{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:40:02Z","timestamp":1791268802093,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1038\/ki.2012.139","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T16:06:22Z","timestamp":1335369982000},"page":"525-536","source":"Crossref","is-referenced-by-count":24,"title":["Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis"],"prefix":"10.1016","volume":"82","author":[{"given":"Gal","family":"Finer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. William","family":"Schnaper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashpal S.","family":"Kanwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert Y.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Hayashida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2012.139_bb0010","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2215\/CJN.04121206","article-title":"A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases","volume":"2","author":"Barisoni","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.139_bb0015","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/ki.2009.424","article-title":"Proteinuria: an enzymatic disease of the podocyte?","volume":"77","author":"Mundel","year":"2010","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.139_bb0020","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1007\/s00467-010-1503-4","article-title":"A conceptual framework for the molecular pathogenesis of progressive kidney disease","volume":"25","author":"Schnaper","year":"2010","journal-title":"Pediatr Nephrol"},{"key":"10.1038\/ki.2012.139_bb0025","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/ki.1994.122","article-title":"Sustained expression of TGF-\u03b21 underlies development of progressive kidney fibrosis","volume":"45","author":"Yamamoto","year":"1994","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.139_bb0030","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ki.1994.68","article-title":"TGF-\u03b21 in glomerulosclerosis and interstitial fibrosis of adriamycin nephropathy","volume":"45","author":"Tamaki","year":"1994","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.139_bb0035","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1097\/01.ASN.0000033611.79556.AE","article-title":"TGF-\u03b2 signaling in renal disease","volume":"13","author":"Bottinger","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.139_bb0040","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.2741\/3389","article-title":"TGF-\u03b2 signal transduction in chronic kidney disease","volume":"14","author":"Schnaper","year":"2009","journal-title":"Front Biosci"},{"key":"10.1038\/ki.2012.139_bb0045","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1096\/fj.03-0037fje","article-title":"Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-\u03b2-dependent responses in human mesangial cells","volume":"17","author":"Hayashida","year":"2003","journal-title":"FASEB J"},{"key":"10.1038\/ki.2012.139_bb0050","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1074\/jbc.M310412200","article-title":"The phosphatidylinositol 3-kinase\/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-\u03b21","volume":"279","author":"Runyan","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2012.139_bb0055","doi-asserted-by":"crossref","first-page":"F413","DOI":"10.1152\/ajprenal.00082.2003","article-title":"Smad3 and PKC\u03b4 mediate TGF-\u03b21-induced collagen I expression in human mesangial cells","volume":"285","author":"Runyan","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2012.139_bb0060","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1097\/01.ASN.0000076079.02452.92","article-title":"Cytoskeletal rearrangement and signal transduction in TGF-\u03b21-stimulated mesangial cell collagen accumulation","volume":"14","author":"Hubchak","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.139_bb0065","doi-asserted-by":"crossref","first-page":"F1316","DOI":"10.1152\/ajprenal.00345.2009","article-title":"Rac1 promotes TGF-\u03b2-stimulated mesangial cell type I collagen expression through a PI3K\/Akt-dependent mechanism","volume":"297","author":"Hubchak","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2012.139_bb0070","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1681\/ASN.2006070754","article-title":"Role of the Akt\/FoxO3a pathway in TGF-\u03b21-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease","volume":"17","author":"Kato","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.139_bb0075","doi-asserted-by":"crossref","first-page":"7667","DOI":"10.1073\/pnas.97.14.7667","article-title":"Transforming growth factor \u03b2 contributes to progressive diabetic nephropathy","volume":"97","author":"Reeves","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2012.139_bb0080","doi-asserted-by":"crossref","first-page":"F215","DOI":"10.1152\/ajprenal.00548.2007","article-title":"Protein kinase B\/Akt activity is involved in renal TGF-\u03b21-driven epithelial-mesenchymal transition in vitro and in vivo","volume":"295","author":"Kattla","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2012.139_bb0085","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1053\/snep.2003.50015","article-title":"Animal models of FSGS: lessons for pathogenesis and treatment","volume":"23","author":"Fogo","year":"2003","journal-title":"Semin Nephrol"},{"key":"10.1038\/ki.2012.139_bb0090","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/ki.1986.28","article-title":"Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease","volume":"29","author":"Okuda","year":"1986","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.139_bb0095","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.2353\/ajpath.2010.091071","article-title":"Adriamycin nephropathy: a failure of endothelial progenitor cell-induced repair","volume":"176","author":"Yasuda","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2012.139_bb0100","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.2353\/ajpath.2006.060169","article-title":"Inhibition of p38 mitogen-activated protein kinase and transforming growth factor-\u03b21\/Smad signaling pathways modulates the development of fibrosis in adriamycin-induced nephropathy","volume":"169","author":"Li","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2012.139_bb0105","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1159\/000166599","article-title":"Rapamycin