{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:27:52Z","timestamp":1791898072069,"version":"4.3.4"},"reference-count":151,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":2380,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1038\/ki.2009.73","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T08:02:08Z","timestamp":1238572928000},"page":"1153-1165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":315,"title":["Uroplakins in urothelial biology, function, and disease"],"prefix":"10.1016","volume":"75","author":[{"given":"Xue-Ru","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Peng","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Pellicer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Kreibich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Tien","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2009.73_bb0010","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0022-5347(17)57034-2","article-title":"The urothelium: a battleground for oncogenesis","volume":"120","author":"Melicow","year":"1978","journal-title":"J Urol"},{"key":"10.1038\/ki.2009.73_bb0015","series-title":"Diagnostic Cytology of the Urinary Tract: with Histopathologic and Clinical Correlations","first-page":"71","article-title":"Tumors of the Bladder","author":"Koss","year":"1996"},{"key":"10.1038\/ki.2009.73_bb0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/aja.1001070202","article-title":"Renewal of cell populations in the female mouse","volume":"102","author":"Walker","year":"1960","journal-title":"Am J Anat"},{"key":"10.1038\/ki.2009.73_bb0025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1469-185X.1975.tb01057.x","article-title":"The mammalian urinary bladder: an accommodating organ","volume":"50","author":"Hicks","year":"1975","journal-title":"Biol Rev Camb Philos Soc"},{"key":"10.1038\/ki.2009.73_bb0030","doi-asserted-by":"crossref","first-page":"F867","DOI":"10.1152\/ajprenal.2000.278.6.F867","article-title":"Everything you wanted to know about the bladder epithelium but were afraid to ask","volume":"278","author":"Lewis","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2009.73_bb0035","first-page":"F886","article-title":"Permeability properties of the intact mammalian bladder epithelium","volume":"271","author":"Negrete","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.2009.73_bb0040","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1083\/jcb.77.3.685","article-title":"Morphometric analysis of the translocation of lumenal membrane between cytoplasm and cell surface of transitional epithelial cells during the expansion-contraction cycles of mammalian urinary bladder","volume":"77","author":"Minsky","year":"1978","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0045","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/297685a0","article-title":"Incorporation of cytoplasmic vesicles into apical membrane of mammalian urinary bladder epithelium","volume":"297","author":"Lewis","year":"1982","journal-title":"Nature"},{"key":"10.1038\/ki.2009.73_bb0050","series-title":"An Introduction to the Fine Structure of Cells and Tissues","author":"Porter","year":"1963"},{"key":"10.1038\/ki.2009.73_bb0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1083\/jcb.26.1.25","article-title":"The fine structure of the transitional epithelium of rat ureter","volume":"26","author":"Hicks","year":"1965","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0060","first-page":"154","article-title":"The asymmetric unit membranes of the epithelium of the urinary bladder of the rat. An electron microscopic study of a mechanism of epithelial maturation and function","volume":"21","author":"Koss","year":"1969","journal-title":"Lab Invest"},{"key":"10.1038\/ki.2009.73_bb0065","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1006\/jmbi.1998.2304","article-title":"Three-dimensional analysis of the 16 nm urothelial plaque particle: luminal surface exposure, preferential head-to-head interaction, and hinge formation","volume":"285","author":"Kachar","year":"1999","journal-title":"J Mol Biol"},{"key":"10.1038\/ki.2009.73_bb0070","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/cm.10077","article-title":"Trajectorial organisation of cytokeratins within the subapical region of umbrella cells","volume":"53","author":"Veranic","year":"2002","journal-title":"Cell Motil Cytoskeleton"},{"key":"10.1038\/ki.2009.73_bb0075","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1091\/mbc.e05-02-0136","article-title":"Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking","volume":"16","author":"Hu","year":"2005","journal-title":"Mol Biol Cell"},{"key":"10.1038\/ki.2009.73_bb0080","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/BF01248042","article-title":"Specializations of the unit membrane","volume":"63","author":"Porter","year":"1967","journal-title":"Protoplasma"},{"key":"10.1038\/ki.2009.73_bb0085","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0022-2836(69)90200-9","article-title":"A hexagonal arrangement of subunits in membrane of mouse urinary bladder","volume":"46","author":"Vergara","year":"1969","journal-title":"J Mol Biol"},{"key":"10.1038\/ki.2009.73_bb0090","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/2241304a0","article-title":"Hexagonal lattice of subunits in the thick luminal membrane of the rat urinary bladder","volume":"224","author":"Hicks","year":"1969","journal-title":"Nature"},{"key":"10.1038\/ki.2009.73_bb0095","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0022-5320(84)90113-8","article-title":"Analysis of the three-dimensional structure of the