{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:53:42Z","timestamp":1792072422262,"version":"4.4.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T00:00:00Z","timestamp":1449446400000},"content-version":"vor","delay-in-days":1558,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1038\/ki.2011.158","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T12:46:45Z","timestamp":1308142005000},"page":"524-534","source":"Crossref","is-referenced-by-count":45,"title":["Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury"],"prefix":"10.1016","volume":"80","author":[{"given":"Lihua","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Quigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2011.158_bb0010","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJM200104053441406","article-title":"Advances in immunology: complement (first of two parts)","volume":"344","author":"Walport","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2011.158_bb0015","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1084\/jem.181.1.151","article-title":"Mouse complement regulatory protein Crry\/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein","volume":"181","author":"Kim","year":"1995","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2011.158_bb0020","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1126\/science.287.5452.498","article-title":"A critical role for murine complement regulator Crry in fetomaternal tolerance","volume":"287","author":"Xu","year":"2000","journal-title":"Science"},{"key":"10.1038\/ki.2011.158_bb0025","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1681\/ASN.2006101176","article-title":"Unrestricted C3 activation occurs in Crry-deficient kidneys and rapidly leads to chronic renal failure","volume":"18","author":"Bao","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.158_bb0030","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.4049\/jimmunol.1000111","article-title":"The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells","volume":"185","author":"Renner","year":"2010","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0035","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0140-6736(68)90589-8","article-title":"Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis","volume":"2","author":"Risdon","year":"1968","journal-title":"Lancet"},{"key":"10.1038\/ki.2011.158_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0272-6386(12)80312-X","article-title":"Tubulointerstitial changes as a major determinant in the progression of renal damage","volume":"20","author":"Nath","year":"1992","journal-title":"Am J Kid Dis"},{"key":"10.1038\/ki.2011.158_bb0045","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1016\/j.molimm.2009.04.027","article-title":"The role of the anaphylatoxins in health and disease","volume":"46","author":"Klos","year":"2009","journal-title":"Mol Immunol"},{"key":"10.1038\/ki.2011.158_bb0050","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1084\/jem.186.2.199","article-title":"The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes","volume":"186","author":"Martin","year":"1997","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2011.158_bb0055","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1073\/pnas.75.8.3943","article-title":"Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes","volume":"75","author":"Chenoweth","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2011.158_bb0060","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1182\/blood.V79.1.152.152","article-title":"Binding of fluorescein-labeled anaphylatoxin C5a to human peripheral blood, spleen, and bone marrow leukocytes","volume":"79","author":"Werfel","year":"1992","journal-title":"Blood"},{"key":"10.1038\/ki.2011.158_bb0065","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.4049\/jimmunol.162.7.4018","article-title":"Human T cells express the C5a receptor and are chemoattracted to C5a","volume":"162","author":"Nataf","year":"1999","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0070","doi-asserted-by":"crossref","first-page":"6599","DOI":"10.4049\/jimmunol.165.11.6599","article-title":"Activated human T lymphocytes express a functional C3a receptor","volume":"165","author":"Werfel","year":"2000","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0075","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1084\/jem.181.6.2119","article-title":"C3a is a chemotaxin for human eosinophils but not for neutrophils. I. C3a stimulation of neutrophils is secondary to eosinophil activation","volume":"181","author":"Daffern","year":"1995","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2011.158_bb0080","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.4049\/jimmunol.162.2.1127","article-title":"A comparison of C3a and C5a-mediated stable adhesion of rolling eosinophils in postcapillary venules and transendothelial migration in vitro and in vivo","volume":"162","author":"DiScipio","year":"1999","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0085","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.4049\/jimmunol.157.4.1693","article-title":"C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway","volume":"157","author":"Nilsson","year":"1996","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0090","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.4049\/jimmunol.134.5.3325","article-title":"Chemotactic responses of human peripheral blood monocytes to the complement-derived peptides C5a and C5a des Arg","volume":"134","author":"Marder","year":"1985","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0095","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1084\/jem.20030374","article-title":"The proinflammatory mediators C3a and C5a are essential for liver regeneration","volume":"198","author":"Strey","year":"2003","journal-title":"J Exp Med"},{"key":"10.1038\/ki.2011.158_bb0100","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.4049\/jimmunol.169.10.5926","article-title":"Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy","volume":"169","author":"Drouin","year":"2002","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0105","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.immuni.2008.02.001","article-title":"Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells","volume":"28","author":"Strainic","year":"2008","journal-title":"Immunity"},{"key":"10.1038\/ki.2011.158_bb0110","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1189\/jlb.0809548","article-title":"The myeloid 7\/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B","volume":"88","author":"Rosas","year":"2010","journal-title":"J Leukoc Biol"},{"key":"10.1038\/ki.2011.158_bb0115","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0022-1759(96)00138-X","article-title":"Flow cytometric identification of murine neutrophils and monocytes","volume":"197","author":"Lagasse","year":"1996","journal-title":"J Immunol Methods"},{"key":"10.1038\/ki.2011.158_bb0120","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/sj.ki.5001567","article-title":"CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney","volume":"70","author":"Soos","year":"2006","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.158_bb0125","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1002\/eji.200324003","article-title":"Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo","volume":"33","author":"Taylor","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1038\/ki.2011.158_bb0130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/art.24185","article-title":"Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout","volume":"60","author":"Martin","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1038\/ki.2011.158_bb0135","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1681\/ASN.2008040434","article-title":"C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy","volume":"20","author":"Tang","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.158_bb0140","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.4049\/jimmunol.178.3.1819","article-title":"C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia\/reperfusion","volume":"178","author":"Thurman","year":"2007","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0145","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1681\/ASN.2006121343","article-title":"Complement