{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:39:47Z","timestamp":1790771987232,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"vor","delay-in-days":1462,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1038\/ki.2012.266","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T10:05:04Z","timestamp":1343815504000},"page":"1114-1120","source":"Crossref","is-referenced-by-count":83,"title":["Mild elevation of urinary biomarkers in prerenal acute kidney injury"],"prefix":"10.1016","volume":"82","author":[{"given":"Kent","family":"Doi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Katagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousuke","family":"Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Hamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yahagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sugaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisei","family":"Noiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2012.266_bb0010","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.ASN.0000048852.53881.D9","article-title":"Transitioning to therapy in ischemic acute renal failure","volume":"14","author":"Molitoris","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.266_bb0015","doi-asserted-by":"crossref","first-page":"864","DOI":"10.2215\/CJN.04851107","article-title":"A framework and key research questions in AKI diagnosis and staging in different environments","volume":"3","author":"Murray","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.266_bb0020","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/sj.ki.5002729","article-title":"Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review","volume":"73","author":"Coca","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.266_bb0025","doi-asserted-by":"crossref","first-page":"F697","DOI":"10.1152\/ajprenal.00448.2010","article-title":"Clearance and beyond: the complementary roles of GFR measurement and injury biomarkers in acute kidney injury (AKI)","volume":"301","author":"Endre","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2012.266_bb0030","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1681\/ASN.2010080796","article-title":"Biological markers of acute kidney injury","volume":"22","author":"Siew","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.266_bb0035","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1007\/s00467-007-0470-x","article-title":"Biomarkers for the early detection of acute kidney injury","volume":"23","author":"Nguyen","year":"2008","journal-title":"Pediatr Nephrol"},{"key":"10.1038\/ki.2012.266_bb0040","doi-asserted-by":"crossref","first-page":"S159","DOI":"10.1097\/CCM.0b013e318168c652","article-title":"New biomarkers of acute kidney injury","volume":"36","author":"Parikh","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1038\/ki.2012.266_bb0045","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/MNH.0b013e3282f08745","article-title":"Biomarkers for the diagnosis of acute kidney injury","volume":"16","author":"Waikar","year":"2007","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1038\/ki.2012.266_bb0050","doi-asserted-by":"crossref","first-page":"F669","DOI":"10.1152\/ajprenal.90513.2008","article-title":"Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury","volume":"296","author":"Noiri","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2012.266_bb0055","doi-asserted-by":"crossref","first-page":"402","DOI":"10.2215\/CJN.06960909","article-title":"Urine microscopy is associated with severity and worsening of acute kidney injury in hospitalized patients","volume":"5","author":"Perazella","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.266_bb0060","doi-asserted-by":"crossref","first-page":"962","DOI":"10.2215\/CJN.04971107","article-title":"Evaluation and initial management of acute kidney injury","volume":"3","author":"Himmelfarb","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.266_bb0065","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrneph.2009.213","article-title":"Fluid balance and acute kidney injury","volume":"6","author":"Prowle","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"10.1038\/ki.2012.266_bb0070","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/ki.2009.159","article-title":"Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury","volume":"76","author":"Bouchard","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.266_bb0075","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/ki.2012.23","article-title":"Some biomarkers of acute kidney injury are increased in pre-renal injury","volume":"81","author":"Nejat","year":"2012","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.266_bb0080","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1097\/CCM.0b013e318225761a","article-title":"Evaluation of new acute kidney injury biomarkers in a mixed intensive care unit","volume":"39","author":"Doi","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1038\/ki.2012.266_bb0085","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/ki.2008.106","article-title":"Renal L-type fatty acid-binding protein mediates the bezafibrate reduction of cisplatin-induced acute kidney injury","volume":"73","author":"Negishi","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.266_bb0090","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.2353\/ajpath.2009.080644","article-title":"Monitoring of urinary L-type fatty acid-binding protein predicts histological severity of acute kidney injury","volume":"174","author":"Negishi","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2012.266_bb0095","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1046\/j.1432-1327.1998.2530743.x","article-title":"Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state","volume":"253","author":"Arteel","year":"1998","journal-title":"Eur J Biochem"},{"key":"10.1038\/ki.2012.266_bb0100","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1681\/ASN.2011040325","article-title":"Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury","volume":"23","author":"Ralib","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.266_bb0105","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7326\/0003-4819-148-11-200806030-00003","article-title":"Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury","volume":"148","author":"Nickolas","year":"2008","journal-title":"Ann Intern Med"},{"key":"10.1038\/ki.2012.266_bb0110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/ki.2011.41","article-title":"Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes","volume":"80","author":"Singer","year":"2011","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.266_bb0115","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nm.2290","article-title":"The Ngal reporter mouse detects the response of the kidney to injury in real time","volume":"17","author":"Paragas","year":"2011","journal-title":"Nat Med"},{"key":"10.1038\/ki.2012.266_bb0120","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1681\/ASN.V113454","article-title":"Relationship between expression of Bcl-2 genes and growth factors in ischemic acute renal failure in the rat","volume":"11","author":"Gobe","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.266_bb0125","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/sj.ki.5002715","article-title":"Urinary biomarkers in the early diagnosis of acute kidney injury","volume":"73","author":"Han","year":"2008","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.266_bb0130","doi-asserted-by":"crossref","first-page":"F628","DOI":"10.1152\/ajprenal.00654.2010","article-title":"Renal cortical albumin gene induction and urinary albumin excretion in response to acute kidney injury","volume":"300","author":"Ware","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1038\/ki.2012.266_bb0135","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1053\/j.ajkd.2003.10.040","article-title":"Urinary interleukin-18 is a marker of human acute tubular necrosis","volume":"43","author":"Parikh","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2012.266_bb0140","doi-asserted-by":"crossref","first-page":"873","DOI":"10.2215\/CJN.04810908","article-title":"Urinary biomarkers in the early detection of acute kidney injury after cardiac surgery","volume":"4","author":"Han","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.266_bb0145","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.athoracsur.2011.10.048","article-title":"Combination of two urinary biomarkers predicts acute kidney injury after adult cardiac surgery","volume":"93","author":"Katagiri","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1038\/ki.2012.266_bb0150","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/ki.2010.555","article-title":"Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function","volume":"79","author":"Endre","year":"2011","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.266_bb0155","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1681\/ASN.2007010097","article-title":"Renal L-type fatty acid-binding protein in acute ischemic injury","volume":"18","author":"Yamamoto","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.266_bb0160","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1097\/CCM.0b013e3181eedac0","article-title":"Urinary L-type fatty acid-binding protein as a new biomarker of sepsis complicated with acute kidney injury","volume":"38","author":"Doi","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1038\/ki.2012.266_bb0165","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.2353\/ajpath.2009.080511","article-title":"Urinary L-type fatty acid-binding protein can reflect renal tubulointerstitial injury","volume":"174","author":"Tanaka","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1038\/ki.2012.266_bb0170","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/sj.ki.5000300","article-title":"Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects","volume":"69","author":"Yasuda","year":"2006","journal-title":"Kidney Int"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815554537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815554537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T22:02:04Z","timestamp":1643061724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815554537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0085253815554537"],"URL":"https:\/\/doi.org\/10.1038\/ki.2012.266","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717968516.793468251","asserted-by":"object"}]},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}