urinary bladder epithelial cell membranes","volume":"87","author":"Taylor","year":"1984","journal-title":"J Ultrastruct Res"},{"key":"10.1038\/ki.2009.73_bb0100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0022-2836(83)80048-5","article-title":"Three-dimensional structure of luminal plasma membrane protein from urinary bladder","volume":"166","author":"Brisson","year":"1983","journal-title":"J Mol Biol"},{"key":"10.1038\/ki.2009.73_bb0105","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1006\/jmbi.1995.0269","article-title":"Towards the molecular architecture of the asymmetric unit membrane of the mammalian urinary bladder epithelium: a closed \u2018twisted ribbon\u2019 structure","volume":"248","author":"Walz","year":"1995","journal-title":"J Mol Biol"},{"key":"10.1038\/ki.2009.73_bb0110","doi-asserted-by":"crossref","first-page":"15020","DOI":"10.1074\/jbc.274.21.15020","article-title":"Primary uroepithelial cultures. A model system to analyze umbrella cell barrier function","volume":"274","author":"Truschel","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2009.73_bb0115","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1091\/mbc.01-09-0435","article-title":"Stretch-regulated exocytosis\/endocytosis in bladder umbrella cells","volume":"13","author":"Truschel","year":"2002","journal-title":"Mol Biol Cell"},{"key":"10.1038\/ki.2009.73_bb0120","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1073\/pnas.98.1.154","article-title":"Urothelial function reconsidered: a role in urinary protein secretion","volume":"98","author":"Deng","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.73_bb0125","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/sj.ki.5002439","article-title":"The uroepithelial-associated sensory web","volume":"72","author":"Apodaca","year":"2007","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2009.73_bb0130","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ncpuro0672","article-title":"Mechanisms of disease: involvement of the urothelium in bladder dysfunction","volume":"4","author":"Birder","year":"2007","journal-title":"Nat Clin Pract Urol"},{"key":"10.1038\/ki.2009.73_bb0135","first-page":"66P","article-title":"Proteins of the plasma membrane lining the lumen of the rat bladder","volume":"122","author":"Ketterer","year":"1971","journal-title":"Biochem J"},{"key":"10.1038\/ki.2009.73_bb0140","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0005-2736(73)90265-4","article-title":"Studies of the chemistry of the luminal plasma membrane of rat bladder epithelial cells","volume":"311","author":"Ketterer","year":"1973","journal-title":"Biochim Biophys Acta"},{"key":"10.1038\/ki.2009.73_bb0145","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1083\/jcb.61.1.83","article-title":"Isolation and characterization of luminal membranes from urinary bladder","volume":"61","author":"Vergara","year":"1974","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0150","doi-asserted-by":"crossref","first-page":"19170","DOI":"10.1016\/S0021-9258(17)30640-3","article-title":"Large scale purification and immunolocalization of bovine uroplakins I, II, and III. Molecular markers of urothelial differentiation","volume":"265","author":"Wu","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2009.73_bb0155","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1242\/jcs.106.1.31","article-title":"Molecular cloning of a 47 kDa tissue-specific and differentiation-dependent urothelial cell surface glycoprotein","volume":"106","author":"Wu","year":"1993","journal-title":"J Cell Sci"},{"key":"10.1038\/ki.2009.73_bb0160","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/S0021-9258(17)42095-3","article-title":"Precursor sequence, processing, and urothelium-specific expression of a major 15-kDa protein subunit of asymmetric unit membrane","volume":"269","author":"Lin","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2009.73_bb0165","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1083\/jcb.125.1.171","article-title":"Uroplakins Ia and Ib, two major differentiation products of bladder epithelium, belong to a family of four transmembrane domain (4TM) proteins","volume":"125","author":"Yu","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0170","doi-asserted-by":"crossref","first-page":"13716","DOI":"10.1016\/S0021-9258(17)36889-8","article-title":"Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins","volume":"269","author":"Wu","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2009.73_bb0175","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ympev.2006.04.023","article-title":"Origin of the tetraspanin uroplakins and their co-evolution with associated proteins: implications for uroplakin structure and function","volume":"41","author":"Garcia-Espana","year":"2006","journal-title":"Mol Phylogenet Evol"},{"key":"10.1038\/ki.2009.73_bb0180","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1083\/jcb.111.3.1207","article-title":"Uroplakin I: a 27-kD protein associated with the asymmetric unit membrane of mammalian urothelium","volume":"111","author":"Yu","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0185","doi-asserted-by":"crossref","first-page":"F562","DOI":"10.1152\/ajprenal.00368.2004","article-title":"Gene deletion in urothelium by specific expression of Cre recombinase","volume":"289","author":"Mo","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2009.73_bb0190","first-page":"3512","article-title":"Urothelium-specific expression of an oncogene in transgenic mice induced the formation of carcinoma in situ and invasive transitional cell