{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:13:15Z","timestamp":1781824395567,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":1711,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1038\/ki.2010.487","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T14:16:40Z","timestamp":1293027400000},"page":"749-756","source":"Crossref","is-referenced-by-count":68,"title":["Protein-energy wasting modifies the association of ghrelin with inflammation, leptin, and mortality in hemodialysis patients"],"prefix":"10.1016","volume":"79","author":[{"given":"Juan J.","family":"Carrero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumu","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul R.","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Lindholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Heimb\u00fcrger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"B\u00e1r\u00e1ny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stenvinkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2010.487_bb0010","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.ki.5002585","article-title":"A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease","volume":"73","author":"Fouque","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.487_bb0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.jrn.2008.10.004","article-title":"Identification of patients with eating disorders: clinical and biochemical signs of appetite loss in dialysis patients","volume":"19","author":"Carrero","year":"2009","journal-title":"J Ren Nutr"},{"key":"10.1038\/ki.2010.487_bb0020","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/sj.ki.5001969","article-title":"Inflammation and wasting in chronic kidney disease: partners in crime","volume":"70","author":"Avesani","year":"2006","journal-title":"Kidney Int Suppl"},{"key":"10.1038\/ki.2010.487_bb0025","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/ajcn\/85.3.695","article-title":"Comparison of nutritional and inflammatory markers in dialysis patients with reduced appetite","volume":"85","author":"Carrero","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1038\/ki.2010.487_bb0030","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/ajcn\/80.2.299","article-title":"Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients","volume":"80","author":"Kalantar-Zadeh","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1038\/ki.2010.487_bb0035","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1053\/j.jrn.2007.10.022","article-title":"Appetite disorders in uremia","volume":"18","author":"Carrero","year":"2008","journal-title":"J Ren Nutr"},{"key":"10.1038\/ki.2010.487_bb0040","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.ki.5001572","article-title":"Anorexia in hemodialysis patients: an update","volume":"70","author":"Bossola","year":"2006","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.487_bb0045","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1046\/j.0894-0959.2004.16086.x","article-title":"Eating behavior disorders in uremia: a question of balance in appetite regulation","volume":"17","author":"Aguilera","year":"2004","journal-title":"Semin Dial"},{"key":"10.1038\/ki.2010.487_bb0050","doi-asserted-by":"crossref","first-page":"R1483","DOI":"10.1152\/ajpregu.2001.280.5.R1483","article-title":"Hemodynamic and hormonal effects of human ghrelin in healthy volunteers","volume":"280","author":"Nagaya","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1038\/ki.2010.487_bb0055","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"10.1038\/ki.2010.487_bb0060","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/ndt\/gfg559","article-title":"Associations between plasma ghrelin levels and body composition in end-stage renal disease: a longitudinal study","volume":"19","author":"Rodriguez Ayala","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2010.487_bb0065","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1097\/01.ASN.0000032420.12455.74","article-title":"Plasma ghrelin and desacyl ghrelin concentrations in renal failure","volume":"13","author":"Yoshimoto","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2010.487_bb0070","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1681\/ASN.2005010039","article-title":"Subcutaneous ghrelin enhances acute food intake in malnourished patients who receive maintenance peritoneal dialysis: a randomized, placebo-controlled trial","volume":"16","author":"Wynne","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2010.487_bb0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ki.2009.114","article-title":"Sustained appetite improvement in malnourished dialysis patients by daily ghrelin treatment","volume":"76","author":"Ashby","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.487_bb0080","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/ki.2009.480","article-title":"A super-agonist of growth hormone-releasing hormone causes rapid improvement of nutritional status in patients with chronic kidney disease","volume":"77","author":"Niemczyk","year":"2010","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.487_bb0085","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1161\/01.CIR.0000149746.62908.BB","article-title":"Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure","volume":"110","author":"Nagaya","year":"2004","journal-title":"Circulation"},{"key":"10.1038\/ki.2010.487_bb0090","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1161\/hc3601.095575","article-title":"Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure","volume":"104","author":"Nagaya","year":"2001","journal-title":"Circulation"},{"key":"10.1038\/ki.2010.487_bb0095","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.peptides.2009.07.002","article-title":"Ghrelin and its therapeutic potential for cachectic patients","volume":"30","author":"Ashitani","year":"2009","journal-title":"Peptides"},{"key":"10.1038\/ki.2010.487_bb0100","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1161\/01.CIR.0000127956.43874.F2","article-title":"Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells","volume":"109","author":"Li","year":"2004","journal-title":"Circulation"},{"key":"10.1038\/ki.2010.487_bb0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1172\/JCI200421134","article-title":"Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells","volume":"114","author":"Dixit","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2010.487_bb0110","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/en.2007-1046","article-title":"Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile","volume":"149","author":"Deboer","year":"2008","journal-title":"Endocrinology"},{"key":"10.1038\/ki.2010.487_bb0115","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1210\/en.2007-0016","article-title":"Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia","volume":"148","author":"DeBoer","year":"2007","journal-title":"Endocrinology"},{"key":"10.1038\/ki.2010.487_bb0120","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.arcmed.2008.08.005","article-title":"Fasting serum total ghrelin level inversely correlates with metabolic syndrome in hemodialysis patients","volume":"39","author":"Lee","year":"2008","journal-title":"Arch Med Res"},{"key":"10.1038\/ki.2010.487_bb0125","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.2337\/diabetes.52.10.2546","article-title":"Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes","volume":"52","author":"Poykko","year":"2003","journal-title":"Diabetes"},{"key":"10.1038\/ki.2010.487_bb0130","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2796.2006.01661.x","article-title":"Plasma