{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:51:49Z","timestamp":1792713109529,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":1923,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1038\/ki.2010.162","type":"journal-article","created":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T12:43:36Z","timestamp":1276087416000},"page":"503-513","source":"Crossref","is-referenced-by-count":263,"title":["Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype"],"prefix":"10.1016","volume":"78","author":[{"given":"Annaick","family":"Pallier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Hillion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Danger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Giral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Racap\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Degauque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Dugast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Ashton-Chess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9gol\u00e8ne","family":"Pettr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Bataille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Devys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Cesbron-Gautier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Braudeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Larrose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Soulillou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Brouard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2010.162_bb0010","first-page":"S89","article-title":"Controlling the incidence of infection and malignancy by modifying immunosuppression","volume":"72","author":"Soulillou","year":"2001","journal-title":"Transplantation"},{"key":"10.1038\/ki.2010.162_bb0015","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/01.TP.0000128636.70499.6E","article-title":"Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology","volume":"78","author":"Nankivell","year":"2004","journal-title":"Transplantation"},{"key":"10.1038\/ki.2010.162_bb0020","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJMra011295","article-title":"Strategies to improve long-term outcomes after renal transplantation","volume":"346","author":"Pascual","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2010.162_bb0025","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/172603a0","article-title":"Activity acquired tolerance of foreign cells","volume":"172","author":"Billingham","year":"1953","journal-title":"Nature"},{"key":"10.1038\/ki.2010.162_bb0030","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1600-6143.2006.01280.x","article-title":"Clinical operational tolerance after kidney transplantation","volume":"6","author":"Roussey-Kesler","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1038\/ki.2010.162_bb0035","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1432-2277.2007.00537.x","article-title":"Variation in numbers of CD4+CD25highFOXP3+ T cells with normal immuno-regulatory properties in long-term graft outcome","volume":"20","author":"Braudeau","year":"2007","journal-title":"Transpl Int"},{"key":"10.1038\/ki.2010.162_bb0040","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/01.tp.0000203166.44968.86","article-title":"Contrasting CD25hiCD4+T cells\/FOXP3 patterns in chronic rejection and operational drug-free tolerance","volume":"81","author":"Louis","year":"2006","journal-title":"Transplantation"},{"key":"10.1038\/ki.2010.162_bb0045","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.1439825","article-title":"B cells turn off virgin but not memory T cells","volume":"258","author":"Fuchs","year":"1992","journal-title":"Science"},{"key":"10.1038\/ki.2010.162_bb0050","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1074-7613(02)00274-1","article-title":"Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation","volume":"16","author":"Mizoguchi","year":"2002","journal-title":"Immunity"},{"key":"10.1038\/ki.2010.162_bb0055","doi-asserted-by":"crossref","first-page":"705","DOI":"10.4049\/jimmunol.176.2.705","article-title":"A case for regulatory B cells","volume":"176","author":"Mizoguchi","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.162_bb0060","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2005.02.008","article-title":"Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs","volume":"22","author":"Sun","year":"2005","journal-title":"Immunity"},{"key":"10.1038\/ki.2010.162_bb0065","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.184.6.2271","article-title":"Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice","volume":"184","author":"Wolf","year":"1996","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2010.162_bb0070","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nri2315","article-title":"Not always the bad guys: B cells as regulators of autoimmune pathology","volume":"8","author":"Fillatreau","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1038\/ki.2010.162_bb0075","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1053\/j.gastro.2007.11.006","article-title":"Helicobacter pylori gastritis in children is associated with a regulatory T-cell response","volume":"134","author":"Harris","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1038\/ki.2010.162_bb0080","doi-asserted-by":"crossref","first-page":"7318","DOI":"10.4049\/jimmunol.180.11.7318","article-title":"Regulatory role of B cells in a murine model of allergic airway