carcinoma","volume":"59","author":"Zhang","year":"1999","journal-title":"Cancer Res"},{"key":"10.1038\/ki.2009.73_bb0195","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/0192623308315672","article-title":"Trans-species comparison of PPAR and RXR expression by rat and human urothelial tissues","volume":"36","author":"Chopra","year":"2008","journal-title":"Toxicol Pathol"},{"key":"10.1038\/ki.2009.73_bb0200","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/nrm1736","article-title":"Tetraspanin functions and associated microdomains","volume":"6","author":"Hemler","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0205","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nri1548","article-title":"The tetraspanin web modulates immune-signalling complexes","volume":"5","author":"Levy","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/ki.2009.73_bb0210","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1083\/jcb.53.1.73","article-title":"Lumenal plasma membrane of the urinary bladder. I. Three-dimensional reconstruction from freeze-etch images","volume":"53","author":"Staehelin","year":"1972","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0215","doi-asserted-by":"crossref","first-page":"29752","DOI":"10.1074\/jbc.270.50.29752","article-title":"Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells","volume":"270","author":"Wu","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2009.73_bb0220","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1042\/bj3550013","article-title":"Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition","volume":"355","author":"Liang","year":"2001","journal-title":"Biochem J"},{"key":"10.1038\/ki.2009.73_bb0225","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1091\/mbc.e02-04-0211","article-title":"Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum","volume":"13","author":"Tu","year":"2002","journal-title":"Mol Biol Cell"},{"key":"10.1038\/ki.2009.73_bb0230","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1006\/jmbi.2001.5128","article-title":"Structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography","volume":"314","author":"Oostergetel","year":"2001","journal-title":"J Mol Biol"},{"key":"10.1038\/ki.2009.73_bb0235","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1083\/jcb.200602086","article-title":"Structural basis for tetraspanin functions as revealed by the cryo-EM structure of uroplakin complexes at 6-A resolution","volume":"173","author":"Min","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0240","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1242\/jcs.00811","article-title":"Structural basis of urothelial permeability barrier function as revealed by Cryo-EM studies of the 16 nm uroplakin particle","volume":"116","author":"Min","year":"2003","journal-title":"J Cell Sci"},{"key":"10.1038\/ki.2009.73_bb0245","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1006\/jmbi.2002.5442","article-title":"Localization of uroplakin Ia, the urothelial receptor for bacterial adhesin FimH, on the six inner domains of the 16 nm urothelial plaque particle","volume":"317","author":"Min","year":"2002","journal-title":"J Mol Biol"},{"key":"10.1038\/ki.2009.73_bb0250","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1242\/jcs.114.22.4095","article-title":"Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding","volume":"114","author":"Zhou","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1038\/ki.2009.73_bb0255","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/BJ20080550","article-title":"Assembly of a membrane receptor complex: roles of the uroplakin II prosequence in regulating uroplakin bacterial receptor oligomerization","volume":"414","author":"Hu","year":"2008","journal-title":"Biochem J"},{"key":"10.1038\/ki.2009.73_bb0260","doi-asserted-by":"crossref","first-page":"F9","DOI":"10.1152\/ajprenal.00035.2006","article-title":"Altered phenotype of cultured urothelial and other stratified epithelial cells: implications for wound healing","volume":"291","author":"Sun","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2009.73_bb0265","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.1242\/jcs.03285","article-title":"Integrity of all four transmembrane domains of the tetraspanin uroplakin Ib is required for its exit from the ER","volume":"119","author":"Tu","year":"2006","journal-title":"J Cell Sci"},{"key":"10.1038\/ki.2009.73_bb0270","first-page":"5338","article-title":"Cloning of a growth arrest-specific and transforming growth factor beta-regulated gene, TI 1, from an epithelial cell line","volume":"11","author":"Kallin","year":"1991","journal-title":"Mol Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0275","first-page":"2900","article-title":"Human uroplakin Ib in ocular surface epithelium","volume":"41","author":"Adachi","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1038\/ki.2009.73_bb0280","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1083\/jcb.151.5.961","article-title":"Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux","volume":"151","author":"Hu","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0285","doi-asserted-by":"crossref","first-page":"9861","DOI":"10.1073\/pnas.1633363100","article-title":"A high-molecular-weight complex of membrane proteins BAP29\/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum","volume":"100","author":"Schamel","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.73_bb0290","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1083\/jcb.200408106","article-title":"Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER","volume":"168","author":"Kota","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0295","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/emboj\/20.10.2443","article-title":"Quality