{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:31:27Z","timestamp":1790854287908,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":2380,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1038\/ki.2009.63","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T13:01:57Z","timestamp":1236171717000},"page":"1316-1321","source":"Crossref","is-referenced-by-count":32,"title":["Hemoglobin is inversely related to flow-mediated dilatation in chronic kidney disease"],"prefix":"10.1016","volume":"75","author":[{"given":"Mahmut I.","family":"Yilmaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Sonmez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutlu","family":"Saglam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahir","family":"Gulec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Kilic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayfun","family":"Eyileten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayser","family":"Caglar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Oguz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulgaffar","family":"Vural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mujdat","family":"Yenicesu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Zoccali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2009.63_bb0010","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ncpneph0847","article-title":"Anemia and anemia correction: surrogate markers or causes of morbidity in chronic kidney disease?","volume":"4","author":"Vaziri","year":"2008","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1038\/ki.2009.63_bb0015","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJM199808273390903","article-title":"The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin","volume":"339","author":"Besarab","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2009.63_bb0020","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMoa062276","article-title":"CREATE Investigators. Normalization of hemoglobin level in patients with chronic kidney disease and anemia","volume":"355","author":"Dr\u00fceke","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2009.63_bb0025","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa065485","article-title":"CHOIR Investigators. Correction of anemia with epoetin alfa in chronic kidney disease","volume":"355","author":"Singh","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2009.63_bb0030","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0140-6736(07)60194-9","article-title":"Mortality and target haemoglobin concentrations in anaemic patients with chronic kidney disease treated with erythropoietin: a meta-analysis","volume":"369","author":"Phrommintikul","year":"2007","journal-title":"Lancet"},{"issue":"Suppl 5","key":"10.1038\/ki.2009.63_bb0035","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/ndt\/17.suppl_5.32","article-title":"Anaemia, rHuEPO resistance, and cardiovascular disease in end-stage renal failure; links to inflammation and oxidative stress","volume":"17","author":"Stenvinkel","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2009.63_bb0040","doi-asserted-by":"crossref","first-page":"9027","DOI":"10.1073\/pnas.96.16.9027","article-title":"The oxyhemoglobin reaction of nitric oxide","volume":"96","author":"Gow","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.63_bb0045","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.physiol.67.060603.090918","article-title":"Chemical physiology of blood flow regulation by red blood cells: the role of nitric oxide and S-nitrosohemoglobin","volume":"67","author":"Singel","year":"2005","journal-title":"Annu Rev Physiol"},{"key":"10.1038\/ki.2009.63_bb0050","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0304-4165(98)00065-8","article-title":"Diffusion of nitric oxide and scavenging by blood in the vasculature","volume":"1425","author":"Butler","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/ki.2009.63_bb0055","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1055\/s-0037-1614066","article-title":"Blood rheology, cardiovascular risk factors, and cardiovascular disease: the West of Scotland Coronary Prevention Study","volume":"84","author":"Lowe","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1038\/ki.2009.63_bb0060","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1046\/j.1365-2141.2001.03092.x","article-title":"Endothelial dysfunction in patients with polycythaemia vera","volume":"115","author":"Neunteufl","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1038\/ki.2009.63_bb0065","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/eurheartj\/ehi113","article-title":"Haematocrit, type 2 diabetes, and endothelium-dependent vasodilatation of resistance vessels","volume":"26","author":"Natali","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1038\/ki.2009.63_bb0070","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0304-4165(98)00065-8","article-title":"Diffusion of nitric oxide and scavenging by blood in the vasculature","volume":"1425","author":"Butler","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/ki.2009.63_bb0075","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1161\/01.ATV.19.5.1168","article-title":"Nitric oxide production is reduced in patients with chronic renal failure","volume":"19","author":"Wever","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1038\/ki.2009.63_bb0080","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1681\/ASN.2004070582","article-title":"Reduced agonist-induced endothelium-dependent vasodilation in uremia is attributable to an impairment of vascular nitric oxide","volume":"16","author":"Passauer","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2009.63_bb0085","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/ki.1997.319","article-title":"Up-regulation of renal and vascular nitric oxide synthase in iron-deficiency anemia","volume":"52","author":"Ni","year":"1997","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2009.63_bb0090","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1681\/ASN.2006040400","article-title":"Local shear stress and brachial artery functions in end-stage renal disease","volume":"18","author":"Verbeke","year":"2007","journal-title":"J Am Soc Nephrol"},{"issue":"Suppl 2","key":"10.1038\/ki.2009.63_bb0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ndt\/16.suppl_2.3","article-title":"Pathophysiology of cardiovascular damage in the early renal population","volume":"16","author":"London","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2009.63_bb0100","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ndt\/6.1.31","article-title":"Reversal of left ventricular hypertrophy following recombinant human erythropoietin treatment of anaemic dialyzed uraemic patients","volume":"6","author":"Canella","year":"1991","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2009.63_bb0105","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0140-6736(90)90733-L","article-title":"Long-term cardiorespiratory effects of amelioration of renal anaemia by erythropoietin","volume":"335","author":"Macdougall","year":"1990","journal-title":"Lancet"},{"key":"10.1038\/ki.2009.63_bb0110","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/377239a0","article-title":"Hypertension in mice lacking the gene for endothelial nitric oxide synthase","volume":"377","author":"Huang","year":"1995","journal-title":"Nature"},{"key":"10.1038\/ki.2009.63_bb0115","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1053\/j.ajkd.2005.09.029","article-title":"The determinants of endothelial dysfunction in CKD: oxidative stress and asymmetric dimethylarginine","volume":"47","author":"Yilmaz","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2009.63_bb0120","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"10.1038\/ki.2009.63_bb0125","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2009.63_bb0130","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1038\/ki.2009.63_bb0135","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/0735-1097(93)90203-D","article-title":"Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents","volume":"22","author":"Celermajer","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"10.1038\/ki.2009.63_bb0140","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0735-1097(01)01746-6","article-title":"Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force","volume":"39","author":"Corretti","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1038\/ki.2009.63_bb0145","series-title":"Applied Regression Analysis and Other Multivariable Methods","first-page":"388","article-title":"Step 2: Specifying a Criterion for Selecting a Model","author":"Kleinbaum","year":"1998"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815536430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815536430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T09:00:59Z","timestamp":1589619659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815536430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0085253815536430"],"URL":"https:\/\/doi.org\/10.1038\/ki.2009.63","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}