{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:22:02Z","timestamp":1781835722795,"version":"3.54.5"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":1954,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1038\/ki.2010.138","type":"journal-article","created":{"date-parts":[[2010,5,19]],"date-time":"2010-05-19T12:41:25Z","timestamp":1274272885000},"page":"396-407","source":"Crossref","is-referenced-by-count":68,"title":["Altered modulation of WNT\u2013\u03b2-catenin and PI3K\/Akt pathways in IgA nephropathy"],"prefix":"10.1016","volume":"78","author":[{"given":"Sharon N.","family":"Cox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Sallustio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Serino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Pontrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Verrienti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pesce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diletta D.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Ancona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Stifanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Zaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco P.","family":"Schena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2010.138_bb0010","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1681\/ASN.V82199","article-title":"Predicting renal outcome in IgA nephropathy","volume":"8","author":"Radford","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2010.138_bb0015","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1053\/ajkd.2000.8966","article-title":"Natural history of idiopathic IgA nephropathy: role of clinical and histological prognostic factors","volume":"36","author":"D'Amico","year":"2000","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2010.138_bb0020","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1046\/j.1523-1755.2001.060003969.x","article-title":"Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients","volume":"60","author":"Allen","year":"2001","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.138_bb0025","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1523-1755.2005.67107.x","article-title":"IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells","volume":"67","author":"Novak","year":"2005","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.138_bb0030","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1093\/ndt\/gfp356","article-title":"Randomized controlled clinical trial of corticosteroids plus ACE-inhibitors with long-term follow-up in proteinuric IgA nephropathy","volume":"24","author":"Manno","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2010.138_bb0035","first-page":"137","article-title":"Recurrence of IgA nephropathy after renal transplantation","volume":"150","author":"Van der Boog","year":"1999","journal-title":"Ann Med Interne"},{"key":"10.1038\/ki.2010.138_bb0040","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1046\/j.1523-1755.2001.00006.x","article-title":"Kidney transplantation in patients with IgA mesangial glomerulonephritis","volume":"60","author":"Ponticelli","year":"2001","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.138_bb0045","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1016\/S0041-1345(97)00957-3","article-title":"Donor-transmitted IgA nephropathy: long-term follow-up of kidney donors and recipients","volume":"29","author":"Koselj","year":"1997","journal-title":"Transplant Proc"},{"key":"10.1038\/ki.2010.138_bb0050","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/00007890-198204000-00006","article-title":"Fate of four cadaveric donor renal allografts with mesangial IgA deposits","volume":"33","author":"Sanfilippo","year":"1982","journal-title":"Transplantation"},{"key":"10.1038\/ki.2010.138_bb0055","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1365-2249.1992.tb03040.x","article-title":"T and B cell responses following immunization with tetanus toxoid in IgA nephropathy","volume":"88","author":"Fortune","year":"1992","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/ki.2010.138_bb0060","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1172\/JCI114269","article-title":"Humoral immune response to influenza vaccination in patients with primary immunoglobulin A nephropathy. An analysis of isotype distribution and size of the influenza-specific antibodies","volume":"84","author":"van den Wall Bake","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2010.138_bb0065","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0272-6386(99)70141-1","article-title":"Exaggerated systemic antibody response to mucosal Helicobacter pylori infection in IgA nephropathy","volume":"33","author":"Barratt","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2010.138_bb0070","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1046\/j.1365-2249.1999.00823.x","article-title":"Enhanced expression of L-selectin on peripheral blood lymphocytes from patients with IgA nephropathy","volume":"115","author":"Kennel-de March","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/ki.2010.138_bb0075","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1093\/ndt\/gfm228","article-title":"T-cell homing