{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:49:14Z","timestamp":1789991354249,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"vor","delay-in-days":1461,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1038\/ki.2011.443","type":"journal-article","created":{"date-parts":[[2012,1,18]],"date-time":"2012-01-18T13:13:07Z","timestamp":1326892387000},"page":"662-673","source":"Crossref","is-referenced-by-count":70,"title":["Inhibition of glycogen synthase kinase-3\u03b2 prevents NSAID-induced acute kidney injury"],"prefix":"10.1016","volume":"81","author":[{"given":"Hao","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shougang","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance D.","family":"Dworkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rujun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2011.443_bb0010","first-page":"289","article-title":"[Acute renal failure and nephrotic syndrome associated with treatment with diclofenac]","volume":"191","author":"Rubio","year":"1992","journal-title":"Rev Clin Esp"},{"key":"10.1038\/ki.2011.443_bb0015","first-page":"81","article-title":"[Acute reversible renal insufficiency during treatment with diclofenac]","volume":"128","author":"Cicuttini","year":"1989","journal-title":"Clin Ter"},{"key":"10.1038\/ki.2011.443_bb0020","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/jhep.2002.31871","article-title":"Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats","volume":"35","author":"Masubuchi","year":"2002","journal-title":"Hepatology"},{"key":"10.1038\/ki.2011.443_bb0025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/abbi.1997.9985","article-title":"Diclofenac sodium and mefenamic acid: potent inducers of the membrane permeability transition in renal cortex mitochondria","volume":"342","author":"Uyemura","year":"1997","journal-title":"Arch Biochem Biophys"},{"key":"10.1038\/ki.2011.443_bb0030","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/abbi.1996.0459","article-title":"In vitro interaction of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation of rat kidney mitochondria: respiration and ATP synthesis","volume":"334","author":"Mingatto","year":"1996","journal-title":"Arch Biochem Biophys"},{"key":"10.1038\/ki.2011.443_bb0035","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0887-2333(03)00105-X","article-title":"Diclofenac induces apoptosis in hepatocytes","volume":"17","author":"Gomez-Lechon","year":"2003","journal-title":"Toxicol In Vitro"},{"key":"10.1038\/ki.2011.443_bb0040","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/j.bcp.2003.08.003","article-title":"Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS","volume":"66","author":"Gomez-Lechon","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1038\/ki.2011.443_bb0045","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0891-5849(01)00560-3","article-title":"Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death","volume":"31","author":"Hickey","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"10.1038\/ki.2011.443_bb0050","doi-asserted-by":"crossref","first-page":"F1053","DOI":"10.1152\/ajprenal.00114.2004","article-title":"Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus","volume":"288","author":"Kotnik","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2011.443_bb0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5049\/EBP.2007.5.2.68","article-title":"Dysregulation of renal cyclooxygenase-2 in rats with lithium-induced nephrogenic diabetes insipidus","volume":"5","author":"Kwon","year":"2007","journal-title":"Electrolyte Blood Press"},{"key":"10.1038\/ki.2011.443_bb0060","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1172\/JCI19906","article-title":"Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore","volume":"113","author":"Juhaszova","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2011.443_bb0065","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2008.12.024","article-title":"Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3beta and mitochondrial permeability transition pore","volume":"604","author":"Xi","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"10.1038\/ki.2011.443_bb0070","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/toxsci\/kfn266","article-title":"Cadmium toxicity toward autophagy through ROS-activated GSK-3beta in mesangial cells","volume":"108","author":"Wang","year":"2009","journal-title":"Toxicol Sci"},{"key":"10.1038\/ki.2011.443_bb0075","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.pa.33.040193.002251","article-title":"Renal toxicity of the nonsteroidal anti-inflammatory drugs","volume":"33","author":"Murray","year":"1993","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1038\/ki.2011.443_bb0080","doi-asserted-by":"crossref","first-page":"7401","DOI":"10.1074\/jbc.M710396200","article-title":"Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cells","volume":"283","author":"Gong","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2011.443_bb0085","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bbrc.2005.02.122","article-title":"Activation of PI3K-Akt-GSK3beta pathway mediates hepatocyte growth factor inhibition of RANTES expression in renal tubular epithelial cells","volume":"330","author":"Gong","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/ki.2011.443_bb0090","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1681\/ASN.2009121214","article-title":"GSK3beta plays dirty in acute kidney injury","volume":"21","author":"Nelson","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.443_bb0095","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/labinvest.2010.142","article-title":"Conditional ablation of glycogen synthase kinase 3beta in postnatal mouse kidney","volume":"91","author":"Ge","year":"2011","journal-title":"Lab Invest"},{"key":"10.1038\/ki.2011.443_bb0100","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1681\/ASN.2009080828","article-title":"GSK3beta promotes apoptosis after renal ischemic injury","volume":"21","author":"Wang","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.443_bb0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/sj.onc.1209004","article-title":"Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase","volume":"25","author":"Wang","year":"2006","journal-title":"Oncogene"},{"key":"10.1038\/ki.2011.443_bb0110","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.bbrc.2008.02.116","article-title":"Nephrotoxic cell death by diclofenac and meloxicam","volume":"369","author":"Ng","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/ki.2011.443_bb0115","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3109\/00498257909042328","article-title":"Biotransformation of diclofenac sodium (Voltaren) in animals and in man. II. Quantitative determination of the unchanged drug and principal phenolic metabolites, in urine and