control of transmembrane domain assembly in the tetraspanin CD82","volume":"20","author":"Cannon","year":"2001","journal-title":"EMBO J"},{"key":"10.1038\/ki.2009.73_bb0300","doi-asserted-by":"crossref","first-page":"14012","DOI":"10.1073\/pnas.2436350100","article-title":"Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes","volume":"100","author":"Chen","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.73_bb0305","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1182\/blood-2003-03-0977","article-title":"A role for Rab27b in NF-E2-dependent pathways of platelet formation","volume":"102","author":"Tiwari","year":"2003","journal-title":"Blood"},{"key":"10.1038\/ki.2009.73_bb0310","doi-asserted-by":"crossref","first-page":"15773","DOI":"10.1073\/pnas.0805636105","article-title":"Rab11a-dependent exocytosis of discoidal\/fusiform vesicles in bladder umbrella cells","volume":"105","author":"Khandelwal","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.73_bb0315","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1083\/jcb.200505035","article-title":"Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacement","volume":"171","author":"Liang","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0320","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ejcb.2004.12.011","article-title":"Urothelial umbrella cells of human ureter are heterogeneous with respect to their uroplakin composition: different degrees of urothelial maturity in ureter and bladder?","volume":"84","author":"Riedel","year":"2005","journal-title":"Eur J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0325","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00441-004-1005-4","article-title":"Differentiation of epithelial cells in the urinary tract","volume":"320","author":"Romih","year":"2005","journal-title":"Cell Tissue Res"},{"key":"10.1038\/ki.2009.73_bb0330","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1046\/j.1432-0436.2000.660207.x","article-title":"Plasticity of the urothelial phenotype: effects of gastro-intestinal mesenchyme\/stroma and implications for urinary tract reconstruction","volume":"66","author":"Li","year":"2000","journal-title":"Differentiation"},{"key":"10.1038\/ki.2009.73_bb0335","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1083\/jcb.96.6.1662","article-title":"Epithelial-mesenchymal interactions in prostatic development. I. morphological observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder","volume":"96","author":"Cunha","year":"1983","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0340","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(80)90150-6","article-title":"Intrinsic and extrinsic regulation of the differentiation of skin, corneal and esophageal epithelial cells","volume":"22","author":"Doran","year":"1980","journal-title":"Cell"},{"key":"10.1038\/ki.2009.73_bb0345","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1002\/dvdy.20886","article-title":"Bladder tissue formation from cultured bladder urothelium","volume":"235","author":"Oottamasathien","year":"2006","journal-title":"Dev Dyn"},{"key":"10.1038\/ki.2009.73_bb0350","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/ng1645","article-title":"Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder","volume":"37","author":"Batourina","year":"2005","journal-title":"Nat Genet"},{"key":"10.1038\/ki.2009.73_bb0355","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1242\/dev.011270","article-title":"The development of the bladder trigone, the center of the anti-reflux mechanism","volume":"134","author":"Viana","year":"2007","journal-title":"Development"},{"key":"10.1038\/ki.2009.73_bb0360","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0140-6736(06)68438-9","article-title":"Tissue-engineered autologous bladders for patients needing cystoplasty","volume":"367","author":"Atala","year":"2006","journal-title":"Lancet"},{"key":"10.1038\/ki.2009.73_bb0365","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/ten.2006.12.635","article-title":"Review: tissue engineering of the urinary bladder: considering structure-function relationships and the role of mechanotransduction","volume":"12","author":"Korossis","year":"2006","journal-title":"Tissue Eng"},{"key":"10.1038\/ki.2009.73_bb0370","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1432-0436.2005.00014.x","article-title":"Molecular, cellular and developmental biology of urothelium as a basis of bladder regeneration","volume":"73","author":"Staack","year":"2005","journal-title":"Differentiation"},{"key":"10.1038\/ki.2009.73_bb0375","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1093\/carcin\/12.10.1975","article-title":"Direct DNA sequencing of the rat neu oncogene transmembrane domain reveals no mutation in urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-methyl-N-nitrosourea","volume":"12","author":"Masui","year":"1991","journal-title":"Carcinogenesis"},{"key":"10.1038\/ki.2009.73_bb0380","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1681\/ASN.2007050537","article-title":"Role of environmental toxins in endemic (Balkan) nephropathy. October 2006, Zagreb, Croatia","volume":"18","author":"Grollman","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2009.73_bb0385","doi-asserted-by":"crossref","first-page":"12129","DOI":"10.1073\/pnas.0701248104","article-title":"Aristolochic acid and the etiology of endemic (Balkan) nephropathy","volume":"104","author":"Grollman","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.73_bb0390","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1083\/jcb.200406025","article-title":"Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases","volume":"167","author":"Kong","year":"2004","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0395","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1083\/jcb.200204102","article-title":"Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly","volume":"159","author":"Deng","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0400","doi-asserted-by":"crossref","first-page":"F1200","DOI":"10.1152\/ajprenal.00043.2002","article-title":"Role of membrane proteins in permeability barrier function: uroplakin ablation elevates urothelial permeability","volume":"283","author":"Hu","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2009.73_bb0405","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1600-0854.2003.00156.x","article-title":"The uroepithelium: not just a passive barrier","volume":"5","author":"Apodaca","year":"2004","journal-title":"Traffic"},{"key":"10.1038\/ki.2009.73_bb0410","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s11934-006-0051-8","article-title":"Dysfunction of bladder urothelium and bladder urothelial cells in interstitial cystitis","volume":"7","author":"Graham","year":"2006","journal-title":"Curr Urol Rep"},{"key":"10.1038\/ki.2009.73_bb0415","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.urology.2006.03.084","article-title":"The role of the urinary epithelium in the pathogenesis of interstitial cystitis\/prostatitis\/urethritis","volume":"69","author":"Parsons","year":"2007","journal-title":"Urology"},{"key":"10.1038\/ki.2009.73_bb0420","doi-asserted-by":"crossref","first-page":"F540","DOI":"10.1152\/ajprenal.2000.278.4.F540","article-title":"Urothelial pathophysiological changes in feline interstitial cystitis: a human model","volume":"278","author":"Lavelle","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2009.73_bb0425","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.urology.2006.03.083","article-title":"Bladder defense molecules, urothelial differentiation, urinary biomarkers, and interstitial cystitis","volume":"69","author":"Hurst","year":"2007","journal-title":"Urology"},{"key":"10.1038\/ki.2009.73_bb0430","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1523-1755.2004.00703.x","article-title":"Lack of major involvement of human uroplakin genes in vesicoureteral reflux: implications for disease heterogeneity","volume":"66","author":"Jiang","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2009.73_bb0435","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/01.ju.0000094802.50650.3d","article-title":"No pathogenic mutations in the uroplakin III gene of 25 patients with primary vesicoureteral reflux","volume":"171","author":"Giltay","year":"2004","journal-title":"J Urol"},{"key":"10.1038\/ki.2009.73_bb0440","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/sj.ejhg.5201322","article-title":"Uroplakin III is not a major candidate gene for primary vesicoureteral reflux","volume":"13","author":"Kelly","year":"2005","journal-title":"Eur J Hum Genet"},{"key":"10.1038\/ki.2009.73_bb0445","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1681\/ASN.2004090776","article-title":"De novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure","volume":"16","author":"Jenkins","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2009.73_bb0450","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1053\/j.ajkd.2006.02.177","article-title":"Mutations in uroplakin IIIA are a rare cause of renal hypodysplasia in humans","volume":"47","author":"Schonfelder","year":"2006","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2009.73_bb0455","series-title":"Colonization of Mucosal Surfaces","article-title":"Allelic variation of the FimH lectin of Escherichia coli Type 1 fimbriae and uropathogenesis","author":"Hasty","year":"2005"},{"key":"10.1038\/ki.2009.73_bb0460","doi-asserted-by":"crossref","first-page":"8829","DOI":"10.1073\/pnas.97.16.8829","article-title":"Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses","volume":"97","author":"Mulvey","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.73_bb0465","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.276.5312.607","article-title":"Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination","volume":"276","author":"Langermann","year":"1997","journal-title":"Science"},{"key":"10.1038\/ki.2009.73_bb0470","doi-asserted-by":"crossref","first-page":"8922","DOI":"10.1073\/pnas.95.15.8922","article-title":"Pathogenic adaptation of Escherichia coli by natural variation of the FimH adhesin","volume":"95","author":"Sokurenko","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.73_bb0475","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/0-306-46840-9_25","article-title":"Role of bacterial lectins in urinary tract infections. Molecular mechanisms for diversification of bacterial surface lectins","volume":"485","author":"Ofek","year":"2000","journal-title":"Adv Exp Med Biol"},{"key":"10.1038\/ki.2009.73_bb0480","first-page":"75","article-title":"Theodore E. Woodward award: host-pathogen interactions in community-acquired urinary tract infections","volume":"117","author":"Stamm","year":"2006","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"10.1038\/ki.2009.73_bb0485","doi-asserted-by":"crossref","first-page":"9630","DOI":"10.1073\/pnas.93.18.9630","article-title":"In vitro binding of type 1-fimbriated Escherichia coli to uroplakins Ia and Ib: relation to urinary