{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:14:27Z","timestamp":1790889267280,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":2107,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1038\/ki.2009.481","type":"journal-article","created":{"date-parts":[[2009,12,16]],"date-time":"2009-12-16T13:39:22Z","timestamp":1260970762000},"page":"436-442","source":"Crossref","is-referenced-by-count":57,"title":["Verapamil inhibits calcification and matrix vesicle activity of bovine vascular smooth muscle cells"],"prefix":"10.1016","volume":"77","author":[{"given":"Neal X.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Kircelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalisha D.","family":"O'Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Moe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2009.481_bb0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0889-857X(21)00966-2","article-title":"Mechanisms of pathologic calcification","volume":"14","author":"Anderson","year":"1988","journal-title":"Rheumatic Diseases Clinics of North America"},{"key":"10.1038\/ki.2009.481_bb0015","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s11926-003-0071-z","article-title":"Matrix vesicles and calcification","volume":"5","author":"Anderson","year":"2003","journal-title":"Curr Rheumatol Rep"},{"key":"10.1038\/ki.2009.481_bb0020","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1074\/jbc.M208868200","article-title":"Annexin-mediated Ca2+ influx regulates growth plate chondrocyte maturation and apoptosis","volume":"278","author":"Wang","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2009.481_bb0025","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1359\/jbmr.2003.18.10.1872","article-title":"Functional differences between growth plate apoptotic bodies and matrix vesicles","volume":"18","author":"Kirsch","year":"2003","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.2009.481_bb0030","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1359\/jbmr.080604","article-title":"Annexin-mediated matrix vesicle calcification in vascular smooth muscle cells","volume":"23","author":"Chen","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.2009.481_bb0035","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1159\/000159111","article-title":"Calcium channels in vascular smooth muscle cells","volume":"32","author":"Hughes","year":"1995","journal-title":"J Vasc Res"},{"key":"10.1038\/ki.2009.481_bb0040","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1096\/fasebj.12.7.593","article-title":"L-type calcium channel expression depends on the differentiated state of vascular smooth muscle cells","volume":"12","author":"Gollasch","year":"1998","journal-title":"FASEB J"},{"key":"10.1038\/ki.2009.481_bb0045","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0006-3495(90)82392-4","article-title":"Direct binding of verapamil to the ryanodine receptor channel of sarcoplasmic reticulum","volume":"58","author":"Valdivia","year":"1990","journal-title":"Biophys J"},{"key":"10.1038\/ki.2009.481_bb0050","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00045391-200311000-00006","article-title":"Calcium antagonists and atherosclerosis protection in hypertension","volume":"10","author":"Hernandez","year":"2003","journal-title":"Am J Ther"},{"key":"10.1038\/ki.2009.481_bb0055","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00001573-200111000-00006","article-title":"Coronary benefits of calcium antagonist therapy for patients with hypertension","volume":"16","author":"Motro","year":"2001","journal-title":"Curr Opin Cardiol"},{"key":"10.1038\/ki.2009.481_bb0060","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1161\/01.HYP.37.6.1410","article-title":"Calcium channel blocker nifedipine slows down progression of coronary calcification in hypertensive patients compared with diuretics","volume":"37","author":"Motro","year":"2001","journal-title":"Hypertension"},{"key":"10.1038\/ki.2009.481_bb0065","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1097\/HJH.0b013e328255e906","article-title":"Distinct effects of amlodipine treatment on vascular elastocalcinosis and stiffness in a rat model of isolated systolic hypertension","volume":"25","author":"Essalihi","year":"2007","journal-title":"J Hypertens"},{"key":"10.1038\/ki.2009.481_bb0070","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/978-1-4757-4441-5_24","article-title":"Inhibition of vitamin D3-induced vascular calcification by carbocromen","volume":"4","author":"Schraven","year":"1983","journal-title":"Adv Myocardiol"},{"key":"10.1038\/ki.2009.481_bb0075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11010-007-9608-1","article-title":"Modulation of calcification of vascular smooth muscle cells in culture by calcium antagonists, statins, and their