{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:21:46Z","timestamp":1771374106539,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"vor","delay-in-days":1462,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1038\/ki.2012.264","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T14:05:04Z","timestamp":1343829904000},"page":"1105-1113","source":"Crossref","is-referenced-by-count":80,"title":["Probenecid prevents acute tubular necrosis in a mouse model of aristolochic acid nephropathy"],"prefix":"10.1016","volume":"82","author":[{"given":"Thomas E.R.","family":"Baudoux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka A.","family":"Pozdzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker M.","family":"Arlt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric G.","family":"De Prez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Antoine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Quellard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Michel","family":"Goujon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00eblle L.","family":"Nortier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2012.264_bb0010","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0140-6736(93)92984-2","article-title":"Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs","volume":"341","author":"Vanherweghem","year":"1993","journal-title":"Lancet"},{"key":"10.1038\/ki.2012.264_bb0015","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0140-6736(94)90964-4","article-title":"Identification of aristolochic acid in Chinese herbs","volume":"343","author":"Vanhaelen","year":"1994","journal-title":"Lancet"},{"key":"10.1038\/ki.2012.264_bb0020","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0272-6386(12)80178-8","article-title":"Pathologic aspects of a newly described nephropathy related to the prolonged use of Chinese herbs","volume":"24","author":"Depierreux","year":"1994","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2012.264_bb0025","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1038\/ki.1994.220","article-title":"Chinese herbs nephropathy: a clue to Balkan endemic nephropathy?","volume":"45","author":"Cosyns","year":"1994","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.264_bb0030","first-page":"2025","article-title":"Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy","volume":"56","author":"Schmeiser","year":"1996","journal-title":"Cancer Res"},{"key":"10.1038\/ki.2012.264_bb0035","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1056\/NEJM200006083422301","article-title":"Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)","volume":"342","author":"Nortier","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2012.264_bb0040","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1046\/j.1523-1755.2001.00731.x","article-title":"Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy?","volume":"59","author":"Cosyns","year":"2001","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.264_bb0045","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1681\/ASN.V132431","article-title":"Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats","volume":"13","author":"Debelle","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.264_bb0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1211\/0022357023051","article-title":"Acute nephrotoxicity of aristolochic acids in mice","volume":"56","author":"Sato","year":"2004","journal-title":"J Pharm Pharmacol"},{"key":"10.1038\/ki.2012.264_bb0055","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1124\/dmd.107.014688","article-title":"Selective toxicity of aristolochic acids I and II","volume":"35","author":"Shibutani","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1038\/ki.2012.264_bb0060","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1093\/ndt\/gfn140","article-title":"Patterns of interstitial inflammation during the evolution of renal injury in experimental aristolochic acid nephropathy","volume":"23","author":"Pozdzik","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.264_bb0065","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/sj.ki.5002714","article-title":"Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation","volume":"73","author":"Pozdzik","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.264_bb0070","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1046\/j.1523-1755.2001.00938.x","article-title":"Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells","volume":"60","author":"Lebeau","year":"2001","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.264_bb0075","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1124\/mol.109.056564","article-title":"Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis","volume":"76","author":"Ahn","year":"2009","journal-title":"Mol Pharmacol"},{"key":"10.1038\/ki.2012.264_bb0080","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/ncpneph0558","article-title":"Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues","volume":"3","author":"Nigam","year":"2007","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1038\/ki.2012.264_bb0085","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1681\/ASN.V113383","article-title":"Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1","volume":"11","author":"Ho","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.264_bb0090","doi-asserted-by":"crossref","first-page":"26391","DOI":"10.1074\/jbc.M111.249292","article-title":"Deletion of multispecific organic anion transporter Oat1\/Slc22a6 protects against mercury-induced kidney injury","volume":"286","author":"Torres","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1038\/ki.2012.264_bb0095","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1254\/jphs.09339SC","article-title":"Interactions of human organic anion transporters with aristolochic acids","volume":"113","author":"Babu","year":"2010","journal-title":"J Pharmacol Sci"},{"key":"10.1038\/ki.2012.264_bb0100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tox.2009.07.014","article-title":"Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy","volume":"264","author":"Bakhiya","year":"2009","journal-title":"Toxicology"},{"key":"10.1038\/ki.2012.264_bb0105","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/taap.1996.0020","article-title":"Acetaminophen nephrotoxicity in the CD-1 mouse. II. Protection by probenecid and AT-125 without diminution of renal covalent binding","volume":"136","author":"Emeigh