receptor expression in IgA nephropathy","volume":"22","author":"Batra","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2010.138_bb0080","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-2249.1995.tb03132.x","article-title":"Increased dimeric IgA-producing B cells in tonsils in IgA nephropathy determined by in situ hybridization for J chain mRNA","volume":"101","author":"Harper","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/ki.2010.138_bb0085","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1136\/jcp.49.1.38","article-title":"Increased dimeric IgA producing B cells in the bone marrow in IgA nephropathy determined by in situ hybridisation for J chain mRNA","volume":"49","author":"Harper","year":"1996","journal-title":"J Clin Pathol"},{"key":"10.1038\/ki.2010.138_bb0090","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1046\/j.1365-2249.2001.01431.x","article-title":"Increase in tonsillar germinal centre B-1 cell numbers in IgA nephropathy (IgAN) patients and reduced susceptibility to Fas-mediated apoptosis","volume":"123","author":"Kodama","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1038\/ki.2010.138_bb0095","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2174\/1566524054553450","article-title":"Molecular basis of IgA nephropathy","volume":"5","author":"Lai","year":"2005","journal-title":"Curr Mol Med"},{"key":"10.1038\/ki.2010.138_bb0100","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1523-1755.2004.00398.x","article-title":"Gene expression profiles of circulating leukocytes correlate with renal disease activity in IgA nephropathy","volume":"65","author":"Preston","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.138_bb0105","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/ng1552","article-title":"Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between WNT signaling pathways","volume":"37","author":"Simons","year":"2005","journal-title":"Nat Genet"},{"key":"10.1038\/ki.2010.138_bb0110","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2010.138_bb0115","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2169\/internalmedicine.45.1837","article-title":"Remission of IgA nephropathy after allogeneic peripheral blood stem cell transplantation followed by immunosuppression for acute lymphocytic leukemia","volume":"45","author":"Iwata","year":"2006","journal-title":"Intern Med"},{"key":"10.1038\/ki.2010.138_bb0120","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0272-6386(88)80040-4","article-title":"Cellular immunoregulatory aspects of IgA nephropathy","volume":"12","author":"Sakai","year":"1988","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2010.138_bb0125","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ki.2008.579","article-title":"Upregulation of the immunoproteasome in peripheral blood mononuclear cells of patients with IgA nephropathy","volume":"75","author":"Coppo","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.138_bb0130","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1182\/blood.V92.9.3410","article-title":"PTEN gene alterations in lymphoid neoplasms","volume":"92","author":"Sakai","year":"1998","journal-title":"Blood"},{"key":"10.1038\/ki.2010.138_bb0135","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1128\/MCB.20.18.6945-6957.2000","article-title":"Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation","volume":"20","author":"Shan","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1038\/ki.2010.138_bb0140","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.4049\/jimmunol.166.7.4713","article-title":"Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of beta-catenin","volume":"166","author":"Monick","year":"2001","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.138_bb0145","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1242\/jcs.114.16.2903","article-title":"PKB\/Akt: a key mediator of cell proliferation, survival and insulin responses?","volume":"114","author":"Lawlor","year":"2001","journal-title":"J Cell Sci"},{"key":"10.1038\/ki.2010.138_bb0150","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10456-005-5612-9","article-title":"Wnt\/\u03b2-catenin signalling induces proliferation, survival and IL-8 in human endothelial cells","volume":"8","author":"Masckauch\u00e1n","year":"2005","journal-title":"Angiogenesis"},{"key":"10.1038\/ki.2010.138_bb0155","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1681\/ASN.2005020134","article-title":"IgA nephropathy","volume":"16","author":"Barratt","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2010.138_bb0160","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1126\/science.285.5436.2122","article-title":"Impaired Fas response and autoimmunity in Pten+\/\u2212 mice","volume":"285","author":"Di