{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:54:03Z","timestamp":1790268843371,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":1461,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1038\/ki.2012.288","type":"journal-article","created":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T12:47:26Z","timestamp":1345034846000},"page":"121-128","source":"Crossref","is-referenced-by-count":125,"title":["Plasma Klotho is not related to kidney function and does not predict adverse outcome in patients with chronic kidney disease"],"prefix":"10.1016","volume":"83","author":[{"given":"Sarah","family":"Seiler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz J.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fehrenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Fl\u00fcgge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Herath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Weihrauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Fliser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar H.","family":"Heine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1038\/ki.2012.288_bb0010","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1097\/01.ASN.0000133041.27682.A2","article-title":"Mineral metabolism, mortality, and morbidity in maintenance hemodialysis","volume":"15","author":"Block","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.288_bb0015","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1053\/j.ajkd.2008.05.020","article-title":"Disordered mineral metabolism in hemodialysis patients: an analysis of cumulative effects in the Hemodialysis (HEMO) Study","volume":"52","author":"Wald","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2012.288_bb0020","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1681\/ASN.2004070602","article-title":"Serum phosphate levels and mortality risk among people with chronic kidney disease","volume":"16","author":"Kestenbaum","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.288_bb0025","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1053\/j.ajkd.2008.03.020","article-title":"Mortality risk for dialysis patients with different levels of serum calcium, phosphorus, and PTH: the Dialysis Outcomes and Practice Patterns Study (DOPPS)","volume":"52","author":"Tentori","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2012.288_bb0030","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ki.2009.288","article-title":"Chronic kidney disease, hypovitaminosis D, and mortality in the United States","volume":"76","author":"Mehrotra","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.288_bb0035","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/ki.2008.501","article-title":"Vitamin D levels and patient outcome in chronic kidney disease","volume":"75","author":"Ravani","year":"2009","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.288_bb0040","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/sj.ki.5002451","article-title":"Vitamin D levels and early mortality among incident hemodialysis patients","volume":"72","author":"Wolf","year":"2007","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.288_bb0045","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1359\/JBMR.0301264","article-title":"FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis","volume":"19","author":"Shimada","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1038\/ki.2012.288_bb0050","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/ki.2011.47","article-title":"Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease","volume":"79","author":"Isakova","year":"2011","journal-title":"Kidney Int"},{"key":"10.1038\/ki.2012.288_bb0055","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.2215\/CJN.08241109","article-title":"Fibroblast growth factor-23 in early chronic kidney disease: additional support in favor of a phosphate-centric paradigm for the pathogenesis of secondary hyperparathyroidism","volume":"5","author":"Evenepoel","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.288_bb0060","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1681\/ASN.2009121311","article-title":"Klotho deficiency causes vascular calcification in chronic kidney disease","volume":"22","author":"Hu","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.288_bb0065","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1053\/j.ajkd.2010.12.027","article-title":"Role of Klotho in aging, phosphate metabolism, and CKD","volume":"58","author":"John","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"10.1038\/ki.2012.288_bb0070","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1093\/ndt\/gfr208","article-title":"The potential roles of FGF23 and Klotho in the prognosis of renal and cardiovascular diseases","volume":"26","author":"Bernheim","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.288_bb0075","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/gerona\/glr058","article-title":"Plasma klotho and mortality risk in older community-dwelling adults","volume":"66","author":"Semba","year":"2011","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1038\/ki.2012.288_bb0080","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.bbrc.2010.06.110","article-title":"Establishment of sandwich ELISA for soluble alpha-Klotho measurement: age-dependent change of soluble alpha-Klotho levels in healthy subjects","volume":"398","author":"Yamazaki","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1038\/ki.2012.288_bb0085","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1681\/ASN.2006080936","article-title":"Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study","volume":"18","author":"Fliser","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.288_bb0090","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1093\/ndt\/gfq309","article-title":"FGF-23 and future cardiovascular events in patients with chronic kidney disease before initiation of dialysis treatment","volume":"25","author":"Seiler","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.288_bb0095","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1001\/jama.2011.826","article-title":"Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease","volume":"305","author":"Isakova","year":"2011","journal-title":"JAMA"},{"key":"10.1038\/ki.2012.288_bb0100","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1056\/NEJMoa0706130","article-title":"Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis","volume":"359","author":"Gutierrez","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1038\/ki.2012.288_bb0105","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2012.288_bb0110","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1093\/ndt\/gfp784","article-title":"The role of FGF-23 in CKD-MBD and cardiovascular disease: friend or foe?","volume":"25","author":"Larsson","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.288_bb0115","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s10157-011-0511-4","article-title":"Circulating levels of soluble alpha-Klotho in patients with chronic kidney disease","volume":"15","author":"Sugiura","year":"2011","journal-title":"Clin Exp Nephrol"},{"key":"10.1038\/ki.2012.288_bb0120","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s10157-011-0582-2","article-title":"The relationship between the soluble Klotho protein and the residual renal function among peritoneal dialysis patients","volume":"16","author":"Akimoto","year":"2012","journal-title":"Clin Exp Nephrol"},{"key":"10.1038\/ki.2012.288_bb0125","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2215\/CJN.09020911","article-title":"Soluble Klotho and autosomal dominant polycystic kidney disease","volume":"7","author":"Pavik","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1038\/ki.2012.288_bb0130","series-title":"Clin Exp Nephrol","article-title":"Serum levels of soluble secreted alpha-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis","author":"Shimamura","year":"2012"},{"key":"10.1038\/ki.2012.288_bb0135","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1309\/AJCPGPMAF7SFRBO4","article-title":"Validation of an immunoassay for soluble Klotho protein: decreased levels in diabetes and increased levels in chronic kidney disease","volume":"137","author":"Devaraj","year":"2012","journal-title":"Am J Clin Pathol"},{"key":"10.1038\/ki.2012.288_bb0140","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/ndt\/gfm672","article-title":"Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23","volume":"23","author":"Marsell","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1038\/ki.2012.288_bb0145","first-page":"4003","article-title":"The parathyroid is a target organ for FGF23 in rats","volume":"117","author":"Ben-Dov","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1038\/ki.2012.288_bb0150","doi-asserted-by":"crossref","first-page":"E352","DOI":"10.1210\/jc.2010-0589","article-title":"Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian variance, effects of treatment, and relationship to parathyroid status","volume":"95","author":"Carpenter","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1038\/ki.2012.288_bb0155","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijcard.2007.02.029","article-title":"HMG-CoA reductase inhibition improves anti-aging klotho protein expression and arteriosclerosis in rats with chronic inhibition of nitric oxide synthesis","volume":"123","author":"Kuwahara","year":"2008","journal-title":"Int J Cardiol"},{"key":"10.1038\/ki.2012.288_bb0160","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijcard.2007.04.054","article-title":"Statins ameliorate atherosclerosis induced by inhibition of nitric oxide synthase: another novel vascular protective mechanism?","volume":"123","author":"Tousoulis","year":"2008","journal-title":"Int J Cardiol"},{"key":"10.1038\/ki.2012.288_bb0165","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1073\/pnas.0611079104","article-title":"Amelioration of progressive renal injury by genetic manipulation of Klotho gene","volume":"104","author":"Haruna","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1038\/ki.2012.288_bb0170","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1096\/fj.10-154765","article-title":"Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule","volume":"24","author":"Hu","year":"2010","journal-title":"FASEB J"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815556883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253815556883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T12:55:01Z","timestamp":1542804901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253815556883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0085253815556883"],"URL":"https:\/\/doi.org\/10.1038\/ki.2012.288","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}