{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:06:46Z","timestamp":1792285606515,"version":"4.4.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,2]],"date-time":"2016-05-02T00:00:00Z","timestamp":1462147200000},"content-version":"vor","delay-in-days":1462,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1038\/ki.2011.241","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T18:34:44Z","timestamp":1312396484000},"page":"942-948","source":"Crossref","is-referenced-by-count":251,"title":["The distant organ effects of acute kidney injury"],"prefix":"10.1016","volume":"81","author":[{"given":"Morgan E.","family":"Grams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Rabb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2011.241_bb0010","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1097\/CCM.0b013e3181a5906f","article-title":"Incidence and outcomes of acute kidney injury in intensive care units: A veterans administration study","volume":"37","author":"Thakar","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1038\/ki.2011.241_bb0015","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.294.7.813","article-title":"Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators. Acute renal failure in critically ill patients: a multinational, multicenter study","volume":"294","author":"Uchino","year":"2005","journal-title":"JAMA"},{"key":"10.1038\/ki.2011.241_bb0020","doi-asserted-by":"crossref","first-page":"844","DOI":"10.2215\/CJN.05191107","article-title":"Diagnosis, epidemiology and outcomes of acute kidney injury","volume":"3","author":"Waikar","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.241_bb0025","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/ki.1996.380","article-title":"Epidemiology of acute renal failure: a prospective, multicenter, community-based study. madrid acute renal failure study group","volume":"50","author":"Liano","year":"1996","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.241_bb0030","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1111\/j.1523-1755.2004.00927.x","article-title":"Program to Improve Care in Acute Renal DiseaseSpectrum of acute renal failure in the intensive care unit: the PICARD experience","volume":"66","author":"Mehta","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.241_bb0035","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1046\/j.1523-1755.1998.00210.x","article-title":"Treatment of acute renal failure","volume":"54","author":"Star","year":"1998","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.241_bb0040","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.amjmed.2005.01.069","article-title":"Has mortality from acute renal failure decreased? A systematic review of the literature","volume":"118","author":"Ympa","year":"2005","journal-title":"Am J Med"},{"key":"10.1038\/ki.2011.241_bb0045","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1056\/NEJMoa0802639","article-title":"Intensity of renal support in critically ill patients with acute kidney injury","volume":"359","author":"VA\/NIH Acute Renal Failure Trial Network","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2011.241_bb0050","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1001\/jama.1996.03530430033035","article-title":"The effect of acute renal failure on mortality. A cohort analysis","volume":"275","author":"Levy","year":"1996","journal-title":"JAMA"},{"key":"10.1038\/ki.2011.241_bb0055","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","volume":"342","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2011.241_bb0060","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1001\/jama.283.15.1995","article-title":"Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial","volume":"283","author":"The ARDS network","year":"2000","journal-title":"JAMA"},{"key":"10.1038\/ki.2011.241_bb0065","first-page":"2755","article-title":"Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury","volume":"35","author":"Liu","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1038\/ki.2011.241_bb0070","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF01708404","article-title":"Outcome prediction of acute renal failure in medical intensive care","volume":"17","author":"Schaefer","year":"1991","journal-title":"Intensive Care Med"},{"key":"10.1038\/ki.2011.241_bb0075","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1001\/archinte.1995.00430140075007","article-title":"Prognostic stratification in critically ill patients with acute renal failure requiring dialysis","volume":"155","author":"Chertow","year":"1995","journal-title":"Arch Intern Med"},{"key":"10.1038\/ki.2011.241_bb0080","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/MNH.0b013e3280dd8c35","article-title":"The incidence and prognostic significance of acute kidney injury","volume":"16","author":"Waikar","year":"2007","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1038\/ki.2011.241_bb0085","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2215\/CJN.02510706","article-title":"Elevated plasma concentrations of IL-6 and elevated APACHE II score predict acute kidney injury in patients with severe sepsis","volume":"2","author":"Chawla","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.241_bb0090","doi-asserted-by":"crossref","first-page":"R104","DOI":"10.1186\/cc7940","article-title":"Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study","volume":"13","author":"Liu","year":"2009","journal-title":"Crit Care"},{"key":"10.1038\/ki.2011.241_bb0095","doi-asserted-by":"crossref","first-page":"c148","DOI":"10.1159\/000232595","article-title":"Interleukin-8 and acute kidney injury following cardiopulmonary bypass: A prospective cohort study","volume":"113","author":"Liangos","year":"2009","journal-title":"Nephron Clin Pract"},{"key":"10.1038\/ki.2011.241_bb0100","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/S0272-6386(03)00206-3","article-title":"Urinary actin, interleukin-6, and interleukin-8 may predict sustained ARF after ischemic injury in renal allografts","volume":"41","author":"Kwon","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2011.241_bb0105","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/j.1523-1755.2004.00512.x","article-title":"Plasma cytokine levels predict mortality in patients with acute renal