bile","volume":"9","author":"Stierlin","year":"1979","journal-title":"Xenobiotica"},{"key":"10.1038\/ki.2011.443_bb0120","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1161\/01.RES.0000338259.37472.b6","article-title":"Overcoming an energy crisis?: an adaptive role of glycogen synthase kinase-3 inhibition in ischemia\/reperfusion","volume":"103","author":"Zhai","year":"2008","journal-title":"Circ Res"},{"key":"10.1038\/ki.2011.443_bb0125","doi-asserted-by":"crossref","first-page":"H1310","DOI":"10.1152\/ajpheart.00339.2009","article-title":"Hydrogen sulfide protects cardiomyocytes from hypoxia\/reoxygenation-induced apoptosis by preventing GSK-3beta-dependent opening of mPTP","volume":"298","author":"Yao","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1038\/ki.2011.443_bb0130","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/cvr\/cvp151","article-title":"Regulation and pharmacology of the mitochondrial permeability transition pore","volume":"83","author":"Zorov","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1038\/ki.2011.443_bb0135","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/sj.ki.5002568","article-title":"The role of mitochondria in oxidative and nitrosative stress during ischemia\/reperfusion in the rat kidney","volume":"72","author":"Plotnikov","year":"2007","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.443_bb0140","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1074\/jbc.M110.172486","article-title":"Regulation of the inner membrane mitochondrial permeability transition by the outer membrane translocator protein (peripheral benzodiazepine receptor)","volume":"286","author":"Sileikyte","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2011.443_bb0145","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nature03434","article-title":"Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death","volume":"434","author":"Baines","year":"2005","journal-title":"Nature"},{"key":"10.1038\/ki.2011.443_bb0150","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"10.1038\/ki.2011.443_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1937-6448(10)84001-8","article-title":"Mitochondrial dynamics","volume":"284","author":"Bereiter-Hahn","year":"2010","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1038\/ki.2011.443_bb0160","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-3-642-00663-0_11","article-title":"Mitochondrial involvement in drug-induced liver injury","volume":"196","author":"Pessayre","year":"2010","journal-title":"Handb Exp Pharmacol"},{"key":"10.1038\/ki.2011.443_bb0165","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbrc.2006.07.089","article-title":"Action of diclofenac on kidney mitochondria and cells","volume":"348","author":"Ng","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/ki.2011.443_bb0170","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1005419617371","article-title":"Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death","volume":"31","author":"Lemasters","year":"1999","journal-title":"J Bioenerg Biomembr"},{"key":"10.1038\/ki.2011.443_bb0175","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.mito.2010.04.006","article-title":"Indirubin-3\u2032-oxime prevents hepatic I\/R damage by inhibiting GSK-3beta and mitochondrial permeability transition","volume":"10","author":"Varela","year":"2010","journal-title":"Mitochondrion"},{"key":"10.1038\/ki.2011.443_bb0180","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/01.shk.0000209545.29671.31","article-title":"Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation","volume":"25","author":"Dugo","year":"2006","journal-title":"Shock"},{"key":"10.1038\/ki.2011.443_bb0185","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1359\/JBMR.041124","article-title":"Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene","volume":"20","author":"Alam","year":"2005","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.2011.443_bb0190","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1097\/01.ASN.0000141962.44300.3A","article-title":"Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES","volume":"15","author":"Gong","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.443_bb0195","doi-asserted-by":"crossref","first-page":"R316","DOI":"10.1186\/bcr793","article-title":"Promoter methylation regulates cyclooxygenase expression in breast cancer","volume":"6","author":"Ma","year":"2004","journal-title":"Breast Cancer Res"},{"key":"10.1038\/ki.2011.443_bb0200","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1471-4159.2004.02155.x","article-title":"Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules","volume":"88","author":"Cho","year":"2004","journal-title":"J Neurochem"},{"key":"10.1038\/ki.2011.443_bb0205","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1681\/ASN.2006020185","article-title":"Anti-inflammatory effect of hepatocyte growth factor in chronic kidney disease: targeting the inflamed vascular endothelium","volume":"17","author":"Gong","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2011.443_bb0210","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1124\/jpet.108.136358","article-title":"Extracellular signal-regulated kinase activation mediates mitochondrial dysfunction and necrosis induced by hydrogen peroxide in renal proximal tubular cells","volume":"325","author":"Zhuang","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/ki.2011.443_bb0215","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.febslet.2008.01.047","article-title":"Activation of NO donors in mitochondria: peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochrome c releases NO and protects cells against apoptosis","volume":"582","author":"Stoyanovsky","year":"2008","journal-title":"FEBS Lett"},{"issue":"Pt 1","key":"10.1038\/ki.2011.443_bb0220","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1042\/bj3070099","article-title":"Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide","volume":"307","author":"Nieminen","year":"1995","journal-title":"Biochem J"},{"key":"10.1038\/ki.2011.443_bb0225","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/ki.2008.380","article-title":"Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockade","volume":"74","author":"Chen","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2011.443_bb0230","doi-asserted-by":"crossref","first-page":"H2079","DOI":"10.1152\/ajpheart.00092.2008","article-title":"Ser9 phosphorylation of mitochondrial GSK-3beta is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis","volume":"295","author":"Ohori","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815553659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815553659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T13:04:17Z","timestamp":1561208657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815553659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0085253815553659"],"URL":"https:\/\/doi.org\/10.1038\/ki.2011.443","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}