (Plavix) desensitization: a case series","volume":"65","author":"Camara","year":"2005","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1038\/ki.2008.613_bb0135","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1056\/NEJM199811263392203","article-title":"Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura","volume":"339","author":"Tsai","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2008.613_bb0140","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0140-6736(66)92422-6","article-title":"Incidence of a positive direct Coombs test in patients on alpha-methyldopa","volume":"2","author":"Carstairs","year":"1966","journal-title":"Lancet"},{"key":"10.1038\/ki.2008.613_bb0145","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/00007890-200209270-00026","article-title":"TTP\/HUS occurring in a simultaneous pancreas\/kidney transplant recipient after clopidogrel treatment: evidence of a nonimmunological etiology","volume":"74","author":"Evens","year":"2002","journal-title":"Transplantation"},{"key":"10.1038\/ki.2008.613_bb0150","first-page":"597","article-title":"Thienopyridines: effects on cultured endothelial cells","volume":"50","author":"Ziemianin","year":"1999","journal-title":"J Physiol Pharmacol"},{"key":"10.1038\/ki.2008.613_bb0155","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.plefa.2004.10.011","article-title":"Endothelial action of thienopyridines and thienopyrimidinones in the isolated guinea pig heart","volume":"72","author":"Jakubowski","year":"2005","journal-title":"Prostagland Leukot Essent Fatty Acids"},{"key":"10.1038\/ki.2008.613_bb0160","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJM199108083250604","article-title":"Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group","volume":"325","author":"Rock","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2008.613_bb0165","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1182\/blood.V96.4.1223","article-title":"How I treat patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome","volume":"96","author":"George","year":"2000","journal-title":"Blood"},{"key":"10.1038\/ki.2008.613_bb0170","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jca.20129","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice: evidence-based approach from the Apheresis Applications Committee of the American Society for Apheresis","volume":"22","author":"Szczepiorkowski","year":"2007","journal-title":"J Clin Apher"},{"key":"10.1038\/ki.2008.613_bb0175","first-page":"E211","article-title":"Use of ticlopidine and cilostazol after intracoronary drug-eluting stent placement in a patient with previous clopidogrel-induced thrombotic thrombocytopenic purpura: a case report","volume":"18","author":"Patel","year":"2006","journal-title":"J Invasive Cardiol"},{"key":"10.1038\/ki.2008.613_bb0180","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1056\/NEJM199811263392202","article-title":"von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome","volume":"339","author":"Furlan","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2008.613_bb0185","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1056\/NEJM200010193431612","article-title":"Clopidogrel and thrombotic thrombocytopenic purpura","volume":"343","author":"Trontell","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2008.613_bb0190","unstructured":"Ticlid (ticlopidine HCl) [package insert]. Roche Laboratories Inc.: Nutley, NJ 2006"},{"key":"10.1038\/ki.2008.613_bb0195","first-page":"56S","article-title":"Clopidogrel associated TTP","volume":"39","author":"Connors","year":"1999","journal-title":"Transfusion"},{"key":"10.1038\/ki.2008.613_bb0200","first-page":"78b","article-title":"Thrombotic thrombocytopenic purpura occurring after exposure to clopidogrel","volume":"94","author":"Carwile","year":"1999","journal-title":"Blood"},{"key":"10.1038\/ki.2008.613_bb0205","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1001\/jama.1996.03540120030022","article-title":"Blood dycrasias and hematologic reactions in ticlopidine users","volume":"276","author":"Wysowksi","year":"1996","journal-title":"JAMA"},{"key":"10.1038\/ki.2008.613_bb0210","unstructured":"A. Zakarija, C.L. Bennett, H.C. Kwaan et al. Idiopathic thrombotic thrombocytopenic purpura: final results from the surveillance, epidemiology, and risk factors for TTP (SERF-TTP). Blood (under review)"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815536090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815536090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T06:00:20Z","timestamp":1589522420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815536090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":41,"alternative-id":["S0085253815536090"],"URL":"https:\/\/doi.org\/10.1038\/ki.2008.613","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}