ghrelin concentrations are positively associated with carotid artery atherosclerosis in males","volume":"260","author":"Poykko","year":"2006","journal-title":"J Intern Med"},{"key":"10.1038\/ki.2010.487_bb0135","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2337\/diabetes.50.4.707","article-title":"Circulating ghrelin levels are decreased in human obesity","volume":"50","author":"Tschop","year":"2001","journal-title":"Diabetes"},{"key":"10.1038\/ki.2010.487_bb0140","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.physbeh.2005.10.015","article-title":"The orexigenic effect of peripheral ghrelin differs between rats of different age and with different baseline food intake, and it may in part be mediated by the area postrema","volume":"87","author":"Gilg","year":"2006","journal-title":"Physiol Behav"},{"key":"10.1038\/ki.2010.487_bb0145","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1210\/jc.2002-020645","article-title":"Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women","volume":"88","author":"Tolle","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/ki.2010.487_bb0150","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/ajcn\/85.4.967","article-title":"Constitutional thinness and lean anorexia nervosa display opposite concentrations of peptide YY, glucagon-like peptide 1, ghrelin, and leptin","volume":"85","author":"Germain","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1038\/ki.2010.487_bb0155","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/ki.2009.411","article-title":"Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease","volume":"77","author":"Barazzoni","year":"2010","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.487_bb0160","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1210\/en.2008-0472","article-title":"Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality","volume":"149","author":"Schwenke","year":"2008","journal-title":"Endocrinology"},{"key":"10.1038\/ki.2010.487_bb0165","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1083\/jcb.200207165","article-title":"Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1\/2 and PI 3-kinase\/AKT","volume":"159","author":"Baldanzi","year":"2002","journal-title":"J Cell Biol"},{"key":"10.1038\/ki.2010.487_bb0170","doi-asserted-by":"crossref","first-page":"H426","DOI":"10.1152\/ajpheart.00643.2007","article-title":"Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction","volume":"294","author":"Soeki","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1038\/ki.2010.487_bb0175","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/0091270007310380","article-title":"Ghrelin agonist (TZP-101): safety, pharmacokinetics and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study","volume":"48","author":"Lasseter","year":"2008","journal-title":"J Clin Pharmacol"},{"key":"10.1038\/ki.2010.487_bb0180","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3109\/08860220903151419","article-title":"Plasma ghrelin levels are associated with coronary microvascular and endothelial dysfunction in peritoneal dialysis patients","volume":"31","author":"Caliskan","year":"2009","journal-title":"Ren Fail"},{"key":"10.1038\/ki.2010.487_bb0185","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1093\/ndt\/gfi011","article-title":"The relationship of plasma ghrelin level to energy regulation, feeding and left ventricular function in non-diabetic haemodialysis patients","volume":"20","author":"Chang","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2010.487_bb0190","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1210\/en.2006-1240","article-title":"Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway","volume":"148","author":"Kohno","year":"2007","journal-title":"Endocrinology"},{"key":"10.1038\/ki.2010.487_bb0195","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/MNH.0b013e328332fc2b","article-title":"The emerging pleiotrophic role of adipokines in the uremic phenotype","volume":"19","author":"Carrero","year":"2010","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1038\/ki.2010.487_bb0200","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nm1372","article-title":"Induction of leptin resistance through direct interaction of C-reactive protein with leptin","volume":"12","author":"Chen","year":"2006","journal-title":"Nat Med"},{"issue":"Suppl 1","key":"10.1038\/ki.2010.487_bb0205","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.2215\/CJN.02720409","article-title":"Persistent inflammation as a catalyst for other risk factors in chronic kidney disease: a hypothesis proposal","volume":"4","author":"Carrero","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2010.487_bb0210","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nrneph.2009.171","article-title":"Nutrition: can ghrelin improve appetite in uremic wasting?","volume":"5","author":"Carrero","year":"2009","journal-title":"Nat Rev Nephrol"},{"key":"10.1038\/ki.2010.487_bb0215","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1111\/j.1523-1755.2005.00761.x","article-title":"Acute plasma ghrelin and leptin responses to oral feeding or intraperitoneal hypertonic glucose-based dialysate in patients with chronic renal failure","volume":"68","author":"Perez-Fontan","year":"2005","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.487_bb0220","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3945\/ajcn.2008.27011","article-title":"Morning ghrelin concentrations are not affected by short-term overfeeding and do not predict ad libitum food intake in humans","volume":"89","author":"Votruba","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"10.1038\/ki.2010.487_bb0225","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/ajcn\/82.1.41","article-title":"A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations","volume":"82","author":"Weigle","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1038\/ki.2010.487_bb0230","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0261-5614(93)90139-U","article-title":"Subjective assessment of nutritional status-validity and reliability of a modified Detsky index in a Swedish setting","volume":"12","author":"Ulander","year":"1993","journal-title":"Clin Nutr (Edinburgh, Scotland)"},{"key":"10.1038\/ki.2010.487_bb0235","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1046\/j.1523-1755.1998.00812.x","article-title":"Factors predicting malnutrition in hemodialysis patients: a cross-sectional study","volume":"53","author":"Qureshi","year":"1998","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2010.487_bb0240","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/014860718701100108","article-title":"What is subjective global assessment of nutritional status?","volume":"11","author":"Detsky","year":"1987","journal-title":"J Parenter Enteral Nutr"},{"key":"10.1038\/ki.2010.487_bb0245","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1053\/ajkd.2002.33921","article-title":"Validity of subjective global assessment as a nutritional marker in end-stage renal disease","volume":"40","author":"Cooper","year":"2002","journal-title":"Am J Kidney Dis"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815548722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815548722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T07:46:49Z","timestamp":1559893609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815548722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0085253815548722"],"URL":"https:\/\/doi.org\/10.1038\/ki.2010.487","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}