{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:15:23Z","timestamp":1791591323447,"version":"4.3.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":1770,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1038\/ki.2010.393","type":"journal-article","created":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T09:03:11Z","timestamp":1286960591000},"page":"331-339","source":"Crossref","is-referenced-by-count":82,"title":["Targeted inhibition of complement activation prevents features of preeclampsia in mice"],"prefix":"10.1016","volume":"79","author":[{"given":"Xiaoping","family":"Qing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia B.","family":"Redecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Burmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivette D.","family":"D'Agati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin L.","family":"Davisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2010.393_bb0010","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1177\/1933719107306232","article-title":"Preeclampsia\u2014a pressing problem: an executive summary of a National Institute of Child Health and Human Development workshop","volume":"14","author":"Ilekis","year":"2007","journal-title":"Reprod Sci"},{"key":"10.1038\/ki.2010.393_bb0015","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1161\/01.HYP.0000188408.49896.c5","article-title":"Preeclampsia: recent insights","volume":"46","author":"Roberts","year":"2005","journal-title":"Hypertension"},{"key":"10.1038\/ki.2010.393_bb0020","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1161\/HYPERTENSIONAHA.107.096594","article-title":"Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expression","volume":"50","author":"Gilbert","year":"2007","journal-title":"Hypertension"},{"key":"10.1038\/ki.2010.393_bb0025","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.ki.5002175","article-title":"Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1","volume":"71","author":"Makris","year":"2007","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.393_bb0030","doi-asserted-by":"crossref","first-page":"R1085","DOI":"10.1152\/ajpregu.00794.2005","article-title":"Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1","volume":"291","author":"Nevo","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1038\/ki.2010.393_bb0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1146\/annurev-pathol-121808-102149","article-title":"Pathogenesis of preeclampsia","volume":"5","author":"Young","year":"2010","journal-title":"Annu Rev Pathol"},{"key":"10.1038\/ki.2010.393_bb0040","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2010.393_bb0045","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2010.393_bb0050","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1053\/j.ajkd.2006.11.039","article-title":"Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis","volume":"49","author":"Zhu","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2010.393_bb0055","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1084\/jem.20061022","article-title":"Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction","volume":"203","author":"Girardi","year":"2006","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2010.393_bb0060","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ajog.2008.07.044","article-title":"Complement activation fragment Bb in early pregnancy and spontaneous preterm birth","volume":"199","author":"Lynch","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1038\/ki.2010.393_bb0065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.molimm.2005.06.017","article-title":"The complement system in the pathophysiology of pregnancy","volume":"43","author":"Girardi","year":"2006","journal-title":"Mol Immunol"},{"key":"10.1038\/ki.2010.393_bb0070","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jri.2007.02.007","article-title":"Antiphospholipid antibodies and pregnancy loss: a disorder of inflammation","volume":"77","author":"Salmon","year":"2008","journal-title":"J Reprod Immunol"},{"key":"10.1038\/ki.2010.393_bb0075","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.placenta.2008.07.008","article-title":"The C5b-9 membrane attack complex of complement activation localizes to villous trophoblast injury in vivo and modulates human trophoblast function in vitro","volume":"29","author":"Rampersad","year":"2008","journal-title":"Placenta"},{"key":"10.1038\/ki.2010.393_bb0080","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1365-2141.2008.07324.x","article-title":"Advances in understanding of pathogenesis of aHUS and HELLP","volume":"143","author":"Fang","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1038\/ki.2010.393_bb0085","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1681\/ASN.2009070706","article-title":"Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations","volume":"21","author":"Fakhouri","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2010.393_bb0090","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1172\/JCI17348","article-title":"Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation","volume":"111","author":"Song","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2010.393_bb0095","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1172\/JCI25208","article-title":"Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection","volume":"115","author":"Atkinson","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2010.393_bb0100","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.4049\/jimmunol.180.2.1231","article-title":"Low-dose targeted complement inhibition protects against renal disease and other manifestations of autoimmune disease in MRL\/lpr