disease","volume":"180","author":"Singh","year":"2008","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.162_bb0085","doi-asserted-by":"crossref","first-page":"15448","DOI":"10.1073\/pnas.0705834104","article-title":"Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance","volume":"104","author":"Brouard","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2010.162_bb0090","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2010.162_bb0095","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/ng1532","article-title":"Reverse engineering of regulatory networks in human B cells","volume":"37","author":"Basso","year":"2005","journal-title":"Nat Genet"},{"key":"10.1038\/ki.2010.162_bb0100","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1101\/gr.201501","article-title":"Changes in gene expression profiles in developing B cells of murine bone marrow","volume":"12","author":"Hoffmann","year":"2002","journal-title":"Genome Res"},{"key":"10.1038\/ki.2010.162_bb0105","doi-asserted-by":"crossref","first-page":"45028","DOI":"10.1074\/jbc.M400061200","article-title":"Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes","volume":"279","author":"Greenbaum","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2010.162_bb0110","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1182\/blood-2002-10-3161","article-title":"Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation","volume":"102","author":"Tarte","year":"2003","journal-title":"Blood"},{"key":"10.1038\/ki.2010.162_bb0115","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/gb-2003-4-4-r28","article-title":"GoMiner: A Resource for Biological Interpretation of Genomic and Proteomic Data","volume":"4","author":"Zeeberg","year":"2003","journal-title":"Genome Biology"},{"key":"10.1038\/ki.2010.162_bb0120","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/jcb.21557","article-title":"Immunosuppressive drug-free operational immune tolerance in human kidney transplants recipients. II: Non-statistical gene microarray analysis","volume":"103","author":"Sivozhelezov","year":"2008","journal-title":"J Cell Biochem"},{"key":"10.1038\/ki.2010.162_bb0125","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.immuni.2006.01.002","article-title":"BANK negatively regulates Akt activation and subsequent B cell responses","volume":"24","author":"Aiba","year":"2006","journal-title":"Immunity"},{"key":"10.1038\/ki.2010.162_bb0130","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1073\/pnas.0500187102","article-title":"TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2\/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs","volume":"102","author":"Hauer","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2010.162_bb0135","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/eji.200636623","article-title":"TACI attenuates antibody production costimulated by BAFF-R and CD40","volume":"37","author":"Sakurai","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1038\/ki.2010.162_bb0140","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1146\/annurev.immunol.21.120601.141152","article-title":"BAFF AND APRIL: a tutorial on B cell survival","volume":"21","author":"Mackay","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1038\/ki.2010.162_bb0145","doi-asserted-by":"crossref","first-page":"793","DOI":"10.4049\/jimmunol.182.2.793","article-title":"Increased CD4+Foxp3+ T cells in BAFF-transgenic mice suppress T cell effector responses","volume":"182","author":"Walters","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.162_bb0150","series-title":"Diabetes","article-title":"CD4+ CD25+ T cells control autoimmunity in the absence of B cells","author":"Mari\u00f1o","year":"2009"},{"key":"10.1038\/ki.2010.162_bb0155","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1111\/j.1600-6143.2009.02738.x","article-title":"B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans","volume":"9","author":"Porcheray","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1038\/ki.2010.162_bb0160","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.1073\/pnas.0900563106","article-title":"Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and \u2018antibodyome\u2019 measures","volume":"106","author":"Li","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2010.162_bb0165","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1600-6143.2006.01621.x","article-title":"Multiparameter immune profiling of operational tolerance in liver transplantation","volume":"7","author":"Martinez-Llordella","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1038\/ki.2010.162_bb0170","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.290.5489.84","article-title":"Immune inhibitory receptors","volume":"290","author":"Ravetch","year":"2000","journal-title":"Science"},{"key":"10.1038\/ki.2010.162_bb0175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/383263a0","article-title":"Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB","volume":"383","author":"Ono","year":"1996","journal-title":"Nature"},{"key":"10.1038\/ki.2010.162_bb0180","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/379346a0","article-title":"Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice","volume":"379","author":"Takai","year":"1996","journal-title":"Nature"},{"key":"10.1038\/ki.2010.162_bb0185","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1126\/science.1105160","article-title":"Restoration of tolerance in lupus by targeted inhibitory receptor