tract infections","volume":"93","author":"Wu","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.73_bb0490","doi-asserted-by":"crossref","first-page":"14644","DOI":"10.1074\/jbc.M600877200","article-title":"Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia","volume":"281","author":"Xie","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2009.73_bb0495","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1126\/science.282.5393.1494","article-title":"Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli","volume":"282","author":"Mulvey","year":"1998","journal-title":"Science"},{"key":"10.1038\/ki.2009.73_bb0500","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/emboj\/19.12.2803","article-title":"Type 1 pilus-mediated bacterial invasion of bladder epithelial cells","volume":"19","author":"Martinez","year":"2000","journal-title":"EMBO J"},{"key":"10.1038\/ki.2009.73_bb0505","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nm1572","article-title":"Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells","volume":"13","author":"Bishop","year":"2007","journal-title":"Nat Med"},{"key":"10.1038\/ki.2009.73_bb0510","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1128\/IAI.69.7.4572-4579.2001","article-title":"Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection","volume":"69","author":"Mulvey","year":"2001","journal-title":"Infect Immun"},{"key":"10.1038\/ki.2009.73_bb0515","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1084550","article-title":"Intracellular bacterial biofilm-like pods in urinary tract infections","volume":"301","author":"Anderson","year":"2003","journal-title":"Science"},{"key":"10.1038\/ki.2009.73_bb0520","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/IAI.01123-06","article-title":"Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation","volume":"75","author":"Garofalo","year":"2007","journal-title":"Infect Immun"},{"key":"10.1038\/ki.2009.73_bb0525","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1371\/journal.pmed.0040329","article-title":"Detection of intracellular bacterial communities in human urinary tract infection","volume":"4","author":"Rosen","year":"2007","journal-title":"PLoS Med"},{"key":"10.1038\/ki.2009.73_bb0530","doi-asserted-by":"crossref","first-page":"16669","DOI":"10.1073\/pnas.0607898104","article-title":"Expression of flagella is coincident with uropathogenic E. coli ascension to the upper urinary tract","volume":"104","author":"Lane","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.73_bb0535","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/CMR.4.1.80","article-title":"Virulence factors in Escherichia coli urinary tract infection","volume":"4","author":"Johnson","year":"1991","journal-title":"Clin Microbiol Rev"},{"key":"10.1038\/ki.2009.73_bb0540","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/sj.ki.5002230","article-title":"Role of P-fimbrial-mediated adherence in pyelonephritis and persistence of uropathogenic Escherichia coli (UPEC) in the mammalian kidney","volume":"72","author":"Lane","year":"2007","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2009.73_bb0545","doi-asserted-by":"crossref","first-page":"F795","DOI":"10.1152\/ajprenal.00357.2003","article-title":"Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli","volume":"286","author":"Mo","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2009.73_bb0550","doi-asserted-by":"crossref","first-page":"9827","DOI":"10.1073\/pnas.93.18.9827","article-title":"Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract","volume":"93","author":"Connell","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.73_bb0555","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1128\/IAI.69.5.2838-2846.2001","article-title":"In vivo dynamics of type 1 fimbria regulation in uropathogenic Escherichia coli during experimental urinary tract infection","volume":"69","author":"Gunther","year":"2001","journal-title":"Infect Immun"},{"key":"10.1038\/ki.2009.73_bb0560","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1128\/IAI.66.8.3856-3861.1998","article-title":"The globoseries glycosphingolipid sialosyl galactosyl globoside is found in urinary tract tissues and is a preferred binding receptor In vitro for uropathogenic Escherichia coli expressing pap-encoded adhesins","volume":"66","author":"Stapleton","year":"1998","journal-title":"Infect Immun"},{"key":"10.1038\/ki.2009.73_bb0565","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0092-8674(01)00388-9","article-title":"Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor","volume":"105","author":"Dodson","year":"2001","journal-title":"Cell"},{"key":"10.1038\/ki.2009.73_bb0570","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/j.1365-2958.1995.tb02327.x","article-title":"Structural requirements for the glycolipid receptor of human uropathogenic Escherichia coli","volume":"16","author":"Striker","year":"1995","journal-title":"Mol Microbiol"},{"key":"10.1038\/ki.2009.73_bb0575","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1099\/mic.0.28677-0","article-title":"Demonstration of regulatory cross-talk between P fimbriae and type 1 fimbriae in uropathogenic Escherichia coli","volume":"152","author":"Holden","year":"2006","journal-title":"Microbiology"},{"key":"10.1038\/ki.2009.73_bb0580","first-page":"1383","article-title":"Uroplakins, specific membrane proteins of urothelial umbrella cells, as histological markers of metastatic transitional cell carcinomas","volume":"147","author":"Moll","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2009.73_bb0585","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/S0002-9440(10)65709-4","article-title":"Uroplakin