{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:17:56Z","timestamp":1787836676453,"version":"build-2784847793"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":1734,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1038\/ki.2011.23","type":"journal-article","created":{"date-parts":[[2011,2,23]],"date-time":"2011-02-23T14:15:07Z","timestamp":1298470507000},"page":"S3-S8","source":"Crossref","is-referenced-by-count":58,"special_numbering":"S121","title":["The intact nephron hypothesis: the concept and its implications for phosphate management in CKD-related mineral and bone disorder"],"prefix":"10.1016","volume":"79","author":[{"given":"Eduardo","family":"Slatopolsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2011.23_bb0010","doi-asserted-by":"crossref","unstructured":"Bright R. Report of medical cases selected with a view of illustrating the symptoms and cure of disease by a reference to morbid anatomy, vol. 1. Longman, Rees, Orme, Brown and Green: London, pp 1827\u20131831.","DOI":"10.1097\/00000441-182801020-00017"},{"key":"10.1038\/ki.2011.23_bb0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0002-9343(60)90225-4","article-title":"The pathologic physiology of chronic Bright's disease. An exposition of the \u2018intact nephron hypothesis\u2019","volume":"28","author":"Bricker","year":"1960","journal-title":"Am J Med"},{"key":"10.1038\/ki.2011.23_bb0020","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1056\/NEJM197205182862009","article-title":"On the pathogenesis of the uremic state. An exposition of the \u2018trade-off hypothesis\u2019","volume":"286","author":"Bricker","year":"1972","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2011.23_bb0025","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1172\/JCI105748","article-title":"Studies on the characteristics of the control system governing sodium excretion in uremic man","volume":"47","author":"Slatopolsky","year":"1968","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.23_bb0030","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1172\/JCI106318","article-title":"On the influence of extracellular fluid volume expansion and of uremia on bicarbonate reabsorption in man","volume":"49","author":"Slatopolsky","year":"1970","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.23_bb0035","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1172\/JCI105877","article-title":"Control of phosphate excretion in uremic man","volume":"47","author":"Slatopolsky","year":"1968","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.23_bb0040","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1172\/JCI106517","article-title":"On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog","volume":"50","author":"Slatopolsky","year":"1971","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.23_bb0045","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/ki.1972.84","article-title":"On the prevention of secondary hyperparathyroidism in experimental chronic renal disease using \u2018proportional reduction\u2019 of dietary phosphorus intake","volume":"2","author":"Slatopolsky","year":"1972","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.23_bb0050","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1172\/JCI112714","article-title":"Regulation by vitamin D metabolites of parathyroid hormone gene transcription in vivo in the rat","volume":"78","author":"Silver","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.23_bb0055","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1073\/pnas.82.12.4270","article-title":"Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells","volume":"82","author":"Silver","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2011.23_bb0060","first-page":"F432","article-title":"Phosphorus restriction reverses hyperparathyroidism in uremia independent of changes in calcium and calcitriol","volume":"259","author":"Lopez-Hilker","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.2011.23_bb0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI112304","article-title":"Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans","volume":"77","author":"Portale","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.23_bb0070","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1172\/JCI118701","article-title":"Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro","volume":"97","author":"Slatopolsky","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.23_bb0075","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/jbmr.5650110714","article-title":"Direct effect of phosphorus on PTH secretion from whole rat parathyroid glands in vitro","volume":"11","author":"Almaden","year":"1996","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.2011.23_bb0080","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/ndt\/11.9.1762","article-title":"A direct effect in vitro of phosphate on PTH release from bovine parathyroid tissue slices but not from dispersed parathyroid cells","volume":"11","author":"Nielsen","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2011.23_bb0085","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1172\/JCI118038","article-title":"Parathyroid hormone gene expression in hypophosphatemic rats","volume":"96","author":"Kilav","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.23_bb0090","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/ki.2008.642","article-title":"Phosphate and the parathyroid","volume":"75","author":"Silver","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.23_bb0095","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0272-6386(96)90473-4","article-title":"Phosphorus accelerates the development of parathyroid hyperplasia and secondary hyperparathyroidism in rats with renal failure","volume":"28","author":"Denda","year":"1996","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2011.23_bb0100","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1046\/j.1523-1755.2002.00265.x","article-title":"Hyperplasia of the parathyroid gland without secondary hyperparathyroidism","volume":"61","author":"Takahashi","year":"2002","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.23_bb0105","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1359\/jbmr.2002.17.12.2206","article-title":"Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function","volume":"17","author":"Ritter","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.2011.23_bb0110","doi-asserted-by":"crossref","first-page":"E729","DOI":"10.1152\/ajpendo.00065.2005","article-title":"Acute regulation of parathyroid hormone by dietary phosphate","volume":"289","author":"Martin","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1038\/ki.2011.23_bb0115","doi-asserted-by":"crossref","first-page":"11085","DOI":"10.1073\/pnas.0704446104","article-title":"Evidence for a signaling axis by which intestinal phosphate rapidly modulates renal phosphate reabsorption","volume":"104","author":"Berndt","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2011.23_bb0120","first-page":"17","article-title":"Novel mechanisms in the regulation of phosphorus homeostasis","volume":"24","author":"Berndt","year":"2009","journal-title":"Physiology (Bethesda)"},{"key":"10.1038\/ki.2011.23_bb0125","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1046\/j.1523-1755.2001.059003855.x","article-title":"p21WAF1 and transforming growth factor-\u03b1 mediate dietary phosphate regulation of parathyroid cell growth","volume":"59","author":"Dusso","year":"2001","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.23_bb0130","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1357-2725(99)00015-1","article-title":"EGF receptor","volume":"31","author":"Wells","year":"1999","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1038\/ki.2011.23_bb0135","doi-asserted-by":"crossref","first-page":"F1096","DOI":"10.1152\/ajprenal.00167.2005","article-title":"A critical role for enhanced TGF-\u03b1 and EGFR expression in the initiation of parathyroid hyperplasia in experimental kidney disease","volume":"289","author":"Cozzolino","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2011.23_bb0140","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jsbmb.2010.03.064","article-title":"Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality","volume":"121","author":"Dusso","year":"2010","journal-title":"J Steroid Biochem Mol Biol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815547698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815547698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T10:51:26Z","timestamp":1637319086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815547698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":27,"alternative-id":["S0085253815547698"],"URL":"https:\/\/doi.org\/10.1038\/ki.2011.23","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}