C5 mediates experimental tubulointerstitial fibrosis","volume":"18","author":"Boor","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.158_bb0150","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/eji.201040355","article-title":"Complement fragments C3a and C5a: the salt and pepper of the immune response","volume":"40","author":"Sacks","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1038\/ki.2011.158_bb0155","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1128\/JVI.01783-06","article-title":"C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression","volume":"81","author":"Melendi","year":"2007","journal-title":"J Virol"},{"key":"10.1038\/ki.2011.158_bb0160","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.4049\/jimmunol.165.10.5406","article-title":"Targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock","volume":"165","author":"Kildsgaard","year":"2000","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0165","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.molimm.2007.10.037","article-title":"Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a","volume":"45","author":"Hollmann","year":"2008","journal-title":"Mol Immunol"},{"key":"10.1038\/ki.2011.158_bb0170","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1681\/ASN.2005040373","article-title":"C5a receptor deficiency attenuates T cell function and renal disease in MRLlpr mice","volume":"16","author":"Wenderfer","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.158_bb0175","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.molimm.2008.12.004","article-title":"C3a receptor deficiency accelerates the onset of renal injury in the MRL\/lpr mouse","volume":"46","author":"Wenderfer","year":"2009","journal-title":"Mol Immunol"},{"key":"10.1038\/ki.2011.158_bb0180","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/35023175","article-title":"A role for the C3a anaphylatoxin receptor in the effector phase of asthma","volume":"406","author":"Humbles","year":"2000","journal-title":"Nature"},{"key":"10.1038\/ki.2011.158_bb0185","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1172\/JCI26582","article-title":"A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma","volume":"116","author":"Kohl","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.158_bb0190","doi-asserted-by":"crossref","first-page":"783","DOI":"10.4049\/jimmunol.174.2.783","article-title":"Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation","volume":"174","author":"Baelder","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0195","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.4049\/jimmunol.0804276","article-title":"A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells","volume":"182","author":"Zhang","year":"2009","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0200","doi-asserted-by":"crossref","first-page":"17892","DOI":"10.1073\/pnas.0906070106","article-title":"CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes","volume":"106","author":"Niedermeier","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2011.158_bb0205","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1681\/ASN.V111152","article-title":"Chemokines, chemokine receptors, and renal disease: from basic science to pathophysiologic and therapeutic studies","volume":"11","author":"Segerer","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.158_bb0210","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.semnephrol.2007.02.003","article-title":"Role of chemokines for the localization of leukocyte subsets in the kidney","volume":"27","author":"Segerer","year":"2007","journal-title":"Semin Nephrol"},{"key":"10.1038\/ki.2011.158_bb0215","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0002-9440(10)63292-0","article-title":"Blockade of CCR2 ameliorates progressive fibrosis in kidney","volume":"165","author":"Kitagawa","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2011.158_bb0220","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/339314a0","article-title":"Rapid induction of neutrophil-endothelial adhesion by endothelial complement fixation","volume":"339","author":"Marks","year":"1989","journal-title":"Nature"},{"key":"10.1038\/ki.2011.158_bb0225","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1365-2249.1993.tb03377.x","article-title":"CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions","volume":"92","author":"Ross","year":"1993","journal-title":"Exp Immunol"},{"key":"10.1038\/ki.2011.158_bb0230","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/jlb.38.2.327","article-title":"Activation of phagocytic cells\u2019 C3 receptors for phagocytosis","volume":"38","author":"Wright","year":"1985","journal-title":"J Leukoc Biol"},{"key":"10.1038\/ki.2011.158_bb0235","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1160\/TH07-02-0156","article-title":"Neutrophil activation via beta2 integrins (CD11\/CD18): molecular mechanisms and clinical implications","volume":"98","author":"Schymeinsky","year":"2007","journal-title":"Thromb Haemost"},{"key":"10.1038\/ki.2011.158_bb0240","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nature05559","article-title":"C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a","volume":"446","author":"Chen","year":"2007","journal-title":"Nature"},{"key":"10.1038\/ki.2011.158_bb0245","first-page":"2304","article-title":"A complement-dependent balance between hepatic ischemia\/reperfusion injury and liver regeneration in mice","volume":"119","author":"He","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.158_bb0250","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S1074-7613(03)00321-2","article-title":"Negligible role of antibodies and C5 in pregnancy loss associated exclusively with C3-dependent mechanisms through complement alternative pathway","volume":"19","author":"Mao","year":"2003","journal-title":"Immunity"},{"key":"10.1038\/ki.2011.158_bb0255","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/383086a0","article-title":"The C5a chemoattractant receptor mediates mucosal defence to infection","volume":"383","author":"Hopken","year":"1996","journal-title":"Nature"},{"key":"10.1038\/ki.2011.158_bb0260","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.4049\/jimmunol.172.4.2629","article-title":"Role of Toll-like receptor 4 in endotoxin-induced acute renal failure","volume":"172","author":"Cunningham","year":"2004","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0265","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.4049\/jimmunol.168.7.3601","article-title":"Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL\/lpr mice","volume":"168","author":"Bao","year":"2002","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0270","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1172\/JCI118291","article-title":"Tubulointerstitial injury induced in rats by a monoclonal antibody which inhibits function of a membrane inhibitor of complement","volume":"96","author":"Nomura","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.158_bb0275","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.4049\/jimmunol.175.3.1947","article-title":"Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis","volume":"175","author":"Bao","year":"2005","journal-title":"J Immunol"},{"key":"10.1038\/ki.2011.158_bb0280","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1172\/JCI36000","article-title":"Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells","volume":"119","author":"Bao","year":"2009","journal-title":"J Clin Invest"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815550710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815550710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T11:37:05Z","timestamp":1686137825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815550710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":55,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0085253815550710"],"URL":"https:\/\/doi.org\/10.1038\/ki.2011.158","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}