gene expression by normal and neoplastic human urothelium","volume":"153","author":"Lobban","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2009.73_bb0590","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/path.1252","article-title":"Uroplakin gene expression in normal human tissues and locally advanced bladder cancer","volume":"199","author":"Olsburgh","year":"2003","journal-title":"J Pathol"},{"key":"10.1038\/ki.2009.73_bb0595","first-page":"1291","article-title":"Uroplakin II gene is expressed in transitional cell carcinoma but not in bilharzial bladder squamous cell carcinoma: alternative pathways of bladder epithelial differentiation and tumor formation","volume":"58","author":"Wu","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/ki.2009.73_bb0600","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.humpath.2007.04.003","article-title":"Persistent uroplakin expression in advanced urothelial carcinomas: implications in urothelial tumor progression and clinical outcome","volume":"38","author":"Huang","year":"2007","journal-title":"Hum Pathol"},{"key":"10.1038\/ki.2009.73_bb0605","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1097\/01.ju.0000181214.32390.75","article-title":"Uroplakin II as a promising marker for molecular diagnosis of nodal metastases from bladder cancer: comparison with cytokeratin 20","volume":"174","author":"Wu","year":"2005","journal-title":"J Urol"},{"key":"10.1038\/ki.2009.73_bb0610","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s004280000315","article-title":"Brenner tumors but not transitional cell carcinomas of the ovary show urothelial differentiation: immunohistochemical staining of urothelial markers, including cytokeratins and uroplakins","volume":"438","author":"Riedel","year":"2001","journal-title":"Virchows Arch"},{"key":"10.1038\/ki.2009.73_bb0615","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000478-200301000-00001","article-title":"Potential utility of uroplakin III, thrombomodulin, high molecular weight cytokeratin, and cytokeratin 20 in noninvasive, invasive, and metastatic urothelial (transitional cell) carcinomas","volume":"27","author":"Parker","year":"2003","journal-title":"Am J Surg Pathol"},{"key":"10.1038\/ki.2009.73_bb0620","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2559.1995.tb00025.x","article-title":"Cytokeratin 20 expression by non-invasive transitional cell carcinomas: potential for distinguishing recurrent from non-recurrent disease","volume":"27","author":"Harnden","year":"1995","journal-title":"Histopathology"},{"key":"10.1038\/ki.2009.73_bb0625","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1053\/hupa.2002.129416","article-title":"Immunohistochemical profile of high-grade urothelial bladder carcinoma and prostate adenocarcinoma","volume":"33","author":"Mhawech","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1038\/ki.2009.73_bb0630","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/cncr.21953","article-title":"Prospective evaluation of the prognostic relevance of molecular staging for urothelial carcinoma","volume":"107","author":"Copp","year":"2006","journal-title":"Cancer"},{"key":"10.1038\/ki.2009.73_bb0635","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1097\/01.ju.0000118648.29024.b7","article-title":"Value of reverse transcription polymerase chain assay in peripheral blood of patients with urothelial cancer","volume":"171","author":"Okegawa","year":"2004","journal-title":"J Urol"},{"key":"10.1038\/ki.2009.73_bb0640","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1158\/1078-0432.CCR-04-2297","article-title":"Detection of micrometastases in pelvic lymph nodes in patients undergoing radical cystectomy for locally invasive bladder cancer by real-time reverse transcriptase-PCR for cytokeratin 19 and uroplakin II","volume":"11","author":"Kurahashi","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1038\/ki.2009.73_bb0645","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.1442-2042.1999.00064.x","article-title":"Expression of transitional cell-specific genes, uroplakin Ia and II, in bladder cancer: detection of circulating cancer cells in the peripheral blood of metastatic patients","volume":"6","author":"Yuasa","year":"1999","journal-title":"Int J Urol"},{"key":"10.1038\/ki.2009.73_bb0650","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/ijc.20366","article-title":"Detection of circulating cancer cells expressing uroplakins and epidermal growth factor receptor in bladder cancer patients","volume":"111","author":"Osman","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1038\/ki.2009.73_bb0655","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/00005392-199909010-00093","article-title":"Detection of circulating uroplakin-positive cells in patients with transitional cell carcinoma of the bladder","volume":"162","author":"Li","year":"1999","journal-title":"J Urol"},{"key":"10.1038\/ki.2009.73_bb0660","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1073\/pnas.92.3.679","article-title":"A tissue-specific promoter that can drive a foreign gene to express in the suprabasal urothelial cells of transgenic mice","volume":"92","author":"Lin","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2009.73_bb0665","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1172\/JCI30062","article-title":"Hyperactivation of Ha-ras oncogene, but not Ink4a\/Arf deficiency, triggers bladder tumorigenesis","volume":"117","author":"Mo","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2009.73_bb0670","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1101\/gad.1158703","article-title":"Activated