attenuates the severity of murine adriamycin nephropathy","volume":"29","author":"Lui","year":"2009","journal-title":"Am J Nephrol"},{"key":"10.1038\/ki.2012.139_bb0110","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1073\/pnas.0409786102","article-title":"A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse","volume":"102","author":"Zheng","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2012.139_bb0115","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1172\/JCI43721","article-title":"Prkdc participates in mitochondrial genome maintenance and prevents adriamycin-induced nephropathy in mice","volume":"120","author":"Papeta","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2012.139_bb0120","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2337\/db06-1018","article-title":"Evidence for a role of transforming growth factor-\u03b21 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor","volume":"56","author":"Russo","year":"2007","journal-title":"Diabetes"},{"key":"10.1038\/ki.2012.139_bb0125","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/nm0905-924","article-title":"Modulating autoimmunity: pick your PI3 kinase","volume":"11","author":"Ohashi","year":"2005","journal-title":"Nat Med"},{"key":"10.1038\/ki.2012.139_bb0130","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/nm1284","article-title":"Blockade of PI3K\u03b3 suppresses joint inflammation and damage in mouse models of rheumatoid arthritis","volume":"11","author":"Camps","year":"2005","journal-title":"Nat Med"},{"key":"10.1038\/ki.2012.139_bb0135","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1681\/ASN.V85697","article-title":"Induction of differentiation in cultured rat and human podocytes","volume":"8","author":"Mundel","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.139_bb0140","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1749-6632.2010.05817.x","article-title":"Hereditary kidney diseases: highlighting the importance of classical Mendelian phenotypes","volume":"1214","author":"Benoit","year":"2010","journal-title":"Ann NY Acad Sci"},{"key":"10.1038\/ki.2012.139_bb0145","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2174\/157339911794273900","article-title":"The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy","volume":"7","author":"Kumar","year":"2011","journal-title":"Curr Diabetes Rev"},{"key":"10.1038\/ki.2012.139_bb0150","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.addr.2010.08.012","article-title":"Targeting podocyte-associated diseases","volume":"62","author":"Leeuwis","year":"2010","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1038\/ki.2012.139_bb0155","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1046\/j.1523-1755.2000.00342.x","article-title":"Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events","volume":"58","author":"Wang","year":"2000","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.139_bb0160","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1160\/TH05-07-0476","article-title":"Signaling through PI3K\u03b3: a common platform for leukocyte, platelet and cardiovascular stress sensing","volume":"95","author":"Hirsch","year":"2006","journal-title":"Thromb Haemost"},{"key":"10.1038\/ki.2012.139_bb0165","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tibs.2005.02.008","article-title":"Signalling by PI3K isoforms: insights from gene-targeted mice","volume":"30","author":"Vanhaesebroeck","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"10.1038\/ki.2012.139_bb0170","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tibs.2009.01.003","article-title":"Regulation of phosphoinositide 3-kinase expression in health and disease","volume":"34","author":"Kok","year":"2009","journal-title":"Trends Biochem Sci"},{"key":"10.1038\/ki.2012.139_bb0175","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/sj.ki.5002691","article-title":"Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes","volume":"73","author":"Zhu","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.139_bb0180","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nm1291","article-title":"PI3K\u03b3 inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus","volume":"11","author":"Barber","year":"2005","journal-title":"Nat Med"},{"issue":"Suppl 1","key":"10.1038\/ki.2012.139_bb0185","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000312132","article-title":"The pathophysiological roles of PI3Ks and therapeutic potential of selective inhibitors in allergic inflammation","volume":"152","author":"Takeda","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1038\/ki.2012.139_bb0190","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1681\/ASN.V102271","article-title":"Renal expression of fibrotic matrix proteins and of transforming growth factor-\u03b2 isoforms in TGF-\u03b2 transgenic mice","volume":"10","author":"Mozes","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.139_bb0195","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1681\/ASN.2004121055","article-title":"TGF-\u03b2 concentration specifies differential signaling profiles of growth arrest\/differentiation and apoptosis in podocytes","volume":"16","author":"Wu","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.139_bb0200","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0022-2143(97)90180-3","article-title":"Cell lines with extended in vitro growth potential from human renal proximal tubule: characterization, response to inducers, and comparison with established cell lines","volume":"129","author":"Racusen","year":"1997","journal-title":"J Lab Clin Med"},{"key":"10.1038\/ki.2012.139_bb0205","doi-asserted-by":"crossref","first-page":"30741","DOI":"10.1074\/jbc.M110.105700","article-title":"Loss of \u03b21-integrin enhances TGF-\u03b21-induced collagen expression in epithelial cells via increased \u03b1v\u03b23-integrin and Rac1 activity","volume":"285","author":"Hayashida","year":"2010","journal-title":"J Biol Chem"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815555877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815555877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T05:00:33Z","timestamp":1642136433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815555877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0085253815555877"],"URL":"https:\/\/doi.org\/10.1038\/ki.2012.139","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}