combination","volume":"308","author":"Trion","year":"2008","journal-title":"Mol Cell Biochem"},{"key":"10.1038\/ki.2009.481_bb0080","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1523-1755.2003.00820.x","article-title":"Uremia induces the osteoblast differentiation factor Cbfa1 in human blood vessels","volume":"63","author":"Moe","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2009.481_bb0085","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1046\/j.1523-1755.2002.00170.x","article-title":"Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins","volume":"61","author":"Moe","year":"2002","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2009.481_bb0090","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1540-8167.1994.tb01156.x","article-title":"The role of the membrane potential of endothelial and smooth muscle cells in the regulation of coronary blood flow","volume":"5","author":"Daut","year":"1994","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1038\/ki.2009.481_bb0095","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/01.RES.78.4.676","article-title":"K+ currents in human coronary artery vascular smooth muscle cells","volume":"78","author":"Gollasch","year":"1996","journal-title":"Circ Res"},{"key":"10.1038\/ki.2009.481_bb0100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/01.RES.76.1.21","article-title":"Differentiation of vascular smooth muscle cells and the regulation of protein kinase C-alpha","volume":"76","author":"Haller","year":"1995","journal-title":"Circ Res"},{"key":"10.1038\/ki.2009.481_bb0105","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1152\/physrev.1997.77.3.699","article-title":"Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions","volume":"77","author":"Franzini-Armstrong","year":"1997","journal-title":"Physiol Rev"},{"key":"10.1038\/ki.2009.481_bb0110","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1161\/01.CIR.95.7.1954","article-title":"Calcifying subpopulation of bovine aortic smooth muscle cells is responsive to 17 beta-estradiol","volume":"95","author":"Balica","year":"1997","journal-title":"Circulation"},{"key":"10.1038\/ki.2009.481_bb0115","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.lfs.2004.12.037","article-title":"Dysfunction of myocardial sarcoplasmic reticulum in rats with myocardial calcification","volume":"77","author":"Bin","year":"2005","journal-title":"Life Sci"},{"key":"10.1038\/ki.2009.481_bb0120","doi-asserted-by":"crossref","first-page":"822","DOI":"10.2741\/1576","article-title":"The role of matrix vesicles in growth plate development and biomineralization","volume":"10","author":"Anderson","year":"2005","journal-title":"Front Biosci"},{"key":"10.1038\/ki.2009.481_bb0125","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrm1661","article-title":"Annexins: linking Ca2+ signalling to membrane dynamics","volume":"6","author":"Gerke","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1038\/ki.2009.481_bb0130","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/S0021-9258(18)61633-3","article-title":"Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein","volume":"262","author":"Cornwell","year":"1987","journal-title":"J Biol Chem"},{"issue":"Part 2","key":"10.1038\/ki.2009.481_bb0135","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/bj2790413","article-title":"Verapamil prevents the effects of daunomycin on the thermotropic phase transition of model lipid bilayers","volume":"279","author":"Canaves","year":"1991","journal-title":"Biochem J"},{"key":"10.1038\/ki.2009.481_bb0140","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0005-2736(98)00098-4","article-title":"Changes of the membrane potential profile induced by verapamil and propranolol","volume":"1373","author":"Pohl","year":"1998","journal-title":"Biochem Biophys Acta"},{"key":"10.1038\/ki.2009.481_bb0145","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1046\/j.1523-1755.2002.00625.x","article-title":"Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells","volume":"62","author":"Chen","year":"2002","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2009.481_bb0150","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1097\/01.ASN.0000128955.83129.9C","article-title":"Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin","volume":"15","author":"Lomashvili","year":"2004","journal-title":"J Am Soc Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815542725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815542725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T05:09:22Z","timestamp":1634360962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815542725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0085253815542725"],"URL":"https:\/\/doi.org\/10.1038\/ki.2009.481","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}