Kras and Ink4a\/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma","volume":"17","author":"Aguirre","year":"2003","journal-title":"Genes Dev"},{"key":"10.1038\/ki.2009.73_bb0675","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1158\/0008-5472.CAN-04-3588","article-title":"Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis","volume":"65","author":"Uhrbom","year":"2005","journal-title":"Cancer Res"},{"key":"10.1038\/ki.2009.73_bb0680","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1101\/gad.11.21.2822","article-title":"Cooperative effects of INK4a and ras in melanoma susceptibility in vivo","volume":"11","author":"Chin","year":"1997","journal-title":"Genes Dev"},{"key":"10.1038\/ki.2009.73_bb0690","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ccr.2004.08.002","article-title":"Focus on bladder cancer","volume":"6","author":"Dinney","year":"2004","journal-title":"Cancer Cell"},{"key":"10.1038\/ki.2009.73_bb0695","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrc1697","article-title":"Urothelial tumorigenesis: a tale of divergent pathways","volume":"5","author":"Wu","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1038\/ki.2009.73_bb0700","first-page":"8108","article-title":"FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder","volume":"63","author":"Bakkar","year":"2003","journal-title":"Cancer Res"},{"key":"10.1038\/ki.2009.73_bb0705","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/cncr.11536","article-title":"Identification of fibroblast growth factor receptor 3 mutations in urine sediment DNA samples complements cytology in bladder tumor detection","volume":"98","author":"Rieger-Christ","year":"2003","journal-title":"Cancer"},{"key":"10.1038\/ki.2009.73_bb0710","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1158\/0008-5472.CAN-03-2421","article-title":"FGFR3 and P53 characterize alternative genetic pathways in the pathogenesis of urothelial cell carcinoma","volume":"64","author":"van Rhijn","year":"2004","journal-title":"Cancer Res"},{"key":"10.1038\/ki.2009.73_bb0715","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1038\/sj.onc.1208705","article-title":"FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma","volume":"24","author":"Jebar","year":"2005","journal-title":"Oncogene"},{"key":"10.1038\/ki.2009.73_bb0720","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ajmg.c.30065","article-title":"Tumor predisposition in Costello syndrome","volume":"137","author":"Gripp","year":"2005","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1038\/ki.2009.73_bb0725","first-page":"179","article-title":"Allelic loss of p53 gene is associated with genesis and maintenance, but not invasion, of mouse carcinoma in situ of the bladder","volume":"63","author":"Cheng","year":"2003","journal-title":"Cancer Res"},{"key":"10.1038\/ki.2009.73_bb0730","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0002-9440(10)64594-4","article-title":"Highly invasive transitional cell carcinoma of the bladder in a simian virus 40 T-antigen transgenic mouse model","volume":"157","author":"Grippo","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2009.73_bb0735","first-page":"1217","article-title":"Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors","volume":"57","author":"Cordon-Cardo","year":"1997","journal-title":"Cancer Res"},{"key":"10.1038\/ki.2009.73_bb0740","first-page":"829","article-title":"p53 and Rb expression predict progression in T1 bladder cancer","volume":"4","author":"Grossman","year":"1998","journal-title":"Clin Cancer Res"},{"key":"10.1038\/ki.2009.73_bb0745","first-page":"1090","article-title":"Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53","volume":"58","author":"Cote","year":"1998","journal-title":"Cancer Res"},{"key":"10.1038\/ki.2009.73_bb0750","doi-asserted-by":"crossref","first-page":"7729","DOI":"10.1038\/sj.onc.1209046","article-title":"SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation","volume":"24","author":"Ahuja","year":"2005","journal-title":"Oncogene"},{"key":"10.1038\/ki.2009.73_bb0755","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.1128\/MCB.15.10.5800","article-title":"Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation","volume":"15","author":"Zalvide","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1038\/ki.2009.73_bb0760","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1479-5876-5-49","article-title":"The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo","volume":"5","author":"Buckley","year":"2007","journal-title":"J Transl Med"},{"key":"10.1038\/ki.2009.73_bb0685","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/003655900750169338","article-title":"Genetic and molecular markers of urothelial premalignancy and malignancy","volume":"205","author":"Cordon-Cardo","year":"2000","journal-title":"Scand J Urol Nephrol Suppl"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815535989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815535989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:47:53Z","timestamp":1758761273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815535989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":151,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0085253815535989"],"URL":"https:\/\/doi.org\/10.1038\/ki.2009.73","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uroplakins in urothelial biology, function, and disease","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1038\/ki.2009.73","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}