expression","volume":"307","author":"McGaha","year":"2005","journal-title":"Science"},{"key":"10.1038\/ki.2010.162_bb0190","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1084\/jem.20072565","article-title":"Distinct cell-specific control of autoimmunity and infection by FcgammaRIIb","volume":"205","author":"Brownlie","year":"2008","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2010.162_bb0195","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.coi.2008.03.015","article-title":"BAFF and the plasticity of peripheral B cell tolerance","volume":"20","author":"Stadanlick","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"10.1038\/ki.2010.162_bb0200","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.smim.2006.04.003","article-title":"Regulation of B cell self-tolerance by BAFF","volume":"18","author":"Brink","year":"2006","journal-title":"Semin Immunol"},{"key":"10.1038\/ki.2010.162_bb0205","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/89790","article-title":"Activation and accumulation of B cells in TACI-deficient mice","volume":"2","author":"Yan","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1038\/ki.2010.162_rf0210","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/emboj\/21.1.83","article-title":"BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor","volume":"21","author":"Yokoyama","year":"2002","journal-title":"EMBO J"},{"key":"10.1038\/ki.2010.162_bb0215","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.immuni.2008.03.017","article-title":"A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses","volume":"28","author":"Yanaba","year":"2008","journal-title":"Immunity"},{"key":"10.1038\/ki.2010.162_bb0220","doi-asserted-by":"crossref","first-page":"13938","DOI":"10.1073\/pnas.96.24.13938","article-title":"Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling","volume":"96","author":"Colgan","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2010.162_bb0225","doi-asserted-by":"crossref","first-page":"906","DOI":"10.4049\/jimmunol.169.2.906","article-title":"Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice","volume":"169","author":"Faveeuw","year":"2002","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.162_bb0230","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2567.2000.00001.x","article-title":"CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes","volume":"100","author":"Exley","year":"2000","journal-title":"Immunology"},{"key":"10.1038\/ki.2010.162_bb0235","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1111\/j.1600-6143.2006.01533.x","article-title":"Humoral and cellular responses to influenza vaccination in human recipients naturally tolerant to a kidney allograft","volume":"6","author":"Ballet","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1038\/ki.2010.162_bb0240","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0923-2494(96)80259-8","article-title":"Natural autoantibodies: the other side of the immune system","volume":"146","author":"Avrameas","year":"1995","journal-title":"Res Immunol"},{"key":"10.1038\/ki.2010.162_bb0245","doi-asserted-by":"crossref","first-page":"27181","DOI":"10.1074\/jbc.M704625200","article-title":"Leupaxin negatively regulates B cell receptor signaling","volume":"282","author":"Chew","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2010.162_bb0250","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1111\/j.1600-6143.2004.00585.x","article-title":"Banff 2003 meeting report: new diagnostic insights and standards","volume":"4","author":"Racusen","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1038\/ki.2010.162_bb0255","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1600-6143.2006.01688.x","article-title":"Banff \u201805 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy (\u2018CAN\u2019)","volume":"7","author":"Solez","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1038\/ki.2010.162_bb0260","first-page":"11","article-title":"PE Applied Biosystems, Method for Gene Expression Monitoring by Real-time PCR","volume":"2","author":"ABI","year":"1997"},{"key":"10.1038\/ki.2010.162_bb0265","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.autrev.2005.06.011","article-title":"B lymphocytes on the front line of autoimmunity","volume":"5","author":"Youinou","year":"2006","journal-title":"Autoimmun Rev"},{"key":"10.1038\/ki.2010.162_bb0270","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.0105-2896.2006.00403.x","article-title":"Understanding and making use of human memory B cells","volume":"211","author":"Lanzavecchia","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1038\/ki.2010.162_bb0275","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/ki.2009.384","article-title":"Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients","volume":"76","author":"Sutherland","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.162_bb0280","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1074\/mcp.M800596-MCP200","article-title":"Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays","volume":"8","author":"Babel","year":"2009","journal-title":"Mol Cell Proteomics"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815545638?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815545638?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T23:26:46Z","timestamp":1559172406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815545638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0085253815545638"],"URL":"https:\/\/doi.org\/10.1038\/ki.2010.162","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}