failure","volume":"65","author":"Simmons","year":"2004","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.241_bb0110","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1378\/chest.107.4.1062","article-title":"Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time","volume":"107","author":"Meduri","year":"1995","journal-title":"Chest"},{"key":"10.1038\/ki.2011.241_bb0115","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1046\/j.1523-1755.1999.00460.x","article-title":"Renal ischemia\/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability","volume":"55","author":"Kramer","year":"1999","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.241_bb0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1681\/ASN.2006050494","article-title":"Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury","volume":"18","author":"Hoke","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.241_bb0125","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0002-9440(10)62318-8","article-title":"Transgenic sickle mice are markedly sensitive to renal ischemia-reperfusion injury","volume":"166","author":"Nath","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2011.241_bb0130","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1046\/j.1523-1755.2003.00753.x","article-title":"Acute renal failure leads to dysregulation of lung salt and water channels","volume":"63","author":"Rabb","year":"2003","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.241_bb0135","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1164\/rccm.200303-372OC","article-title":"Alpha-melanocyte-stimulating hormone inhibits lung injury after renal ischemia\/reperfusion","volume":"169","author":"Deng","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1038\/ki.2011.241_bb0140","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/ki.2008.314","article-title":"Interleukin-6 mediates lung injury following ischemic acute kidney injury or bilateral nephrectomy","volume":"74","author":"Klein","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.241_bb0145","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/sj.ki.5002471","article-title":"Deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia","volume":"72","author":"Tracz","year":"2007","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.241_bb0150","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1159\/000095588","article-title":"Comparison of experimental lung injury from acute renal failure with injury due to sepsis","volume":"73","author":"Kim","year":"2006","journal-title":"Respiration"},{"key":"10.1038\/ki.2011.241_bb0155","doi-asserted-by":"crossref","first-page":"F30","DOI":"10.1152\/ajprenal.00023.2007","article-title":"Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy","volume":"293","author":"Hassoun","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2011.241_bb0160","doi-asserted-by":"crossref","first-page":"F125","DOI":"10.1152\/ajprenal.90666.2008","article-title":"Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis","volume":"297","author":"Hassoun","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2011.241_bb0165","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ki.2008.648","article-title":"Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury","volume":"75","author":"Awad","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.241_bb0170","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1681\/ASN.2006040358","article-title":"Acute uremia but not renal inflammation attenuates aseptic acute lung injury: A critical role for uremic neutrophils","volume":"17","author":"Zarbock","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.241_bb0175","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1001\/jama.289.16.2104","article-title":"Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome","volume":"289","author":"Imai","year":"2003","journal-title":"JAMA"},{"key":"10.1038\/ki.2011.241_bb0180","doi-asserted-by":"crossref","first-page":"F900","DOI":"10.1152\/ajprenal.00357.2007","article-title":"Effects of acid aspiration-induced acute lung injury on kidney function","volume":"294","author":"Hoag","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2011.241_bb0185","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jacc.2008.07.051","article-title":"Cardiorenal syndrome","volume":"52","author":"Ronco","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1038\/ki.2011.241_bb0190","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/cc5713","article-title":"Acute Kidney Injury Network. Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury","volume":"11","author":"Mehta","year":"2007","journal-title":"Crit Care"},{"key":"10.1038\/ki.2011.241_bb0195","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/eurjhf\/hfp108","article-title":"COACH investigators. Both in- and out-hospital worsening of renal function predict outcome in patients with heart failure: Results from the coordinating study evaluating outcome of advising and counseling in heart failure (COACH)","volume":"11","author":"Damman","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1038\/ki.2011.241_bb0200","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0140-6736(99)01213-1","article-title":"Haemodialysis-membrane biocompatibility and mortality of patients with dialysis-dependent acute renal failure: a prospective randomised multicentre trial. International Multicentre Study Group","volume":"354","author":"Jorres","year":"1999","journal-title":"Lancet"},{"key":"10.1038\/ki.2011.241_bb0205","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.semnephrol.2005.09.003","article-title":"Acute renal failure: much more than a kidney disease","volume":"26","author":"Kelly","year":"2006","journal-title":"Semin Nephrol"},{"key":"10.1038\/ki.2011.241_bb0210","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0735-1097(96)00268-9","article-title":"Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension","volume":"28","author":"Testa","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"10.1038\/ki.2011.241_bb0215","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1161\/01.CIR.103.16.2055","article-title":"Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the vesnarinone trial (VEST)","volume":"103","author":"Deswal","year":"2001","journal-title":"Circulation"},{"key":"10.1038\/ki.2011.241_bb0220","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1161\/01.CIR.0000057810.48709.F6","article-title":"Framingham Heart Study. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: The framingham heart study","volume":"107","author":"Vasan","year":"2003","journal-title":"Circulation"},{"key":"10.1038\/ki.2011.241_bb0225","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1253\/circj.68.747","article-title":"Ongoing myocardial damage in chronic heart failure is related to activated tumor necrosis factor and Fas\/Fas ligand system","volume":"68","author":"Setsuta","year":"2004","journal-title":"Circ J"},{"key":"10.1038\/ki.2011.241_bb0230","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0735-1097(97)00055-7","article-title":"Plasma fas ligand, an inducer of apoptosis, and plasma soluble fas, an inhibitor of apoptosis, in patients with chronic congestive heart failure","volume":"29","author":"Nishigaki","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1038\/ki.2011.241_bb0235","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1097\/01.ASN.0000064946.94590.46","article-title":"Distant effects of experimental renal ischemia\/reperfusion injury","volume":"14","author":"Kelly","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.241_bb0240","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jhep.2009.11.025","article-title":"The evaluation of renal function and disease in patients with cirrhosis","volume":"52","author":"Francoz","year":"2010","journal-title":"J Hepatol"},{"key":"10.1038\/ki.2011.241_bb0245","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/ki.2010.4","article-title":"Afferent mechanisms of sodium retention in cirrhosis and hepatorenal syndrome","volume":"77","author":"Oliver","year":"2010","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.241_bb0250","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1067\/mlc.2002.122832","article-title":"Leukocyte accumulation and changes in extra-renal organs during renal ischemia reperfusion in mice","volume":"139","author":"Miyazawa","year":"2002","journal-title":"J Lab Clin Med"},{"key":"10.1038\/ki.2011.241_bb0255","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/ki.2008.683","article-title":"Ischemic and non-ischemic acute kidney injury cause hepatic damage","volume":"75","author":"Golab","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.241_bb0260","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/labinvest.2010.151","article-title":"Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy","volume":"91","author":"Park","year":"2011","journal-title":"Lab Invest"},{"key":"10.1038\/ki.2011.241_bb0265","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1006\/jsre.2002.6513","article-title":"Changes in hepatic TNF-alpha levels, antioxidant status, and oxidation products after renal ischemia\/reperfusion injury in mice","volume":"107","author":"Serteser","year":"2002","journal-title":"J Surg Res"},{"key":"10.1038\/ki.2011.241_bb0270","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1136\/jnnp.65.6.810","article-title":"Neurology and the kidney","volume":"65","author":"Burn","year":"1998","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1038\/ki.2011.241_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clineuro.2004.07.012","article-title":"Neurological complications in renal failure: a review","volume":"107","author":"Brouns","year":"2004","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1038\/ki.2011.241_bb0280","doi-asserted-by":"crossref","first-page":"143","DOI":"10.7326\/0003-4819-109-2-143","article-title":"Nervous system complications in uremia","volume":"109","author":"Fraser","year":"1988","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2011.241_bb0285","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1161\/STROKEAHA.108.545210","article-title":"Renal dysfunction as an independent predictor of outcome after aneurysmal subarachnoid hemorrhage: a single-center cohort study","volume":"40","author":"Zacharia","year":"2009","journal-title":"Stroke"},{"key":"10.1038\/ki.2011.241_bb0290","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2215\/CJN.04110808","article-title":"Long-term prognosis of acute kidney injury after first acute stroke","volume":"4","author":"Tsagalis","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.241_bb0295","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1600-6143.2011.03466.x","article-title":"Donor brain death predisposes human kidney grafts to a proinflammatory reaction after transplantation","volume":"11","author":"de Vries","year":"2011","journal-title":"Am J Transplant"},{"key":"10.1038\/ki.2011.241_bb0300","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1172\/JCI107571","article-title":"Calcium metabolism of brain in acute renal failure. Effects of uremia, hemodialysis, and parathyroid hormone","volume":"53","author":"Arieff","year":"1974","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.241_bb0305","first-page":"194","article-title":"Uremic encephalopathy: studies on biochemical alterations in the brain","volume":"2","author":"Arieff","year":"1975","journal-title":"Kidney Int Suppl"},{"key":"10.1038\/ki.2011.241_bb0310","first-page":"F195","article-title":"Abnormalities of cell volume regulation and their functional consequences","volume":"239","author":"Pollock","year":"1980","journal-title":"Am J Physiol"},{"key":"10.1038\/ki.2011.241_bb0315","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s001340101067","article-title":"Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats","volume":"27","author":"Adachi","year":"2001","journal-title":"Intensive Care Med"},{"key":"10.1038\/ki.2011.241_bb0320","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1681\/ASN.2007080901","article-title":"Acute kidney injury leads to inflammation and functional changes in the brain","volume":"19","author":"Liu","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.241_bb0325","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/ki.2008.390","article-title":"Uremic lung: new insights into a forgotten condition","volume":"74","author":"Scheel","year":"2008","journal-title":"Kidney Int"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815551922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815551922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T18:53:47Z","timestamp":1543604027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815551922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":64,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0085253815551922"],"URL":"https:\/\/doi.org\/10.1038\/ki.2011.241","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}