{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:10:48Z","timestamp":1791274248724,"version":"4.1.0"},"reference-count":13,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":1832,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1038\/ki.2010.344","type":"journal-article","created":{"date-parts":[[2010,11,15]],"date-time":"2010-11-15T09:58:40Z","timestamp":1289815120000},"page":"1060-1063","source":"Crossref","is-referenced-by-count":85,"title":["Tenofovir-induced kidney disease: an acquired renal tubular mitochondriopathy"],"prefix":"10.1016","volume":"78","author":[{"given":"Mark A.","family":"Perazella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2010.344_bb0010","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrneph.2009.142","article-title":"The nephrotoxic effects of HAART","volume":"5","author":"Izzedine","year":"2009","journal-title":"Nat Rev Nephrol"},{"key":"10.1038\/ki.2010.344_bb0015","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/jac\/dkn252","article-title":"Trends in the prescription of antiretroviral drugs and impact on plasma HIV-RNA measurements","volume":"62","author":"Jimenez-Nacher","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"10.1038\/ki.2010.344_bb0020","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1053\/hupa.2001.25586","article-title":"Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion","volume":"32","author":"Tanji","year":"2001","journal-title":"Hum Pathol"},{"key":"10.1038\/ki.2010.344_bb0025","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1097\/00002030-200404300-00019","article-title":"Renal safety of tenofovir in HIV treatment-experienced patients","volume":"18","author":"Izzedine","year":"2004","journal-title":"AIDS"},{"key":"10.1038\/ki.2010.344_bb0030","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1097\/QAD.0b013e3280b07b33","article-title":"The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years","volume":"21","author":"Nelson","year":"2007","journal-title":"AIDS"},{"key":"10.1038\/ki.2010.344_bb0035","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1128\/AAC.46.3.716-723.2002","article-title":"Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors","volume":"46","author":"Birkus","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1038\/ki.2010.344_bb0040","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.amjmed.2004.03.025","article-title":"Tenofovir-associated nephrotoxicity: Fanconi syndrome and renal failure","volume":"117","author":"Rifkin","year":"2004","journal-title":"Am J Med"},{"key":"10.1038\/ki.2010.344_bb0045","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/135965350601100108","article-title":"Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy","volume":"11","author":"Cote","year":"2006","journal-title":"Antivir Ther"},{"key":"10.1038\/ki.2010.344_bb0050","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/labinvest.2009.14","article-title":"Tenofovir renal toxicity targets mitochondria of renal proximal tubules","volume":"89","author":"Kohler","year":"2009","journal-title":"Lab Invest"},{"key":"10.1038\/ki.2010.344_bb0055","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/QAI.0b013e3181a666eb","article-title":"Mitochondrial tubulopathy in tenofovir disoproxil fumarate-treated rats","volume":"51","author":"Lebrecht","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1038\/ki.2010.344_bb0060","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/ki.2010.318","article-title":"Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities","volume":"78","author":"Herlitz","year":"2010","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.344_bb0065","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2215\/CJN.02050309","article-title":"Renal vulnerability to drug toxicity","volume":"4","author":"Perazella","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2010.344_bb0070","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1086\/508546","article-title":"Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy","volume":"194","author":"Izzedine","year":"2006","journal-title":"J Infect Dis"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815544463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815544463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T06:19:05Z","timestamp":1685859545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815544463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0085253815544463"],"URL":"https:\/\/doi.org\/10.1038\/ki.2010.344","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}