Hart","year":"1996","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1038\/ki.2012.264_bb0110","first-page":"210","article-title":"Distribution of enkephalinase (membrane metalloendopeptidase, E.C. 3.4.24.11) in rat organs. Detection using a monoclonal antibody","volume":"58","author":"Ronco","year":"1988","journal-title":"Lab Invest"},{"key":"10.1038\/ki.2012.264_bb0115","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/ndt\/gfi042","article-title":"Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies","volume":"20","author":"Lebeau","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.264_bb0120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/ijc.25324","article-title":"Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice","volume":"128","author":"Arlt","year":"2011","journal-title":"Int J Cancer"},{"key":"10.1038\/ki.2012.264_bb0125","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2007.05.003","article-title":"PCNA, the maestro of the replication fork","volume":"129","author":"Moldovan","year":"2007","journal-title":"Cell"},{"key":"10.1038\/ki.2012.264_bb0130","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/ki.2008.129","article-title":"Aristolochic acid nephropathy: a worldwide problem","volume":"74","author":"Debelle","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.264_bb0135","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/ndt\/gfr291","article-title":"Aristolochic acid nephropathy: variation in presentation and prognosis","volume":"27","author":"Yang","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.264_bb0140","doi-asserted-by":"crossref","first-page":"8241","DOI":"10.1073\/pnas.1119920109","article-title":"Aristolochic acid-associated urothelial cancer in Taiwan","volume":"109","author":"Chen","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2012.264_bb0145","doi-asserted-by":"crossref","first-page":"F1807","DOI":"10.1152\/ajprenal.90409.2008","article-title":"Renal organic anion transporter 1 is maldistributed and diminishes in proximal tubule cells but increases in vasculature after ischemia and reperfusion","volume":"295","author":"Kwon","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2012.264_bb0150","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1021\/mp100418u","article-title":"Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I","volume":"8","author":"Xue","year":"2011","journal-title":"Mol Pharm"},{"key":"10.1038\/ki.2012.264_bb0155","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/ndt\/18.2.426","article-title":"Invasive urothelial carcinoma after exposure to Chinese herbal medicine containing aristolochic acid may occur without severe renal failure","volume":"18","author":"Nortier","year":"2003","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.264_bb0160","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1124\/jpet.111.180984","article-title":"Physiological and molecular characterization of aristolochic acid transport by the kidney","volume":"338","author":"Dickman","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1038\/ki.2012.264_bb0165","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1111\/j.1523-1755.2005.00277.x","article-title":"Structure activity relationships of aristolochic acid analogues: toxicity in cultured renal epithelial cells","volume":"67","author":"Balachandran","year":"2005","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.264_bb0170","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/ki.2008.125","article-title":"Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid","volume":"73","author":"Stiborova","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.264_bb0175","first-page":"141","article-title":"Chemical and molecular basis of the carcinogenicity of aristolochia plants","volume":"12","author":"Schmeiser","year":"2009","journal-title":"Curr Opin Drug Discov Devel"},{"key":"10.1038\/ki.2012.264_bb0180","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.taap.2007.03.029","article-title":"Role of mitochondrial permeability transition in human renal tubular epithelial cell death induced by aristolochic acid","volume":"222","author":"Qi","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1038\/ki.2012.264_bb0185","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1007\/s10495-006-0289-0","article-title":"Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells","volume":"11","author":"Hsin","year":"2006","journal-title":"Apoptosis"},{"key":"10.1038\/ki.2012.264_bb0190","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.tiv.2011.01.016","article-title":"Aristolochic acid I induced oxidative DNA damage associated with glutathione depletion and ERK1\/2 activation in human cells","volume":"25","author":"Yu","year":"2011","journal-title":"Toxicol In Vitro"},{"key":"10.1038\/ki.2012.264_bb0195","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s00204-006-0090-4","article-title":"Aristolochic acid I-induced DNA damage and cell cycle arrest in renal tubular epithelial cells in vitro","volume":"80","author":"Li","year":"2006","journal-title":"Arch Toxicol"},{"key":"10.1038\/ki.2012.264_bb0200","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.fct.2006.08.020","article-title":"Aristolochic acid-induced cell cycle G1 arrest in human urothelium SV-HUC-1 cells","volume":"45","author":"Chang","year":"2007","journal-title":"Food Chem Toxicol"},{"key":"10.1038\/ki.2012.264_bb0205","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","article-title":"Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury","volume":"16","author":"Yang","year":"2010","journal-title":"Nat Med"},{"key":"10.1038\/ki.2012.264_bb0210","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1038\/nprot.2007.394","article-title":"The 32P-postlabeling assay for DNA adducts","volume":"2","author":"Phillips","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1038\/ki.2012.264_bb0215","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/ijc.25324","article-title":"Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice","volume":"128","author":"Arlt","year":"2011","journal-title":"Int J Cancer"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815554525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815554525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T03:02:03Z","timestamp":1643079723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815554525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0085253815554525"],"URL":"https:\/\/doi.org\/10.1038\/ki.2012.264","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}