Cristofano","year":"1999","journal-title":"Science"},{"key":"10.1038\/ki.2010.138_bb0165","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1084\/jem.20021101","article-title":"Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination","volume":"197","author":"Suzuki","year":"2003","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2010.138_bb0170","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4049\/jimmunol.167.1.42","article-title":"Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation","volume":"167","author":"Parsons","year":"2001","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.138_bb0175","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1074-7613(00)00004-2","article-title":"Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism","volume":"13","author":"Reya","year":"2000","journal-title":"Immunity"},{"key":"10.1038\/ki.2010.138_bb0180","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1086\/510135","article-title":"Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci","volume":"79","author":"Bisceglia","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.1038\/ki.2010.138_bb0185","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1038\/sj.onc.1210053","article-title":"WNTs as ligands: processing, secretion and reception","volume":"25","author":"Mikels","year":"2006","journal-title":"Oncogene"},{"key":"10.1038\/ki.2010.138_bb0190","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cellsig.2007.11.005","article-title":"Differential mediation of the Wnt canonical pathway by mammalian dishevelleds-1, -2, and -3","volume":"20","author":"Lee","year":"2008","journal-title":"Cell Signal"},{"key":"10.1038\/ki.2010.138_bb0195","doi-asserted-by":"crossref","first-page":"22429","DOI":"10.1074\/jbc.R600015200","article-title":"WNT signaling: multiple pathways, multiple receptors, and multiple transcription factors","volume":"281","author":"Gordon","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2010.138_bb0200","doi-asserted-by":"crossref","first-page":"7981","DOI":"10.4049\/jimmunol.175.12.7981","article-title":"Stabilized \u03b2-catenin extends thymocyte survival by up-regulating Bcl-xL","volume":"175","author":"Xie","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.138_rf0205","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2360","article-title":"WNT signalling in the immune system: WNT is spreading its wings","volume":"8","author":"Staal","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/ki.2010.138_bb0210","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.4049\/jimmunol.167.12.6786","article-title":"Regulation and possible function of beta-catenin in human monocytes","volume":"167","author":"Thiele","year":"2001","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.138_bb0215","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/ATVBAHA.107.160952","article-title":"Wnt pathway: a new role in regulation of inflammation","volume":"28","author":"George","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1038\/ki.2010.138_bb0220","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1182\/blood-2005-12-5046","article-title":"The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation","volume":"108","author":"Blumenthal","year":"2006","journal-title":"Blood"},{"key":"10.1038\/ki.2010.138_bb0225","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S1471-4914(02)02405-X","article-title":"Pathogenic significance of IgA receptor interactions in IgA nephropathy","volume":"8","author":"Monteiro","year":"2002","journal-title":"Trends Mol Med"},{"key":"10.1038\/ki.2010.138_bb0230","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1084\/jem.191.11.1999","article-title":"Fc\u03b1 receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease): evidence for pathogenic soluble receptor\u2013IgA complexes in patients and CD89 transgenic mice","volume":"191","author":"Launay","year":"2000","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2010.138_bb0235","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.4049\/jimmunol.162.4.2146","article-title":"Identification of residues in the first domain of human Fc\u03b1 receptor essential for interaction with IgA","volume":"162","author":"Wines","year":"1999","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.138_bb0240","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1182\/blood.V95.6.2037","article-title":"A critical role for PI3-kinase in cytokine-induced Fcalpha-receptor activation","volume":"95","author":"Bracke","year":"2000","journal-title":"Blood"},{"key":"10.1038\/ki.2010.138_bb0245","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/sj.gene.6364098","article-title":"Expression levels for many genes in human peripheral blood cells are highly sensitive to ex vivo incubation","volume":"5","author":"Baechler","year":"2004","journal-title":"Genes Immun"},{"key":"10.1038\/ki.2010.138_bb0250","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/clinchem\/48.11.1883","article-title":"Stabilization of mRNA expression in whole blood samples","volume":"48","author":"Rainen","year":"2002","journal-title":"Clin Chem"},{"key":"10.1038\/ki.2010.138_bb0255","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genome wide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815545456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815545456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T06:39:49Z","timestamp":1685601589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815545456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0085253815545456"],"URL":"https:\/\/doi.org\/10.1038\/ki.2010.138","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}