mice","volume":"180","author":"Atkinson","year":"2008","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.393_bb0105","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.4049\/jimmunol.0901826","article-title":"Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice","volume":"183","author":"Banda","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.393_bb0110","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4049\/jimmunol.160.2.545","article-title":"Cytokine-dependent abortion in CBA \u00d7 DBA\/2 mice is mediated by the procoagulant fgl2 prothrombinase [correction of prothombinase]","volume":"160","author":"Clark","year":"1998","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.393_bb0115","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1093\/clinchem\/44.8.1845","article-title":"Useful laboratory tests for studying thrombogenesis in acute cardiac syndromes","volume":"44","author":"Fareed","year":"1998","journal-title":"Clin Chem"},{"key":"10.1038\/ki.2010.393_bb0120","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.1182\/blood-2008-12-194258","article-title":"Pravastatin prevents miscarriages in mice: role of tissue factor in placental and fetal injury","volume":"113","author":"Redecha","year":"2009","journal-title":"Blood"},{"key":"10.1038\/ki.2010.393_bb0125","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ki.1980.132","article-title":"Renal morphology in preeclampsia","volume":"18","author":"Sheehan","year":"1980","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.393_bb0130","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0950-3552(05)80330-X","article-title":"Renal pathology in pre-eclampsia","volume":"8","author":"Gaber","year":"1994","journal-title":"Baillieres Clin Obstet Gynaecol"},{"key":"10.1038\/ki.2010.393_bb0135","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0272-6386(12)81119-X","article-title":"The renal lesion of preeclampsia revisited","volume":"17","author":"Kincaid-Smith","year":"1991","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2010.393_bb0140","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1530\/rep.0.1260149","article-title":"Uterine natural killer cells: insights into their cellular and molecular biology from mouse modelling","volume":"126","author":"Croy","year":"2003","journal-title":"Reproduction"},{"key":"10.1038\/ki.2010.393_bb0145","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1073\/pnas.0611365104","article-title":"Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males","volume":"104","author":"Caron","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2010.393_bb0150","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1136\/bmj.309.6966.1395","article-title":"Eclampsia in the United Kingdom","volume":"309","author":"Douglas","year":"1994","journal-title":"Bmj"},{"key":"10.1038\/ki.2010.393_bb0155","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.4049\/jimmunol.177.10.7266","article-title":"Complement-dependent P-selectin expression and injury following ischemic stroke","volume":"177","author":"Atkinson","year":"2006","journal-title":"J Immunol"},{"key":"10.1038\/ki.2010.393_bb0160","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1084\/jem.175.1.121","article-title":"Distinct receptor and regulatory properties of recombinant mouse complement receptor 1 (CR1) and Crry, the two genetic homologues of human CR1","volume":"175","author":"Molina","year":"1992","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2010.393_bb0165","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1096\/fj.14.10.1289","article-title":"Placental isoprostane is significantly increased in preeclampsia","volume":"14","author":"Walsh","year":"2000","journal-title":"Faseb J"},{"key":"10.1038\/ki.2010.393_bb0170","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1053\/plac.2002.0819","article-title":"Recent Insights into the pathogenesis of pre-eclampsia","volume":"23","author":"Roberts","year":"2002","journal-title":"Placenta"},{"key":"10.1038\/ki.2010.393_bb0175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1477-7827-2-53","article-title":"The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia","volume":"2","author":"Fisher","year":"2004","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1038\/ki.2010.393_bb0180","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"key":"10.1038\/ki.2010.393_bb0185","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.med.59.110106.214058","article-title":"Preeclampsia and angiogenic imbalance","volume":"59","author":"Maynard","year":"2008","journal-title":"Annu Rev Med"},{"key":"10.1038\/ki.2010.393_bb0190","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1172\/JCI200318817","article-title":"Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome","volume":"112","author":"Girardi","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2010.393_bb0195","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble endoglin and other circulating antiangiogenic factors in preeclampsia","volume":"355","author":"Levine","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2010.393_bb0200","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/HYPERTENSIONAHA.107.092098","article-title":"Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia","volume":"50","author":"Li","year":"2007","journal-title":"Hypertension"},{"key":"10.1038\/ki.2010.393_bb0205","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/HYPERTENSIONAHA.109.141937","article-title":"Recombinant vascular endothelial growth factor 121 infusion lowers blood pressure and improves renal function in rats with placentalischemia-induced hypertension","volume":"55","author":"Gilbert","year":"2010","journal-title":"Hypertension"},{"key":"10.1038\/ki.2010.393_bb0210","series-title":"Early Pregnancy Loss: Mechanisms and Treatment","first-page":"89","article-title":"Genetic aspects of the CBA \u00d7 DBA\/2 and B10 \u00d7 B10. A model of murine abortion and its prevention by lymphocytes immunization","author":"Chaouat","year":"1988"},{"key":"10.1038\/ki.2010.393_bb0215","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0002-9440(10)62302-4","article-title":"Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model","volume":"166","author":"Zenclussen","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2010.393_bb0220","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"10.1038\/ki.2010.393_bb0225","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1172\/JCI28462","article-title":"Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice","volume":"116","author":"Li","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2010.393_bb0230","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature06951","article-title":"Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia","volume":"453","author":"Kanasaki","year":"2008","journal-title":"Nature"},{"key":"10.1038\/ki.2010.393_bb0235","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1161\/CIRCULATIONAHA.106.660134","article-title":"Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1","volume":"115","author":"Cudmore","year":"2007","journal-title":"Circulation"},{"key":"10.1038\/ki.2010.393_bb0240","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nm.1856","article-title":"Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice","volume":"14","author":"Zhou","year":"2008","journal-title":"Nat Med"},{"key":"10.1038\/ki.2010.393_bb0245","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1126\/science.287.5452.498","article-title":"A critical role for murine complement regulator crry in fetomaternal tolerance","volume":"287","author":"Xu","year":"2000","journal-title":"Science"},{"key":"10.1038\/ki.2010.393_bb0250","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1084\/jem.200116116","article-title":"Complement C3 activation is required for antiphospholipid antibody-induced fetal loss","volume":"195","author":"Holers","year":"2002","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2010.393_bb0255","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/83183","article-title":"Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy","volume":"2","author":"Mellor","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1038\/ki.2010.393_bb0260","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1084\/jem.20050019","article-title":"A critical role for the programmed death ligand 1 in fetomaternal tolerance","volume":"202","author":"Guleria","year":"2005","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2010.393_bb0265","doi-asserted-by":"crossref","first-page":"16939","DOI":"10.1074\/jbc.M808166200","article-title":"Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury","volume":"284","author":"Thurman","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2010.393_bb0270","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1056\/NEJMoa0707330","article-title":"VEGF inhibition and renal thrombotic microangiopathy","volume":"358","author":"Eremina","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2010.393_bb0275","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ajog.2008.10.033","article-title":"Circulating angiogenic factors in gestational proteinuria without hypertension","volume":"200","author":"Holston","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1038\/ki.2010.393_bb0280","first-page":"19","article-title":"Complement, neutrophil, and macrophage activation in women with severe preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count","volume":"79","author":"Haeger","year":"1992","journal-title":"Obstet Gynecol"},{"key":"10.1038\/ki.2010.393_bb0285","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1538-7836.2008.03230.x","article-title":"Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia: a pilot randomized controlled trial","volume":"7","author":"Rey","year":"2009","journal-title":"J Thromb Haemost"},{"key":"10.1038\/ki.2010.393_bb0290","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/nm1121","article-title":"Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation","volume":"10","author":"Girardi","year":"2004","journal-title":"Nat Med"},{"key":"10.1038\/ki.2010.393_bb0295","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1182\/blood-2009-01-199117","article-title":"Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid (aPL) antibodies","volume":"114","author":"Seshan","year":"2009","journal-title":"Blood"},{"key":"10.1038\/ki.2010.393_bb0300","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/hy02t2.102904","article-title":"Discovery of a spontaneous genetic mouse model of preeclampsia","volume":"39","author":"Davisson","year":"2002","journal-title":"Hypertension"},{"key":"10.1038\/ki.2010.393_bb0305","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/HYPERTENSIONAHA.107.107219","article-title":"Chronic tempol prevents hypertension, proteinuria, and poor feto-placental outcomes in BPH\/5 mouse model of preeclampsia","volume":"51","author":"Hoffmann","year":"2008","journal-title":"Hypertension"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815548047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815548047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T16:09:30Z","timestamp":1685808570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815548047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0085253815548047"],"URL":"https:\/\/doi.org\/10.1038\/ki.2010.393","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.5881956.5870054","asserted-by":"object"}]},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}